Early child adversity and psychopathology in adulthood: HPA axis and cognitive dysregulations as potential mechanisms
Publication date: 13 July 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 85 Author(s): Catherine Raymond, Marie-France Marin, Danie Majeur, Sonia Lupien Early adversity (EA) has been shown to be a potent risk factor for developing a psychopathology in adulthood. Alterations of the stress system in addition to changes in brain development have been suggested to explain some of the psychopathologies associated with EA. The stress response involves the activation of the hypothalamic-pituitary-adrenal (HPA)-axis, which leads to the production of glucocorticoids (GCs; cortisol in humans). Be...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - May 18, 2018 Category: Psychiatry Source Type: research

Pharmacogenetic tests to guide drug treatment in depression: Comparison of the available testing kits and clinical trials
Publication date: 30 August 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 86 Author(s): Chiara Fabbri, Joseph Zohar, Alessandro Serretti The empirical approach to drug choice and dosing in depression often results into inadequate response and side effects. Pharmacogenetic (PGx) testing appears a promising way to implement personalized treatments. A systematic review was performed to identify available PGx tests, compare the genes they include with clinical guidelines and drug labels, and assess the quality of published clinical studies. ~40 commercial PGx tests are available and potent...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - May 18, 2018 Category: Psychiatry Source Type: research

The basolateral amygdala dopaminergic system contributes to the improving effect of nicotine on stress-induced memory impairment in rats
Publication date: 30 August 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 86 Author(s): Elnaz Keshavarzian, Zahra Ghasemzadeh, Ameneh Rezayof Stress seems to be an important risk factor in the beginning and continuing stages of cigarette tobacco smoking in humans. Considering that both of nicotine administration and stress exposure affect cognitive functions including memory formation, the aim of the present study was 1) to evaluate the effect of subcutaneous (s.c.) administration of nicotine on memory formation under stress and 2) to assess the possible role of the basolateral amygdal...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - May 18, 2018 Category: Psychiatry Source Type: research

Estradiol-induced enhancement of fear extinction in female rats: The role of NMDA receptor activation
Publication date: 30 August 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 86 Author(s): Bronwyn M. Graham, Elliot Scott Converging cross-species evidence indicates that fear extinction (the laboratory basis of exposure therapy for anxiety disorders) in females is modulated by endogenous and exogenous estradiol. The mechanisms underlying estradiol's influences on fear extinction are largely undefined. However, one likely candidate is the NMDA-receptor (NMDAr), activation of which is necessary for estradiol-mediated enhancements in structural and functional neural plasticity, as well as ...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - May 17, 2018 Category: Psychiatry Source Type: research

Hyperglycemia elicits anxiety-like behaviors in zebrafish: Protective role of dietary diphenyl diselenide
Publication date: 13 July 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 85 Author(s): Matheus M. dos Santos, Gabriel T. de Macedo, Alessandro S. Prestes, Vânia L. Loro, Graciela M. Heidrich, Rochele S. Picoloto, Denis B. Rosemberg, Nilda V. Barbosa Diabetes mellitus (DM) is a chronic metabolic disease that may comorbid with various psychiatric disorders, such as anxiety and depression. The search for effective therapeutics to alleviate hyperglycemia and complications resulting from DM is continuous. Here we investigate the effects of diphenyl diselenide (DD), an organoselenium co...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - May 8, 2018 Category: Psychiatry Source Type: research

Sleep EEG spectral power is correlated with subjective-objective discrepancy of sleep onset latency in major depressive disorder
We examined relative power values in standard frequency bands of the EEG spectra during the first Non-Rapid Eye Movement (NREM) sleep period as correlates of SOD of SOL between sleep diary and polysomnography in MDD (n = 36), PI (n = 19), and NSC (n = 23) groups. We also compared the relative spectral power of sleep EEG among MDD (n = 40), PI (n = 19), and NSC (n = 23) groups. SOD of SOL in MDD patients was positively correlated with relative sigma (r = 0.622, p corrected < 0.001), beta power (r = 0.559, p corrected = 0.002), and alpha power (r = 0.469, p corrected = 0...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - May 2, 2018 Category: Psychiatry Source Type: research

Alcohol, microbiome, and their effect on psychiatric disorders
Publication date: 13 July 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 85 Author(s): Thomas Hillemacher, Oliver Bachmann, Kai G. Kahl, Helge Frieling There is accumulating evidence that alcohol consumption and especially alcohol withdrawal increase brain levels of known innate immune signaling molecules and cause neuroinflammation. It has been shown that microbiota play a pivotal role in this process and affect central neurochemistry and behavior. Disruption of or alterations in the intimate cross-talk between microbiome and brain may be a significant factor in many psychiatric disord...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - April 30, 2018 Category: Psychiatry Source Type: research

Reduced clearance of venlafaxine in a combined treatment with quetiapine
Publication date: 13 July 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 85 Author(s): Michael Paulzen, Georgios Schoretsanitis, Christoph Hiemke, Gerhard Gründer, Ekkehard Haen, Marc Augustin Venlafaxine and the atypical antipsychotic quetiapine are often administered concomitantly. Both drugs share several metabolic hepatic pathways. However, pharmacokinetic interactions between venlafaxine and quetiapine have not been studied yet. A therapeutic drug monitoring database containing serum concentrations of venlafaxine (VEN) and its active metabolite O-desmethylvenlafaxine (ODVEN) w...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - April 30, 2018 Category: Psychiatry Source Type: research

Downregulation in Helios transcription factor signaling is associated with immune dysfunction in blood leukocytes of autistic children
Publication date: 13 July 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 85 Author(s): Sheikh F. Ahmad, Ahmed Nadeem, Mushtaq A. Ansari, Saleh A. Bakheet, Laila Yousef AL-Ayadhi, Sabry M. Attia Autism spectrum disorder (ASD) is a complex heterogeneous neurodevelopmental disorder in which immunological imbalance has been suggested to be a major etiological component. Helios, a transcription factor, has been studied extensively in the context of human T cell regulation in health and disease, yet the role of Helios signaling has not been examined in children with ASD. In the present study,...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - April 27, 2018 Category: Psychiatry Source Type: research

Prenatal ethanol induces an anxiety phenotype and alters expression of dynorphin & amp; nociceptin/orphanin FQ genes
Publication date: 13 July 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 85 Author(s): Aranza Wille-Bille, Roberto Sebastián Miranda-Morales, Mariangela Pucci, Fabio Bellia, Claudio D'Addario, Ricardo Marcos Pautassi Animal models have suggested that prenatal ethanol exposure (PEE) alters the κ opioid receptor system. The present study investigated the brain expression of dynorphin and nociceptin/orphanin FQ related genes and assessed anxiety-like behavior in the light-dark box (LDB), shelter-seeking and risk-taking behaviors in the concentric square field (CSF) test, and e...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - April 25, 2018 Category: Psychiatry Source Type: research

Minocycline adjunctive treatment to risperidone for negative symptoms in schizophrenia: Association with pro-inflammatory cytokine levels
Conclusions Schizophrenia patients showed a significant improvement in negative symptoms with the addition of minocycline to risperidone. Reducing pro-inflammatory cytokines may play an important role in the potential mechanism for efficacy. (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - April 24, 2018 Category: Psychiatry Source Type: research

Abnormal target detection and novelty processing neural response in posttraumatic stress disorder
Publication date: 13 July 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 85 Author(s): Pilar M. Sanjuan, Chloe Andrews, Eric D. Claus Attention impairments are common symptoms of posttraumatic stress disorder (PTSD); however, the nature of these impairments remains elusive. Attention impairment may arise as the result of either excessive response to task-irrelevant stimuli or reduced response to task-relevant information. To test the association between PTSD and response to task-relevant and task-irrelevant stimuli, we used a 3-tone novelty auditory oddball task (AOD). We hypothesized t...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - April 23, 2018 Category: Psychiatry Source Type: research

Self-reported pain in patients with schizophrenia. Results from the national first-step FACE-SZ cohort
Conclusion The present findings suggest that community-dwelling SZ outpatients report a high rate of self-reported physical pain, associated with headache, depression and anxiety and history of childhood trauma. Physical pain should be systematically assessed and specifically treated, when needed, in patients with SZ. (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - April 23, 2018 Category: Psychiatry Source Type: research

Increased temporal variability of striatum region facilitating the early antidepressant response in patients with major depressive disorder
Publication date: 13 July 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 85 Author(s): Zhenghua Hou, Youyong Kong, Xiaofu He, Yingying Yin, Yuqun Zhang, Yonggui Yuan The aim of this study is to identify the difference of temporal variability among major depressive disorder (MDD) patients (with different early antidepressant responses) and healthy controls (HC), and further explore the relationship between pre-treatment temporal variability and early antidepressant response. At baseline, 77 treatment-naïve inpatients with MDD and 42 matched HC received clinical assessments and 3.0 T...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - April 19, 2018 Category: Psychiatry Source Type: research

Placebo analgesia persists during sleep: An experimental study
Publication date: 13 July 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 85 Author(s): Danièle Laverdure-Dupont, Pierre Rainville, Cédric Renancio, Jacques Montplaisir, Gilles Lavigne Although placebo analgesia is a well-recognized phenomenon with important clinical implications, the possibility that placebo effects occur during sleep has received little attention. This experimental study examined whether responsiveness to acute heat pain stimuli applied during sleep could be reduced following a placebo conditioning procedure administered before sleep. Healthy individuals ...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - April 14, 2018 Category: Psychiatry Source Type: research

Neurodevelopmental synaptopathies: Insights from behaviour in rodent models of synapse gene mutations
Publication date: 8 June 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 84, Part B Author(s): J. Luo, R.H. Norris, S.L. Gordon, J. Nithianantharajah The genomic revolution has begun to unveil the enormous complexity and heterogeneity of the genetic basis of neurodevelopmental disorders such as such epilepsy, intellectual disability, autism spectrum disorder and schizophrenia. Increasingly, human mutations in synapse genes are being identified across these disorders. These neurodevelopmental synaptopathies highlight synaptic homeostasis pathways as a convergence point underlying disease ...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - April 12, 2018 Category: Psychiatry Source Type: research

SHANK genes in autism: Defining therapeutic targets
Publication date: 8 June 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 84, Part B Author(s): Adele Mossa, Federica Giona, Jessica Pagano, Carlo Sala, Chiara Verpelli (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - April 12, 2018 Category: Psychiatry Source Type: research

Synaptopathology in autism spectrum disorders: Complex effects of synaptic genes on neural circuits
Publication date: 8 June 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 84, Part B Author(s): Xinxing Wang, Rachel Kery, Qiaojie Xiong (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - April 12, 2018 Category: Psychiatry Source Type: research

Synaptic dysfunction in amygdala in intellectual disorder models
Publication date: 8 June 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 84, Part B Author(s): Marianne Aincy, Hamid Meziane, Yann Herault, Yann Humeau The amygdala is a part of the limbic circuit that has been extensively studied in terms of synaptic connectivity, plasticity and cellular organization since decades (Ehrlich et al., 2009; Ledoux, 2000; Maren, 2001). Amygdala sub-nuclei, including lateral, basolateral and central amygdala appear now as “hubs” providing in parallel and in series neuronal processing enabling the animal to elicit freezing or escaping behavior in r...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - April 12, 2018 Category: Psychiatry Source Type: research

The promise of induced pluripotent stem cells for neurodevelopmental disorders
Publication date: 8 June 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 84, Part B Author(s): Katrin Linda, Carol Fiuza, Nael Nadif Kasri A major challenge in clinical genetics and medicine is represented by genetically and phenotypically highly diverse neurodevelopmental disorders, like for example intellectual disability and autism. Intellectual disability is characterized by substantial limitations in cognitive function and adaptive behaviour. At the cellular level, this is reflected by deficits in synaptic structure and plasticity and therefore has been coined as a synaptic disorder...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - April 12, 2018 Category: Psychiatry Source Type: research

Dendritic spine actin cytoskeleton in autism spectrum disorder
Publication date: 8 June 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 84, Part B Author(s): Merja Joensuu, Vanessa Lanoue, Pirta Hotulainen Dendritic spines are small actin-rich protrusions from neuronal dendrites that form the postsynaptic part of most excitatory synapses. Changes in the shape and size of dendritic spines correlate with the functional changes in excitatory synapses and are heavily dependent on the remodeling of the underlying actin cytoskeleton. Recent evidence implicates synapses at dendritic spines as important substrates of pathogenesis in neuropsychiatric disorde...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - April 12, 2018 Category: Psychiatry Source Type: research

Synaptic proteomics as a means to identify the molecular basis of mental illness: Are we getting there?
Publication date: 8 June 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 84, Part B Author(s): Rita Reig-Viader, Carlos Sindreu, Àlex Bayés Synapses are centrally involved in many brain disorders, particularly in psychiatric and neurodevelopmental ones. However, our current understanding of the proteomic alterations affecting synaptic performance in the majority of mental illnesses is limited. As a result, novel pharmacotherapies with improved neurological efficacy have been scarce over the past decades. The main goal of synaptic proteomics in the context of mental illnesse...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - April 12, 2018 Category: Psychiatry Source Type: research

Kinases in synaptic development and neurological diseases
We describe recent advances on roles of kinases TAOK2, TNIK and CDKL5 in neuronal development and the converging pathways of LRRK2, PINK1 and GAK in Parkinson's Disease. (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - April 12, 2018 Category: Psychiatry Source Type: research

Glutamatergic synapses in neurodevelopmental disorders
Publication date: 8 June 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 84, Part B Author(s): Edoardo Moretto, Luca Murru, Giuseppe Martano, Jenny Sassone, Maria Passafaro Neurodevelopmental disorders (NDDs) are a group of diseases whose symptoms arise during childhood or adolescence and that impact several higher cognitive functions such as learning, sociability and mood. Accruing evidence suggests that a shared pathogenic mechanism underlying these diseases is the dysfunction of glutamatergic synapses. We summarize present knowledge on autism spectrum disorders (ASD), intellectual dis...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - April 12, 2018 Category: Psychiatry Source Type: research

The chromatin basis of neurodevelopmental disorders: Rethinking dysfunction along the molecular and temporal axes
Publication date: 8 June 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 84, Part B Author(s): Michele Gabriele, Alejandro Lopez Tobon, Giuseppe D'Agostino, Giuseppe Testa The complexity of the human brain emerges from a long and finely tuned developmental process orchestrated by the crosstalk between genome and environment. Vis à vis other species, the human brain displays unique functional and morphological features that result from this extensive developmental process that is, unsurprisingly, highly vulnerable to both genetically and environmentally induced alterations. One of ...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - April 12, 2018 Category: Psychiatry Source Type: research

Connecting the dots in mental illness: The synapse as the intersection of brain function and disease
Publication date: 8 June 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 84, Part B Author(s): Nael Nadif Kasri, Jess Nithianantharajah (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - April 12, 2018 Category: Psychiatry Source Type: research

The cerebellum in fear and anxiety-related disorders
Publication date: 13 July 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 85 Author(s): Josep Moreno-Rius Fear and anxiety-related disorders are highly prevalent psychiatric conditions characterized by avoidant and fearful reactions towards specific stimuli or situations, which are disproportionate given the real threat such stimuli entail. These conditions comprise the most common mental disorder group. There are a high proportion of patients who fail to achieve remission and the presence of high relapse rates indicate the therapeutic options available are far from being fully efficient...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - April 12, 2018 Category: Psychiatry Source Type: research

A schizophrenia-like behavioral trait in the SHR model: Applying confirmatory factor analysis as a new statistical tool
Publication date: 13 July 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 85 Author(s): Fernanda Fiel Peres, Raí Álvares Eufrásio, Douglas Albuquerque Gouvêa, Mariana Cepollaro Diana, Camila Maurício Santos, Walter Swardfager, Vanessa Costhek Abílio, Hugo Cogo-Moreira Questionnaires that assess symptoms of schizophrenia patients undergo strict statistical validation, often using confirmatory factor analysis (CFA). CFA allows testing the existence of a trait that both collectively explains the symptoms and gathers the information in a single genera...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - April 12, 2018 Category: Psychiatry Source Type: research

Transdiagnostic and diagnosis-specific dynamic functional connectivity anchored in the right anterior insula in major depressive disorder and bipolar depression
In this study, we examined the dynamic functional connectivity (dFC) of the rAI of 30 patients with BD, 30 patients with MDD, and 30 healthy controls. In the functional separation of rAI, the right dorsal AI (rdAI) and ventral AI (rvAI) were defined as seed regions. Sliding-window correlation of rAI subregions was implemented to measure the variance of dFC. BD and MDD shared abnormality in dFC, such as the decreased dFC between the rvAI and right ventrolateral prefrontal cortex. Others were disorder-specific and included MDD-related increases in dFC between the rvAI and right precuneus, temporal pole, and left dorsolateral...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - April 6, 2018 Category: Psychiatry Source Type: research

Meta-analysis: Risk of dry mouth with second generation antidepressants
Conclusions The current meta-analysis suggests that SSRIs, SNRIs, and atypical antidepressants are all associated with varying degrees of increased risk of dry mouth. SNRIs were associated with a significantly greater risk of dry mouth compared to SSRIs. (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - March 30, 2018 Category: Psychiatry Source Type: research

Meta regression: Relationship between antipsychotic receptor binding profiles and side-effects
Publication date: 8 June 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 84, Part A Author(s): Baris Olten, Michael H. Bloch Our objective was to examine the association between antipsychotic receptor binding profiles and the magnitude of common side-effects. We used regression analysis to examine the association between the receptor binding affinities of antipsychotic agents (log Ki) and degree of specific antipsychotic side-effects. Data on magnitude of weight gain, prolactin increase and QTc prolongation (in Standardized Mean Difference) and risk of sedation and extrapyramidal symptom...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - March 30, 2018 Category: Psychiatry Source Type: research

Zebrafish models relevant to studying central opioid and endocannabinoid systems
Publication date: Available online 28 March 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry Author(s): Konstantin A. Demin, Darya A. Meshalkina, Elana V. Kysil, Kristina A. Antonova, Andrey D. Volgin, Oleg A. Yakovlev, Polina A. Alekseeva, Maria M. Firuleva, Anton M. Lakstygal, Murilo S. de Abreu, Leonardo J.G. Barcellos, Wandong Bao, Ashton J. Friend, Tamara G. Amstislavskaya, Denis B. Rosemberg, Pavel E. Musienko, Cai Song, Allan V. Kalueff The endocannabinoid and opioid systems are two interplaying neurotransmitter systems that modulate drug abuse, anxiety, pain, cognition, neurogenesis and i...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - March 29, 2018 Category: Psychiatry Source Type: research

Differentiating between bipolar and unipolar depression in functional and structural MRI studies
Publication date: Available online 28 March 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry Author(s): Kyu-Man Han, Domenico De Berardis, Michele Fornaro, Yong-Ku Kim Distinguishing depression in bipolar disorder (BD) from unipolar depression (UD) solely based on clinical clues is difficult, which has led to the exploration of promising neural markers in neuroimaging measures for discriminating between BD depression and UD. In this article, we review structural and functional magnetic resonance imaging (MRI) studies that directly compare UD and BD depression based on neuroimaging modalities incl...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - March 28, 2018 Category: Psychiatry Source Type: research

Chronic administration of amphetamines disturbs development of neural progenitor cells in young adult nonhuman primates
Publication date: Available online 28 March 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry Author(s): Rahul R. Dutta, Michael A. Taffe, Chitra D. Mandyam The detrimental effects of amphetamines on developmental stages of NPCs are limited to rodent brain and it is not known if these effects occur in nonhuman primates which are the focus of the current investigation. Young adult rhesus macaques either experienced MDMA only, a combination of amphetamines (MDMA, MDA and methamphetamine) or no amphetamines (controls) and hippocampal tissue was processed for immunohistochemical analysis. Quantitative...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - March 28, 2018 Category: Psychiatry Source Type: research

Unpredictable chronic prenatal stress and manifestation of generalized anxiety and panic in rat's offspring
Publication date: Available online 26 March 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry Author(s): Flaviane Cristina de Brito Guzzo Soliani, Rafael Cabbia, Vinícius Dias Kümpel, Matheus Fitipaldi Batistela, Amarylis Garcia Almeida, Luiz Yamauchi Junior, Telma Gonçalves Carneiro Spera de Andrade Often the manifestation of anxiety cannot be explained by known environmental or hereditary factors. With this perspective, it has been reported that prenatal stress may lead to emotional disturbances in the offspring. However, studies relating prenatal stress to anxiety are controv...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - March 27, 2018 Category: Psychiatry Source Type: research

Applying ketamine to alleviate the PTSD-like effects by regulating the HCN1-related BDNF
Conclusion Ketamine affects the HCN1-related BDNF signaling pathways to alleviate PTSD-like effects in rat. (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - March 27, 2018 Category: Psychiatry Source Type: research

Modulatory role of conspecific alarm substance on aggression and brain monoamine oxidase activity of two zebrafish populations
Publication date: Available online 26 March 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry Author(s): Vanessa A. Quadros, Fabiano V. Costa, Julia Canzian, Cristina W. Nogueira, Denis B. RosembergGraphical abstract (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - March 26, 2018 Category: Psychiatry Source Type: research

Neurometabolite levels in antipsychotic-na ïve/free patients with schizophrenia: A systematic review and meta-analysis of 1H-MRS studies
Conclusions Our findings suggest that impaired neuronal integrity in the thalamus may be a potential trait maker in the early stages of schizophrenia. (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - March 24, 2018 Category: Psychiatry Source Type: research

Downregulation of plasma SELENBP1 protein in patients with recent-onset schizophrenia
In this study, we examined SELENBP1 mRNA expression in whole blood and protein expression in plasma from patients with recent-onset schizophrenia (n = 30), treatment-resistant schizophrenia (n = 71) and healthy controls (n = 57). We also examined the effects of SELENBP1 genetic variation on gene and protein expression. We found lower SELENBP1 plasma protein level in patients with recent-onset schizophrenia (p = 0.042) but not in treatment-resistant schizophrenia (p = 0.81). Measurement of peripheral mRNA levels showed no difference between treatment-resistant schizophrenia and healthy controls (p = ...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - March 23, 2018 Category: Psychiatry Source Type: research

mTOR signaling in the nucleus accumbens mediates behavioral sensitization to methamphetamine
Publication date: Available online 21 March 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry Author(s): Shin-Han Huang, Wan-Rong Wu, Li-Ming Lee, Pei-Rong Huang, Jin-Chung Chen Chronic psychostimulant treatment in rodents readily produces behavioral sensitization, which reflects altered brain function in response to repeated drug exposure. Numerous morphological and biochemical investigations implicate altered neural plasticity in striatal medium spiny neurons (MSNs) as an essential component in behavioral sensitization. The mammalian target of the rapamycin (mTOR) signaling pathway, a key regula...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - March 22, 2018 Category: Psychiatry Source Type: research

Intravenous infusion of xenon-containing liposomes generates rapid antidepressant-like effects
Conclusion Xe-liposomes mediate a rapid antidepressant-like effect through activation of AKT/mTOR/BDNF signaling pathway. (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - March 19, 2018 Category: Psychiatry Source Type: research

A double dissociation between two psychotic phenotypes: Periodic catatonia and cataphasia
Publication date: Available online 17 March 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry Author(s): Foucher Jack René, Zhang Yi Fan, Roser Mathilde, Lamy Julien, De Sousa Paulo Loureiro, Weibel Sébastien, Vidailhet Pierre, Mainberger Olivier, Berna Fabrice Schizophrenia as a single liability model was confronted to the multiple psychotic phenotypes model proposed by the Wernicke-Kleist-Leonhard school, focusing on two: periodic catatonia (PC) and cataphasia (C). Both are stable and heritable psychotic phenotypes with no crossed liability and are coming with the buildup of specif...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - March 19, 2018 Category: Psychiatry Source Type: research

The role of striatum and prefrontal cortex in the prevention of amphetamine-induced schizophrenia-like effects mediated by nitric oxide compounds
Publication date: Available online 16 March 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry Author(s): Ana Carolina Issy, Maurício dos-Santos-Pereira, João Francisco Cordeiro Pedrazzi, Regina Celia Cussa Kubrusly, Elaine Del-Bel Pharmacological manipulation of nitric oxide (NO) has been suggested as a promising treatment for schizophrenia symptoms. A single infusion of sodium nitroprusside, a NO donor with short half-life, was found to improve schizophrenia symptoms. However, an increasing number of preclinical studies have demonstrated the potential beneficial effects of both NO d...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - March 17, 2018 Category: Psychiatry Source Type: research

Aripiprazole as an adjuvant treatment for obsessive and compulsive symptoms in manic phase of bipolar disorder: A randomized, double-blind, placebo-controlled clinical trial
Conclusions The results of our study revealed that aripiprazole can be used as an effective adjuvant agent for treatment of obsessive and compulsive symptoms in manic patients. (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - March 13, 2018 Category: Psychiatry Source Type: research

Outcome of a three-phase treatment algorithm for inpatients with melancholic depression
Conclusion The favorable outcome of the 3-phase treatment algorithm emphasizes the importance of pursuing stepwise antidepressant treatment in patients who are nonresponsive to the first antidepressant. Clinical trial registration This study protocol is registered at http://www.controlled-trials.com, “Pharmacological Treatment of Depression” (identifier: ISRCTN73221288). (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - March 13, 2018 Category: Psychiatry Source Type: research

Anterior cingulate activation to implicit threat before and after treatment for pediatric anxiety disorders
Conclusions Effective treatments for pediatric anxiety may enhance rostral ACC response during attempts to filter out threat-relevant stimuli. These findings highlight rostral ACC activity during implicit emotion processing as a possible mechanism of CBT and SSRI treatment change among youth with anxiety disorders. (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - March 10, 2018 Category: Psychiatry Source Type: research

Neutrophil/lymphocyte ratio and platelet/lymphocyte ratio in mood disorders: A meta-analysis
Publication date: Available online 10 March 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry Author(s): Mario Gennaro Mazza, Sara Lucchi, Agnese Grazia Maria Tringali, Aurora Rossetti, Eugenia Rossana Botti, Massimo Clerici The immune and inflammatory system is involved in the etiology of mood disorders. Neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and monocyte/lymphocyte ratio (MLR) are inexpensive and reproducible biomarkers of inflammation. This is the first meta-analysis exploring the role of NLR and PLR in mood disorder. We identified 11 studies according to our inclusi...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - March 10, 2018 Category: Psychiatry Source Type: research

Interactive effects of genetic polymorphisms and childhood adversity on brain morphologic changes in depression
Publication date: Available online 10 March 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry Author(s): Yong-Ku Kim, Byung-Joo Ham, Kyu-Man Han The etiology of depression is characterized by the interplay of genetic and environmental factors and brain structural alteration. Childhood adversity is a major contributing factor in the development of depression. Interactions between childhood adversity and candidate genes for depression could affect brain morphology via the modulation of neurotrophic factors, serotonergic neurotransmission, or the hypothalamus-pituitary-adrenal (HPA) axis, and this pa...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - March 10, 2018 Category: Psychiatry Source Type: research

Altered brain functional connectivity and behaviour in a mouse model of maternal alcohol binge-drinking
Publication date: Available online 8 March 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry Author(s): Lídia Cantacorps, Héctor González-Pardo, Jorge L. Arias, Olga Valverde, Nélida M. Conejo Prenatal and perinatal alcohol exposure caused by maternal alcohol intake during gestation and lactation periods can have long-lasting detrimental effects on the brain development and behaviour of offspring. Children diagnosed with Foetal Alcohol Spectrum Disorders (FASD) display a wide range of cognitive, emotional and motor deficits, together with characteristic morphological ab...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - March 9, 2018 Category: Psychiatry Source Type: research

MDMA-assisted psychotherapy for PTSD: Are memory reconsolidation and fear extinction underlying mechanisms?
Publication date: Available online 7 March 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry Author(s): Allison A. Feduccia, Michael C. Mithoefer MDMA-assisted psychotherapy for treatment of PTSD has recently progressed to Phase 3 clinical trials and received Breakthrough Therapy designation by the FDA. MDMA used as an adjunct during psychotherapy sessions has demonstrated effectiveness and acceptable safety in reducing PTSD symptoms in Phase 2 trials, with durable remission of PTSD diagnosis in 68% of participants. The underlying psychological and neurological mechanisms for the robust effects in...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - March 8, 2018 Category: Psychiatry Source Type: research