Right temporal pole volume reduction in PTSD
In this study, healthy controls (n = 67) were matched for demographic characteristics (age, sex, race) and psychiatric controls (n = 67) were matched for demographic characteristics plus all other psychiatric diagnoses (past and current) to a group of PTSD patients (N = 67). We assessed group differences of 34 bilateral cortical structure volumes using statistically defined brain regions-of-interest from FreeSurfer between PTSD patients and healthy controls. We found 10 regions to be significantly different between PTSD and healthy controls and analyzed the group differences between PTSD and psychiatric control...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 19, 2020 Category: Psychiatry Source Type: research

Anomalous intrinsic connectivity within and between visual and auditory networks in major depressive disorder
ConclusionsOverall, our results demonstrated that abnormalities of FC in perception systems including intrinsic visual and auditory networks may explain neurobiological mechanisms underlying MDD and could serve as a potential effective biomarker. (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 16, 2020 Category: Psychiatry Source Type: research

Digital autoradiography for efficient functional imaging without anesthesia in experimental animals: Reversing phencyclidine-induced functional alterations using clozapine
Publication date: Available online 12 February 2020Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Okko Alitalo, Tomi Rantamäki, Tuulia HuhtalaAbstractAutoradiography (ARG) is a high-resolution imaging method for localization of radiolabeled biomarkers in ex vivo specimen. ARG using 2-deoxy-d-glucose (2-DG) method is used in to study drug actions on brain functional activity, as it provides results comparable to clinically used functional positron-emission tomography (PET). The requirement of slow analog detection methods and emerging advances in small animal PET imaging have, however,...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 13, 2020 Category: Psychiatry Source Type: research

Improved and residual functional abnormalities in major depressive disorder after electroconvulsive therapy
Publication date: Available online 12 February 2020Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Jiaojian Wang, Yang Ji, Xuemei Li, Zhengyu He, Qiang Wei, Tongjian Bai, Yanghua Tian, Kai WangAbstractElectroconvulsive therapy (ECT) can induce fast remission of depression but still retain the residual functional impairments in major depressive disorder (MDD) patients. To delineate the different functional circuits of effective antidepressant treatment and residual functional impairments is able to better guide clinical therapy for depression. Herein, voxel-level whole brain functional conne...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 13, 2020 Category: Psychiatry Source Type: research

Striatal dynamics as determinants of reduced gambling vulnerability in the NHE rat model of ADHD
In conclusion, the dynamics of reward systems could link an attention deficit with a decreased vulnerability to pathological gambling. (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 10, 2020 Category: Psychiatry Source Type: research

Mini-review: Aging of the neuroendocrine system: Insights from nonhuman primate models
Publication date: 8 June 2020Source: Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 100Author(s): Jacques Epelbaum, Jérémy TerrienAbstractThe neuroendocrine system (NES) plays a crucial role in synchronizing the physiology and behavior of the whole organism in response to environmental constraints. The NES consists of a hypothalamic-pituitary-target organ axis that acts in coordination to regulate growth, reproduction, stress and basal metabolism. The growth (or somatotropic), hypothalamic-pituitary-gonadal (HPG), hypothalamic-pituitary-adrenal (HPA) and hypothalamic-pituitary-thyroid ...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 10, 2020 Category: Psychiatry Source Type: research

New mechanism of neuroinflammation in Alzheimer's disease: The activation of NLRP3 inflammasome mediated by gut microbiota
In this study, the gut microbiota from AD patients were transplanted into APP/PS1 double transgenic mice. As a result, the expression of NLRP3 was increased in the intestinal tract of mice, and the expression levels of inflammatory factors in peripheral blood were also increased. Consistently, the cognitive impairment was more severe in mice receiving gut microbiota from AD patients than those did not, with activation of microglia in the central hippocampus of mice, and increased expression of neuroinflammatory factors. In APP/PS1 mice transplanted with gut microbiota from AD patients, transplantation of healthy human gut ...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 6, 2020 Category: Psychiatry Source Type: research

Inhibition of Lrrk2 reduces ethanol preference in a model of acute exposure in zebrafish
Publication date: Available online 4 February 2020Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Isadora Marques Paiva, Luana Martins de Carvalho, Isabela Martins Di Chiaccio, Isadora de Lima Assis, Elena Naranjo Sánchez, Manuel Bernabé Garcia, Felipe Norberto Alves Ferreira, Maria Luisa Cayuela, Luis David Solis Murgas, Ana Lúcia Brunialti GodardAbstractDue to its multifactorial and yet to be fully understood origin, ethanol addiction is a field that still requires studies for the elucidation of novel genes and pathways that potentially influence the establishment and...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 6, 2020 Category: Psychiatry Source Type: research

Prenatal THC exposure raises kynurenic acid levels in the prefrontal cortex of adult rats
Publication date: Available online 4 February 2020Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Sarah Beggiato, Alessandro Ieraci, Maria Cristina Tomasini, Robert Schwarcz, Luca FerraroAbstractCannabis remains one of the most widely used illicit drugs during pregnancy. The main psychoactive component of marijuana (Δ9-tetrahydrocannabinol, THC) is correlated with untoward physiological effects in the offspring. Neurobehavioral and cognitive impairments have been reported in longitudinal studies on children and adolescents prenatally exposed to marijuana, and a link to psychiatric dis...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 6, 2020 Category: Psychiatry Source Type: research

The relationship between dispositional attention to feelings and visual attention to emotion
Publication date: Available online 4 February 2020Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Anna Bujanow, Charlott Maria Bodenschatz, Monika Szymanska, Anette Kersting, Lauriane Vulliez-Coady, Thomas SuslowAbstractAttention to feelings is a core dimension of individual differences in the perception of one's emotions. It concerns the frequency with which own emotions are attended to. The aim of the present eye-tracking investigation was to examine the relationship of dispositional attention to feelings with early and late attentional processes in the visual perception of emotional info...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 4, 2020 Category: Psychiatry Source Type: research

Combination of olanzapine and samidorphan has no clinically relevant effects on ECG parameters, including the QTc interval: Results from a phase 1 QT/QTc study
ConclusionsThis thorough QT study in patients with stable schizophrenia demonstrated that OLZ/SAM, in doses and plasma concentrations up to supratherapeutic levels, does not have a clinically relevant effect on ECG parameters, including QT/QTc prolongation. (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - January 29, 2020 Category: Psychiatry Source Type: research

Hormonal responses in gambling versus alcohol abuse: A review of human studies
Publication date: Available online 28 January 2020Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Yansong Li, Nicolas Ramoz, Edmund Derrington, Jean-Claude DreherAbstractThe endocrine system plays an essential role in communication between various organs of the body to maintain homeostasis. Both substance use disorders (SUDs) and non-substance abuse disrupt this system and lead to hormonal dysregulations. Here, we focus on the comparison between the function of the endocrine system in gambling disorders and alcohol addiction to understand the commonalities and differences in their neurobiol...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - January 29, 2020 Category: Psychiatry Source Type: research

Pre-onset sub-threshold psychotic symptoms and cortical organization in the first episode of psychosis
Publication date: Available online 28 January 2020Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): R.J. Rosengard, C. Makowski, M. Chakravarty, A.K. Malla, R. Joober, J.L. Shah, M. LepageAbstractIndividuals with sub-threshold psychotic symptoms (STPS) are considered at clinical high risk for psychosis (CHR). Imaging studies comparing CHR and patients shortly after a first episode of psychosis (FEP) support progressive cortical thinning by illness stage. However, at least 30% of FEP patients deny pre-onset STPS, suggesting no history of CHR. This calls into question the generalizability of pr...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - January 28, 2020 Category: Psychiatry Source Type: research

Cross-reinstatement between 3,4-methylenedioxypyrovalerone (MDPV) and cocaine using conditioned place preference
Publication date: Available online 25 January 2020Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Leticia Duart-Castells, M. Carmen Blanco-Gandía, Carmen Ferrer-Pérez, Brigitte Puster, David Pubill, José Miñarro, Elena Escubedo, Marta Rodríguez AriasAbstract3,4-Methylenedioxypyrovalerone (MDPV) is a new psychoactive substance (NPS) considered to be a cocaine-like psychostimulant. The substitution of an established illicit drug as cocaine with an NPS is a pattern of use reported among drug users. The aim of this study was to investigate the relationship bet...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - January 26, 2020 Category: Psychiatry Source Type: research

Improving the treatment and remission of major depression in homeless people with severe mental illness: The multicentric French Housing First (FHF) program
ConclusionMDD seems to be highly prevalent, underdiagnosed and undertreated in BD and SZ homeless subjects. Beyond antidepressants, add-on strategies including complementary agents, lithium, lamotrigine/carbamazepine or anti-inflammatory drugs and the specific care of alcohol and substance use disorders may be recommended to improve the prognosis of this specific population in addition to other interventions including housing and resocialization. Violent victimization is also frequent and should be specifically prevented in this vulnerable population. (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - January 25, 2020 Category: Psychiatry Source Type: research

Ketamine effects on anxiety and fear-related behaviors: Current literature evidence and new findings
Publication date: Available online 23 January 2020Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Gabriela P. Silote, Sabrina F.S. de Oliveira, Deidiane E. Ribeiro, Mayara S. Machado, Roberto Andreatini, Sâmia R.L. Joca, Vanessa BeijaminiAbstractKetamine, a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist, presents a rapid and sustained antidepressant effect in clinical and preclinical studies. Regarding ketamine effects on anxiety, there is a widespread discordance among pre-clinical studies. To address this issue, the present study reviewed the literature (electronic ...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - January 25, 2020 Category: Psychiatry Source Type: research

Understanding the neurobiological effects of drug abuse: Lessons from zebrafish models
Publication date: Available online 22 January 2020Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Talise E. Müller, Barbara D. Fontana, Kanandra T. Bertoncello, Francini Franscescon, Nathana J. Mezzomo, Julia Canzian, Flavia V. Stefanello, Matthew O. Parker, Robert Gerlai, Denis B. RosembergAbstractDrug abuse and brain disorders related to drug comsumption are public health problems with harmful individual and social consequences. The identification of therapeutic targets and precise pharmacological treatments to these neuropsychiatric conditions associated with drug abuse are urgently...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - January 23, 2020 Category: Psychiatry Source Type: research

Subcortical structural covariance in young children with autism spectrum disorder
In this study, using volumetric-based methodology and structural covariance approach, we investigated structural covariance of subcortical brain volume in 40 young children with ASD (
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - January 23, 2020 Category: Psychiatry Source Type: research

Dose-dependent induction of CPP or CPA by intra-pVTA ethanol: Role of mu opioid receptors and effects on NMDA receptors
Publication date: Available online 22 January 2020Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Yolanda Campos-Jurado, Lucía Martí-Prats, Jose A. Morón, Ana Polache, Luis Granero, Lucía HipólitoAbstractThe neurobiological mechanisms underlying alcohol motivational properties are still not fully understood, however, the mu-opioid receptors (MORs) have been evidenced as central elements in the manifestation of the alcohol reinforcing properties. Drug-associated environmental stimuli can trigger alcohol relapse and promote alcohol consumption whereby N-meth...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - January 22, 2020 Category: Psychiatry Source Type: research

Antidepressants normalize brain flexibility associated with multi-dimensional symptoms in major depressive patients
Conclusions“Hypoflexible” CCN may involve in anxiety syndrome. Low flexibility in DMN may be indicative of hysteresis. These suggest an important pathophysiology of depressive manifestation of MDD. The antidepressant-induced normalization of the “hypoflexibility” suggests a selective pathway through which antidepressants may alleviate symptoms in depression. (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - January 22, 2020 Category: Psychiatry Source Type: research

Glycine transporter type 1 (GlyT1) inhibition improves conspecific-provoked immobility in Balb/c mice: Analysis of corticosterone response and glucocorticoid gene expression in cortex and hippocampus
Publication date: Available online 18 January 2020Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Jessica A. Burket, Jerrah C. Pickle, Allison M. Rusk, Bronson A. Haynes, Julia A. Sharp, Stephen I. DeutschAbstractStress reactivity and glucocorticoid signaling alterations are reported in mouse models of autism spectrum disorder (ASD). Balb/c mice display decreased locomotor activity in the presence of stimulus mice and spend less time exploring enclosed stimulus mice; this mouse strain has been validated as an ASD model. VU0410120, a glycine type 1 transporter (GlyT1) inhibitor, improved soc...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - January 20, 2020 Category: Psychiatry Source Type: research

White matter microstructural organizations in patients with severe treatment-resistant schizophrenia: A diffusion tensor imaging study
Publication date: Available online 18 January 2020Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Ryo Ochi, Yoshihiro Noda, Shohei Tsuchimoto, Ryosuke Tarumi, Shiori Honda, Karin Matsushita, Sakiko Tsugawa, Eric Plitman, Fumi Masuda, Kamiyu Ogyu, Masataka Wada, Takahiro Miyazaki, Shinya Fujii, M. Mallar Chakravarty, Ariel Graff-Guerrero, Hiroyuki Uchida, Masaru Mimura, Shinichiro NakajimaAbstractPrevious diffusion tensor imaging (DTI) studies have reported white matter alterations in patients with schizophrenia. Notably, one third of this population does not respond to first-line antipsycho...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - January 20, 2020 Category: Psychiatry Source Type: research

The anhedonia is differently modulated by structural covariance network of NAc in bipolar disorder and major depressive disorder
Publication date: Available online 18 January 2020Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Shaoqiang Han, Qian Cui, Xiao Wang, Yuyan Chen, Di Li, Liang Li, Xiaonan Guo, Yun-Shuang Fan, Jing Guo, Wei Sheng, Feng-Mei Lu, Zongling He, Huafu ChenAbstractDuring depressive episode, bipolar disorder (BD) patients share indistinguishable depression symptoms with major depressive disorder (MDD).However, whether neural correlates underlying the anhedonia, a core feature of depression, is different between BD and MDD remains unknown. To explore neural correlates underlying the anhedonia in BD a...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - January 20, 2020 Category: Psychiatry Source Type: research

Clinical implications of oxidative stress in schizophrenia: Acute relapse and chronic stable phase
This study aimed to investigate the platelet oxidative stress in different stages of schizophrenia (i.e., chronic stable and acute relapse) in order to clarify the clinical implications of oxidative stress and the treatment effects. We recruited 43 chronic stable patients with schizophrenia and 48 non-psychiatric controls. Platelets were collected for measuring the level of nitric oxide (NO), lipid peroxidation (LPO), and glutathione (GSH) and the activity of GSH peroxidase (GPx) and superoxide dismutase (SOD). The levels and activity were compared between patients and controls and were examined for their relationship with...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - January 17, 2020 Category: Psychiatry Source Type: research

Validation study of microRNAs previously associated with antidepressant response in older adults treated for late-life depression with venlafaxine
Publication date: Available online 16 January 2020Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Victoria S. Marshe, Farhana Islam, Malgorzata Maciukiewicz, Laura M. Fiori, Volodymyr Yerko, Jennie Yang, Gustavo Turecki, Jane A. Foster, Sidney H. Kennedy, Daniel M. Blumberger, Jordan F. Karp, James L. Kennedy, Benoit H. Mulsant, Charles F. Reynolds, Eric J. Lenze, Daniel J. MüllerAbstractBackgroundMicroRNAs (miRNAs) are small 22 nucleotides long, non-coding RNAs that are potential biomarkers for antidepressant treatment response. We aimed to replicate previous associations of miRNAs wi...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - January 17, 2020 Category: Psychiatry Source Type: research

Reduced rate of revascularization in schizophrenic patients with acute myocardial infarction: A systematic review and meta-analysis
Publication date: Available online 16 January 2020Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Minjing Shao, Chuanjun Zhuo, Xiangyang Gao, Ce Chen, Yong Xu, Hongjun Tian, Gongying Li, Deguo Jiang, Wenqiang WangAbstractImportanceIt has been suggested that patients with schizophrenia have higher than expected mortality following acute coronary events. However, the in-hospital revascularization rate in patients with schizophrenia and acute myocardial infarction (AMI) compared to mentally healthy patients remains unknown.ObjectiveTo evaluate the revascularization rate in schizophrenic patien...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - January 17, 2020 Category: Psychiatry Source Type: research

The GLP-1 receptor agonist liraglutide reverses mania-like alterations and memory deficits induced by D-amphetamine and augments lithium effects in mice: Relevance for bipolar disorder
This study points to LIRA as a promising adjunctive tool for BD treatment and provides the first rationale for the design of clinical trials investigating its possible antimanic effect. (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - January 17, 2020 Category: Psychiatry Source Type: research

Maladaptive consequences of repeated intermittent exposure to uncertainty
Publication date: Available online 15 January 2020Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Paola Mascia, Qiang Wang, Jason Brown, Kathryn M. Nesbitt, Robert T. Kennedy, Paul VezinaAbstractRecently we reported that nucleus accumbens (NAcc) dopamine (DA) tracks uncertainty during operant responding for non-caloric saccharin. We also showed that repeated intermittent exposure to this uncertainty, like exposure to drugs of abuse, leads to sensitization of the locomotor and NAcc DA effects of amphetamine and promotes the subsequent self-administration of the drug. Here we review these fin...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - January 16, 2020 Category: Psychiatry Source Type: research

From sign-tracking to attentional bias: Implications for gambling and substance use disorders
Publication date: Available online 10 January 2020Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Patrick Anselme, Mike J.F. RobinsonAbstractSign-tracking behavior in Pavlovian autoshaping is known to be a relevant index of the incentive salience attributed to reward-related cues. Evidence has accumulated to suggest that animals that exhibit a sign-tracker phenotype are especially vulnerable to addiction and relapse due to their proneness to attribute incentive salience to drug cues, and their relatively weak cognitive and attentional control over their behavior. Interestingly, sign-trackin...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - January 11, 2020 Category: Psychiatry Source Type: research

Staging and profiling for schizophrenia spectrum disorders: Inter-rater reliability after a short training course
ConclusionThis study demonstrated that inter-rater reliability in clinical staging was sufficient after training. However, inter-rater reliability for clinical profile characteristics was highly variable. The general implementation of the clinical staging model for schizophrenia spectrum disorders is therefore feasible but clinical profile characteristics should be used with caution. (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - January 11, 2020 Category: Psychiatry Source Type: research

A temporal chronnectomic framework: Cigarette smoking preserved the prefrontal dysfunction in schizophrenia
This study assumed that smoking-related alterations on the prefrontal dynamics of information integration (chronnectome) were different between healthy control (HC) and schizophrenia patient (SP). We recruited SP smokers (N = 22)/nonsmokers (N = 27) and HC smokers (N = 22)/nonsmokers (N = 21) who underwent resting-state functional magnetic resonance imaging (rsfMRI) with a total of 240 volumes (lasting for 480 s). We employed a chronnectomic density analysis on the rsfMRI signal by using a sliding-window method. We examined the interaction effect between smoking status and diagnosis utilizing two-way anal...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - January 10, 2020 Category: Psychiatry Source Type: research

A transnosographic approach of negative symptoms pathophysiology in schizophrenia and depressive disorders
Conclusion: Pathophysiological hypotheses are specific to each dimension of negative symptoms and overlap across diagnostic boundaries, possibly underpinning the observed clinical continuum. (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - January 10, 2020 Category: Psychiatry Source Type: research

Prevalence, clinical correlates of suicide attempt and its relationship with empathy in patients with schizophrenia
Publication date: Available online 10 January 2020Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Wenjia Wang, Yongjie Zhou, Jiesi Wang, Hang Xu, Shuochi Wei, Dongmei Wang, Li Wang, Xiangyang ZhangAbstractObjectivesPrevious studies have shown that cognitive impairment plays a key role in suicide, an important factor leading to premature death in schizophrenia (SCZ) patients. Empathy has received extensive attention recently; however, the relationship of empathy with suicide in schizophrenia is still unknown. The main aim of this study was to investigate the prevalence of suicide attempts an...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - January 10, 2020 Category: Psychiatry Source Type: research

The role of microglia in neuroprogressive disorders: mechanisms and possible neurotherapeutic effects of induced ketosis
Publication date: Available online 7 January 2020Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Gerwyn Morris, Basant K. Puri, Michael Maes, Lisa Olive, Michael Berk, Andre F. CarvalhoAbstractA comprehensive review of molecular mechanisms involved in the promotion and maintenance of distinct microglia phenotypes is provided. The acquisition and perpetuation of predominantly pro-inflammatory microglial phenotypes have been implicated in the pathophysiology of several neuroprogressive diseases and is associated with reduced ATP production via oxidative phosphorylation, increased ATP generati...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - January 8, 2020 Category: Psychiatry Source Type: research

Developmental stage-dependent deficits induced by embryonic ethanol exposure in zebrafish: A neurochemical analysis
Publication date: Available online 7 January 2020Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Amanda Facciol, Celine Bailleul, Samuel Nguyen, Robert GerlaiAbstractFASD results from the developing fetus being exposed to alcohol, and is characterized by morphological, behavioural and cognitive deficits. However, the expression, severity and age of onset of these symptoms has been found to show variation. This variation may partly be due to the developmental stage at which alcohol reached the developing fetus. Previously, alcohol was shown to lead to significant concentration dependent beha...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - January 7, 2020 Category: Psychiatry Source Type: research

Global DNA hypomethylation and its correlation to the betaine level in peripheral blood of patients with schizophrenia
In this study, we identified decrease of global DNA methylation level in FESZ (N = 24 patients vs N = 42 controls), and found that global DNA methylation level was inversely correlated with scores on the global assessment of functioning (GAF) scale, and positively correlated with plasma betaine level. Notably, correlations between levels of betaine and its metabolites (N,N-dimethylglycine and sarcosine, N-methylglycine) were lower or lost in FESZ plasma, but remained high in controls. We further examined LINE-1 DNA methylation levels in patients with chronic SZ (N = 388) and BD (N = 414) as well as controls...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - January 4, 2020 Category: Psychiatry Source Type: research

Opioid receptors mRNAs expression and opioids agonist-dependent G-protein activation in the rat brain following neuropathy
In this study we explored the effect of chronic constriction of the sciatic nerve over 7 and 30 days (CCI-7d and CCI-30d, respectively) on MOR, DOR and KOR mRNAs expression, using in situ hybridization, and the efficacy of G-protein stimulation by DAMGO, DPDPE and U-69593 (MOR, DOR and KOR specific agonists, respectively), using [35S]GTPγS binding, within opioid-sensitive brain structures.After CCI-7d, CCI-30d or both, opioid receptor mRNAs expression was altered throughout the brain: MOR – in the paracentral/centrolateral thalamic nuclei, ventral posteromedial thalamic nuclei, superior olivary complex, parab...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - January 3, 2020 Category: Psychiatry Source Type: research

Aging of the neuroendocrine system: Insights from nonhuman primate models
Publication date: Available online 28 December 2019Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Jacques Epelbaum, Jérémy TerrienAbstractThe neuroendocrine system (NES) plays a crucial role in synchronizing the physiology and behavior of the whole organism in response to environmental constraints. The NES consists of a hypothalamic-pituitary-target organ axis that acts in coordination to regulate growth, reproduction, stress and basal metabolism. The growth (or somatotropic), hypothalamic-pituitary-gonadal (HPG), hypothalamic-pituitary-adrenal (HPA) and hypothalamic-pituitar...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - December 28, 2019 Category: Psychiatry Source Type: research

Gambling and substance use: Comorbidity and treatment implications
Publication date: Available online 24 December 2019Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Jon E. Grant, Samuel R. ChamberlainAbstractGambling disorder is a common condition that was previously listed as an impulse control disorder, but is now considered a substance-related and addictive disorder. Gambling disorder has been associated with various untoward long-term outcomes including impaired quality of life, relationship break-ups, debt and mortgage foreclosure, and elevated risk of suicidality. This paper provides a concise primer on gambling disorder, with a special focus on its...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - December 25, 2019 Category: Psychiatry Source Type: research

Dopaminergic signaling of uncertainty and the aetiology of gambling addiction
This article focusses on reward uncertainty, which is proposed to be the core feature of gambling that creates the capacity for addiction. We describe the neuro-dynamics of the dopamine response to uncertainty that may allow a similar escalation of incentive salience, and its relevance to behavioral addictions. We review translational evidence from both preclinical animal models and human clinical research, including studies in people with gambling disorder. Further, we describe the evidence for 1) the effects of the omission of expected reward as a stressor and to promote sensitization, 2) the effect of the resolution of ...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - December 21, 2019 Category: Psychiatry Source Type: research

Caffeine-dependent changes of sleep-wake regulation: Evidence for adaptation after repeated intake
ConclusionsThe typical pattern of caffeine intake with consumption in both the morning and afternoon hours may not necessarily result in a circadian phase shift in the evening nor lead to clear-cut benefits in alertness. The time-of-day independent effects of caffeine withdrawal on evening nap sleep, sleepiness and performance suggest an adaptation to the substance, presumably in the homeostatic aspect of sleep-wake regulation. (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - December 20, 2019 Category: Psychiatry Source Type: research

Efficacy and tolerability of deep transcranial magnetic stimulation for treatment-resistant depression: A systematic review and meta-analysis
This study aimed to investigate the efficacy of deep transcranial magnetic stimulation (dTMS) for treatment-resistant depression (TRD).MethodsThis study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. PubMed, Medline, PsycINFO, Embase, and Cochrane Library were systematically searched from the time of their inception until July 17, 2019. Data were pooled using a random-effects model. Primary outcomes were mean change of depression and anxiety severity. Secondary outcomes were response and remission rate of depression.ResultsFifteen studies including three randomized controlled tr...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - December 19, 2019 Category: Psychiatry Source Type: research

Efficient parameters of vagus nerve stimulation to enhance extinction learning in an extinction-resistant rat model of PTSD
This study provides the first evidence that brief bursts of VNS can enhance extinction training, reduce relapse and support symptom remission using much less VNS than previous protocols. These findings suggest that VNS parameters can be adjusted in order to minimize total charge delivery and maximize therapeutic effectiveness. (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - December 19, 2019 Category: Psychiatry Source Type: research

Common neurobiological and psychological underpinnings of gambling and substance-use disorders
Publication date: Available online 17 December 2019Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Iris M. Balodis, Marc N. PotenzaAbstractBoth psychological and neurobiological studies in gambling disorder have increased in the past 10–15 years. This review examines the current state of the literature, with a focus on recent magnetic resonance imaging (MRI) neuroimaging studies in gambling disorder. The review compares and contrasts findings across gambling and substance-use disorders. Additionally, features with arguably particular relevance to gambling disorder (e.g., “near...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - December 18, 2019 Category: Psychiatry Source Type: research

Sex-dependent effects of Cacna1c haploinsufficiency on behavioral inhibition evoked by conspecific alarm signals in rats
Publication date: Available online 17 December 2019Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Markus Wöhr, Maria Willadsen, Theresa M. Kisko, Rainer K.W. Schwarting, Markus FendtAbstractDeficits in processing social signals leads to reduced social functioning and is typically associated with neuropsychiatric disorders, including autism spectrum disorder, schizophrenia, and major depressive disorder. The cross-disorder risk gene CACNA1C is implicated in the etiology of all of these disorders and single-nucleotide polymorphisms within CACNA1C are ranked among the best replicated and...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - December 18, 2019 Category: Psychiatry Source Type: research

Efficacy and acceptability of transcranial direct current stimulation (tDCS) for major depressive disorder: An individual patient data meta-analysis
Publication date: Available online 16 December 2019Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Adriano H. Moffa, Donel Martin, Angelo Alonzo, Djamila Bennabi, Daniel M. Blumberger, Isabela M. Benseñor, Zafiris Daskalakis, Felipe Fregni, Emmanuel Haffen, Sarah H. Lisanby, Frank Padberg, Ulrich Palm, Lais B. Razza, Bernardo Sampaio-Jr, Colleen Loo, Andre R. BrunoniAbstractWe evaluated the efficacy and acceptability of transcranial direct current stimulation (tDCS) for treating acute depressive episodes using individual patient data that provide more precise estimates than aggregate...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - December 17, 2019 Category: Psychiatry Source Type: research

Editorial Board
Publication date: 2 March 2020Source: Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 98Author(s): (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - December 15, 2019 Category: Psychiatry Source Type: research

Simultaneous EEG/fMRI recorded during ketamine infusion in patients with major depressive disorder
Publication date: Available online 13 December 2019Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Rebecca McMillan, Rachael Sumner, Anna Forsyth, Doug Campbell, Gemma Malpas, Elizabeth Maxwell, Carolyn Deng, John Hay, Rhys Ponton, Frederick Sundram, Suresh MuthukumaraswamyAbstractA single subanaesthetic dose of ketamine rapidly alleviates the symptoms of major depressive disorder (MDD). However, few studies have investigated the acute effects of ketamine on the BOLD pharmacological magnetic resonance imaging (phMRI) response and EEG spectra. In a randomised, double-blind, active placebo-co...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - December 14, 2019 Category: Psychiatry Source Type: research

Neuroanatomical profiles of treatment-resistance in patients with schizophrenia spectrum disorders
Publication date: Available online 13 December 2019Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Julia Kim, Eric Plitman, Yusuke Iwata, Shinichiro Nakajima, Wanna Mar, Raihaan Patel, Sofia Chavez, Jun Ku Chung, Fernando Caravaggio, M. Mallar Chakravarty, Gary Remington, Philip Gerretsen, Ariel Graff-GuerreroAbstractMounting evidence suggests neuroanatomical compromise in subcortical brain regions in patients with schizophrenia. However, only a few existing studies have examined the structural profiles of patients with treatment-resistant schizophrenia. The aim of this study was to compare...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - December 14, 2019 Category: Psychiatry Source Type: research

Social dysfunction in mood disorders and schizophrenia: Clinical modulators in four independent samples
Conclusion: Our results demonstrated that a significant percentage of patients affected by both mood disorders and schizophrenia shows relevant social dysfunction. Social dysfunction is related, but not completely explained by psychopathological severity. In several patients, it tends to persist also during remission state. Socio-demographic and lifestyle factors were also found to play a role and should therefore be taken into consideration in further studies investigating social dysfunction. (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - December 12, 2019 Category: Psychiatry Source Type: research