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Effect of distress on transient network dynamics and topological equilibrium in phantom sound perception
Publication date: 8 June 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 84, Part A Author(s): Anusha Mohan, Sandra Jovanovic Alexandra, Cliff V. Johnson, Dirk De Ridder, Sven Vanneste Distress is a domain-general behavioral symptom whose neural correlates have been under investigation for a long time now. Although some studies suggest that distress is encoded by changes in alpha activity and functional connectivity between specific brain regions, no study that we know has delved into the whole brain temporal dynamics of the distress component. In the current study, we compare the change...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 17, 2018 Category: Psychiatry Source Type: research

Serum IL-1ra, a novel biomarker predicting olanzapine-induced hypercholesterolemia and hyperleptinemia in schizophrenia
Publication date: 8 June 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 84, Part A Author(s): Yezhe Lin, Yanmin Peng, Shen He, Jinjie Xu, Yuan Shi, Yousong Su, Cuizhen Zhu, Xinyi Zhang, Rubai Zhou, Donghong Cui Olanzapine (OLZ) is efficacious whereas leads to adverse metabolic effects thus lead to higher risk of cardiovascular diseases (CVD) on schizophrenia. Cytokines have been found associated with metabolic disorders. Therefore, pretreatment prediction of OLZ-induced adverse metabolic effects is urgently needed. To investigate if baseline cytokine levels could become biomarkers for p...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 16, 2018 Category: Psychiatry Source Type: research

Notch1 knockdown disturbed neural oscillations in the hippocampus of C57BL mice
Publication date: 8 June 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 84, Part A Author(s): Qun Li, Xiaochen Zhang, Ning Cheng, Chunxiao Yang, Tao Zhang Neural oscillations and their interactions are associated with the coordination of neural groups, which provide a mechanism underlying information processing of brain functions. Notch1 receptor is involved in the neurological and psychiatric disorders, such as neurodevelopmental deficits, cerebral ischemia, Alzheimer's disease and depression. Here, we investigated the dynamics of neural oscillations in hippocampus of Notch1+/− m...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 16, 2018 Category: Psychiatry Source Type: research

Longitudinal associations between glucocorticoid receptor methylation and late-life depression
Publication date: 8 June 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 84, Part A Author(s): Hee-Ju Kang, Kyung-Yeol Bae, Sung-Wan Kim, Il-Seon Shin, Hye-Ran Kim, Myung-Geun Shin, Jin-Sang Yoon, Jae-Min Kim It has been suggested that hypothalamus–pituitary–adrenal (HPA) axis dysregulation plays a role in the etiology of depression. HPA axis function is mediated by glucocorticoid receptors (GRs), which are influenced by epigenetic mechanisms (DNA methylation). The association between the DNA methylation of the GR gene (nuclear receptor subfamily 3, group C, member 1; NR3C1) ...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 16, 2018 Category: Psychiatry Source Type: research

The effects of vitamin D and probiotic co-supplementation on mental health parameters and metabolic status in type 2 diabetic patients with coronary heart disease: A randomized, double-blind, placebo-controlled trial
Conclusions Overall, vitamin D and probiotic co-supplementation after 12 weeks among diabetic people with CHD had beneficial effects on mental health parameters, serum hs-CRP, plasma NO, TAC, glycemic control and HDL-cholesterol levels. Clinical trial registration number http://www.irct.ir: IRCT2017073033941N4. (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 14, 2018 Category: Psychiatry Source Type: research

Neural correlates of working memory in first episode and recurrent depression: An fMRI study
Conclusions Although we failed to find behavioral differences between the groups, results suggest differing BOLD signal in fronto-parietal brain regions in MDD vs. HC, and in RDE vs. FDE. Moreover, both HC and FDE show similar trends in activation shapes. This indicates a link between levels of complexity-dependent activation in fronto-parietal brain regions and the stage of MDD. We therefore assume that load-dependent BOLD signal during WM is impaired in MDD, and that it is particularly affected in RDE. We also suspect neurobiological compensatory mechanisms of the reported brain regions in (working) memory functioning. (...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 12, 2018 Category: Psychiatry Source Type: research

The tail of the ventral tegmental area in behavioral processes and in the effect of psychostimulants and drugs of abuse
Publication date: 8 June 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 84, Part A Author(s): Marc Fakhoury The tail of the ventral tegmental area (tVTA) is a recently identified structure that exerts a major inhibitory drive onto midbrain dopamine (DA) neurons. Also referred to as the rostromedial tegmental nucleus (RMTg), the tVTA is a cluster of gamma-aminobutyric acid (GABA)ergic neurons that starts within the posterior end of the VTA, where it is restricted dorsolateral to the caudal part of the interpeduncular nucleus, and extends into the pons. First identified in the rat, the tV...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 9, 2018 Category: Psychiatry Source Type: research

Presumed structural and functional neural recovery after long-term abstinence from cocaine in male military veterans
Publication date: 8 June 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 84, Part A Author(s): Qinghua He, Xiaolu Huang, Ofir Turel, Marya Schulte, David Huang, April Thames, Antoine Bechara, Yih-Ing Hser Cumulative evidence suggests that cocaine use could alter the structure and function of different brain systems. However, the extent to which the altered brain structure and function possibly recover over time after cocaine abstinence remains less clear. The present study examines 39 male military veterans with different stages of cocaine addiction and long-term abstinence (from 1 yea...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 8, 2018 Category: Psychiatry Source Type: research

Effects of vortioxetine on biomarkers associated with glutamatergic activity in an SSRI insensitive model of depression in female rats
In conclusion, vortioxetine, but not paroxetine, enabled reversals of TRP depletion-induced changes of depression-like behavior and markers of glutamatergic activity. These observations support the hypothesis that vortioxetine's antidepressant activity may involve mechanisms beyond SERT inhibition. (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 6, 2018 Category: Psychiatry Source Type: research

Therapeutic effect of adjunctive N-acetyl cysteine (NAC) on symptoms of chronic schizophrenia: A double-blind, randomized clinical trial
Conclusion The present study detected improvement in positive, negative, general and total psychopathology symptoms as well as cognitive performance with NAC treatment. It is also well-tolerated, safe and easy-to-use agent as an effective therapeutic strategy to improve outcome in schizophrenia treatment. (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 6, 2018 Category: Psychiatry Source Type: research

Effects of chronic social defeat on social behaviors in adult female mandarin voles (Microtus mandarinus): Involvement of the oxytocin system in the nucleus accumbens
Publication date: 2 March 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 82 Author(s): Limin Wang, Wenjuan Hou, Zhixiong He, Wei Yuan, Jinfeng Yang, Yang Yang, Rui Jia, Zhenxiang Zhu, Yue Zhou, Fadao Tai Chronic social defeat affects many aspects of behavior. Most previous studies have focused on effects on males and defeat during adolescence. The extents to which chronic social defeat can impact female social behavior in adulthood and the neural mechanisms of such effects are poorly understood. Using highly social and aggressive female mandarin voles (Microtus mandarinus), the present ...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 6, 2018 Category: Psychiatry Source Type: research

The P2RX7 polymorphism rs2230912 is associated with depression: A meta-analysis
Publication date: 2 March 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 82 Author(s): D. Czamara, B. Müller-Myhsok, S. Lucae Various studies have investigated whether single nucleotide polymorphisms (SNPs) in the gene purinergic receptor P2X7 (P2RX7), and rs2230912 specifically, were associated with mood disorders. While some studies found positive evidence, a large number of studies reported no significant associations. In a previously published meta-analysis, Feng et al. did not find a significant association and only moderate odds ratios (ORs) in case-control studies. They repo...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 6, 2018 Category: Psychiatry Source Type: research

Side effect burden of antipsychotic drugs in real life – Impact of gender and polypharmacy
Conclusion Patients with psychotic disorders have a high occurrence of symptoms associated with use of antipsychotics, and polypharmacy and female gender are seemingly risk factors for reporting a severe side effect burden. Due to the cross-sectional design evaluation of causality is tentative, and these findings should be further investigated in prospective studies. (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 6, 2018 Category: Psychiatry Source Type: research

Neural indices of emotional reactivity and regulation predict course of PTSD symptoms in combat-exposed veterans
Publication date: 2 March 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 82 Author(s): Jacklynn M. Fitzgerald, Stephanie M. Gorka, Autumn Kujawa, Julia A. DiGangi, Eric Proescher, Justin E. Greenstein, Darrin M. Aase, Christopher Schroth, Kaveh Afshar, Amy E. Kennedy, Greg Hajcak, K. Luan Phan After diagnosis, veterans with posttraumatic stress disorder (PTSD) display significant variability in the natural course of illness (Bonanno et al., 2012)). Cross-sectional work reveals that abnormal neural response during emotion reactivity—measured using the late positive potential (LPP)&...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 6, 2018 Category: Psychiatry Source Type: research

Brain-derived neurotrophic factor in adjuvant-induced arthritis in rats. Relationship with inflammation and endothelial dysfunction
Conclusions Our study reveals that arthritis decreases BDNF levels in the brain and that endothelial dysfunction rather than inflammation contributes to the decrease. It also identifies a disconnection between serum and brain BDNF levels in arthritis. (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 6, 2018 Category: Psychiatry Source Type: research

Disrupted focal white matter integrity in autism spectrum disorder: A voxel-based meta-analysis of diffusion tensor imaging studies
Conclusions Consistent focal white matter reductions in ASD could be identified by using FA, highlighting the cerebral peduncle which is usually overlooked in studies focusing on major white matter tracts. These focal reductions in the splenium and the cerebral peduncle may be associated with sensorimotor impairments seen in individuals with ASD. (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 6, 2018 Category: Psychiatry Source Type: research

Neural correlates of impaired self-regulation in male youths with autism spectrum disorder: A voxel-based morphometry study
Publication date: 2 March 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 82 Author(s): Hsing-Chang Ni, Hsiang-Yuan Lin, Wen-Yih Isaac Tseng, Yen-Nan Chiu, Yu-Yu Wu, Wen-Che Tsai, Susan Shur-Fen Gau Although recent studies revealed impaired self-regulation (dysregulation) in autism spectrum disorder (ASD), neural correlates of dysregulation and its impacts on autistic neuroanatomy remain unclear. Voxel-based morphometry was applied on structural MRI images in 81 ASD and 61 typically developing (TD) boys aged 7–17years. Dysregulation was defined by the sum of T-scores of Attention, ...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 6, 2018 Category: Psychiatry Source Type: research

A systematic review and meta-analysis of deep brain stimulation in treatment-resistant depression
Conclusions DBS significantly alleviates depressive symptoms in TRD patients by targeting the SCG, VC/VS, MFB, and NAcc. Several adverse events might occur during DBS therapy, although it is uncertain whether some AEs can be linked to DBS treatment. Further confirmatory trials are required involving larger sample sizes. (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 6, 2018 Category: Psychiatry Source Type: research

Estrogen levels, emotion regulation, and emotional symptoms of women with premenstrual dysphoric disorder: The moderating effect of estrogen receptor 1 α polymorphism
Conclusions The results demonstrate the association between estrogen and anxiety in PMDD, supporting the claim that women with PMDD differ in their responses to normal estrogen levels. Furthermore, this association and dysfunctional emotional regulation in PMDD existed only among the G carriers of ESR α-Xbal polymorphism. Future studies should investigate the effect of estrogen on brain functions involving emotional regulation in women with PMDD, stratified by ESR α-Xbal polymorphism. (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 6, 2018 Category: Psychiatry Source Type: research

Differential use of danger and safety signals in an animal model of anxiety vulnerability: The behavioral economics of avoidance
Publication date: 2 March 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 82 Author(s): Kevin M. Spiegler, Ashley M. Fortress, Kevin C.H. Pang Differential processing of danger and safety signals may underlie symptoms of anxiety disorders and posttraumatic stress disorder. One symptom common to these disorders is pathological avoidance. The present study examined whether danger and safety signals influence avoidance differently in anxiety-vulnerable Wistar-Kyoto (WKY) rats and Sprague Dawley (SD) rats. SD and WKY rats were tested in a novel progressive ratio avoidance task with and witho...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 6, 2018 Category: Psychiatry Source Type: research

Altered neuro-inflammatory gene expression in hippocampus in major depressive disorder
Publication date: 2 March 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 82 Author(s): Gouri J. Mahajan, Eric J. Vallender, Michael R. Garrett, Lavanya Challagundla, James C. Overholser, George Jurjus, Lesa Dieter, Maryam Syed, Damian G. Romero, Hamed Benghuzzi, Craig A. Stockmeier Major Depressive Disorder (MDD) is a common psychiatric disorder for which available medications are often not effective. The high prevalence of MDD and modest response to existing therapies compels efforts to better understand and treat the disorder. Decreased hippocampal volume with increasing duration of d...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 6, 2018 Category: Psychiatry Source Type: research

Interaction between DRD2 and lead exposure on the cortical thickness of the frontal lobe in youth with attention-deficit/hyperactivity disorder
Conclusions The present findings demonstrated significant interaction effects of DRD2 and lead exposure on the cortical thickness of the frontal lobe in ADHD. Replication studies with larger sample sizes, using a prospective design, are warranted to confirm these findings. (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 6, 2018 Category: Psychiatry Source Type: research

m-Trifluoromethyl-diphenyl diselenide promotes resilience to social avoidance induced by social defeat stress in mice: Contribution of opioid receptors and MAPKs
Publication date: 2 March 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 82 Author(s): Suzan Gonçalves Rosa, Ana Paula Pesarico, Cristina Wayne Nogueira Depressive symptoms precipitated by stress are prevalent in population. In experimental models of social stress, endogenous opioids mediate different aspects of defensive and submissive behaviors. The present study investigated the opioid receptors, mitogen-activated protein kinase (MAPKs) and protein kinase B (Akt) contribution to m-trifluoromethyl-diphenyl diselenide [(m-CF3-PhSe)2] effects on social avoidance induced by social...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 6, 2018 Category: Psychiatry Source Type: research

Regional gray matter volume and structural network strength in somatic vs. non-somatic delusional disorders
Conclusion The data support the notion that dysfunctional somatosensory and peripersonal networks could mediate somatic delusions in patients with DI in contrast to delusional disorders without somatic content. The data also suggest putative content-specific neural signatures in delusional disorders and in delusion formation per se. (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 6, 2018 Category: Psychiatry Source Type: research

Distinguish self- and hetero-perceived stress through behavioral imaging and physiological features
Publication date: 2 March 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 82 Author(s): Michel Spodenkiewicz, Jonathan Aigrain, Nadège Bourvis, Séverine Dubuisson, Mohamed Chetouani, David Cohen Stress reactivity is a complex phenomenon associated to multiple and multimodal expressions. Response to stressors has an obvious survival function and may be seen as an internal regulation to adapt to threat or danger. The intensity of this internal response can be assessed as the self-perception of the stress response. In species with social organization, this response also serves...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 6, 2018 Category: Psychiatry Source Type: research

Loss of Lypd6 leads to reduced anxiety-like behaviour and enhanced responses to nicotine
Publication date: 2 March 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 82 Author(s): Maria Arvaniti, Filip S. Polli, Kristi A. Kohlmeier, Morten S. Thomsen, Jesper T. Andreasen Nicotine consumption through smoking affects anxious states in humans. However, the precise role of nicotinic acetylcholine receptor (nAChR) circuitry in the regulation of anxiety remains elusive. The Lynx protein Lypd6 is highly enriched in synaptic loci and has been previously identified as an endogenous inhibitor of neuronal nAChR function in vitro. Here, we investigate the effect of Lypd6 in anxiety-related...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 6, 2018 Category: Psychiatry Source Type: research

Interactive effects of morphine and nicotine on memory function depend on the central amygdala cannabinoid CB1 receptor function in rats
Publication date: 2 March 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 82 Author(s): Fatemeh Tirgar, Ameneh Rezayof, Sakineh Alijanpour, Nima Yazdanbakhsh The present study investigated the possible involvement of the central amygdala (CeA) cannabinoid receptors type-1 (CB1Rs) in the interactive effects of morphine and nicotine on memory formation in a passive avoidance learning task. Our results showed that systemic administration of morphine (3 and 6mg/kg, s.c.) immediately after training phase impaired memory consolidation and induced amnesia. Administration of nicotine (0.3 and 0....
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 6, 2018 Category: Psychiatry Source Type: research

Immunomodulatory effects of a rationally designed peptide mimetic of human IFN β in EAE model of multiple sclerosis
In this study, for the first time we investigated the impact of a computationally designed peptide mimetic of IFNβ, called MSPEP27, in the animal model of MS. A peptide library was constructed using the Rosetta program based on the predominant IFNAR1-binding site of IFNβ. Molecular docking studies were carried out using ClusPro and HADDOCK tools. The GROMACS package was subsequently used for molecular dynamics (MD) simulations. Validation of peptide-receptor interaction was carried out using intrinsic fluorescence measurements. To explore in silico findings further, experimental autoimmune encephalomyelitis (EAE)...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 6, 2018 Category: Psychiatry Source Type: research

Thalidomide attenuates development of morphine dependence in mice by inhibiting PI3K/Akt and nitric oxide signaling pathways
Publication date: 2 March 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 82 Author(s): Muhammad Imran Khan, Majid Momeny, Sattar Ostadhadi, Samane Jahanabadi, Shahram Ejtemaei-Mehr, Bilqees Sameem, Ghazaleh Zarrinrad, Ahmad Reza Dehpour Morphine dependence and the subsequent withdrawal syndrome restrict its clinical use in management of chronic pain. The precise mechanism for the development of dependence is still elusive. Thalidomide is a glutamic acid derivative, recently has been reconsidered for its clinical use due to elucidation of different clinical effects. Phosphoinositide 3-ki...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 6, 2018 Category: Psychiatry Source Type: research

Transcranial direct current stimulation of 20- and 30-minutes combined with sertraline for the treatment of depression
Conclusions tDCS of 20- or 30-minutes combined with sertraline are efficient for the treatment of mild and moderate depression; the effect of 30min stimulation exceeds the one obtained from 20min. (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 6, 2018 Category: Psychiatry Source Type: research

The theta burst transcranial magnetic stimulation over the right PFC affects electroencephalogram oscillation during emotional processing
Publication date: 2 March 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 82 Author(s): Dan Cao, Yingjie Li, Margaret A. Niznikiewicz, Yingying Tang, Jijun Wang Prefrontal cortex (PFC) plays an important role in emotional processing and therefore is one of the most frequently targeted regions for non-invasive brain stimulation such as repetitive transcranial magnetic stimulation (rTMS) in clinical trials, especially in the treatment of emotional disorders. As an approach to enhance the effectiveness of rTMS, continuous theta burst stimulation (cTBS) has been demonstrated to be efficient ...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 6, 2018 Category: Psychiatry Source Type: research

Common variation in ZNF804A (rs1344706) is not associated with brain morphometry in schizophrenia or healthy participants
Conclusions Contrary to some – but not all – previous findings, this study of a large sample of schizophrenia cases and healthy controls reveals no evidence for association between grey matter alterations and variation in rs1344706 (ZNF804A). Differences in sample sizes and ethnicities may account for discrepant findings between the present and previous studies. (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 6, 2018 Category: Psychiatry Source Type: research

Repeated methamphetamine and modafinil induce differential cognitive effects and specific histone acetylation and DNA methylation profiles in the mouse medial prefrontal cortex
Publication date: 2 March 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 82 Author(s): Betina González, Subramaniam Jayanthi, Natalia Gomez, Oscar V. Torres, Máximo H. Sosa, Alejandra Bernardi, Francisco J. Urbano, Edgar García-Rill, Jean-Lud Cadet, Verónica Bisagno Methamphetamine (METH) and modafinil are psychostimulants with different long-term cognitive profiles: METH is addictive and leads to cognitive decline, whereas modafinil has little abuse liability and is a cognitive enhancer. Increasing evidence implicates epigenetic mechanisms of gene regulation...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 6, 2018 Category: Psychiatry Source Type: research

Telomerase level increase is related to n-3 polyunsaturated fatty acid efficacy in first episode schizophrenia: Secondary outcome analysis of the OFFER randomized clinical trial
Publication date: 20 April 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 83 Author(s): Tomasz Pawełczyk, Marta Grancow-Grabka, Elżbieta Trafalska, Janusz Szemraj, Natalia Żurner, Agnieszka Pawełczyk Schizophrenia is associated with shortening of the lifespan mainly due to cardiovascular events, cancer and chronic obstructive pulmonary disease. Both telomere attrition and decrease of telomerase levels were observed in schizophrenia. Polyunsaturated fatty acids (PUFA) influence multiple biochemical mechanisms which are postulated to accelerate telomere shortening and limit the longev...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 6, 2018 Category: Psychiatry Source Type: research

Cocaine use may induce telomere shortening in individuals with HIV infection
Conclusions Our findings suggest that cocaine use may promote premature aging in HIV-infected individuals who are on ART. Our results emphasize the importance of cocaine abstinence/reduced use, which may retard HIV-associated premature aging. (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 6, 2018 Category: Psychiatry Source Type: research

White matter volume loss in amyotrophic lateral sclerosis: A meta-analysis of voxel-based morphometry studies
This study aimed to perform a quantitative voxel-based meta-analysis using effect-size signed differential mapping (ES-SDM) to establish a statistical consensus between published studies for WM volume alterations in ALS. The pooled meta-analysis revealed significant WM volume losses in the bilateral supplementary motor areas (SMAs), bilateral precentral gyri (PGs), left middle cerebellar peduncle and right cerebellum in patients with ALS, involving the corticospinal tract (CST), interhemispheric fibers, subcortical arcuate fibers, projection fibers to the striatum and cortico-ponto-cerebellar tract. The meta-regression sho...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 4, 2018 Category: Psychiatry Source Type: research

Targeting cytokines in reduction of depressive symptoms: A comprehensive review
The objectives of the current narrative review are to critically evaluate the literature about the effects of cytokine blockers on clinical outcomes in MDD and in the reduction of depressive symptom severity in individuals using these medications primarily to treat inflammatory conditions. A small number of clinical trials assessing the effects of cytokine blockers for depression and depressive symptoms have been completed. These trials suggest that in individuals with immune dysfunction (e.g. elevated pro-inflammatory cytokine levels), cytokine blockers may allow for improved clinical outcomes in MDD that would not be ach...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 4, 2018 Category: Psychiatry Source Type: research

Olfactory identification deficit and its relationship with hedonic traits in patients with first-episode schizophrenia and individuals with schizotypy
Conclusion Our findings support olfactory identification impairment as a trait marker for schizophrenia. (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 4, 2018 Category: Psychiatry Source Type: research

Diazepam fails to alter anxiety-like responses but affects motor function in a white-black test paradigm in larval zebrafish (Danio rerio)
Publication date: 20 April 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 83 Author(s): Hifsa Zahid, Benjamin Tsang, Hira Ahmed, Richard Chi Yeung Lee, Steven Tran, Robert Gerlai The growing popularity of zebrafish in psychopharmacology and behavioral brain research is partly due to the practicality and simplicity of drug administration in this species. Several drugs may be administered to zebrafish by immersing the fish in the drug solution. Furthermore, numerous drugs developed for mammals, including humans, have been found to show a similar effect profile in the zebrafish. Thus, the ...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 4, 2018 Category: Psychiatry Source Type: research

Resting-state functional connectivity of neurotransmitter producing sites in female patients with borderline personality disorder
Publication date: 20 April 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 83 Author(s): Gerd Wagner, Annegret Krause-Utz, Feliberto de la Cruz, Andy Schumann, Christian Schmahl, Karl-Jürgen Bär Impulsive behavior, difficulties in controlling anger and suicidal behavior are typical patterns of affective/behavioral dysregulation in patients with borderline personality disorder (BPD). Previous functional MRI studies in the resting state condition demonstrated altered functional connectivity (FC) between the anterior cingulate cortex (ACC) and the frontoparietal executive control ...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 4, 2018 Category: Psychiatry Source Type: research

Hippocampal astrocyte atrophy in a mouse depression model induced by corticosterone is reversed by fluoxetine instead of benzodiazepine diazepam
In this study, we utilized a repeated corticosterone (CORT) injection paradigm to develop a mouse depression model wherein we examined the occurrence of alterations in hippocampal astrocyte population by using two astrocytic markers, namely, glial fibrillary acidic protein (GFAP) and S100β. Moreover, we determined the effects of fluoxetine and diazepam on CORT-induced astrocytic alterations to assess the predictive validity. Results showed that repeated CORT injections showed no effects on the number of GFAP+ and S100β+ astrocytes, but they decreased the protrusion length of GFAP+ astrocytes and GFAP protein expr...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 4, 2018 Category: Psychiatry Source Type: research

APBB2 is associated with amphetamine use and plasma beta-amyloids in patients receiving methadone maintenance treatment
In this study, we reported the first time that the genetic variants in the APBB2 gene were associated with use of amphetamine in opioid dependent patients undergoing methadone maintenance treatment (MMT). 344 heroin-dependent patients undergoing MMT were recruited and assessed for use of amphetamine and opioids by urine toxicology, withdrawal severity, and side effects. DNAs were genome-widely genotyped for all patients. Single nucleotide polymorphisms (SNPs) in APBB2 were selected for association analyses for methadone treatment responses. Gene expression levels of APBB2 were measured by real-time polymerase chain reactio...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 4, 2018 Category: Psychiatry Source Type: research

A supplementary functional connectivity microstate attached to the default mode network in depression revealed by resting-state magnetoencephalography
Publication date: 20 April 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 83 Author(s): Siqi Zhang, Shui Tian, Mohammad Ridwan Chattun, Hao Tang, Rui Yan, Kun Bi, Zhijian Yao, Qing Lu Default mode network (DMN) has discernable involvement in the representation of negative, self-referential information in depression. Both increased and decreased resting-state functional connectivity between the anterior and posterior DMN have been observed in depression. These conflicting connectivity differences necessitated further exploration of the resting-state DMN dysfunction in depression. Hence, ...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 4, 2018 Category: Psychiatry Source Type: research

Atypical antipsychotics, insulin resistance and weight; a meta-analysis of healthy volunteer studies
Publication date: 20 April 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 83 Author(s): Kyle J. Burghardt, Berhane Seyoum, Abdullah Mallisho, Paul R. Burghardt, Renu A. Kowluru, Zhengping Yi Atypical antipsychotics increase the risk of diabetes and cardiovascular disease through their side effects of insulin resistance and weight gain. The populations for which atypical antipsychotics are used carry a baseline risk of metabolic dysregulation prior to medication which has made it difficult to fully understand whether atypical antipsychotics cause insulin resistance and weight gain direct...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 4, 2018 Category: Psychiatry Source Type: research

Genetic variants of the folate metabolic system and mild hyperhomocysteinemia may affect ADHD associated behavioral problems
Publication date: 8 June 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 84, Part A Author(s): Tanusree Saha, Mahasweta Chatterjee, Deepak Verma, Anirban Ray, Swagata Sinha, Usha Rajamma, Kanchan Mukhopadhyay An etiologically complex disorder, Attention Deficit Hyperactivity Disorder (ADHD), is often associated with various levels of cognitive deficit. Folate/vitamin B9 is crucial for numerous biochemical pathways including neural stem cell proliferation and differentiation, regulation of gene expression, neurotransmitter synthesis, myelin synthesis and repair, etc. and a scarcity has of...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 3, 2018 Category: Psychiatry Source Type: research

Effects of early-life malnutrition on neurodevelopment and neuropsychiatric disorders and the potential mechanisms
Publication date: 20 April 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 83 Author(s): Xintian Yan, Xinzhi Zhao, Juxue Li, Lin He, Mingqing Xu Lines of evidence have demonstrated that early-life malnutrition is highly correlated with neurodevelopment and adulthood neuropsychiatric disorders, while some findings are conflicting with each other. In addition, the biological mechanisms are less investigated. We systematically reviewed the evidence linking early-life nutrition status with neurodevelopment and clinical observations in human and animal models. We summarized the effects of spe...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - January 12, 2018 Category: Psychiatry Source Type: research

Deficits in episodic memory and mental time travel in patients with post-traumatic stress disorder
Publication date: 20 April 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 83 Author(s): Armin Zlomuzica, Marcella L. Woud, Alla Machulska, Katharina Kleimt, Lisa Dietrich, Oliver T. Wolf, Hans-Joerg Assion, Joseph P. Huston, Maria A. De Souza Silva, Ekrem Dere, Jürgen Margraf Post-traumatic stress disorder (PTSD) is characterized by impairments in mnestic functions, especially in the domain of episodic memory. These alterations might affect different aspects of episodic memory functioning. Here we tested PTSD patients and healthy controls (matched for age, sex and education) in a n...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - January 9, 2018 Category: Psychiatry Source Type: research

Increased serum levels and promoter polymorphisms of macrophage migration inhibitory factor in schizophrenia
Conclusions These results suggest that serum MIF level is a potential pharmacodynamic and/or monitoring marker of schizophrenia, and is related to a novel antipsychotic effect beyond dopamine antagonism. Furthermore, the MIF gene polymorphisms are associated with the risk for schizophrenia especially in adolescent females, and are potential stratification markers of schizophrenia. Further studies of MIF are warranted to elucidate the pathophysiology of schizophrenia and the effects of antipsychotics. (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - January 7, 2018 Category: Psychiatry Source Type: research

Structural and functional brain abnormalities in schizophrenia: A cross-sectional study at different stages of the disease
Publication date: 20 April 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 83 Author(s): Chao Zhao, Jiajia Zhu, Xiaoyi Liu, Chengcheng Pu, Yunyao Lai, Lei Chen, Xin Yu, Nan Hong Structural and functional deficits associated with schizophrenia are observed prior to the onset of psychosis and differ according to the stage of illness. However, most previous studies concentrated on a limited period during the illness, and it remains uncertain how these abnormalities develop throughout the entire disease course. In the current study, we investigated the gray matter (GM) and regional neural ac...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - January 7, 2018 Category: Psychiatry Source Type: research

Prior stress promotes the generalization of contextual fear memories: Involvement of the gabaergic signaling within the basolateral amygdala complex
Publication date: 20 April 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 83 Author(s): C.L. Bender, A. Otamendi, G.D. Calfa, V.A. Molina Fear generalization occurs when a response, previously acquired with a threatening stimulus, is transferred to a similar one. However, it could be maladaptive when stimuli that do not represent a real threat are appraised as dangerous, which is a hallmark of several anxiety disorders. Stress exposure is a major risk factor for the occurrence of anxiety disorders and it is well established that it influences different phases of fear memory; nevertheles...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - December 30, 2017 Category: Psychiatry Source Type: research