The interaction between the ZNF804A gene and cannabis use on the risk of psychosis in a non-clinical sample
This study aimed to investigate: i) the association of lifetime cannabis use (and its dose effect) with schizotypal personality traits, and ii) whether the genetic variability at ZNF804A gene modulates that association.Our sample consisted of 385 Spanish non-clinical subjects (43.1% males, mean age = 21.11(2.19)). Schizotypy was evaluated using the three factors of the Schizotypal Personality Questionnaire-Brief (SPQ-B): Cognitive-Perceptual (SPQ-CP), Interpersonal (SPQ-I) and Disorganized (SPQ-D). Subjects were classified according to their frequency of cannabis consumption, and dichotomized as users or non-users. The...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - August 14, 2018 Category: Psychiatry Source Type: research

Diagnostic neuroimaging markers of obsessive-compulsive disorder: Initial evidence from structural and functional MRI studies
Publication date: Available online 11 August 2018Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Willem Bruin, Damiaan Denys, Guido van WingenAbstractAs of yet, no diagnostic biomarkers are available for obsessive-compulsive disorder (OCD), and its diagnosis relies entirely upon the recognition of behavioural features assessed through clinical interview. Neuroimaging studies have shown that various brain structures are abnormal in OCD patients compared to healthy controls. However, the majority of these results are based on average differences between groups, which limits diagnostic usage i...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - August 11, 2018 Category: Psychiatry Source Type: research

Reprint of: Efficacy, tolerability, and safety of non-pharmacological therapies for chronic pain: An umbrella review on various CAM approaches
ConclusionAlthough several CAM were found effective for chronic pain relief, it remains unclear when these modalities are a reasonable choice against or in conjunction with mainstream treatments. In that sense, future research with a clear emphasis on concurrent evaluation of CAM overall efficacy and patient adherence/tolerance is needed. (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - August 11, 2018 Category: Psychiatry Source Type: research

Functional MRI findings, pharmacological treatment in major depression and clinical response
Publication date: Available online 9 August 2018Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Danilo ArnoneAbstractMajor depressive disorders are common conditions with relatively limited response to treatment. In order to improve response to treatment, a better understanding of functional neuroanatomy is necessary to improve treatment targets at brain level. This work summarises the literature of longitudinal functional magnetic resonance imaging studies in major depression to identify brain regions where aberrant neural activity normalises after clinical response following treatment wit...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - August 10, 2018 Category: Psychiatry Source Type: research

Long-term impact of chronic variable stress in adolescence versus adulthood
Publication date: Available online 7 August 2018Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Evelin M. Cotella, Antonela Scarponi Gomez, Paige Lemen, Carrie Chen, Guillermo Fernández, Christian Hansen, James P. Herman, María Gabriela PagliniAbstractAdolescence is a period of active development of stress regulatory neurocircuitry. As a consequence, mechanisms that control the responses to stress are not fully matured during this developmental period, which may result in vulnerability to chronic stress. We hypothesized that adolescent chronic stress would have negative conseq...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - August 7, 2018 Category: Psychiatry Source Type: research

Spontaneous resurgence of conditioned fear weeks after successful extinction in brain injured mice
This study shows for the first time that a mild brain injury can generate a spontaneous resurgence of conditioned fear associated with defective BDNF signalling in the prefrontal cortex, PTSD-like behaviors, and have enduring effects on the brain. (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - August 7, 2018 Category: Psychiatry Source Type: research

Posttraumatic stress disorder with secondary psychotic features (PTSD-SP): Diagnostic and treatment challenges
Publication date: Available online 6 August 2018Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Ebele Compean, Mark HamnerAbstractTrauma exposure leads to various psychiatric disorders including depression, anxiety, bipolar disorders, personality disorders, psychotic disorders, and trauma related disorders, especially posttraumatic stress disorder (PTSD). There are some overlapping symptoms of both PTSD and psychosis that make diagnosis challenging. Despite this overlap, the evidence of PTSD with comorbid psychosis as a distinct entity lies in the research showing biologic, genetic and trea...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - August 7, 2018 Category: Psychiatry Source Type: research

The association of BDNF gene polymorphism with cognitive impairment in insomnia patients
Publication date: Available online 1 August 2018Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Nevin F.W. Zaki, Elsayed Saleh, Mahmoud Elwasify, Elhasanein Mahmoud, John Zaki, David Warren Spence, Ahmed S. BaHammam, Seithikurippu R. Pandi-PerumalAbstractBackgroundReductions in BDNF activity have shown associations with depressed mood. Other evidence has demonstrated that the BDNF Val66Met polymorphism (rs6265) appears to reduce neural plasticity. A limited number of studies have investigated the influence of these genetic polymorphisms in insomnia. The present study sought to confirm the p...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - August 2, 2018 Category: Psychiatry Source Type: research

The association of excitation and inhibition signaling with the relative symptom expression of autism and psychosis-proneness: Implications for psychopharmacology
This study investigates the extent to which the degree of autistic tendency and psychosis-proneness exclusively and interactively predict excitatory and inhibitory neurotransmitter concentrations in the superior temporal cortex (STC). In 38 adults (18 male, 18–40 years), we obtained autistic tendencies (Autism-Spectrum Quotient [AQ]) and psychosis-proneness scores (Schizotypal Personality Questionnaire [PP]); magnetic resonance spectroscopy (MRS) quantified glutamate and GABA+ concentrations from the STC. Results demonstrated a negative AQ/PP interaction with glutamate concentration for the left STC voxel, where PP...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - July 31, 2018 Category: Psychiatry Source Type: research

Ketamine promotes rapid and transient activation of AMPA receptor-mediated synaptic transmission in the dorsal raphe nucleus
Publication date: Available online 31 July 2018Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Nerea Llamosas, Laura Perez-Caballero, Esther Berrocoso, Cristina Bruzos-Cidon, Luisa Ugedo, Maria TorrecillaAbstractAccumulating evidence indicates that the antidepressant effects of ketamine are, in part, mediated by an increase in the AMPA receptor-mediated neurotransmission in depression related areas, such as the prefrontal cortex (PFC). Therefore, activity in PFC-projecting areas related to major depression, such as the dorsal raphe nucleus (DR), may also be modulated by ketamine. We used wh...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - July 31, 2018 Category: Psychiatry Source Type: research

The effects of single-dose injections of modafinil and methamphetamine on epigenetic and functional markers in the mouse medial prefrontal cortex: potential role of dopamine receptors
In this study, we measured the effects of single-dose injections of modafinil and METH on the protein levels of acetylated histone H3 (H3ac) and H4ac, deacetylases HDAC1 and HDAC2, and of the NMDA subunit GluN1 in the medial PFC (mPFC) of mice euthanized 1 h after drug administration. To test if dopamine (DA) receptors (DRs) participate in the biochemical effects of the two drugs, we injected the D1Rs antagonist, SCH23390, or the D2Rs antagonist, raclopride, 30 min before administration of METH and modafinil. We evaluated each drug effect on glutamate synaptic transmission in D1R-expressing layer V pyramidal neurons. W...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - July 27, 2018 Category: Psychiatry Source Type: research

Overlaps in pharmacology for the treatment of chronic pain and mental health disorders
Publication date: Available online 25 July 2018Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Ainsley M. Sutherland, Judith Nicholls, James Bao, Hance ClarkeAbstractThere is significant overlap in the pharmacological management of pain and psychological disorders. Appropriate treatment of patients' comorbid psychological disorders, including sleep disturbances often leads to an improvement in reported pain intensity. The three first line agents for neuropathic pain include tricyclic antidepressants and serotonin norepinephrine reuptake inhibitors which are medications originally developed ...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - July 26, 2018 Category: Psychiatry Source Type: research

Lithium interacts with cardiac remodeling: the fundamental value in the pharmacotherapy of bipolar disorder
Publication date: Available online 24 July 2018Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Pao-Huan Chen, Tze-Fan Chao, Yu-Hsun Kao, Yi-Jen ChenAbstractPatients with bipolar disorder (BD) have an increased risk of cardiovascular morbidity and mortality during the course of their illness. For over half a century, lithium has been the gold-standard medication used to treat the mood burdens of BD. In addition, lithium possesses several biological effects that may modulate cardiovascular risk in patients with BD. In this review, we update the current knowledge of cellular and molecular mech...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - July 25, 2018 Category: Psychiatry Source Type: research

The need to improve detection and treatment of physical pain of homeless people with schizophrenia and bipolar disorders. Results from the French Housing First Study
ConclusionPhysical pain was highly reported in homeless patients with severe mental illness with insufficient care. Physical pain should be systematically explored and treated in this population. Bipolar disorders, antidepressant consumption and female gender may be targeted in priority. Age and psychotic symptomatology were found to influence self-reported pain in a marginal way. (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - July 25, 2018 Category: Psychiatry Source Type: research

Altered methyltetrahydrofolate reductase gene polymorphism in mothers of children with attention deficit and hyperactivity disorder
Publication date: Available online 24 July 2018Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Saliha Baykal, Bahadır Batar, Ayşin Nalbantoğlu, Yakup Albayrak, Halil Hancı, Nihan Potas, Ferit Durankuş, Murat Beyazyüz, Koray KarabekiroğluAbstractAttention Deficit and Hyperactivity Disorder (ADHD) is one of the most common psychiatric disorders in childhood and causes significant functional impairments in children. Behavioral genetic and molecular genetic studies have provided significant evidence in terms of highlighting the etiology of ADHD. Folate deficiency during pregnancy is ...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - July 25, 2018 Category: Psychiatry Source Type: research

Reframing addiction: habit, choice, cues and compulsivity
Publication date: Available online 11 July 2018Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Robyn M. Brown, Heather B. Madsen (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - July 21, 2018 Category: Psychiatry Source Type: research

Basolateral amygdalar inactivation blocks chronic stress-induced lamina-specific reduction in prefrontal cortex volume and associated anxiety-like behavior
Publication date: Available online 21 July 2018Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Sunil Jamuna Tripathi, Suwarna Chakraborty, B.N. Srikumar, T.R. Raju, B.S. Shankaranarayana RaoAbstractChronic exposure to stress causes cognitive deficits, anxiety and depression. Earlier studies have suggested that the prefrontal cortex (PFC) and basolateral amygdala (BLA) can differentially modulate the stress-induced alterations either by their action on HPA axis or via direct reciprocal connections between them. The PFC dysfunction and BLA hypertrophy following stress are known to cause anxie...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - July 21, 2018 Category: Psychiatry Source Type: research

Gene expression changes related to immune processes associate with cognitive endophenotypes of schizophrenia
Publication date: Available online 18 July 2018Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): L. Ukkola-Vuoti, M. Torniainen-Holm, A. Ortega-Alonso, V. Sinha, A. Tuulio-Henriksson, T. Paunio, J. Lönnqvist, J. Suvisaari, W. HennahAbstractSchizophrenia is a heterogeneous disorder characterized by a spectrum of symptoms and many different underlying causes. Thus, instead of using the broad diagnosis, intermediate phenotypes can be used to possibly decrease the underlying complexity of the disorder. Alongside the classical symptoms of delusions and hallucinations, cognitive deficits are a...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - July 18, 2018 Category: Psychiatry Source Type: research

Effect of age onset on schizophrenia-like phenotypes and underlying mechanisms in model mice
Publication date: Available online 17 July 2018Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Jun Ju, Luping Liu, Yujie Zhang, Qiang ZhouAbstractIn humans, schizophrenia with onset in adolescence or adult has distinct features. To understand whether schizophrenia with either adolescence- or adult-onset have distinct phenotypes and cellular mechanisms in schizophrenia model mice, we altered Nrg1 signaling during either adolescence or adult mice via injection of anti-Nrg1 antibodies. We found that in either early-onset schizophrenia (EOS)- or late-onset schizophrenia (LOS)-like mice, certain...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - July 18, 2018 Category: Psychiatry Source Type: research

Metabolomic and glycomic findings in posttraumatic stress disorder
Publication date: Available online 17 July 2018Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Marcela Konjevod, Lucija Tudor, Dubravka Svob Strac, Gordana Nedic Erjavec, Coral Barbas, Neven Zarkovic, Matea Nikolac Perkovic, Suzana Uzun, Oliver Kozumplik, Gordan Lauc, Nela PivacAbstractPosttraumatic stress disorder (PTSD) is a stressor-related disorder that develops in a subset of individuals exposed to a traumatic experience. Factors associated with vulnerability to PTSD are still not fully understood. PTSD is frequently comorbid with various psychiatric and somatic disorders, moderate res...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - July 18, 2018 Category: Psychiatry Source Type: research

Knockdown of CLC-3 in the hippocampal CA1 impairs contextual fear memory
Publication date: Available online 17 July 2018Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Ye-Fei Chen, Zi-Xiang Chen, Run-Hua Wang, Yan-Wei Shi, Li Xue, Xiao-Guang Wang, Hu ZhaoAbstractPrevious studies support a critical role of hippocampus in contextual fear memory. Structural and functional alterations of hippocampus occur frequently in posttraumatic stress disorders (PTSD). Recent reports reveal that knockout of CLC-3, a member of the CLC family of anion channels and transporters, leads to neuronal degeneration and loss of hippocampus. However, the role of CLC-3 in contextual fear m...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - July 18, 2018 Category: Psychiatry Source Type: research

Multidimensional imaging techniques for prediction of treatment response in major depressive disorder
In this study, we used three different tasks across domains of function (emotion processing, reward anticipation, and cognitive control, plus resting state connectivity completed prior to start of medication to predict treatment response in 13–36 adults with MDD. For each experiment, adults with MDD were prescribed only label duloxetine (all experiments), whereas another subset were prescribed escitalopram. We used a KeyNet (both Task derived masks and Key intrinsic Network derived masks) approach to targeting brain systems in a specific match to tasks. The most robust predictors were (Dichter et al., 2010) positive ...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - July 18, 2018 Category: Psychiatry Source Type: research

The prevalence of psychological distress in Parkinson's disease patients: The brief symptom inventory (BSI-18) versus the Hopkins symptom checklist (SCL-90-R)
Publication date: Available online 12 July 2018Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Danilo Carrozzino, Chiara Siri, Per BechAbstractThe prevalence of psychological distress in Parkinson's disease (PD) patients has been evaluated by many different assessment instruments and with diverse control groups. The most frequently used distress symptom scale has been the Hopkins Symptom Checklist (SCL-90-R), although it contains many symptoms with problematic validity clinically. The 18-item subscale of the SCL-90-R, the Brief Symptom Inventory (BSI-18) has recently been shown to have a su...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - July 12, 2018 Category: Psychiatry Source Type: research

Differential effects of citalopram on sleep-deprivation-induced depressive-like behavior and memory impairments in mice
In this study, we aimed to examine whether subchronic treatment of citalopram (CTM), an antidepressant, can attenuate the negative effects of S-Dep in mice. Three-month-old C57BL/6J mice were divided into control, S-Dep, CTM control and CTM + S-Dep groups. CTM and CTM + S-Dep group treated with citalopram for 5 consecutive days at a dose of 10 mg/kg per day before experimental procedure. S-Dep and CTM + S-Dep group mice were sleep deprived for 24 h using an automated treadmill method. Our results revealed that S-Dep animals displayed an increased depressive-like behavior in forced swim, tail suspension and ...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - July 12, 2018 Category: Psychiatry Source Type: research

Carbamoylated erythropoietin induces a neurotrophic gene profile in neuronal cells
Publication date: Available online 11 July 2018Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Neeraj K. Tiwari, Monica Sathyanesan, William Schweinle, Samuel S. NewtonAbstractErythropoietin (EPO), a cytokine molecule, is best-known for its role in erythropoiesis. Preclinical studies have demonstrated that EPO has robust neuroprotective effects that appear to be independent of erythropoiesis. It is also being clinically tested for the treatment of neuropsychiatric illnesses due to its behavioral actions. A major limitation of EPO is that long-term administration results in excessive red blo...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - July 12, 2018 Category: Psychiatry Source Type: research

Exploring the relationship between fairness and ‘brain types’ in children with high-functioning autism spectrum disorder
Publication date: Available online 11 July 2018Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Yao Wang, Yunhua Xiao, Yun Li, Kangkang Chu, Min Feng, Chunyan Li, Nana Qiu, Jiao Weng, Xiaoyan KeAbstractBackgroundExisting research typically focuses on only one domain of cognition with regard to fairness—theory of mind or executive function. However, children with High-functioning autism spectrum disorder (HF-ASD) are cognitively impaired in both domains. Moreover, little is known about fairness characteristics in children with HF-ASD in relation to both domains of cognition.MethodsThirt...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - July 12, 2018 Category: Psychiatry Source Type: research

Serum level of brain-derived neurotrophic factor in Parkinson's disease: a meta-analysis
Publication date: Available online 11 July 2018Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Lina Jiang, Hainan Zhang, Chunyu Wang, Fengyu Ming, Xiao-liu Shi, Mei YangAbstractBrain-derived neurotrophic factor (BDNF), a critical modulator in the neurodevelopment and maintenance of both central and peripheral nervous systems, is regarded as a potential therapeutic target of Parkinson's disease (PD). However, its association with PD remains unclear and the data are inconsistent. To explore the correlation, studies reporting BDNF levels in PD patients and healthy controls are searched and a s...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - July 12, 2018 Category: Psychiatry Source Type: research

Speech structure links the neural and socio-behavioural correlates of psychotic disorders
Conclusions: The results provide novel evidence that speech dysconnectivity could emerge from neurodevelopmental deficits and associated dysconnectivity in psychosis. (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - July 12, 2018 Category: Psychiatry Source Type: research

Foreword
Publication date: Available online 11 July 2018Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - July 11, 2018 Category: Psychiatry Source Type: research

Cognitive behavioural therapy in pain and psychological disorders: Towards a hybrid future
This article provides a brief description of the core characteristics of CBT and the transformation this therapeutic model has brought to our understanding and management of chronic pain. Current evidence on efficacy of CBT for chronic pain is then reviewed, followed by a critical consideration of the advantages and disadvantages of the new hybrid treatment approach that conceptualises and treats chronic pain in connection with its comorbidities. Recent progress made in the area of pain and insomnia is highlighted as an example to project therapeutic innovations in the near future. (Source: Progress in Neuro Psychopharmaco...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - July 10, 2018 Category: Psychiatry Source Type: research

Corticolimbic circuitry in the modulation of chronic pain and substance abuse
Publication date: Available online 10 May 2017Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Anna M.W. TaylorAbstractThe transition from acute to chronic pain is accompanied by increased engagement of emotional and motivational circuits. Adaptations within this corticolimbic circuitry contribute to the cellular and behavioral maladaptations associated with chronic pain. Central regions within the corticolimbic brain include the mesolimbic dopamine system, the amygdala, and the medial prefrontal cortex. The evidence reviewed herein supports the notion that chronic pain induces significant c...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - July 10, 2018 Category: Psychiatry Source Type: research

Epidemiology of pain and relation to psychiatric disorders
Publication date: Available online 15 May 2017Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Ana Miriam Velly, Shrisha MohitAbstractChronic pain is a common pain condition. Some psychiatric disorders, such as anxiety and depression, are also common in the general population. Epidemiological studies found that some psychiatric disorders are more commonly found among persons with chronic pain (e.g., headache, back pain) than those without chronic pain. Why those psychiatric disorders co-occur with chronic pain, however, is not well understood. Further, studies demonstrated that some psychiat...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - July 10, 2018 Category: Psychiatry Source Type: research

Pain with traumatic brain injury and psychological disorders
Publication date: Available online 13 June 2017Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Samar Khoury, Rodrigo BenavidesAbstractTraumatic brain injury (TBI) is the cause for long-term disability in more than 3 million patients in the US alone, with chronic pain being the most frequently reported complain. To date, predisposing mechanisms for chronic pain in TBI patients are largely unknown. Psychological disorders, including post-traumatic stress disorder, depression and anxiety following TBI are commonly reported comorbidities to post-traumatic pain. Long term consequences can be deb...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - July 10, 2018 Category: Psychiatry Source Type: research

Role of placebo effects in pain and neuropsychiatric disorders
Publication date: Available online 14 June 2017Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Annabelle M. Belcher, Sergi Ferré, Pedro E. Martinez, Luana CollocaAbstractThe placebo (and the nocebo) effect is a powerful determinant of health outcomes in clinical disease treatment and management. Efforts to completely eradicate placebo effects have shifted dynamically, as increasingly more researchers are tuned to the potentially beneficial effects of incorporating those uncontrollable placebo effects into clinical therapeutic strategies. In this review, we highlight the major finding...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - July 10, 2018 Category: Psychiatry Source Type: research

Defining the place of habit in substance use disorders
Publication date: Available online 27 June 2017Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Youna Vandaele, Patricia H. JanakAbstractIt has long been suggested that alcohol or substance use disorders could emerge from the progressive development and dominance of drug habits. Like habits, drug-related behaviors are often triggered by drug-associated cues. Like habits, addictive behaviors are strong, rigid and “hard to break”. Like habits, these behaviors are insensitive to their outcome and persist despite negative consequences. “Pathological habit” thus appears as...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - July 10, 2018 Category: Psychiatry Source Type: research

Palatable food self-administration and reinstatement are not affected by dual orexin receptor antagonism
Publication date: Available online 27 June 2017Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Shaun Yon-Seng Khoo, Kelly J. Clemens, Gavan P. McNallyAbstractThe orexins are widely regarded potential therapeutic targets for a range of disorders of appetitive motivation, including obesity. The motivational activator theory, the first coherent account of the orexin system's role in appetitive motivation, predicts that orexin release motivates appetitive behaviour when the reinforcer is highly salient, available under a high unit-cost or when reward seeking is cue-driven. The present study tes...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - July 10, 2018 Category: Psychiatry Source Type: research

Substance-related disorders: A review of prevalence and correlates among patients with chronic pain
Publication date: Available online 29 June 2017Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Marc O. Martel, Yoram Shir, Mark A. WareAbstractOver the past few decades, research has revealed high rates of substance-related disorders among patients with chronic pain. In addition to their potentially deleterious health consequences, substance-related disorders have consistently been associated with negative pain-related outcomes among patients with chronic pain. The goal of this narrative review was to provide an overview of studies that have examined the prevalence and correlates of substan...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - July 10, 2018 Category: Psychiatry Source Type: research

The clinical utility of repetitive transcranial magnetic stimulation in reducing the risks of transitioning from acute to chronic pain in traumatically injured patients
Publication date: Available online 8 July 2017Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Marianne Jodoin, Dominique Rouleau, Camille Larson-Dupuis, Nadia Gosselin, Louis De BeaumontAbstractPain is a multifaceted condition and a major ongoing challenge for healthcare professionals having to treat patients in whom pain put them at risk of developing other conditions. Significant efforts have been invested in both clinical and research settings in an attempt to demystify the mechanisms at stake and develop optimal treatments as well as to reduce individual and societal costs. It is now un...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - July 10, 2018 Category: Psychiatry Source Type: research

Sleep, chronic pain, and opioid risk for apnea
Publication date: Available online 19 July 2017Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Serguei Marshansky, Pierre Mayer, Dorrie Rizzo, Marc Baltzan, Ronald Denis, Gilles J. LavigneAbstractPain is an unwelcome sleep partner. Pain tends to erode sleep quality and alter the sleep restorative process in vulnerable patients. It can contribute to next-day sleepiness and fatigue, affecting cognitive function.Chronic pain and the use of opioid medications can also complicate the management of sleep disorders such as insomnia (difficulty falling and/or staying asleep) and sleep-disordered br...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - July 10, 2018 Category: Psychiatry Source Type: research

Punishment of alcohol-reinforced responding in alcohol preferring P rats reveals a bimodal population: Implications for models of compulsive drug seeking
Publication date: Available online 25 July 2017Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Nathan J. Marchant, Erin J. Campbell, Konstantin KaganovskyAbstractIndividual variations in animal behaviour can be used to describe relationships between different constructs, as well as the underlying neurobiological mechanisms responsible for such variation. In humans, variation in the expression of certain traits contributes to the onset of psychopathologies, such as drug addiction. Addiction is characterised by persistent drug use despite negative consequences, but it occurs in only a sub-pop...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - July 10, 2018 Category: Psychiatry Source Type: research

The risk for problematic opioid use in chronic pain: What can we learn from studies of pain and reward?
Publication date: Available online 1 August 2017Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Patrick H. Finan, Bethany Remeniuk, Kelly E. DunnAbstractProblematic prescription opioid use is cited as a primary contributor to the current ‘opioid epidemic’ in the United States, which is characterized by recent rapid increases in individuals seeking treatment for opioid dependence and staggering rates of opioid overdose deaths. Individuals with chronic pain are commonly prescribed opioids to treat pain, and by this mere exposure are at increased risk for the development of problem...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - July 10, 2018 Category: Psychiatry Source Type: research

A comprehensive literature review of chronic pain and memory
Publication date: Available online 8 August 2017Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Stéphanie Mazza, Maud Frot, Amandine E. ReyAbstractChronic pain patients often complain of their “poor memory” and numerous studies objectively confirmed such difficulties in reporting working memory (WM) and long-term memory (LTM) dysfunctions. This paper provides a comprehensive review of the literature on memory impairment in chronic pain (CP) patients.Twenty-four observational studies evaluating WM or/and LTM in a chronic pain group and a control group were included in this...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - July 10, 2018 Category: Psychiatry Source Type: research

Chronic pain and suicide risk: A comprehensive review
Publication date: Available online 26 August 2017Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Mélanie RacineAbstractDeath by suicide is one of the leading causes of mortality worldwide. Because individuals with chronic pain are at least twice as likely to report suicidal behaviors or to complete suicide, it is of utmost importance to target which risk factors contribute the most to increasing suicidality. This comprehensive review aims to provide an update on research advancements relating to the identification of potential risk factors for suicidality in individuals with chronic ...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - July 10, 2018 Category: Psychiatry Source Type: research

Behavioral and neural mechanisms underlying habitual and compulsive drug seeking
Publication date: Available online 5 September 2017Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Rachel J. Smith, Lillian S. LaiksAbstractAddiction is characterized by compulsive drug use despite negative consequences. Here we review studies that indicate that compulsive drug use, and in particular punishment resistance in animal models of addiction, is related to impaired cortical control over habitual behavior. In humans and animals, instrumental behavior is supported by goal-directed and habitual systems that rely on distinct corticostriatal networks. Chronic exposure to addictive drug...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - July 10, 2018 Category: Psychiatry Source Type: research

Early life adversity potentiates expression of addiction-related traits
Publication date: Available online 9 September 2017Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Tristan J. Hynes, Catherine S. Thomas, Alicia S. Zumbusch, Anna Samson, Ioana Petriman, Una Mrdja, Angélique Orr, Emilie Cutts, Bruce G. Ruzindana, Alimohamed Hazari, Margaret Zjadewicz, Vedran LovicAbstractMany individuals sporadically and circumstantially sample addictive drugs, yet few become addicted. The individual vulnerabilities underlying the development of addiction are not well understood. Correlational findings show that early life adversity is associated with a greater prope...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - July 10, 2018 Category: Psychiatry Source Type: research

Pain, aging and dementia: Towards a biopsychosocial model
Publication date: Available online 22 September 2017Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Lucia Gagliese, Lynn R. Gauthier, Nadine Narain, Tamlyn FreedmanAbstractDementia is a progressive disease associated with irreversible impairment and loss of cognitive abilities. About half of older people with dementia experience pain. In this paper, we propose that pain in older people with dementia can be conceptualized as the final result of the interaction of three heterogeneous phenomena, pain, aging, and dementia, which are created and influenced by the interactions of predisposing, li...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - July 10, 2018 Category: Psychiatry Source Type: research

Trying to make sense of rodents' drug choice behavior
Publication date: Available online 28 September 2017Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Serge H. AhmedAbstractSince the first experimental hint for the existence of “an actual desire or striving for the drug” in nonhuman animals by Sidney Spragg in the late 1930s, much effort has been expended by lab researchers to try to model in a valid manner the key behavioral aspects and signs of addiction in animals, typically in rodents (i.e., mainly rats and, to a lesser extent, mice). Despite much advances, there still remains a lingering doubt about the disordered status of...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - July 10, 2018 Category: Psychiatry Source Type: research

Astroglial correlates of neuropsychiatric disease: From astrocytopathy to astrogliosis
Publication date: Available online 6 October 2017Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Ronald Kim, Kati L. Healey, Marian T. Sepulveda-Orengo, Kathryn J. ReissnerAbstractComplex roles for astrocytes in health and disease continue to emerge, highlighting this class of cells as integral to function and dysfunction of the nervous system. In particular, escalating evidence strongly implicates a range of changes in astrocyte structure and function associated with neuropsychiatric diseases including major depressive disorder, schizophrenia, and addiction. These changes can range from as...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - July 10, 2018 Category: Psychiatry Source Type: research

Pain and consciousness
Publication date: Available online 12 October 2017Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Luis Garcia-Larrea, Hélène BastujiAbstractThe aversive experience we call “pain” results from the coordinated activation of multiple brain areas, commonly described as a “pain matrix”. This is not a fixed arrangement of structures but rather a fluid system composed of several interacting networks: A ‘nociceptive matrix’ includes regions receiving input from ascending nociceptive systems, and ensures the bodily characteristics of physical pain. A...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - July 10, 2018 Category: Psychiatry Source Type: research

Chronic pain and pain processing in Parkinson's disease
Publication date: Available online 12 October 2017Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Pierre J. Blanchet, Christine Brefel-CourbonAbstractPain is experienced by the vast majority of patients living with Parkinson's disease. It is most often of nociceptive origin, but may also be ascribed to neuropathic (radicular or central) or miscellaneous sources. The recently validated King's Parkinson's Disease Pain Scale is based on 7 domains including musculoskeletal pain, chronic body pain (central or visceral), fluctuation-related pain, nocturnal pain, oro-facial pain, pain with discolo...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - July 10, 2018 Category: Psychiatry Source Type: research