Activation of the TRKB receptor mediates the panicolytic-like effect of the NOS inhibitor aminoguanidine
Publication date: Available online 13 April 2019Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Deidiane Elisa Ribeiro, Plinio Cabrera Casarotto, Ailton Spiacci Júnior, Gabriel Gripp Fernandes, Lucas César Pinheiro, José Eduardo Tanus dos Santos, Hélio Zangrossi Júnior, Francisco Silveira Guimarães, Samia Regiane Lourenço Joca, Caroline BiojoneAbstractNitric oxide (NO) triggers escape reactions in the dorsal periaqueductal gray matter (dPAG), a core structure mediating panic-associated response, and decreases the release of BDNF in vitro. BDN...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - April 15, 2019 Category: Psychiatry Source Type: research

S 47445 counteracts the behavioral manifestations and hippocampal neuroplasticity changes in bulbectomized mice
Publication date: Available online 10 April 2019Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Fuencisla Pilar-Cuellar, Elena Castro, Sylvie Bretin, Elisabeth Mocaer, Ángel Pazos, Álvaro DíazAbstractS 47445 is a positive allosteric modulator of glutamate AMPA-type receptors that possesses procognitive, neurotrophic and enhancing synaptic plasticity properties. Its chronic administration promotes antidepressant- and anxiolytic-like effects in different rodent models of depression.We have evaluated the behavioral effects of S 47445 in the bilateral olfactory bulbectomy m...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - April 12, 2019 Category: Psychiatry Source Type: research

Resistance to fear memory destabilization triggers exaggerated emotional-like responses following memory reactivation
Publication date: Available online 9 April 2019Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Vanesa Ortiz, Gastón Diego Calfa, Víctor Alejandro Molina, Irene Delia MartijenaAbstractFear memory reactivation does not always lead to memory destabilization-reconsolidation. For instance, fear memories formed following withdrawal from chronic ethanol consumption or a stressful event are less likely to become destabilized after reactivation, with the effect of recall of these memories on the affective state still requiring elucidation. Here, we investigated the negative emotional-l...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - April 10, 2019 Category: Psychiatry Source Type: research

Differential levels of prefrontal cortex glutamate+glutamine in adults with antisocial personality disorder and bipolar disorder: A proton magnetic resonance spectroscopy study
Publication date: Available online 5 April 2019Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Areti Smaragdi, Sofia Chavez, Nancy J. Lobaugh, Jeffrey H. Meyer, Nathan J. KollaAbstractAs the main excitatory neurotransmitter in the central nervous system, glutamate, as measured in combination with glutamine (Glx), is implicated in several psychopathologies when levels are aberrant. One illness that shows heightened Glx levels is bipolar disorder (BD), an illness characterized by high impulsivity. In addition, although animal studies have reported elevated levels of Glx in aggressive and impu...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - April 7, 2019 Category: Psychiatry Source Type: research

Assessment of DNA repair efficiency in the inbred BTBR T+tf/J autism spectrum disorder mouse model exposed to gamma rays and treated with JNJ7777120
Publication date: Available online 5 April 2019Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): H.A. Al-Mazroua, H.A. Alomar, S.F. Ahmad, Attia MSA, A. Nadeem, S.A. Bakheet, Alsaad AMS, M.R. Alotaibi, S.M. AttiaAbstractInformation regarding DNA repair in autism is limited to a few studies, which have reported inconsistent results. Therefore, we designed a study to determine whether DNA repair efficiency is altered in autism and to investigate whether the H4 ligand JNJ7777120 can enhance DNA repair efficiency in BTBR T+tf/J (BTBR) mice; we also attempted to elucidate the mechanism(s) underlyi...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - April 7, 2019 Category: Psychiatry Source Type: research

Collaborative interdisciplinary approaches for a heterogeneous group of neurodevelopmental disorders; A “Way” forward!
Publication date: 13 July 2019Source: Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 93Author(s): Stephen I. Deutsch, Jessica A. Burket, Maria R. Urbano (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - April 5, 2019 Category: Psychiatry Source Type: research

Alteration of GABAergic signaling is associated with anxiety-like behavior in temporal lobe epilepsy mice
Publication date: Available online 2 April 2019Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Xinjian Zhu, Yuanyuan Yao, Xiaolin Li, Jingde Dong, Aifeng ZhangAbstractTemporal lobe epilepsy (TLE), which is one of the most common neurological diseases, is accompanied by a high incidence of psychiatric disorders. Among these psychiatric disorders, anxiety is one of the major psychiatric comorbidities in epilepsy patients. However, anxiety in epilepsy patients often remains unrecognized and untreated. It is believed that the inhibitory networks of γ-aminobutyric acid (GABA) neurotransmis...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - April 4, 2019 Category: Psychiatry Source Type: research

Fear memory-induced alterations in the mRNA expression of G proteins in the mouse brain and the impact of immediate posttraining treatment with morphine
Publication date: Available online 3 April 2019Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Agnieszka Zelek-Molik, Marco Costanzi, Katarzyna Rafa-Zabłocka, Grzegorz Kreiner, Adam Roman, Jerzy Vetulani, Clelia Rossi-Arnaud, Vincenzo Cestari, Irena NalepaAbstractDisturbances in fear-evoked signal transduction in the hippocampus (HP), the nuclei of the amygdala (AMY), and the prefrontal cortex (PFC) underlie anxiety-related disorders. However, the molecular mechanisms underlying these effects remain elusive. Heterotrimeric G proteins (GPs) are divided into the following four families based...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - April 4, 2019 Category: Psychiatry Source Type: research

Cannabinoid interventions for PTSD: Where to next?
This article makes the strengths and challenges of different potential cannabinoid treatments accessible to psychological researchers interested in cannabinoid therapeutics and aims to aid selection of appropriate tools for future clinical trials. (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - April 2, 2019 Category: Psychiatry Source Type: research

Synergistic effects between ADORA2A and DRD2 genes on anxiety disorders in children with ADHD
Publication date: Available online 1 April 2019Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Thailan T. Fraporti, Verônica Contini, Luciana Tovo-Rodrigues, Mariana Recamonde-Mendoza, Diego L. Rovaris, Luís Augusto Rohde, Mara Helena Hutz, Angélica Salatino-Oliveira, Júlia Pasqualini GenroAbstractThe prevalence of anxiety disorders in patients with Attention Deficit/Hyperactivity Disorder (ADHD) is around 15–40%, three times higher than in the general population. The dopaminergic system, classically associated with ADHD, interacts directly with the adenosin...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - April 2, 2019 Category: Psychiatry Source Type: research

Withdrawal effects following repeated ethanol exposure are prevented by N-acetylcysteine in zebrafish
Publication date: Available online 1 April 2019Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Ricieri Mocelin, Matheus Marcon, Alex Sander da Rosa Araujo, Ana Paula Herrmann, Angelo PiatoAbstractAlcohol abuse is a highly prevalent condition that substantially contributes to global morbidity and mortality. Most available pharmacological treatments offer little efficacy as relapse rates are high, due in part to the symptoms experienced during abstinence. The roles of oxidative stress and glutamatergic transmission in alcohol withdrawal have been demonstrated in several studies, suggesting th...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - April 2, 2019 Category: Psychiatry Source Type: research

Young frequent binge drinkers show no behavioral deficits in inhibitory control and cognitive flexibility
Publication date: Available online 1 April 2019Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Wiebke Bensmann, Özlem Feray Kayali, Christian Beste, Ann-Kathrin StockAbstractAlcohol intoxication and abuse are well-known to cause impairments in executive functioning and control. Still, we know surprisingly little about individuals engaging in frequent binge drinking, even though they have an increased risk to develop an alcohol use disorder (AUD) later in life. As this risk has been suggested to be linked to (premorbid) executive deficits, we assessed changes in cognitive flexibility an...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - April 2, 2019 Category: Psychiatry Source Type: research

Early intervention with electroacupuncture prevents PTSD-like behaviors in rats through enhancing hippocampal endocannabinoid signaling
Publication date: Available online 1 April 2019Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Fen Xue, Shan-shan Xue, Ling Liu, Han-fei Sang, Quan-rui Ma, Qing-rong Tan, Hua-ning Wang, Cui-hong Zhou, Zheng-wu PengAbstractElectroacupuncture (EA) is a clinically useful physiological therapy that has been recently adopted to treat several brain disorders. However, the potential role of early EA intervention in the prevention of posttraumatic stress disorder (PTSD) as well as its potential cellular and molecular mechanism has never been investigated previously. In the present study, we used an...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - April 2, 2019 Category: Psychiatry Source Type: research

Behavioral and biological markers for predicting compulsive-like drinking in schedule-induced polydipsia
Publication date: Available online 30 March 2019Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): A. Merchán, A. Sánchez-Kuhn, A. Prados-Pardo, B. Gago, F. Sánchez-Santed, M. Moreno, P. FloresAbstractSchedule-induced polydipsia (SIP), characterized by the development of persistent and excessive drinking under intermittent food-reinforcement schedules, is an animal model of compulsive behavior that can differentiate two populations: high drinkers (HD) and low drinkers (LD). The aim of the present study was to identify behavioral and biological markers to predict the vulner...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - April 1, 2019 Category: Psychiatry Source Type: research

Ketamine ameliorates severe traumatic event-induced antidepressant-resistant depression in a rat model through ERK activation
Publication date: Available online 30 March 2019Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Chi-Wei Lee, Yi-Ju Chen, Han-Fang Wu, Yueh-Jung Chung, Yi-Chao Lee, Cheng-Ta Li, Hui-Ching LinAbstractTreatment-resistant depression (TRD) is a major public health issue, as it is common for patients with depression to fail to respond to adequate trials of antidepressants. However, a well-established animal model of TRD is still warranted. The present study focused on selective serotonin reuptake inhibitor (SSRI) resistance, and aimed to investigate whether higher levels of traumatic stress cause...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - April 1, 2019 Category: Psychiatry Source Type: research

Response to the comment on “An animal model of what? the case of spontaneously hypertensive rats”
Publication date: Available online 30 March 2019Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): F.F. Peres, V.C. Abilio (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - March 30, 2019 Category: Psychiatry Source Type: research

An animal model of what? The case of spontaneously hypertensive rats
Publication date: Available online 30 March 2019Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Alana C. Panzenhagen, Claiton H.D. Bau, Eugenio H. Grevet, Diego L. Rovaris (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - March 30, 2019 Category: Psychiatry Source Type: research

Autism Spectrum disorders: Biological insights into these descriptively heterogeneous disorders and opportunities for pharmacotherapy
Publication date: Available online 29 March 2019Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Stephen I. Deutsch, Jessica A. Burket, Maria R. Urbano (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - March 29, 2019 Category: Psychiatry Source Type: research

Altered network homogeneity of the default-mode network in drug-naive obsessive−compulsive disorder
ConclusionThese findings contribute new evidence of the participation of the altered NH of the DMN in the pathophysiology of OCD.Trial RegistrationStudy on the mechanism of brain network in obsessive-compulsive disorder with multi-model magnetic resonance imaging (ChiCTR-COC-17013301). (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - March 22, 2019 Category: Psychiatry Source Type: research

The genomics of schizophrenia: Shortcomings and solutions
Publication date: Available online 20 March 2019Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Chuanjun Zhuo, Weihong Hou, Gongying Li, Fuqiang Mao, Shen Li, Xiaodong Lin, Deguo Jiang, Yong Xu, Hongjun Tian, Wenqiang Wang, Langlang ChengAbstractDue to recent advances in human genomic technologies, there have been explosive interests and extensive research on the genomics of schizophrenia, a severe psychiatric disorder characterized by social cognitive deficits, hallucinations, and delusions. These new technologies, including next-generation sequencing (NGS), genome-wide association studies...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - March 21, 2019 Category: Psychiatry Source Type: research

Advances and challenges in development of precision psychiatry through clinical metabolomics on mood and psychotic disorders
The objective of this review is to comprehensively assess the literature on metabolomics in mood disorders and schizophrenia and provide data for mental health researchers about the challenges and potentials of metabolomics. The majority of studies in metabolomics in Psychiatry uses peripheral blood or urine. The most widely used analytical techniques in metabolomics research are nuclear magnetic resonance (NMR) and mass spectrometry (MS). They are multiparametric and provide extensive structural and conformational information on multiple chemical classes. NMR is useful in untargeted analysis, which focuses on biosignature...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - March 21, 2019 Category: Psychiatry Source Type: research

Shared genetic risk factors for depression and stroke
ConclusionThese findings suggest that shared genetic pathways may contribute to the comorbidity of MDD and stroke. Studies to evaluate the shared genetic variations between MDD and stroke may provide insights into the molecular mechanisms that trigger disease progression. (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - March 20, 2019 Category: Psychiatry Source Type: research

Structure/function interrelationships in patients with schizophrenia who have persistent auditory verbal hallucinations: A multimodal MRI study using parallel ICA
Publication date: Available online 16 March 2019Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Katharina M. Kubera, Mahmoud Rashidi, Mike M. Schmitgen, Anja Barth, Dusan Hirjak, Fabio Sambataro, Vince D. Calhoun, Robert C. WolfAbstractThere is accumulating neuroimaging evidence for both structural and functional abnormalities in schizophrenia patients with persistent auditory verbal hallucinations (AVH). So far, the direct interrelationships between altered structural and functional changes underlying AVH are unknown. Recently, it has become possible to reveal hidden patterns of neural dys...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - March 17, 2019 Category: Psychiatry Source Type: research

Whole-brain functional connectivity during script-driven aggression in borderline personality disorder
ConclusionsWe identified a large network showing a significantly stronger increase in connectivity from baseline to the aggression phase in female patients with BPD compared to healthy women. The regions constituting this network belong to four previously described functional networks: The frontoparietal cognitive control network, the extended default mode network, the visual system, and the motor system. This stronger increase in connectivity between regions of different functional brain systems associated with cognitive control of behavior, socio-affective and self-referential thinking, as well as salience processing and...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - March 17, 2019 Category: Psychiatry Source Type: research

Taurine prevents memory consolidation deficits in a novel alcohol-induced blackout model in zebrafish
Publication date: Available online 14 March 2019Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Kanandra T. Bertoncello, Talise E. Müller, Barbara D. Fontana, Francini Franscescon, Gilvan L.B. Filho, Denis B. RosembergAbstractEthanol is one of the most consumed substance worldwide that impairs learning and memory processes, resulting in amnesia or blackout. Due to the genetic conservation, rich behavioral repertoire, and high pharmacological tractability, the zebrafish (Danio rerio) has emerged as a powerful model organism for assessing preventive strategies against the noxious effects...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - March 15, 2019 Category: Psychiatry Source Type: research

Non-invasive brain stimulation in generalized anxiety disorder: A systematic review
Publication date: Available online 12 March 2019Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Laura Sagliano, Danilo Atripaldi, Dalila De Vita, Francesca D'Olimpio, Luigi TrojanoAbstractIn the last years, several studies using non-invasive brain stimulation (NIBS) techniques demonstrated that the dorsolateral prefrontal cortex (DLPFC) plays a key role in the neurobiological bases of anxiety disorders. Both transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) applied primarily over the prefrontal cortex have been shown to modulate anxiety symptomatolog...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - March 14, 2019 Category: Psychiatry Source Type: research

Exposure to early and persistent maternal depression impairs the neural basis of attachment in preadolescence
Publication date: Available online 12 March 2019Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Maayan Pratt, Maor Zeev-Wolf, Abraham Goldstein, Ruth FeldmanAbstractMaternal depression increases child vulnerability to psychopathology, loneliness, and social maladjustment; yet, its long-term effects on the social brain are unknown. In this prospective longitudinal study we examined the impact of early and persistent maternal depression on the neural basis of attachment in preadolescence. A community cohort was followed in two groups; children exposed to maternal depression from birth to 6 ...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - March 14, 2019 Category: Psychiatry Source Type: research

Ghrelin exhibited antidepressant and anxiolytic effect via the p38-MAPK signaling pathway in hippocampus
Publication date: Available online 8 March 2019Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Qiu-Qin Han, Hui-Jie Huang, Ya-Lin Wang, Liu Yang, Adam Pilot, Xiao-Cang Zhu, Rui Yu, Jing Wang, Xiao-Rong Chen, Qiong Liu, Bing Li, Gen-Cheng Wu, Jin YuAbstractGhrelin, a peptide derived from stomach, is an endogenous ligand for growth hormone secretagogue receptor (GHSR). So far, the exact role of ghrelin in depression and anxiety is still being debated. The p38 mitogen-activated protein kinase (p38-MAPK) is known to be activated in response to various stress stimuli. Thus, we hypothesize that g...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - March 8, 2019 Category: Psychiatry Source Type: research

Novel insights into the mechanisms underlying depression-associated experimental autoimmune encephalomyelitis
Publication date: Available online 5 March 2019Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Eduardo Duarte-Silva, Danielle Macedo, Michael Maes, Christina Alves PeixotoAbstractMultiple Sclerosis (MS) is a chronic autoimmune disease characterized by neuroinflammation, demyelination and neuroaxonal degeneration affecting>2 million people around the world. MS is often accompanied by psychiatric comorbidities such as major depressive disorder (MDD), which presents a lifetime prevalence of around 50% in MS patients. Experimental Autoimmune Encephalomyelitis (EAE) is an animal model exten...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - March 6, 2019 Category: Psychiatry Source Type: research

Effect of newer anti-epileptic drugs (AEDs) on the cognitive status in pentylenetetrazol induced seizures in a zebrafish model
Publication date: Available online 4 March 2019Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Brandon Choo Kar Meng, Uday P. Kundap, Muhammad Faiz bin Johan Arief, Yatinesh Kumari, Yap Jia Ling, Wong Chee Piau, Iekhsan Othman, Mohd. Farooq ShaikhAbstractEpilepsy is marked by seizures that are a manifestation of excessive brain activity and is symptomatically treatable by anti-epileptic drugs (AEDs). Unfortunately, the older AEDs have many side effects, with cognitive impairment being a major side effect that affects the daily lives of people with epilepsy. Thus, this study aimed to determi...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - March 5, 2019 Category: Psychiatry Source Type: research

The effects of processing speed on memory impairment in patients with major depressive disorder
ConclusionProcessing speed is an important factor regarding learning and memory impairment in patients with current MDD. Thereby, our results highlight novel targets for treatment of diminished learning and memory performance via enhancement of processing speed using pharmacological as well as therapeutic interventions. (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - March 4, 2019 Category: Psychiatry Source Type: research

Sensitization-dependent nicotine place preference in the adult zebrafish
Publication date: Available online 28 February 2019Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): A. Pisera-Fuster, L. Rocco, M.P. Faillace, R. BernabeuAbstractSensitization of motor activity is a behavioural test to evaluate the effects of psychostimulants. Conditioned place preference (CPP) is an associative learning procedure to examine the rewarding properties of drugs. We aimed to assess whether motor sensitization to drugs of abuse can make zebrafish more vulnerable to establishing drug-induced CPP. We first evaluated sensitization of locomotor activity of zebrafish to repeated admin...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 28, 2019 Category: Psychiatry Source Type: research

Src deficient mice demonstrate behavioral and electrophysiological alterations relevant to psychiatric and developmental disease
Publication date: Available online 28 February 2019Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Katelyn R. Ward, Robert E. Featherstone, Melissa J. Naschek, Olga Melnychenko, Anamika Banerjee, Janice Yi, Raymond L. Gifford, Karin E. Borgmann-Winter, Michael W. Salter, Chang-Gyu Hahn, Steven J. SiegelAbstractMuch evidence suggests that hypofunction of the N-methyl-d-aspartate glutamate receptor (NMDAR) may contribute broadly towards a subset of molecular, cognitive and behavioral abnormalities common among psychiatric and developmental diseases. However, little is known about the specific...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 28, 2019 Category: Psychiatry Source Type: research

Pharmacokinetics and toxicity of high-dose baclofen in ICU patients
ConclusionsThe a priori planned algorithm for dose adaptation according to renal clearance appeared to be suitable in our population. Daily administration of 150 mg of baclofen in ICU patients with preserved renal function did not lead to toxic concentrations in the plasma. A dose reduction of approximately 40%, 60% and 70% in patients with mild, moderate and severe renal failure could be suggested. (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 28, 2019 Category: Psychiatry Source Type: research

Functional connectivity of the default mode network is associated with prospection in schizophrenia patients and individuals with social anhedonia
ConclusionAltered functional connectivity of the key nodes of the MTL subsystem was found in both patients with schizophrenia and individuals with SocAhn. Moreover, hypo-connectivity of the vMPFC was found to be correlated with prospection impairments in schizophrenia patients. (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 27, 2019 Category: Psychiatry Source Type: research

Copy number variants in autism spectrum disorders
Publication date: Available online 20 February 2019Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Vicari Stefano, Napoli Eleonora, Cordeddu Viviana, Menghini Deny, Alesi Viola, Loddo Sara, Novelli Antonio, Tartaglia MarcoAbstractIn recent years, there has been an explosive increase in genetic studies related to autism spectrum disorder (ASD). This implicated the accumulation of a large amount of molecular data that may be used to verify various hypotheses and models developed to explore the complex genetic component of ASD. Several lines of evidence support the view that structural genomic...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 21, 2019 Category: Psychiatry Source Type: research

Psychopathology and extrapyramidal side effects in smoking and non-smoking patients with schizophrenia: Systematic review and meta-analysis of comparative studies
Publication date: Available online 19 February 2019Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Hui Huang, Min Dong, Ling Zhang, Bao-Liang Zhong, Chee H. Ng, Gabor S. Ungvari, Zhen Yuan, Xiangfei Meng, Yu-Tao XiangAbstractThe association between smoking and psychopathology and extrapyramidal symptoms in schizophrenia has been controversial. This systematic review and meta-analysis compared psychopathology and extrapyramidal symptoms between smoking and non-smoking schizophrenia patients. The PubMed, EMBASE, PsycINFO, Cochrane Library, and Web of Science databases were independently and s...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 20, 2019 Category: Psychiatry Source Type: research

Structural connectivity in schizophrenia and bipolar disorder: Effects of chronicity and antipsychotic treatment
Publication date: Available online 18 February 2019Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Benjamín Cea-Cañas, Rodrigo de Luis, Alba Lubeiro, Javier Gomez-Pilar, Eva Sotelo, Pilar del Valle, Marta Gómez-García, Adrián Alonso-Sánchez, Vicente MolinaAbstractPrevious studies based on graph theory parameters applied to diffusion tensor imaging support an alteration of the global properties of structural connectivity network in schizophrenia. However, the specificity of this alteration and its possible relation with chronicity and treatment have ...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 19, 2019 Category: Psychiatry Source Type: research

Schizophrenia, cannabis use and Catechol-O-Methyltransferase (COMT): Modeling the interplay on cognition
In conclusions, results highlight the need to better disentangle the biological pathways in which cannabis use and COMT are converging, as possible treatment targets, as well as the importance to assess these factors in clinical to optimize individualized interventions. (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 19, 2019 Category: Psychiatry Source Type: research

Members of the same pharmacological family are not alike: Different opioids, different consequences, hope for the opioid crisis?
Publication date: Available online 18 February 2019Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Michael A. Emery, Shoshana EitanAbstractPain management is the specialized medical practice of modulating pain perception and thus easing the suffering and improving the life quality of individuals suffering from painful conditions. Since this requires the modulation of the activity of endogenous systems involved in pain perception, and given the large role that the opioidergic system plays in pain perception, opioids are currently the most effective pain treatment available and are likely to ...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 18, 2019 Category: Psychiatry Source Type: research

LDL cholesterol relates to depression, its severity, and the prospective course
ConclusionsSerum lipid levels are associated with depression per se, the depression severity, and the prospective 3-week course. These observations build the basis for future investigations on individualized lipid metabolism-related treatment strategies in depressed patients. (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 17, 2019 Category: Psychiatry Source Type: research

Recruitment of central angiotensin II type 1 receptor associated neurocircuits in carbon dioxide associated fear
Publication date: Available online 16 February 2019Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Andrew Winter, Rebecca Ahlbrand, Renu SahAbstractIndividuals with fear-associated conditions such as panic disorder (PD) and posttraumatic stress disorder (PTSD) display increased emotional responses to interoceptive triggers, such as CO2 inhalation, that signal a threat to physiological homeostasis. Currently, effector systems and mechanisms underlying homeostatic modulation of fear memory are not well understood. In this regard, the renin angiotensin system (RAS), particularly the angiotensi...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 17, 2019 Category: Psychiatry Source Type: research

The predictive value of neural reward processing on exposure therapy outcome: Results from a randomized controlled trial
ConclusionResults indicate that individual differences in reward sensitivity can specifically predict exposure therapy outcome. Although activation in regions of interest were not related to therapy outcome, regions involved in attentional processing of reward cues were predictive of phobic symptom change following exposure therapy but not PMR. (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 17, 2019 Category: Psychiatry Source Type: research

High-mobility group box 1-mediated microglial activation induces anxiodepressive-like behaviors in mice with neuropathic pain
Publication date: Available online 11 February 2019Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Kazue Hisaoka-Nakashima, Yoshiaki Tomimura, Toshiki Yoshii, Kazuto Ohata, Naoki Takada, Fang Fang Zhang, Yoki Nakamura, Keyue Liu, Hidenori Wake, Masahiro Nishibori, Yoshihiro Nakata, Norimitsu MoriokaAbstractClinical evidence indicates that major depression is a common comorbidity of chronic pain, including neuropathic pain. However, the cellular basis for chronic pain-mediated major depression remains unclear. High-mobility group box 1 protein (HMGB1) has a key role in innate immune response...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 12, 2019 Category: Psychiatry Source Type: research

The predictive value of neural reward processing in exposure therapy outcome: Results from a randomized controlled trial
ConclusionResults indicate that individual differences in reward sensitivity can specifically predict exposure therapy outcome. Although activation in regions of interest were not related to therapy outcome, regions involved in attentional processing of reward cues were predictive of phobic symptom change following exposure therapy but not PMR. (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 12, 2019 Category: Psychiatry Source Type: research

Nitric oxide in the dorsal periaqueductal gray mediates the panic-like escape response evoked by exposure to hypoxia
Publication date: Available online 10 February 2019Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Gabriel Gripp Fernandes, Alana Tercino Frias, Ailton Spiacci Jr, Lucas C. Pinheiro, José Eduardo Tanus-Santos, Hélio Zangrossi JrAbstractExposure of rats to an environment with low O2 levels evokes a panic-like escape behavior and recruits the dorsal periaqueductal gray (dPAG), which is considered to be a key region in the pathophysiology of panic disorder. The neurochemical basis of this response is, however, currently unknown. We here investigated the role played by nitric oxid...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 10, 2019 Category: Psychiatry Source Type: research

Delayed creatine supplementation counteracts reduction of GABAergic function and protects against seizures susceptibility after traumatic brain injury in rats
Publication date: Available online 8 February 2019Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Rogerio R. Gerbatin, Luiz Fernando Almeida Silva, Maurício S. Hoffmann, Iuri D. Della-Pace, Patricia Severo do Nascimento, Aline Kegler, Viviane Nogueira de Zorzi, Jane Marçal Cunha, Priscilla Botelho, João Bento Torres Neto, Ana Flavia Furian, Mauro Schneider Oliveira, Michele R. Fighera, Luiz Fernando Freire RoyesAbstractTraumatic brain injury (TBI) is a devastating disease frequently followed by behavioral disabilities including post-traumatic epilepsy (PTE). Although re...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 9, 2019 Category: Psychiatry Source Type: research

The glycine site of NMDA receptors: A target for cognitive enhancement in psychiatric disorders
Publication date: Available online 6 February 2019Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Bahareh Peyrovian, Joshua D. Rosenblat, Zihang Pan, Michelle Iacobucci, Elisa Brietzke, Roger S. McIntyreAbstractCognitive dysfunction is a principal determinant of functional impairment in major depressive disorder (MDD) and often persists during periods of euthymia. Abnormalities in the glutamate system, particularly in N-methyl-d-aspartate receptors (NMDARs) activity, have been shown to contribute to both mood and cognitive symptoms in MDD. The current narrative review aims to evaluate the p...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 7, 2019 Category: Psychiatry Source Type: research

Theranostic approach to PTSD
Publication date: 8 June 2019Source: Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 92Author(s): Nela Pivac (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 1, 2019 Category: Psychiatry Source Type: research

Insomnia in patients with schizophrenia: current understanding and treatment options
Publication date: Available online 29 January 2019Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Ian Robertson, Amy Cheung, Xiaoduo FanAbstractIn patients with schizophrenia, insomnia is a common yet often overlooked comorbidity. With sleep disturbances inextricably linked to increased severity of schizophrenia and worsening clinical outcomes, insomnia is an important therapeutic target within this patient population. Thus, through a review of the current literature, this paper reiterates the important etiological link between these two conditions, while evaluating the safety, efficacy, an...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - January 30, 2019 Category: Psychiatry Source Type: research