Machine learning for predicting psychotic relapse at 2 years in schizophrenia in the national FACE-SZ cohort
Publication date: Available online 12 December 2018Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): G. Fond, E. Bulzacka, M. Boucekine, F. Schürhoff, F. Berna, O. Godin, B. Aouizerate, D. Capdevielle, I. Chereau, T. D'Amato, C. Dubertret, J. Dubreucq, C. Faget, S. Leignier, C. Lançon, J. Mallet, D. Misdrahi, C. Passerieux, R. Rey, A. SchandrinAbstractBackgroundPredicting psychotic relapse is one of the major challenges in the daily care of schizophrenia.ObjectivesTo determine the predictors of psychotic relapse and follow-up withdrawal in a non-selected national sample of stabili...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - December 12, 2018 Category: Psychiatry Source Type: research

Differential effects of chemogenetic inhibition on dopamine and norepinephrine neurons in the mouse 5-choice serial reaction time task
In this study, we employ Designer Receptor Exclusively Activated by Designer Drugs (DREADDs) together with the mouse 5-Choice Serial Reaction Time Task (5-CSRTT) to investigate the necessary roles of these catecholamines in ADHD-related behaviors, including attention, impulsivity, and motivation. By selective inhibition of tyrosine hydroxylase (TH)-positive VTA dopamine neurons expressing the Gi-coupled DREADD (hM4Di), we observed a marked impairment of effort-based motivation and subsequently speed and overall vigor of responding. At the highest clozapine N-oxide (CNO) dose tested (i.e. 2 mg/kg) to activate hM4Di, we de...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - December 7, 2018 Category: Psychiatry Source Type: research

Theranostic pharmacology in PTSD: Neurobiology and timing
This article will review recent developments in psychopharmacology for PTSD, with a focus on current clinical data that apply putative neurobiologic mechanisms to medication use—i.e., a theranostic approach. A theranostic approach however, also requires consideration of timing, pre, peri or post trauma in conjunction with underlying dynamic processes affecting synaptic plasticity, the HPA axis, hippocampal activation, PFC-amygdala circuitry and fear memory. (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - December 6, 2018 Category: Psychiatry Source Type: research

NMDA receptor dependence of reversal learning and the flexible use of cognitively demanding search strategies in mice
In conclusion, NMDA receptors appear to be involved in the flexible cognitive processes that underlie reversal learning in spatial as well as non-spatial tasks. Our results also indicate that reversal learning as well as the use of cognitively demanding strategies are more sensitive to NMDA receptor blockage than some other functions that have been suggested to be NMDA receptor dependent. (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - December 6, 2018 Category: Psychiatry Source Type: research

Oxidative and inflammatory mediators are upregulated in neutrophils of autistic children: Role of IL-17A receptor signaling
Publication date: Available online 6 December 2018Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Ahmed Nadeem, Sheikh F. Ahmad, Sabry M. Attia, Laila Y. AL-Ayadhi, Saleh A. Bakheet, Naif O. Al-HarbiAbstractAutism spectrum disorder (ASD) is characterized by repetitive behaviors, impaired social communication and stereotyped interests, and often associated with dysregulations in innate/adaptive immune cells. IL-17A has been linked with abnormal behavioral patterns observed in autistic children and animal models of autism. However, it is yet to be investigated if IL-17A and its receptors are ...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - December 6, 2018 Category: Psychiatry Source Type: research

N-3 polyunsaturated fatty acids and clozapine abrogates poly I: C-induced immune alterations in primary hippocampal neurons
Publication date: Available online 1 December 2018Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Bruna Mara Machado Ribeiro, Adriano José Maia Chaves Filho, Deiziane Viana da Silva Costa, Antônio Teles de Menezes, Anna Carolina Carvalho da Fonseca, Clarissa S. Gama, Vivaldo Moura Neto, David Freitas de Lucena, Mariana Lima Vale, Danielle S. MacêdoAbstractThe viral mimetic polyinosinic:polycytidylic acid (poly I:C) is an important tool to study the consequences of viral infection to the development of neuropsychiatric disorders. Here, based on the premise of omega-3 polyu...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - December 1, 2018 Category: Psychiatry Source Type: research

DNA methylation correlates of PTSD: Recent findings and technical challenges
Publication date: Available online 30 November 2018Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Filomene G. Morrison, Mark W. Miller, Mark W. Logue, Michele Assef, Erika J. WolfAbstractThere is increasing evidence that epigenetic factors play a critical role in posttraumatic stress disorder (PTSD), by mediating the impact of environmental exposures to trauma on the regulation of gene expression. DNA methylation is one epigenetic mark that has been highly studied in PTSD. This review will begin by providing an overview of DNA methylation (DNAm) methods, and will then highlight two major b...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - November 30, 2018 Category: Psychiatry Source Type: research

Elevated cleavage of neuregulin-1 by beta-secretase 1 in plasma of schizophrenia patients
Publication date: Available online 27 November 2018Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Zhengrong Zhang, Jie Cui, Feng Gao, Yuhong Li, Guofu Zhang, Min Liu, Riqiang Yan, Yong Shen, Rena LiAbstractNeuregulin 1 (NRG1) is a key candidate susceptibility gene for schizophrenia. It is reported that the function of NRG1 can be regulated by cleavage via the β-Secretase (BACE1), particularly during early development. While current knowledge suggested that schizophrenia might have different phenotypes, it is unknown whether BACE1-cleaved-NRG1 (BACE1-NRG1) activity is related to clinic...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - November 28, 2018 Category: Psychiatry Source Type: research

Altered resting-state cerebral blood flow and functional connectivity of striatum in bipolar disorder and major depressive disorder
ConclusionsPatients with BD and those with MDD had a common deficit in their prefrontal-limbic-striatal circuits. The altered striato-precuneus FC can be considered as a marker for the differentiation of patients with BD from those with MDD. (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - November 28, 2018 Category: Psychiatry Source Type: research

Young spontaneously hypertensive rats (SHRs) display prodromal schizophrenia-like behavioral abnormalities
Publication date: Available online 28 November 2018Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Suzy Tamie Niigaki, Fernanda Fiel Peres, Lizia Ferreira, Tania Libanio, Douglas Albuquerque Gouvea, Raquel Levin, Valeria Almeida, Neide Derci Silva, Mariana Cepollaro Diana, Mayra Akimi Suiama, Mariana Bendlin Calzavara, Vanessa Costhek AbilioAbstractThe Spontaneously Hypertensive Rat (SHR) strain has been suggested as an animal model of schizophrenia, considering that adult SHRs display behavioral abnormalities that mimic the cognitive, psychotic and negative symptoms of the disease and are ...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - November 28, 2018 Category: Psychiatry Source Type: research

Neuroendocrinological treatment targets for posttraumatic stress disorder
Publication date: Available online 28 November 2018Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Seoyoung Yoon, Yong-Ku KimAbstractPosttraumatic stress disorder (PTSD) is prevalent, disabling, and frequently becomes chronic. Despite this, only two selective serotonergic reuptake inhibitors have been approved to date for its treatment by the United States Food and Drug Administration, and treatment results are often disappointing, with a remission rate of
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - November 28, 2018 Category: Psychiatry Source Type: research

Body mass index and craving predict 24-month hospital readmissions of alcohol-dependent in-patients following withdrawal
Publication date: Available online 26 November 2018Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Christian Weinland, Christiane Mühle, Johannes Kornhuber, Bernd LenzAbstractObjectiveAddictive alcohol drinking, craving, and overeating share common etiopathological mechanisms. We investigated whether body mass index (BMI) and craving predict outcome of alcohol-dependent in-patients.MethodThe prospective study included 101 male and 72 female early-abstinent alcohol-dependent in-patients. Craving was quantified by Obsessive-Compulsive Drinking scale (OCDS) scores. We documented alcohol-r...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - November 27, 2018 Category: Psychiatry Source Type: research

Significantly lower serum and hair magnesium levels in children with attention deficit hyperactivity disorder than controls: A systematic review and meta-analysis
Publication date: Available online 26 November 2018Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Yu-Hui Huang, Bing-Yan Zeng, Dian-Jeng Li, Yu-Shian Cheng, Tien-Yu Chen, Hsin-Yi Liang, Wei-Chieh Yang, Pao-Yen Lin, Yen-Wen Chen, Ping-Tao Tseng, Ching-Hua LinAbstractThe pathophysiology of attention deficient hyperactivity disorder (ADHD) is still obscure. Some studies have discussed that magnesium levels are lower in the serum and erythrocytes of children with ADHD. However, these findings are controversial. The aim of our study is to identify whether magnesium levels are in fact lower in c...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - November 27, 2018 Category: Psychiatry Source Type: research

Metabotropic functions of the NMDA receptor and an evolving rationale for exploring NR2A-selective positive allosteric modulators for the treatment of autism spectrum disorder
Publication date: Available online 24 November 2018Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Jessica A. Burket, Stephen I. DeutschAbstractNMDA receptors are widely distributed throughout the brain and major therapeutic challenges include targeting specific NMDA receptor subtypes while preserving spatial and temporal specificity during their activation. The NR2A-subunit containing NMDA receptor is implicated in regulating synchronous oscillatory output of cortical pyramidal neurons, which may be disturbed in clinical presentations of autism spectrum disorder (ASD). Because NR2A-selecti...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - November 25, 2018 Category: Psychiatry Source Type: research

Zebrafish models of diabetes-related CNS pathogenesis
Publication date: Available online 23 November 2018Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Anton M. Lakstygal, Murilo S. de Abreu, Dmitry Lifanov, Edina A. Wappler-Guzetta, Nazar Serikuly, Erik T. Alpsychov, DongMei Wang, MengYao Wang, ZhiChong Tang, NiDong Yan, Konstantin A. Demin, Andrey D. Volgin, Tamara G. Amstislavskaya, JiaJia Wang, Cai Song, Polina Alekseeva, Allan V. KalueffAbstractDiabetes mellitus (DM) is a common metabolic disorder that affects multiple organ systems. DM also affects brain processes, contributing to various CNS disorders, including depression and Alzheime...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - November 24, 2018 Category: Psychiatry Source Type: research

Neuroinflammation and aberrant hippocampal plasticity in a mouse model of emotional stress evoked by exposure to ultrasound of alternating frequencies
Publication date: Available online 22 November 2018Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Dmitrii Pavlov, Lucien Bettendorff, Anna Gorlova, Andrey Olkhovik, Allan Kalueff, Eugene Ponomarev, Anatoly Inozemtsev, Vladimir Chekhonin, Klaus-Peter Lesсh, Daniel C. Anthony, Tatyana StrekalovaAbstractEmotional stress is a form of stress evoked by processing negative mental experience rather than an organic or physical disturbance and is a frequent cause of neuropsychiatric pathologies, including depression. Susceptibility to emotional stress is commonly regarded as a human-specific trait ...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - November 23, 2018 Category: Psychiatry Source Type: research

Noradrenergic terminals are the primary source of α2-adrenoceptor mediated dopamine release in the medial prefrontal cortex
Publication date: Available online 23 November 2018Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Paola Devoto, Giovanna Flore, Pierluigi Saba, Simona Scheggi, Giovanna Mulas, Carla Gambarana, Saturnino Spiga, Gian Luigi GessaAbstractIn various psychiatric disorders, deficits in dopaminergic activity in the prefrontal cortex (PFC) are implicated. Treatments involving selective augmentation of dopaminergic activity in the PFC primarily depend on the inhibition of α2-adrenoreceptors singly or in combination with the inhibition of the norepinephrine transporter (NET).We aimed to clarify...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - November 23, 2018 Category: Psychiatry Source Type: research

Modelling posttraumatic stress disorders in animals
Publication date: Available online 20 November 2018Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Bibiana Török, Eszter Sipos, Nela Pivac, Dóra ZelenaAbstractAnimal models of posttraumatic stress disorder are useful tools to reveal the neurobiological basis of the vulnerability to traumatic events, and to develop new treatment strategies, as well as predicting treatment response contributing to personalized medicine approach.Different models have different construct, face and predictive validity and they model different symptoms of the disease. The most prevalent models ar...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - November 21, 2018 Category: Psychiatry Source Type: research

Endocannabinoid interactions in the regulation of acquisition of contextual conditioned fear
Publication date: Available online 17 November 2018Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Zoltan Balogh, Laszlo Szente, Laszlo Biro, Zoltan K. Varga, Jozsef Haller, Mano AliczkiAbstractEndocannabinoids (eCBs) anandamide (AEA) and 2-arachidonoylglycerol (2-AG) were shown to be involved in the basis of trauma-induced behavioral changes, particularly contextual conditioned fear, however, their ligand-specific effects and possible interactions are poorly understood. Here we assessed specific eCB effects and interactions on acquisition of contextual conditioned fear employing electric f...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - November 18, 2018 Category: Psychiatry Source Type: research

Editorial Board
Publication date: 8 March 2019Source: Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 89Author(s): (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - November 18, 2018 Category: Psychiatry Source Type: research

Alterations in white matter microstructure and regional volume are related to motor functions in boys with autism spectrum disorder
ConclusionsAs the first study to demonstrate altered WM properties in the left somatosensory area, and its descending pathway connecting to the cerebellum in ASD, current results may highlight a potential new target of interventions for motor performance in ASD. (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - November 17, 2018 Category: Psychiatry Source Type: research

Genomic updates in understanding PTSD
Publication date: Available online 16 November 2018Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Sumeet Sharma, Kerry J. ResslerAbstractTwin studies as well as more recent genetics-based heritability analyses demonstrate that up to 40 to 50% of the variance in predicting PTSD following trauma is heritable. However, most of the specific gene pathways and mechanism that mediate risk vs. resilience for PTSD following trauma exposure have yet to be elucidated. This review will examine the latest results from large scale Genome-wide association studies as well as other approaches aimed at unde...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - November 17, 2018 Category: Psychiatry Source Type: research

Neuroimaging research in posttraumatic stress disorder – Focus on amygdala, hippocampus and prefrontal cortex
Publication date: Available online 9 November 2018Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Neven Henigsberg, Petra Kalember, Zrnka Kovačić Petrović, Ana ŠečićAbstractNeuroimaging research reflects the complexity of post-traumatic stress disorder and shares some common difficulties of post-traumatic stress disorder research, such as the different classifications of the disorder over time, changes in diagnostic criteria, and extensive comorbidities, as well as precisely delineated and prevailing genetic and environmental determinants in the development of the disorder and i...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - November 11, 2018 Category: Psychiatry Source Type: research

Changes in motor cortical excitability in schizophrenia following transcranial direct current stimulation
Publication date: Available online 10 November 2018Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Pedro Caldana Gordon, Leandro Lane da Costa Valiengo, Vanessa Jesus Rodrigues de Paula, Ricardo Galhardoni, Ulf Ziemann, Daniel Ciampi de Andrade, Andre Russowsky BrunoniAbstractSchizophrenia is a disorder associated with cortical inhibition deficits. Transcranial direct current stimulation (tDCS) induces changes in cortical excitability in healthy subjects and individuals with neuropsychiatric disorders depending on the stimulation parameters. Our aim was to investigate whether a previously p...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - November 11, 2018 Category: Psychiatry Source Type: research

Illness and drug modifiable factors associated with violent behavior in homeless people with severe mental illness: results from the French Housing First (FHF) program
Publication date: Available online 10 November 2018Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): G. Fond, L. Boyer, M. Boucekine, V. Girard, S. Loubière, C. Lenoir, P. Auquier, A. Tinland, French Housing First Study GroupAbstractObjectiveThe aim of this study was to investigate the factors associated with violent behavior in a large multicenter sample of Homeless Schizophrenia (SZ) and Bipolar Disorder (BD) (HSB) subjects.MethodsThis multicenter study was conducted in 4 French cities: Lille, Marseille, Paris and Toulouse. Violent behavior was defined by at least one episode of verb...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - November 11, 2018 Category: Psychiatry Source Type: research

Schizophrenia and gut-flora related epigenetic factors
ConclusionGut flora is sensitive to both internal and environmental stimuli and the synthesis of some key molecules that participate in the epigenetic modulation of gene expression. Therefore, it is possible that gut flora is a converging point where environmental factors interact with genetic and epigenetic factors in the pathogenesis of SZ. (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - November 11, 2018 Category: Psychiatry Source Type: research

Altered resting-state dynamics in autism spectrum disorder: Causal to the social impairment?
Publication date: Available online 7 November 2018Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Stephen J. Gotts, Michal Ramot, Kyle Jasmin, Alex MartinAbstractAutism spectrum disorder (ASD) is characterized by profound impairments in social abilities and by restricted interests and repetitive behaviors. Much work in the past decade has been dedicated to understanding the brain-bases of ASD, and in the context of resting-state functional connectivity fMRI in high-functioning adolescents and adults, the field has established a set of reliable findings: decreased cortico-cortical interactio...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - November 7, 2018 Category: Psychiatry Source Type: research

Nitrergic neurotransmission in the paraventricular nucleus of the hypothalamus modulates autonomic, neuroendocrine and behavioral responses to acute restraint stress in rats
Publication date: Available online 3 November 2018Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Cristiane Busnardo, Carlos C. Crestani, América A. Scopinho, Benjamin A. Packard, Leonardo B.M. Resstel, Fernando M.A. Correa, James P. HermanAbstractWe investigated the involvement of nitrergic neurotransmission within the paraventricular nucleus of the hypothalamus (PVN) in modulation of local neuronal activation, autonomic and neuroendocrine responses and behavioral consequences of acute restraint stress in rats. Bilateral microinjections of the selective neuronal nitric oxide (NO) sy...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - November 3, 2018 Category: Psychiatry Source Type: research

A visual analog scale to measure psychological and physical pain: A preliminary validation of the PPP-VAS in two independent samples of depressed patients
ConclusionThe PPP-VAS appears to be a valid tool in terms of discriminative capacities and convergent-divergent validities. Validation in different samples, including adolescents and elderly, and in various psychiatric and medical conditions will have to be conducted, in addition to the assessment of concurrent and predictive validities, and the confirmation of sensitivity to change. The role of psychological pain in the suicidal process needs to be further elucidated. (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - November 2, 2018 Category: Psychiatry Source Type: research

FCPR16, a novel phosphodiesterase 4 inhibitor, produces an antidepressant-like effect in mice exposed to chronic unpredictable mild stress
Publication date: Available online 1 November 2018Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Qiuping Zhong, Hui Yu, Chang Huang, Jiahong Zhong, Haitao Wang, Jiangping Xu, Yufang ChengAbstractThe canonical phosphodiesterase 4 (PDE4) inhibitors produce antidepressant-like effects in a variety of animal models. However, severe side effects, particularly vomiting and nausea, limit their clinical application. FCPR16 is a novel PDE4 inhibitor with less vomiting potential. However, whether it will exert an antidepressant-like effect remains unclear. Here, we aimed to evaluate the effect of FC...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - November 2, 2018 Category: Psychiatry Source Type: research

Effect of prenatal stress on neural oscillations in developing hippocampal formation
Publication date: Available online 31 October 2018Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Hui Zhang, Qun Li, Yingchun Shang, Xi Xiao, Xinxin Xu, Jianhai Zhang, Tao ZhangAbstractThe effect of prenatal stress (PS) on offspring's behavior was reported previously. Several studies attempted to reveal the mechanisms of PS on synaptic and molecular levels. However, the influences of PS on neural oscillations and their interaction in hippocampus are still unknown. In the present study, a PS rat model was established by using restraint stress. The local-field potentials (LFPs) were simultane...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - November 1, 2018 Category: Psychiatry Source Type: research

Chronic mild corticosterone exposure during adolescence enhances behaviors and upregulates neuroplasticity-related proteins in rat hippocampus
This study also highlights mild elevation of CORT levels during adolescence as a potential approach of promoting adaptive behaviors. (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - October 29, 2018 Category: Psychiatry Source Type: research

Impaired inhibition as an intermediate phenotype for PTSD risk and treatment response
Publication date: Available online 28 October 2018Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Sanne J.H. van Rooij, Tanja JovanovicAbstractInhibition of fear involves learning and then appropriately responding to safety signals, and has been shown to be impaired in PTSD patients. Response inhibition refers to cognitive control and likely uses the same prefrontal cortex circuits as fear inhibition, and has also been implicated in PTSD. Impaired inhibition can serve as an intermediate phenotype for PTSD and can be measured with neuroimaging and psychophysiological tools. We first review t...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - October 29, 2018 Category: Psychiatry Source Type: research

Insular function in autism: Update and future directions in neuroimaging and interventions
Publication date: Available online 28 October 2018Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Jason S. Nomi, Istvan Molnar-Szakacs, Lucina Q. UddinAbstractThe insular cortex, hidden within the lateral sulcus of the human brain, participates in a range of cognitive, affective, and sensory functions. Autism spectrum disorder (ASD), a neurodevelopmental condition affecting all of these functional domains, has increasingly been linked with atypical activation and connectivity of the insular cortices. Here we review the latest research linking atypical insular function to a range of behavior...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - October 29, 2018 Category: Psychiatry Source Type: research

Convergent and divergent altered patterns of default mode network in deficit and non-deficit schizophrenia
ConclusionThe present study demonstrates convergent and divergent altered patterns of the DMN in both DS and NDS patients. Importantly, the specific altered regions of the DMN in DS patients may be associated with extensive deficient neurocognition, indicating novel insights into the pathogenesis of cognitive impairment in schizophrenia. (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - October 26, 2018 Category: Psychiatry Source Type: research

Tianeptine antagonizes the reduction of PV+ and GAD67 cells number in dorsal hippocampus of socially isolated rats
Publication date: Available online 25 October 2018Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Perić Ivana, Stanisavljević Andrijana, Inta Dragos, Gass Peter, Undine E. Lang, Borgwardt Stefan, Filipović DraganaAbstractAdult male rats exposed to chronic social isolation (CSIS) show depressive- and anxiety-like behaviors and reduce the numbers of parvalbumin-positive (PV+) interneurons in the dorsal hippocampus. We aimed to determine whether tianeptine (Tian), administered during the last three weeks of a six-week-social isolation (10 mg/kg/day), may reverse CSIS-induced behavioral ch...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - October 26, 2018 Category: Psychiatry Source Type: research

Role of corticosterone in anxiety- and depressive-like behavior and HPA regulation following prenatal alcohol exposure
Publication date: Available online 24 October 2018Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Vivian Y.Y. Lam, Charlis Raineki, Lisa Y. Wang, Melissa Chiu, Grace Lee, Linda Ellis, Wayne Yu, Joanne WeinbergAbstractPrenatal alcohol exposure (PAE) is known to cause dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, including hyperresponsivity to stressors. Dysregulation of the HPA axis plays a role in vulnerability to stress-related disorders, such as anxiety and depression. Thus, the effects of PAE on HPA function may result in increased vulnerability to the effects of stress...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - October 24, 2018 Category: Psychiatry Source Type: research

Peripheral blood E2F1 mRNA in depression and following electroconvulsive therapy
Publication date: Available online 24 October 2018Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Claire L. McGrory, Karen M. Ryan, Erik Kolshus, Declan M. McLoughlinAbstractThe E2F transcription factors are a group of proteins that bind to the promotor region of the adenovirus E2 gene. E2F1, the first family member to be cloned, is linked to functions including cell proliferation and apoptosis, DNA repair, cell senescence and metabolism. We recently performed a deep sequencing study of micro-RNA changes in whole blood following ECT. Two micro-RNAs (miR-126-3p and miR-106a-5p) were identifi...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - October 24, 2018 Category: Psychiatry Source Type: research

The hypothalamic-pituitary-adrenal axis in PTSD: Pathophysiology and treatment interventions
Publication date: Available online 17 October 2018Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Boadie W. Dunlop, Andrea WongAbstractQuestions of how altered functioning of the hypothalamic pituitary adrenal (HPA) axis contribute to the development and maintenance of posttraumatic stress disorder (PTSD) have been the focus of extensive animal and human research. As a rule, results have been inconsistent across studies, likely due to a variety of confounding variables that have received inadequate attention. Important confounding factors include the effects of early life stress, biological...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - October 18, 2018 Category: Psychiatry Source Type: research

Less differentiated facial responses to naturalistic films of another person's emotional expressions in adolescents and adults with High-Functioning Autism Spectrum Disorder
ConclusionsThe unusual or awkward patterns of facial emotional responses in ASD may hamper the recognition of affect in other people as well as the interaction partner's sense of interpersonal resonance, and thereby lead to social disadvantage in individuals with ASD. (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - October 16, 2018 Category: Psychiatry Source Type: research

Identifying standardized definitions of treatment response in trichotillomania: A meta-analysis
ConclusionThis study provides empirically determined cut-points of treatment response on the MGH-HPS and NIMH-TSS. These data-driven cut-points will benefit future research in trichotillomania by providing definitions of treatment response that can be defined a priori in clinical trials. (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - October 16, 2018 Category: Psychiatry Source Type: research

The dynamic Duo: Combining noninvasive brain stimulation with cognitive interventions
Publication date: Available online 9 October 2018Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Aakash V. Sathappan, Bruce M. Luber, Sarah H. LisanbyAbstractPharmacotherapy, psychotherapy, and non-invasive brain stimulation (NIBS)1 each show efficacy in the treatment of psychiatric disorders; however, more efficacious interventions are needed as reflected by an overall unmet need in mental health care. While each modality has typically been studied and developed as a monotherapy, in practice they are typically used in combination. Research has begun to emerge studying the potential synergi...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - October 9, 2018 Category: Psychiatry Source Type: research

Effect of a binge-like dosing regimen of methamphetamine on dopamine levels and tyrosine hydroxylase expressing neurons in the rat brain
This study examined the effect of binge-like methamphetamine (MA) dosing (4 × 4 mg/kg, s.c., 2 h apart) on regional dopamine and dopaminergic metabolite levels in rat brain at a range of early time points after final dose (2–48 h). Body temperature was elevated when measured 2 h after the last dose. MA increased dopamine levels in the frontal cortex 2 and 24 h after the last dose. The dopamine level was also increased in the amygdala at 24 h. No change was observed in the striatum at any time point, but levels of the dopamine metabolite DOPAC were markedly reduced at 24 and 48 h. Tyrosine hydr...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - October 6, 2018 Category: Psychiatry Source Type: research

Protective role of Apelin-13 on amyloid β25–35-induced memory deficit; Involvement of autophagy and apoptosis process
Publication date: Available online 5 October 2018Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Samaneh Aminyavari, Maryam Zahmatkesh, Maryam Farahmandfar, Fariba Khodagholi, Leila Dargahi, Mohammad-Reza ZarrindastAbstractAlzheimer's disease (AD) by progressive neurodegenerative pattern is associated with autophagy stress which is suggested as a potential cause of amyloid β (Aβ) aggregation and neural loss. Apelin-13, a neuropeptide with modulatory effect on autophagy, has been shown the beneficial effects on neural cell injuries. We investigated the effect of Apelin-13 on A&beta...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - October 6, 2018 Category: Psychiatry Source Type: research

Association between increased retinal background noise and co-occurrent regular cannabis and alcohol use
ConclusionsThe increase in background noise may reflect the neurotoxicity of cannabis, potentiated by alcohol consumption, on retinal neurons dynamic. This neural disruption of the response generated by retinal stimulation may be attributable to altered neurotransmitter release. (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - October 6, 2018 Category: Psychiatry Source Type: research

Cooperation of the vestibular and cerebellar networks in anxiety disorders and depression
Publication date: Available online 5 October 2018Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Pascal Hilber, Jan Cendelin, Anne Le Gall, Marie-Laure Machado, Jan Tuma, Stephane BesnardAbstractThe discipline of affective neuroscience is concerned with the neural bases of emotion and mood. The past decades have witnessed an explosion of research in affective neuroscience, increasing our knowledge of the brain areas involved in fear and anxiety. Besides the brain areas that are classically associated with emotional reactivity, accumulating evidence indicates that both the vestibular and cer...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - October 6, 2018 Category: Psychiatry Source Type: research

Promising neural diagnostic biomarkers and predictors of treatment outcomes for psychiatric disorders: Novel neuroimaging approaches
Publication date: Available online 5 October 2018Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Kyu-Man Han, Yong-Ku Kim (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - October 6, 2018 Category: Psychiatry Source Type: research

Maternal immune activation in rats blunts brain cytokine and kynurenine pathway responses to a second immune challenge in early adulthood
Publication date: Available online 27 September 2018Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Sarah M. Clark, Francesca M. Notarangelo, Xin Li, Shuo Chen, Robert Schwarcz, Leonardo H. TonelliAbstractMaternal immune activation (MIA) with the viral mimic poly I:C provides an established rodent model for studying schizophrenia (SZ) and other human neurodevelopmental disorders. Postnatal infections are additional risk factors in SZ and may cumulatively contribute to the emergence of pathophysiology. Underlying mechanisms may involve metabolites of the kynurenine pathway (KP) of tryptophan...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - October 4, 2018 Category: Psychiatry Source Type: research

Translational machine learning for psychiatric neuroimaging
This article introduces some fundamentals of a translational machine learning approach before selectively reviewing literature to-date. Promising initial results are then balanced by the description of limitations that should be considered in order to interpret existing research and maximize the possibility of future translation. Future directions are then presented in order to inspire further research and progress the field towards clinical translation. (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - October 4, 2018 Category: Psychiatry Source Type: research

Clinical considerations for the inclusion of individuals with autism spectrum disorder in clinical trials
Publication date: Available online 2 October 2018Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Maria R. Urbano, C. Teal Raffaele, Nicole L. Kreiser, Jennifer M. Flaherty, Kathrin HartmannAbstractDiagnoses of autism spectrum disorder (ASD) have increased considerably over the past 20 years. Because of this rise and the inherent complexity of ASD, there is a need for an increased number of scientifically valid basic and clinical research studies addressing this disorder. This manuscript serves as an introduction to the clinical presentation of ASD as well as the unique challenges and modi...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - October 4, 2018 Category: Psychiatry Source Type: research