A role for Galanin N-terminal fragment (1-15) In anxiety and depression in rats

Galanin (GAL) is involved in several functions including mood regulation. The GAL N-terminal fragment (1-15) [GAL(1-15)] also participates at central level and a differential role of GAL(1-15) compared with GAL has been proposed. In this work we have analysed if GAL(1-15) contributes to depression- and anxiety -related behaviours using the forced swimming test, tail suspension test, open field and light/dark test. We tested the involvement of the GAL receptor 2 (GALR2) in GAL(1-15) effects with the GAL receptor antagonist M871 and with an in vivo model of siRNA GALR2 knockdown rats.

Source: Neuropeptides - October 1, 2017 Category: Neuroscience Authors: Carmelo Mill ón, Antonio Flores-Burguess, Manuel Narváez, Dasiel Borroto-Escuela, Luis Santín, Jose Angel Narváez, Kjell Fuxe, Zaida Díaz-Cabiale Source Type: research