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Condition: Heart Attack

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Total 280 results found since Jan 2013.

ILK regulates MSCs survival and angiogenesis partially through AKT and mTOR signaling pathways.
This study examined the role and mechanism of ILK in MSCs survival and angiogenesis. In hypoxic condition, upregulation of ILK expression increased the phosphorylation of Akt and mTOR, resulting in markedly enchanced MSCs survival and VEGF expression; while significantly inhibited MSCs survival and VEGF expression was detected in MSCs with ILK kinase inactivation, which was associated with a reduction of phosphorylation of Akt and mTOR. In addition, it also caused an inhibitory effects of ILK on MSCs survival and VEGF expression, which was abolished by Akt or mTOR inhibitor. Furthermore, it was observed that ILK-overexpres...
Source: Acta Histochemica - April 28, 2017 Category: Biochemistry Authors: Zeng B, Liu L, Wang S, Dai Z Tags: Acta Histochem Source Type: research

Insufficient activation of Akt upon reperfusion because of its novel modification by reduced PP2A-B55 α contributes to enlargement of infarct size by chronic kidney disease
AbstractChronic kidney disease (CKD) increases myocardial infarct size by an unknown mechanism. Here we examined the hypothesis that impairment of protective PI3K-PDK1-Akt and/or mTORC-Akt signaling upon reperfusion contributes to CKD-induced enlargement of infarct size. CKD was induced in rats by 5/6 nephrectomy (SNx group) 4  weeks before myocardial infarction experiments, and sham-operated rats served as controls (Sham group). Infarct size as a percentage of area at risk after ischemia/reperfusion was significantly larger in the SNx group than in the Sham group (56.3 ± 4.6 vs. 41.4 ± 2.0%). In SNx group, myocard ...
Source: Basic Research in Cardiology - April 18, 2017 Category: Cardiology Source Type: research

Molecular therapy set to protect at-risk patients against heart attack and stroke
Even a single dose of a specific ribonucleic acid molecule, known as a small interfering RNA (siRNA), offers patients at high risk of cardiovascular disease long-lasting protection against high LDL cholesterol -- one of the main risk factors for heart attack and stroke -- conclude researchers.
Source: ScienceDaily Headlines - March 30, 2017 Category: Science Source Type: news

Smooth muscle cell-specific deletion of Col15a1 unexpectedly leads to impaired development of advanced atherosclerotic lesions.
Abstract Atherosclerotic plaque rupture with subsequent embolic events is a major cause of sudden death from myocardial infarction or stroke. Although smooth muscle cells (SMC) produce and respond to collagens in vitro, there is no direct evidence in vivo that SMC are a crucial source of collagens and that this impacts lesion development or fibrous cap formation. We sought to determine how conditional SMC specific knockout of collagen type XV (COL15A1) in SMC lineage tracing mice affects advanced lesion formation given: 1) we previously identified a Col15a1 sequence variant associated with age related atherosclero...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 9, 2017 Category: Physiology Authors: Durgin BG, Cherepanova OA, Gomez D, Karaoli T, Alencar GF, Butcher JT, Zhou YQ, Bendeck MP, Isakson BE, Owens GK, Connelly JJ Tags: Am J Physiol Heart Circ Physiol Source Type: research

Ghrelin protected neonatal rat cardiomyocyte against hypoxia/reoxygenation injury by inhibiting apoptosis through Akt-mTOR signal.
In conclusion, Ghrelin can reduce the H/R damage on NRCMs and inhibit the apoptosis by activating Akt-mTOR signaling pathway. PMID: 28281036 [PubMed - as supplied by publisher]
Source: Molecular Biology Reports - March 8, 2017 Category: Molecular Biology Authors: Wang L, Lu Y, Liu X, Wang X Tags: Mol Biol Rep Source Type: research

The role of α-smooth muscle actin in fibroblast-mediated matrix contraction and remodeling
Publication date: Available online 4 November 2016 Source:Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease Author(s): Arti V. Shinde, Claudio Humeres, Nikolaos G. Frangogiannis Cardiac myofibroblasts play an important role in myocardial remodeling. Although α-smooth muscle actin (α-SMA) expression is the hallmark of mature myofibroblasts, its role in regulating fibroblast function remains poorly understood. We explore the effects of the matrix environment in modulating cardiac fibroblast phenotype, and we investigate the role of α-SMA in fibroblast function using loss- and gain-of-function approaches. I...
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - November 3, 2016 Category: Molecular Biology Source Type: research

LncRNA MIAT enhances cardiac hypertrophy partly through sponging miR-150.
CONCLUSIONS: MIAT is significantly increased in Ang II induced cardiac hypertrophy and contributes to the pathological development. MIAT can suppress miR-150 expression in cardiomyocytes and miR-150 is a downstream effector of MIAT in the development of cardiac hypertrophy. PMID: 27649667 [PubMed - as supplied by publisher]
Source: European Review for Medical and Pharmacological Sciences - September 23, 2016 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Atorvastatin alleviates cardiomyocyte apoptosis by suppressing TRB3 induced by acute myocardial infarction and hypoxia
Conclusion Treatment of atorvastatin inhibits the expression of TRB3 and cardiomyocyte apoptosis induced by AMI and hypoxia.
Source: Journal of the Formosan Medical Association - September 17, 2016 Category: Journals (General) Source Type: research

Atorvastatin alleviates cardiomyocyte apoptosis by suppressing TRB3 induced by acute myocardial infarction and hypoxia.
CONCLUSION: Treatment of atorvastatin inhibits the expression of TRB3 and cardiomyocyte apoptosis induced by AMI and hypoxia. PMID: 27645622 [PubMed - as supplied by publisher]
Source: J Formos Med Assoc - September 15, 2016 Category: Journals (General) Authors: Cheng WP, Lo HM, Wang BW, Chua SK, Lu MJ, Shyu KG Tags: J Formos Med Assoc Source Type: research

Activation of Cannabinoid Receptor Type II by AM1241 Ameliorates Myocardial Fibrosis < b > < i > via < /i > < /b > Nrf2-Mediated Inhibition of TGF- β1/Smad3 Pathway in Myocardial Infarction Mice
Conclusion:CB2 receptor agonist AM1241 alleviated myocardial interstitial fibrosisvia Nrf2 -mediated down-regulation of TGF- β1/Smad3 pathway, which suggested that CB2 receptor activation might represent a promising target for retarding cardiac fibrosis after MI.Cell Physiol Biochem 2016;39:1521-1536
Source: Cellular Physiology and Biochemistry - September 9, 2016 Category: Cytology Source Type: research

Angiogenic Factor AGGF1 Activates Autophagy with an Essential Role in Therapeutic Angiogenesis for Heart Disease
by Qiulun Lu, Yufeng Yao, Zhenkun Hu, Changqing Hu, Qixue Song, Jian Ye, Chengqi Xu, Annabel Z. Wang, Qiuyun Chen, Qing Kenneth Wang AGGF1 is an angiogenic factor with therapeutic potential to treat coronary artery disease (CAD) and myocardial infarction (MI). However, the underlying mechanism for AGGF1-mediated therapeutic angiogenesis is unknown. Here, we show for the first time that AGGF1 activates autophagy, a housekeeping catabolic cellular process, in endothelial cells (ECs), HL1, H9C2, and vascular smooth muscle cells. Studies withAtg5 small interfering RNA (siRNA) and the autophagy inhibitors bafilomycin A1 (Baf) ...
Source: PLoS Biology: Archived Table of Contents - August 10, 2016 Category: Biology Authors: Qiulun Lu Source Type: research

OxLDL receptor chromatography from live human U937 cells identifies SYK(L) that regulates phagocytosis of oxLDL.
Abstract The binding and activation of macrophages by microscopic aggregates of oxLDL in the intima of the arteries may be an important step towards atherosclerosis leading to heart attack and stroke. Microbeads coated with oxLDL were used to activate, capture and isolate the oxLDL receptor complex from the surface of live cells. Analysis of the resulting tryptic peptides by liquid chromatography and tandem mass spectrometry revealed the Spleen Tyrosine Kinase (SYK), and many of SYK's known interaction network including Fc receptors (FCGR2A, FCER1G and FCGR1A) Toll receptor 4 (TLR4), as well as RNA binding and met...
Source: Analytical Biochemistry - August 6, 2016 Category: Biochemistry Authors: Howard JC, Florentinus-Mefailoski A, Bowden P, Trimble W, Grinstein S, Marshall JG Tags: Anal Biochem Source Type: research

Silencing cardiomyocyte TLR4 reduces injury following hypoxia.
Abstract Toll-like receptor 4 (TLR4), the receptor for lipopolysaccharide (LPS) of gram-negative pathogens expressed in the heart, is activated by several endogenous ligands associated with tissue injury in response to myocardial infarction (MI). The aim of this study was to investigate the involvement of TLR4 signaling in cardiomyocytes dysfunction following hypoxia (90minutes) using multiple methodologies such as knocking down TLR4 and small interfering RNA (siTLR4). Cardiomyocytes of C57Bl/6 mice (WT) subjected to hypoxic stress showed increased cardiac release of LDH, HMGB1, IκB, TNF-α and myocardial apoptot...
Source: Experimental Cell Research - July 18, 2016 Category: Cytology Authors: Avlas O, Srara S, Shainberg A, Aravot D, Hochhauser E Tags: Exp Cell Res Source Type: research