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Condition: Heart Attack
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Total 280 results found since Jan 2013.
NADPH oxidase 4 contributes to oxidative stress in a mouse model of myocardial infarction
Physiol Res. 2023 Apr 30;72(2):177-186. doi: 10.33549/physiolres.934992.ABSTRACTOxidative stress closely related to the progression and severity of myocardial infarction (MI). Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 4 (NOX4) is one of the major enzymes that generate reactive oxygen species (ROS) in cardiovascular system. Here, we aim to elucidate the pathological role of NOX4 in MI. MI mouse model was created by the coronary artery ligation. NOX4 was specifically knocked down in heart through intramyocardial injection of siRNA. NOX4 expression and oxidative stress indicators were determined at different...
Source: Physiological Research - May 9, 2023 Category: Physiology Authors: Q Huang Y Chen Source Type: research
Resveratrol ameliorates myocardial ischemia/reperfusion induced necroptosis through inhibition of the Hippo pathway
J Bioenerg Biomembr. 2022 Dec 23. doi: 10.1007/s10863-022-09954-3. Online ahead of print.ABSTRACTMyocardial ischemia-reperfusion (I/R) injury is a major cause of poor hemodynamic reconstitution outcomes after myocardial infarction or circulatory arrest. Currently, the search for effective therapeutic agents and tools is a focus of research in the field of myocardial I/R injury. Resveratrol (Res) has been extensively studied in recent years because of its good cardiovascular therapeutic effects, but its specific mechanism of action has not been fully elucidated. Therefore, the aim of this study was to investigate the mechan...
Source: Cell Research - December 23, 2022 Category: Cytology Authors: Hao Tian Yonghong Xiong Zhongyuan Xia Source Type: research
DJ-1 activates the AMPK/mTOR pathway by binding RACK1 to induce autophagy and protect the myocardium from ischemia/hypoxia injury
In conclusion, DJ-1 could activate adaptive autophagy by the RACK1/AMPK/mTOR pathway and protect the myocardium against ischemia injury.PMID:36410277 | DOI:10.1016/j.bbrc.2022.10.100
Source: Biochemical and Biophysical Research communications - November 21, 2022 Category: Biochemistry Authors: Xiao-Yan Zhao Jian-Min Ren Hui-Ru Liu Ting-Ting Zhou Xue-Ying Wang Song Liu He-Ping Chen Source Type: research
Reducing brain TACE activity improves neuroinflammation and cardiac function in heart failure rats
Tumor necrosis factor (TNF)-α converting enzyme (TACE) is a key metalloprotease mediating ectodomain shedding of a variety of inflammatory mediators, substrates, and growth factors. We previously reported that TACE-mediated production of TNF-α in the hypothalamic paraventricular nucleus (PVN) contributes to sympathetic excitation in heart failure (HF). Here, we sought to determine whether central interventions in TACE activity attenuate neuroinflammation and improve cardiac function in heart failure. Myocardial infarction-induced HF or sham-operated (SHAM) rats were treated with bilateral paraventricular nucleus microinj...
Source: Frontiers in Physiology - November 9, 2022 Category: Physiology Source Type: research
PCSK9 Knockdown Can Improve Myocardial Ischemia/Reperfusion Injury by Inhibiting Autophagy
This study investigates the effect and mechanism of proprotein convertase subtilisin/Kexin type 9 (PCSK9) on myocardial ischemia-reperfusion injury (MIRI) and provides a reference for clinical prevention and treatment of acute myocardial infarction (AMI). We established a rat model of myocardial ischemia/reperfusion (I/R) and AC16 hypoxia/reoxygenation (H/R) model. A total of 48 adult 7-week-old male Sprague-Dawley rats were randomly assigned to three groups (n = 16): control, I/R, and I/R + SiRNA. In I/R and I/R + siRNA groups, myocardial ischemia was induced via occlusion of the left anterior descending branch (LAD) of t...
Source: Cardiovascular Toxicology - November 7, 2022 Category: Cardiology Authors: Guangwei Huang Xiyang Lu Zonggang Duan Kai Zhang Lei Xu Hailong Bao Xinlin Xiong Muzhi Lin Chao Li Yunquan Li Haiyan Zhou Zhenhua Luo Wei Li Source Type: research
Integrin subunit β-like 1 mediates angiotensin II-induced myocardial fibrosis by regulating the forkhead box Q1/Snail axis
Arch Biochem Biophys. 2022 Sep 29:109422. doi: 10.1016/j.abb.2022.109422. Online ahead of print.ABSTRACTCardiac fibrosis is a severe condition with limited therapeutic options and often occurs in chronic cardiovascular diseases such as hypertension and myocardial infarction. There is currently a clear need to identify novel mediators of cardiac fibrosis to facilitate the development of more effective therapeutic strategies targeting cardiac fibrosis. Integrin subunit β-like 1 (ITGBL1), an extracellular matrix protein, has previously been implicated in various fibrotic diseases. However, the precise role of ITGBL1 in regul...
Source: Archives of Biochemistry and Biophysics - October 2, 2022 Category: Biochemistry Authors: Hui Zhu Hongxue Ji Weiming Chen Lu Han Liangzhu Yu Source Type: research
