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Condition: Heart Attack
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Total 280 results found since Jan 2013.
Integrin subunit β-like 1 mediates angiotensin II-induced myocardial fibrosis by regulating the forkhead box Q1/Snail axis
Arch Biochem Biophys. 2022 Sep 29:109422. doi: 10.1016/j.abb.2022.109422. Online ahead of print.ABSTRACTCardiac fibrosis is a severe condition with limited therapeutic options and often occurs in chronic cardiovascular diseases such as hypertension and myocardial infarction. There is currently a clear need to identify novel mediators of cardiac fibrosis to facilitate the development of more effective therapeutic strategies targeting cardiac fibrosis. Integrin subunit β-like 1 (ITGBL1), an extracellular matrix protein, has previously been implicated in various fibrotic diseases. However, the precise role of ITGBL1 in regul...
Source: Archives of Biochemistry and Biophysics - October 2, 2022 Category: Biochemistry Authors: Hui Zhu Hongxue Ji Weiming Chen Lu Han Liangzhu Yu Source Type: research
A-kinase anchoring protein 5-ancored calcineurin regulates the remodeling of H9c2 cardiomyocytes exposed to hypoxia and reoxygenation
CONCLUSIONS: AKAP5 downregulation aggravated the remodeling of cardiomyocytes after H/R. AKAP5 may anchor CaN to form a complex, which in turn activates NFATc3 dephosphorylation and expression of hypertrophy-related proteins.PMID:36115111 | DOI:10.1016/j.biopha.2022.113689
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 17, 2022 Category: Drugs & Pharmacology Authors: Feng Zhu Chi Yuan Xu Zhang Zhi Wang Qiushu Wang Hegui Wang Source Type: research
Dexmedetomidine attenuates myocardial ischemia/reperfusion-induced ferroptosis via AMPK/GSK-3 β/Nrf2 axis
In conclusion, Dex protects hearts against MIRI-induced ferroptosis via activation of Nrf2 through AMPK/GSK-3β signaling pathway.PMID:35988428 | DOI:10.1016/j.biopha.2022.113572
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - August 21, 2022 Category: Drugs & Pharmacology Authors: Zhuoran Wang Mengran Yao Leyu Jiang Lingyan Wang Yuqiao Yang Quan Wang Xi Qian Yu Zhao Jinqiao Qian Source Type: research
Long Noncoding RNA MIAT Regulates Hyperosmotic Stress-Induced Corneal Epithelial Cell Injury via Inhibiting the Caspase-1-Dependent Pyroptosis and Apoptosis in Dry Eye Disease
CONCLUSION: The lncRNA MIAT is involved in HS-induced pyroptosis and apoptosis and the inflammatory response of HCECs and provides a new understanding of the pathogenesis of dry eye.PMID:35676970 | PMC:PMC9169976 | DOI:10.2147/JIR.S361541
Source: Cell Research - June 9, 2022 Category: Cytology Authors: Jinjian Li Kun Yang Xinghui Pan Hui Peng Chenting Hou Jie Xiao Qing Wang Source Type: research
A < sub > 1 < /sub > and A < sub > 2b < /sub > adenosine receptors regulate GPX4 against ferroptosis of cardiomyocytes in myocardial infarction rat model and in vitro
CONCLUSION: A1AR and A2bAR could regulate GPX4, thereby affecting ferroptosis of cardiomyocytes in a rat model of MIR.PMID:35653908 | DOI:10.1016/j.tice.2022.101828
Source: Tissue and Cell - June 2, 2022 Category: Cytology Authors: Weili Zhang Weiwei Qiao Luning Zuo Source Type: research
mTORC1 is a key regulator that mediates OGD- and TGF β1-induced myofibroblast transformation and chondroitin-4-sulfate expression in cardiac fibroblasts
Exp Ther Med. 2022 Jun;23(6):413. doi: 10.3892/etm.2022.11340. Epub 2022 Apr 27.ABSTRACTIschemia-reperfusion infarct-derived chondroitin sulfate proteoglycans (CSPGs) are important for sustaining denervation of the infarct. Sympathetic denervation within the heart after myocardial infarction (MI) predicts the probability of a higher risk for serious ventricular arrhythmias. Chondroitin-4-sulfate (C4S) is the predominant chondroitin sulfate component in the heart. However, the mechanisms that induce CSPG expression in fibroblasts following MI remain to be elucidated. The present study found that oxygen-glucose deprivation (...
Source: Experimental and Therapeutic Medicine - May 23, 2022 Category: General Medicine Authors: Chao Li Zheng Zhang Yu Peng Yanying Zhang Wanrong Kang Yingdong Li Yang Hai Source Type: research
Muscone Inhibits the Excessive Inflammatory Response in Myocardial Infarction by Targeting TREM-1
Evid Based Complement Alternat Med. 2022 May 10;2022:9112479. doi: 10.1155/2022/9112479. eCollection 2022.ABSTRACTThe inhibitory effect of muscone on the hyperinflammatory response after myocardial ischemia reperfusion injury (MIRI) was investigated, and the target and signal pathways of muscone were explored. The levels of inflammatory cytokines interleukin-1β, interleukin-6, and tumor necrosis factor alpha were detected through qRT-PCR and ELISA. The expression levels of p38 and NF-κB signaling pathway-related proteins were detected through Western blot. TREM-1 siRNA was transfected into macrophages in vitro. The rat m...
Source: Evidence-based Complementary and Alternative Medicine - May 20, 2022 Category: Complementary Medicine Authors: Hong Zhang Jian Ye Xu Wang Zongjun Liu Tao Chen Junqing Gao Source Type: research
