Filtered By:
Condition: Heart Attack

This page shows you your search results in order of date. This is page number 19.

Order by Relevance | Date

Total 280 results found since Jan 2013.

Silencing of Pellino1 improves post-infarct cardiac dysfunction and attenuates left ventricular remodelling in mice
Conclusions Our data demonstrate that Pellino1 plays an important role in the pathogenesis of MI. Targeting Pellino1 may ameliorate cardiac dysfunction and remodelling following MI.
Source: Cardiovascular Research - March 18, 2014 Category: Cardiology Authors: Wu, W., Hu, Y., Li, J., Zhu, W., Ha, T., Que, L., Liu, L., Zhu, Q., Chen, Q., Xu, Y., Li, C., Li, Y. Tags: Cardiac biology and remodelling Source Type: research

Plasma Cholesterol–Induced Lesion Networks Activated before Regression of Early, Mature, and Advanced Atherosclerosis
by Johan L. M. Björkegren, Sara Hägg, Husain A. Talukdar, Hassan Foroughi Asl, Rajeev K. Jain, Cecilia Cedergren, Ming-Mei Shang, Aránzazu Rossignoli, Rabbe Takolander, Olle Melander, Anders Hamsten, Tom Michoel, Josefin Skogsberg Plasma cholesterol lowering (PCL) slows and sometimes prevents progression of atherosclerosis and may even lead to regression. Little is known about how molecular processes in the atherosclerotic arterial wall respond to PCL and modify responses to atherosclerosis regression. We studied atherosclerosis regression and global gene expression responses to PCL (≥80%) and to atherosclerosis regr...
Source: PLoS Genetics - February 27, 2014 Category: Genetics & Stem Cells Authors: Johan L. M. Björkegren et al. Source Type: research

COX-2 Signaling and Cancer: New Players in Old Arena.
Abstract Cancer is a leading cause of death worldwide. The expression of COX-2 and prostaglandins has not only been associated with various types of cancer but is also directly proportional to their aggressiveness including metastasis. Thus, inhibition of COX-2 activity has been one of the preferred targets for cancer reduction. Broad spectrum inhibition of all forms of COX (using NSAIDs) is associated with various side effects ranging from gastric ulceration to renal problems. Even specific COX-2 inhibitors (COXIBS) are associated with side effects like myocardial infarction. Alternative strategies including siRN...
Source: Current Drug Targets - January 26, 2014 Category: Drugs & Pharmacology Authors: Misra S, Sharma K Tags: Curr Drug Targets Source Type: research

New cholesterol drug shows promise
Conclusion Media headlines reporting on this phase I trial concentrated on the secondary outcome (that ALN-PCS reduced LDL cholesterol levels). However, these results will need to be confirmed during phase II and phase III clinical trials, which will involve more participants who would normally receive cholesterol-lowering treatment. While it is tempting to focus on the results of the cholesterol levels, phase I clinical trials are designed to test the safety of a new drug to make sure it is safe enough to test further. They also aim to determine what the highest tolerable dose is, so the appropriate one can be used in la...
Source: NHS News Feed - October 3, 2013 Category: Consumer Health News Tags: Heart/lungs Medical practice Medication Source Type: news

Hypoxia activates muscle-restricted coiled-coil protein (MURC) expression via transforming growth factor-{beta} in cardiac myocytes
In conclusion, hypoxia in cultured rat neonatal cardiomyocytes increased MURC expression via the induction of TGF-β, SRF and the ERK pathway. These findings suggest that MURC plays a role in hypoxia-induced hypertrophy in cardiomyocytes.
Source: Clinical Science - September 4, 2013 Category: Biomedical Science Authors: K Shyu, W Cheng, B Wang, H Chang Source Type: research

Vascular Connexins in Restenosis After Balloon Injury
Atherosclerosis is an arterial progressive disease characterized by accumulation of lipids, macrophages, T lymphocytes, and smooth muscle cells in large- and medium-sized arteries. Erosion and rupture of the atherosclerotic plaque may induce myocardial infarction and cerebrovascular accidents that are responsible for a large percentage of sudden death. Atherosclerosis is often treated by angioplasty generally followed by stent implantation. Although angioplasty and stent implantation are necessary for the survival of the patient, they induce a trauma in the vessel wall that favors a vascular reaction called restenosis and ...
Source: Springer protocols feed by Molecular Medicine - September 4, 2013 Category: Molecular Biology Source Type: news

Delivery of Nox2-NADPH oxidase siRNA with polyketal nanoparticles for improving cardiac function following myocardial infarction.
This study highlights the potential of polyketals as siRNA delivery vehicles to the MI heart and represents a viable therapeutic approach for targeting oxidative stress. PMID: 23856052 [PubMed - as supplied by publisher]
Source: Biomaterials - July 12, 2013 Category: Materials Science Authors: Somasuntharam I, Boopathy AV, Khan RS, Martinez MD, Brown ME, Murthy N, Davis ME Tags: Biomaterials Source Type: research

Acute hyperglycaemia enhances oxidative stress and aggravates myocardial ischaemia/reperfusion injury: role of thioredoxin‐interacting protein
This study aimed to investigate whether or not hyperglycaemia enhances Txnip expression in myocardial ischaemia/reperfusion (MI/R) and consequently exacerbates MI/R injury. Rats were subjected to 30 min. of left coronary artery ligation followed by 4 hrs of reperfusion and treated with saline or high glucose (HG, 500 g/l, 4 ml/kg/h intravenously). In vitro study was performed on cultured rat cardiomyocytes subjected to simulated ischaemia/reperfusion (SI/R) and incubated with HG (25 mM) or normal glucose (5.6 mM) medium. In vivo HG infusion during MI/R significantly impaired cardiac function, aggravated myocardial in...
Source: Journal of Cellular and Molecular Medicine - January 11, 2013 Category: Molecular Biology Authors: Hui Su, Lele Ji, Wenjuan Xing, Wei Zhang, Heping Zhou, Xinhong Qian, Xiaoming Wang, Feng Gao, Xin Sun, Haifeng Zhang Tags: Original Article Source Type: research

Acute hyperglycaemia enhances oxidative stress and aggravates myocardial ischaemia/reperfusion injury: role of thioredoxin-interacting protein.
This study aimed to investigate whether or not hyperglycaemia enhances Txnip expression in myocardial ischaemia/reperfusion (MI/R) and consequently exacerbates MI/R injury. Rats were subjected to 30 min. of left coronary artery ligation followed by 4 hrs of reperfusion and treated with saline or high glucose (HG, 500 g/l, 4 ml/kg/h intravenously). In vitro study was performed on cultured rat cardiomyocytes subjected to simulated ischaemia/reperfusion (SI/R) and incubated with HG (25 mM) or normal glucose (5.6 mM) medium. In vivo HG infusion during MI/R significantly impaired cardiac function, aggravated myocardial in...
Source: J Cell Mol Med - January 11, 2013 Category: Molecular Biology Authors: Su H, Ji L, Xing W, Zhang W, Zhou H, Qian X, Wang X, Gao F, Sun X, Zhang H Tags: J Cell Mol Med Source Type: research

Mechanism of TNF-α autocrine effects in hypoxic cardiomyocytes: Initiated by hypoxia inducible factor 1α, presented by exosomes
In this study, we investigated direct effects of hypoxia on TNF-α expression of cardiomyocytes, the role of hypoxia inducible factor-1α (HIF-1α) in TNF-α regulation and potential secretory pathway of TNF-α. Elevated TNF-α expression and HIF-1α activation in primary cultured cardiomyocytes under hypoxia were detected by real-time PCR, Western blotting and immunofluorescence. TNF-α mRNA elevation and protein secretion were obviously inhibited by nucleofection of HIF-1α small interfering RNA (siRNA) and treatment with 2-methoxyestradiol (inhibitor of HIF-1α protein). Similar results were observed in HEK293 and HepG2...
Source: Journal of Molecular and Cellular Cardiology - October 19, 2012 Category: Cytology Authors: Xian Yu, Lingyan Deng, Dan Wang, Na Li, Xiao Chen, Xiang Cheng, Jin Yuan, Xingli Gao, Mengyang Liao, Min Wang, Yuhua Liao Tags: Original Articles Source Type: research