Hypoxia activates muscle-restricted coiled-coil protein (MURC) expression via transforming growth factor-{beta} in cardiac myocytes

In conclusion, hypoxia in cultured rat neonatal cardiomyocytes increased MURC expression via the induction of TGF-β, SRF and the ERK pathway. These findings suggest that MURC plays a role in hypoxia-induced hypertrophy in cardiomyocytes.
Source: Clinical Science - Category: Biomedical Science Authors: Source Type: research