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Condition: Heart Attack
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Total 280 results found since Jan 2013.
Long non-coding RNA MIAT impairs neurological function in ischemic stroke via up-regulating microRNA-874-3p-targeted IL1B
CONCLUSION: Shortly, this study figures out that MIAT impairs neurological function in IS via up-regulating miR-874-3p-targeted IL1B.PMID:34265390 | DOI:10.1016/j.brainresbull.2021.07.005
Source: Brain Research Bulletin - July 15, 2021 Category: Neurology Authors: Shuai Zhang Yue Zhang Na Wang Yu Wang Huan Nie Yueyue Zhang Huiying Han Shan Wang Wenjuan Liu Chunrui Bo Source Type: research
Radiation-induced lipoprotein-associated phospholipase A2 increases lysophosphatidylcholine and induces endothelial cell damage
In this study, radiation-induced LPC accumulation in human aortic endothelial cells (HAECs) increased reactive oxygen species (ROS) production and senescence-associated-beta-galactosidase staining, in addition to decreasing their tube-forming ability. Knockdown of lipoprotein-associated phospholipase A2 (Lp-PLA2) with small interfering RNA (siRNA) inhibited the increased LPC production induced by radiation, and reduced the radiation-induced cell damage produced by ROS and oxidized low-density lipoprotein (LDL). Lp-PLA2 depletion abolished the induction of proinflammatory factors, such as interleukin 1β, tumor necrosis fac...
Source: Toxicology - July 3, 2021 Category: Toxicology Authors: So-Ra Kim Jong-Ik Heo Jeong-Woo Park Chang-Mo Kang Kwang Seok Kim Source Type: research
Inhibition of lncRNA < em > SNHG8 < /em > plays a protective role in hypoxia-ischemia-reoxygenation-induced myocardial injury by regulating miR-335 and RASA1 expression
Mol Med Rep. 2021 Aug;24(2):597. doi: 10.3892/mmr.2021.12236. Epub 2021 Jun 24.ABSTRACTLong non‑coding (lnc)RNAs serve a role in a number of diseases, including different types of cancer and acute myocardial infarction. The aim of the present study was to investigate the protective role of lncRNA small nucleolar RNA host gene 8 (SNHG8) in hypoxia‑ischemia‑reoxygenation (HI/R)‑induced myocardial injury and its potential mechanism of action. Cell viability, proliferation, creatine kinase myocardial band, cell apoptosis and protein expression levels were determined by Cell Counting Kit‑8 assay, EdU assay, ELISA, flo...
Source: Molecular Medicine Reports - June 24, 2021 Category: Molecular Biology Authors: Yanfeng Liu Ping Zhou Fengxiao Wang Xuehong Zhang Dongmei Yang Lang Hong Dongyun Ruan Source Type: research
Activation of Autophagic Flux Blunts Cardiac Ischemia/Reperfusion Injury
Conclusions: Induction of autophagy at the time of reperfusion is sufficient to mitigate myocardial reperfusion injury by reducing ROS and cell death. Maintenance of appropriate autophagic flux may emerge as a viable clinical therapy to reduce reperfusion injury in acute myocardial infarction.PMID:34111934 | DOI:10.1161/CIRCRESAHA.120.318601
Source: Circulation Research - June 11, 2021 Category: Cardiology Authors: Min Xie Geoffrey W Cho Yongli Kong Dan L Li Francisco Altamirano Xiang Luo Cyndi R Morales Nan Jiang Gabriele G Schiattarella Herman I May Jessica Medina John M Shelton Anwarul Ferdous Thomas G Gillette Joseph A Hill Source Type: research
Age-related defects in autophagy alter the secretion of paracrine factors from bone marrow mononuclear cells
Aging (Albany NY). 2021 Jun 4;13. doi: 10.18632/aging.203127. Online ahead of print.ABSTRACTBone marrow mononuclear cell therapy improves cardiac repair after myocardial infarction (MI), in-part through signaling to resident cardiac cells, such as fibroblasts, which regulate scar formation. The efficacy of cell therapy declines with age, as aging of both donor and recipient cells decreases repair responses. Autophagy regulates the microenvironment by both extracellular vesicle (EV)-dependent and independent secretion pathways. We hypothesized that age-related autophagy changes in bone marrow cells (BMCs) alter paracrine si...
Source: Aging - June 5, 2021 Category: Biomedical Science Authors: Azadeh Yeganeh Faisal J Alibhai Stephanie W Tobin Fievel Lim Jun Wu Shuhong Li Richard D Weisel Ren-Ke Li Source Type: research
CircRNA 010567 plays a significant role in myocardial infarction via the regulation of the miRNA-141/DAPK1 axis
CONCLUSIONS: Our results demonstrated that circRNA 010567-siRNA played a protective role in hypoxia-induced cardiomyocyte damage via regulating the miR-141/DAPK1 axis, indicating that circRNA 010567-siRNA may be a promising target for MI therapy.PMID:34012592 | PMC:PMC8107568 | DOI:10.21037/jtd-21-212
Source: Journal of Thoracic Disease - May 20, 2021 Category: Respiratory Medicine Authors: Qinge Zhao Weichao Li Wei Pan Ziyao Wang Source Type: research
