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Total 280 results found since Jan 2013.
The regulation of circRNA and lncRNAprotein binding in cardiovascular diseases: Emerging therapeutic targets
Biomed Pharmacother. 2023 Jun 29;165:115067. doi: 10.1016/j.biopha.2023.115067. Online ahead of print.ABSTRACTNoncoding ribonucleic acids (ncRNAs) are a class of ribonucleic acids (RNAs) that carry cellular information and perform essential functions. This class encompasses various RNAs, such as small nuclear ribonucleic acids (snRNA), small interfering ribonucleic acids (siRNA) and many other kinds of RNA. Of these, circular ribonucleic acids (circRNAs) and long noncoding ribonucleic acids (lncRNAs) are two types of ncRNAs that regulate crucial physiological and pathological processes, including binding, in several organs...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 1, 2023 Category: Drugs & Pharmacology Authors: Huilei Zhao Ziqi Tan Jin Zhou Yifan Wu Qingwen Hu Qing Ling Jitao Ling Menglu Liu Jianyong Ma Deju Zhang Yue Wang Jing Zhang Peng Yu Yuan Jiang Xiao Liu Source Type: research
HSP90-Dependent Upregulation of EZH2 Promotes Hypoxia/Reoxygenation-Induced Pyroptosis by Inhibiting miR-22 in Endothelial Cells
CONCLUSION: H/R induces pyroptosis via the HSP90/EZH2/miR-22/NLRP3 signaling axis in endothelial cells.PMID:37360624 | PMC:PMC10289174 | DOI:10.2147/JIR.S403531
Source: Cell Research - June 26, 2023 Category: Cytology Authors: Paihe Deng Huimin Hu Source Type: research
Neocryptotanshinone ameliorates insufficient energy production in heart failure by targeting retinoid X receptor alpha
In conclusion, we confirmed that NCTS improves myocardial energy metabolism, including fatty acid oxidation and mitochondrial biogenesis, by regulating the RXRα/PPARα pathway in mice with HF post-AMI.PMID:37201263 | DOI:10.1016/j.biopha.2023.114868
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 18, 2023 Category: Drugs & Pharmacology Authors: Lin Ma Mingyan Shao Wenkun Cheng Jinchi Jiang Xu Chen Nannan Tan Guanjing Ling Ye Yang Qian Wang Ran Yang Chun Li Yong Wang Source Type: research
NADPH oxidase 4 contributes to oxidative stress in a mouse model of myocardial infarction
Physiol Res. 2023 Apr 30;72(2):177-186.ABSTRACTOxidative stress closely related to the progression and severity of myocardial infarction (MI). Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 4 (NOX4) is one of the major enzymes that generate reactive oxygen species (ROS) in cardiovascular system. Here, we aim to elucidate the pathological role of NOX4 in MI. MI mouse model was created by the coronary artery ligation. NOX4 was specifically knocked down in heart through intramyocardial injection of siRNA. NOX4 expression and oxidative stress indicators were determined at different time points using qRT-PCR, Weste...
Source: Physiological Research - May 9, 2023 Category: Physiology Authors: Q Huang Y Chen Source Type: research
