Prognostic factors on outcomes of follicular thyroid cancer
ConclusionsDynamic distant metastases and locoregional recurrences were the most dominant risk factors influencing FTC-specific hazard and cumulative incidence for FTC death by accounting for non-FTC death as a competing risk for FTC patients. (Source: Journal of the Formosan Medical Association)
Source: Journal of the Formosan Medical Association - December 10, 2018 Category: General Medicine Source Type: research

Taiwan consensus statement on the management of chronic hepatitis B
Publication date: Available online 6 December 2018Source: Journal of the Formosan Medical AssociationAuthor(s): Rong-Nan Chien, Jia-Horng Kao, Cheng-Yuan Peng, Chien-Hung Chen, Chun-Jen Liu, Yi-Hsiang Huang, Tsung-Hui Hu, Hwa-I Yang, Sheng-Nan Lu, Yen-Hsuan Ni, Won-Long Chuang, Chuan-Mo Lee, Jaw-Chin Wu, Pei-Jer Chen, Yun-Fan LiawThe experts of Taiwan Association for the Study of Liver (TASL) have actively participated and led the guidelines on hepatitis B virus (HBV) management by Asian Pacific Association for the Study of Liver (APASL) which is the first international association for the study of liver to publish the sta...
Source: Journal of the Formosan Medical Association - December 6, 2018 Category: General Medicine Source Type: research

Trends, demographics, and conditions of emergency dental visits in Taiwan 1997–2013: A nationwide population-based retrospective study
ConclusionTaken together, these demographic data could serve as a reference for the authorities concerned to improve the current situation of ED in Taiwan. (Source: Journal of the Formosan Medical Association)
Source: Journal of the Formosan Medical Association - December 6, 2018 Category: General Medicine Source Type: research

Clinical characteristics and prognosis of HCC occurrence after antiviral therapy for HCV patients between sustained and non-sustained responders
ConclusionsLiver cirrhosis plays a key role in HCC occurrence after antiviral therapies. SVR patients may have lower HCC recurrence and longer survival rates than non-SVR patients. Only APRI was associated with HCC recurrence; and post-IFN AFP and HCC recurrence were predictive of subsequent mortality independently. (Source: Journal of the Formosan Medical Association)
Source: Journal of the Formosan Medical Association - December 5, 2018 Category: General Medicine Source Type: research

Efficacy and safety of 12 weeks of daclatasvir, asunaprevir plus ribavirin for HCV genotype-1b infection without NS5A resistance-associated substitutions
ConclusionsTruncated regimen of DCV + ASV plus ribavirin for 12 weeks was highly effective and safe in HCV-1b patients without NS5A L31/Y93 RAS. (Source: Journal of the Formosan Medical Association)
Source: Journal of the Formosan Medical Association - December 5, 2018 Category: General Medicine Source Type: research

Nonintubated laryngomicrosurgery with Transnasal Humidified Rapid-Insufflation Ventilatory Exchange: A case series
ConclusionsNonintubated LMS with THRIVE is a feasible and safe alternative to intubated LMS with a small size tracheal tube to provide a better surgical field. However, for patients with easy-bleeding tumor, intubated LMS remains suggestive for better airway protection. (Source: Journal of the Formosan Medical Association)
Source: Journal of the Formosan Medical Association - December 4, 2018 Category: General Medicine Source Type: research

Clinical relevance of different handgrip strength indexes and cardiovascular disease risk factors: A cross-sectional study in suburb-dwelling elderly Chinese
Publication date: Available online 3 December 2018Source: Journal of the Formosan Medical AssociationAuthor(s): Hairui Yu, Xiaoyu Chen, Renwei Dong, Wen Zhang, Peipei Han, Li Kang, Yixuan Ma, Liye Jia, Liyuan Fu, Lin Hou, Xing Yu, Lu Wang, Xiaodong Zhu, Fengying Yang, Qi GuoBackgroundReduced muscle strength, as measured by handgrip strength (HS), has been associated with an increased risk of cardiovascular disease (CVD). The aim of this study was to examine the association between different HS indexes and CVD risk factors in elderly Chinese individuals. We also determine optimal cutoffs of HS indexes for predicting CVD ris...
Source: Journal of the Formosan Medical Association - December 4, 2018 Category: General Medicine Source Type: research

Gut microbiota and pediatric obesity/non-alcoholic fatty liver disease
Publication date: Available online 1 December 2018Source: Journal of the Formosan Medical AssociationAuthor(s): Yao-Jong Yang, Yen-Hsuan NiHuge amount microorganisms resides in human intestine, and many contribute to the maturation and homeostasis of immune system. The diversity of gut ecology are affected by the gestational age, delivery type, feeding sources, and antibiotics use in neonates. Recent studies pointed out that disturbance of gut microbiota, so called dysbiosis, could result in several pediatric diseases including obesity, non-alcoholic fatty liver disease (NAFLD), metabolic syndromes, allergic diseases, and ...
Source: Journal of the Formosan Medical Association - December 1, 2018 Category: General Medicine Source Type: research

Checklist
Publication date: December 2018Source: Journal of the Formosan Medical Association, Volume 117, Issue 12Author(s): (Source: Journal of the Formosan Medical Association)
Source: Journal of the Formosan Medical Association - November 29, 2018 Category: General Medicine Source Type: research

Editorial Board
Publication date: December 2018Source: Journal of the Formosan Medical Association, Volume 117, Issue 12Author(s): (Source: Journal of the Formosan Medical Association)
Source: Journal of the Formosan Medical Association - November 29, 2018 Category: General Medicine Source Type: research

Highlights
Publication date: December 2018Source: Journal of the Formosan Medical Association, Volume 117, Issue 12Author(s): Jia-Horng Kao (Source: Journal of the Formosan Medical Association)
Source: Journal of the Formosan Medical Association - November 29, 2018 Category: General Medicine Source Type: research

Comparative efficacy and tolerability of beclomethasone/formoterol and fluticasone/salmeterol fixed combination in Taiwanese asthmatic patients
ConclusionThe BDP/F combination is comparable in efficacy and tolerability to FP/S combination in Taiwanese asthmatic patients, with the advantage of rapid onset of improvement of FVC, consistent with the faster improvement of pulmonary hyperinflation with BDP/F. (Source: Journal of the Formosan Medical Association)
Source: Journal of the Formosan Medical Association - November 29, 2018 Category: General Medicine Source Type: research

A cone-beam computed tomography study of C-shaped root canal systems in mandibular second premolars in a Taiwan Chinese subpopulation
ConclusionThere was a 2–3% morphologic variation of the mandibular second premolar with a C-shaped root canal system among the Taiwan Chinese subpopulation investigated in this study. Detailed knowledge of the morphological characteristics of teeth may be valuable when choosing clinical treatments. (Source: Journal of the Formosan Medical Association)
Source: Journal of the Formosan Medical Association - November 29, 2018 Category: General Medicine Source Type: research

Is quality of registry treatment data related to registrar experience and workload? A study of Taiwan cancer registry data
ConclusionThe accuracy rate for the first course of cancer treatment was affected by the cancer type and the experience of cancer registrars, but it was not affected by the workload of cancer registrars. We recommend that cancer registrars with basic licenses upgrade to advanced licenses as soon as possible. Medical record collaboration should establish documentation for checklist of radiotherapy and surgical operation records. (Source: Journal of the Formosan Medical Association)
Source: Journal of the Formosan Medical Association - November 29, 2018 Category: General Medicine Source Type: research

Increased cancer incidence of Changhua residents living in Taisi Village north to the No. 6 Naphtha Cracking Complex
ConclusionWe conclude that all-cause cancer risk was significantly increased for Taisi residents living near the No. 6 Naphtha Cracking Complex for 10–16 years after the complex began operating. (Source: Journal of the Formosan Medical Association)
Source: Journal of the Formosan Medical Association - November 29, 2018 Category: General Medicine Source Type: research

Extramedullary hematopoiesis involving the thyroid: A rare cytologic finding in otherwise healthy patients and review of literature
ConclusionFour patients were noted to have bone marrow elements on the smears among 63,361 thyroid FNA samples. These four Taiwanese women presented with nodular goiter and foci of hematopoietic elements by thyroid FNA without any chronic disease of hematopoietic tissue or any evidence of a thyroid malignancy. (Source: Journal of the Formosan Medical Association)
Source: Journal of the Formosan Medical Association - November 29, 2018 Category: General Medicine Source Type: research

Curcumin inhibits TGF-β1-induced connective tissue growth factor expression through the interruption of Smad2 signaling in human gingival fibroblasts
ConclusionCurcumin can suppress TGF-β1-induced CTGF expression through the interruption of Smad2 signaling. (Source: Journal of the Formosan Medical Association)
Source: Journal of the Formosan Medical Association - November 29, 2018 Category: General Medicine Source Type: research

Guide for Authors
Publication date: December 2018Source: Journal of the Formosan Medical Association, Volume 117, Issue 12Author(s): (Source: Journal of the Formosan Medical Association)
Source: Journal of the Formosan Medical Association - November 29, 2018 Category: General Medicine Source Type: research

Authorship statement
Publication date: December 2018Source: Journal of the Formosan Medical Association, Volume 117, Issue 12Author(s): (Source: Journal of the Formosan Medical Association)
Source: Journal of the Formosan Medical Association - November 29, 2018 Category: General Medicine Source Type: research

Copyright transfer statement
Publication date: December 2018Source: Journal of the Formosan Medical Association, Volume 117, Issue 12Author(s): (Source: Journal of the Formosan Medical Association)
Source: Journal of the Formosan Medical Association - November 29, 2018 Category: General Medicine Source Type: research

Validation of a concise screening tool for the identification of palliative care needs among inpatients: A prospective study in hospital setting
ConclusionsThe TW-PCST demonstrated a good sensitivity and specificity in identification of inpatients with palliative care needs. A total-ABCD score ≥2 may be considered as a trigger for further referral. (Source: Journal of the Formosan Medical Association)
Source: Journal of the Formosan Medical Association - November 28, 2018 Category: General Medicine Source Type: research

Phase II study of metabolic response to one-cycle chemotherapy in patients with locally advanced esophageal squamous cell carcinoma
ConclusionsOur study failed to validate the predefined early metabolic response for pCR to neoadjuvant chemoradiotherapy in locally advanced ESCC patients. However, postchemotherapy SUVmax may be prognostic and predictive, and warrants further study. (Source: Journal of the Formosan Medical Association)
Source: Journal of the Formosan Medical Association - November 28, 2018 Category: General Medicine Source Type: research

Reply to the Letters to the Editor regarding Elevated body mass index is a risk factor associated with possible liver cirrhosis across different etiologies of chronic liver disease: More questions than answer?
Publication date: Available online 24 November 2018Source: Journal of the Formosan Medical AssociationAuthor(s): Yi-Hao Yen, Tsung-Hui Hu (Source: Journal of the Formosan Medical Association)
Source: Journal of the Formosan Medical Association - November 24, 2018 Category: General Medicine Source Type: research

Promoting dentinogenesis of DPSCs through inhibiting microRNA-218 by using magnetic nanocarrier delivery
ConclusionWe identified that miR-218 had a negative regulation role in the dentinogenesis of DPSCs. By inhibiting miR-218, the mineralization potentials of DPSCs were promoted after induction. In addition, we also confirmed that the highly efficient magnetic GCC-Fe3O4 nanocarrier not only was suitable for gene manipulation in biomedical studies, but also ideal for future clinical applications due to its serum endurable property. (Source: Journal of the Formosan Medical Association)
Source: Journal of the Formosan Medical Association - November 23, 2018 Category: General Medicine Source Type: research

Long-term histological change in chronic hepatitis C patients who had received peginterferon plus ribavirin therapy with sustained virological response
ConclusionThe progression of hepatic fibrosis and inflammation can be reversed in some patients who had long-term virological suppression. Patients with advanced baseline fibrosis and higher inflammatory stages seemed to receive more histologic benefit from successful antiviral treatments. (Source: Journal of the Formosan Medical Association)
Source: Journal of the Formosan Medical Association - November 23, 2018 Category: General Medicine Source Type: research

Is a bleeding scan prior to single-balloon enteroscopy necessary in patients with obscure gastrointestinal bleeding?
Publication date: Available online 23 November 2018Source: Journal of the Formosan Medical AssociationAuthor(s): Chih-Wei Yang, Hsuan-Wei Chen, Bao-Chung Chen, Peng-Jen Chen, Yu-Lueng Shih, Wei-Kuo Chang, Tsai-Yuan Hsieh, Tien-Yu HuangBackground/purposeTo evaluate the efficacy and accuracy of bleeder localization in a pre-enteroscopic bleeding scan in patients with obscure gastrointestinal bleeding (OGIB).MethodsFrom January 2009 to December 2014, 98 patients with OGIB undergoing single-balloon enteroscopy (SBE) were enrolled. These patients were classified based on their history of a previous bleeding scan; 56 patients ha...
Source: Journal of the Formosan Medical Association - November 23, 2018 Category: General Medicine Source Type: research

A nationwide survey of the prevalence and psychosocial correlates of internet addictive disorders in Taiwan
ConclusionAge and psychopathology were identified as major determinants of IAD. The IGD criteria in DMS-5 is applicable to identify the internet addictive problems that enhances early engagement for high-risk populations across the ages. (Source: Journal of the Formosan Medical Association)
Source: Journal of the Formosan Medical Association - November 21, 2018 Category: General Medicine Source Type: research

Outcome assessment of apical surgery: A study of 234 teeth
The objective of this study was to investigate the correlation between the demography, preoperative, postoperative factors and healed rate of apical surgery.MethodsSubjects were retrospectively collected from patients who received apical surgery/apicoectomy at the Endodontic Department, National Taiwan University Hospital from January 2013 to June 2015. The standard apical surgery procedures were performed. The demography, preoperative clinical and radiographic examination data as well as postoperative variables were collected. The outcome assessment was carried out after surgery. Statistical analysis was performed by chi ...
Source: Journal of the Formosan Medical Association - November 17, 2018 Category: General Medicine Source Type: research

Real-world anti-viral treatment decisions among chronic hepatitis C patients in Taiwan: The INITIATE study
ConclusionA minority of Taiwanese CHC patients were recommended PEG-IFN/RBV, of which few were willing to receive treatment. (Source: Journal of the Formosan Medical Association)
Source: Journal of the Formosan Medical Association - November 17, 2018 Category: General Medicine Source Type: research

Down-regulation of miR-200b-targeting Slug axis by cyclosporine A in human gingival fibroblasts
ConclusionRepression of miR-200b after CsA administration led to an increase in Slug expression. Our results suggested that miR-200b was an upstream effector of the CsA-induced EMT and may act as a therapeutic target for CsA-induced gingival overgrowth. (Source: Journal of the Formosan Medical Association)
Source: Journal of the Formosan Medical Association - November 17, 2018 Category: General Medicine Source Type: research

Achieving hepatitis C elimination in Taiwan—Overcoming barriers by setting feasible strategies
Publication date: Available online 16 November 2018Source: Journal of the Formosan Medical AssociationAuthor(s): Grace Hui-Min Wu, Raoh-Fang Pwu, Shih-Chung Chen (Source: Journal of the Formosan Medical Association)
Source: Journal of the Formosan Medical Association - November 17, 2018 Category: General Medicine Source Type: research

Recurrent aphthous stomatitis – Etiology, serum autoantibodies, anemia, hematinic deficiencies, and management
Publication date: Available online 14 November 2018Source: Journal of the Formosan Medical AssociationAuthor(s): Chun-Pin Chiang, Julia Yu-Fong Chang, Yi-Ping Wang, Yu-Hsueh Wu, Yang-Che Wu, Andy SunRecurrent aphthous stomatitis (RAS) is one of the most common oral mucosal diseases characterized by recurrent and painful ulcerations on the movable or nonkeratinized oral mucosae. Clinically, three types of RAS, namely minor, major, and herpetiform types, can be identified. RAS more commonly affects labial mucosa, buccal mucosa, and tongue. Previous studies indicate that RAS is a multifactorial T cell-mediated immune-dysregul...
Source: Journal of the Formosan Medical Association - November 14, 2018 Category: General Medicine Source Type: research

Sleep and emotional disturbance in patients with non-dialysis chronic kidney disease
Publication date: Available online 9 November 2018Source: Journal of the Formosan Medical AssociationAuthor(s): Chao-Ying Tu, Yu-Hsiang Chou, Yu-Hsuan Lin, Wei-Lieh HuangBackground/PurposeSleep disorder and depression are prevalent in patients on dialysis but less investigated in earlier-stage chronic kidney disease (CKD) patients. We aimed to evaluate the prevalence of depression, anxiety, health anxiety, and sleep disturbance and explore the association between CKD stage, psychological symptoms and sleep quality.MethodsWe recruited 326 patients with CKD (stage 1–5) not on dialysis from the nephrology clinic. All pa...
Source: Journal of the Formosan Medical Association - November 9, 2018 Category: General Medicine Source Type: research

Erythropoietin modulates macrophages but not post-ischemic acute kidney injury in mice
ConclusionUse of rHuEPO can modulate macrophage function but not the post-ischemic AKI severity, functional recovery and survival in mice. (Source: Journal of the Formosan Medical Association)
Source: Journal of the Formosan Medical Association - November 8, 2018 Category: General Medicine Source Type: research

Association of initial mucogingival status with clinical outcome of non-surgical periodontal therapy: A retrospective analysis of 204 patients
This study was conducted to evaluate the influence of mucogingival parameters, including keratinized mucosa (KM) and attached gingiva (AG), on the outcome of non-surgical periodontal therapy (NSPT).MethodsA total of 204 non-smoking patients with generalized chronic periodontitis who received NSPT between 2012 and 2014 were included. The Mantel–Haenszel chi-square test was used to assess the associations between initial mucogingival parameters and initial clinical parameters on the buccal aspect, and the associations between initial mucogingival parameters and outcome clinical parameters on the buccal aspect of the si...
Source: Journal of the Formosan Medical Association - November 6, 2018 Category: General Medicine Source Type: research

Reply letter to “Chikungunya in Bolivia: Domestic imported case series in Cochabamba”
Publication date: Available online 3 November 2018Source: Journal of the Formosan Medical AssociationAuthor(s): Cheng-Hui Tsai, Hwa-Jen Teng (Source: Journal of the Formosan Medical Association)
Source: Journal of the Formosan Medical Association - November 4, 2018 Category: General Medicine Source Type: research

Night eating syndrome in patients with eating disorders: Is night eating syndrome distinct from bulimia nervosa?
ConclusionNES has its clinical significance; however, it overlaps with BN in several dimensions of psychopathology. Presence of night eating in a BN group may not contribute clinically meaningful psychopathology. (Source: Journal of the Formosan Medical Association)
Source: Journal of the Formosan Medical Association - November 3, 2018 Category: General Medicine Source Type: research

Elevated body mass index is a risk factor associated with possible liver cirrhosis across different etiologies of chronic liver disease: More questions than answer?
Publication date: Available online 3 November 2018Source: Journal of the Formosan Medical AssociationAuthor(s): Po-Zi Chen, Chia-Chi Wang (Source: Journal of the Formosan Medical Association)
Source: Journal of the Formosan Medical Association - November 3, 2018 Category: General Medicine Source Type: research

The association between Type 1 diabetes mellitus and periodontal diseases
ConclusionT1DM patients are at higher risk of developing PDs than non-T1DM individuals. Our results further showed that the number of T1DM interventions; that is, annual emergency visits and hospitalizations were associated with increased the risk of developing PDs. (Source: Journal of the Formosan Medical Association)
Source: Journal of the Formosan Medical Association - November 2, 2018 Category: General Medicine Source Type: research

Chikungunya in Bolivia: Domestic imported case series in Cochabamba
Publication date: Available online 30 October 2018Source: Journal of the Formosan Medical AssociationAuthor(s): Juan Pablo Escalera-Antezana, David R. Murillo-García, Christian Gómez, Roberto Carlos Unzueta-Quiroga, Alfonso J. Rodríguez-Morales (Source: Journal of the Formosan Medical Association)
Source: Journal of the Formosan Medical Association - October 31, 2018 Category: General Medicine Source Type: research

Survival outcomes of liver transplantation versus liver resection among patients with hepatocellular carcinoma: A SEER-based longitudinal study
This study aimed to compare the survival benefit in hepatocellular carcinoma (HCC) patients following liver transplantation or surgical resection utilizing Surveillance, Epidemiology, and End Results Program (SEER) database (2004–2013).MethodsOverall and cancer-specific mortality were evaluated in HCC patients who were treated by liver resection or transplantation. Patients newly-diagnosed with primary HCC were included.ResultsKaplan-Meier survival curves found that patients with liver transplantation had lower risk of overall mortality and cancer-free mortality than patients who received liver resection (P 
Source: Journal of the Formosan Medical Association - October 26, 2018 Category: General Medicine Source Type: research

Combination of left atrial appendage closure and catheter ablation in a single procedure for patients with atrial fibrillation: Multicenter experience
ConclusionThe combination therapy with LAAC and AF ablation in a single procedure was efficacious and safe in the Chinese symptomatic AF population with high risk for stroke and bleeding. (Source: Journal of the Formosan Medical Association)
Source: Journal of the Formosan Medical Association - October 26, 2018 Category: General Medicine Source Type: research

Risk factors for upper gastrointestinal bleeding among aspirin users: An old issue with new findings from a population-based cohort study
ConclusionIn addition to age, male gender, H. pylori infection, and concomitant use of NSAIDs, COX-2 inhibitors, steroids, and thienopyridines, underlying co-morbidities including diabetes, CKD, cirrhosis, history of PUD are also important risk factors for first-time occurrence of non-variceal UGIB in aspirin users. (Source: Journal of the Formosan Medical Association)
Source: Journal of the Formosan Medical Association - October 24, 2018 Category: General Medicine Source Type: research

The prospects and opportunities of age-friendly Taiwan
Publication date: Available online 24 October 2018Source: Journal of the Formosan Medical AssociationAuthor(s): Li-Ju Lin, Yu-Chang Hsu, Hsien-Wen Kuo (Source: Journal of the Formosan Medical Association)
Source: Journal of the Formosan Medical Association - October 24, 2018 Category: General Medicine Source Type: research

Guardian of economic security-National Pension Insurance
Publication date: Available online 24 October 2018Source: Journal of the Formosan Medical AssociationAuthor(s): Chia-Yen Chung (Source: Journal of the Formosan Medical Association)
Source: Journal of the Formosan Medical Association - October 24, 2018 Category: General Medicine Source Type: research

Checklist
Publication date: November 2018Source: Journal of the Formosan Medical Association, Volume 117, Issue 11Author(s): (Source: Journal of the Formosan Medical Association)
Source: Journal of the Formosan Medical Association - October 24, 2018 Category: General Medicine Source Type: research

Editorial Board
Publication date: November 2018Source: Journal of the Formosan Medical Association, Volume 117, Issue 11Author(s): (Source: Journal of the Formosan Medical Association)
Source: Journal of the Formosan Medical Association - October 24, 2018 Category: General Medicine Source Type: research

Highlights
Publication date: November 2018Source: Journal of the Formosan Medical Association, Volume 117, Issue 11Author(s): Jia-Horng Kao (Source: Journal of the Formosan Medical Association)
Source: Journal of the Formosan Medical Association - October 24, 2018 Category: General Medicine Source Type: research

The effect of dietary carbohydrate on gastroesophageal reflux disease
ConclusionMore acid reflux symptoms are found after high carbohydrate diet. High carbohydrate diet could induce more acid reflux in low esophagus and more reflux symptoms in patients with gastroesophageal reflux disease. (Source: Journal of the Formosan Medical Association)
Source: Journal of the Formosan Medical Association - October 24, 2018 Category: General Medicine Source Type: research

Association between Helicobacter pylori infection and cognitive impairment in the elderly
ConclusionOur findings disclosed a positive association between serum H. pylori level and cognitive impairment, which provides important information for the primary prevention of cognitive impairment through the eradication of H. pylori. (Source: Journal of the Formosan Medical Association)
Source: Journal of the Formosan Medical Association - October 24, 2018 Category: General Medicine Source Type: research