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Condition: Fatty Liver Disease (FLD)

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Total 185 results found since Jan 2013.

Erythropoietin alleviates hepatic Steatosis by activating SIRT1-mediated autophagy.
Abstract Erythropoietin (EPO), besides its stimulatory effect on erythropoiesis, is beneficial to insulin resistance and obesity. However, its role in hepatic steatosis remains unexplored. Activating autophagy seems a promising mechanism for improving fatty liver disease. The present study investigated the role of EPO in alleviating hepatic steatosis and sought to determine whether its function is mediated by the activation of autophagy. Here, we show that EPO decreased hepatic lipid content significantly in vivo and in vitro. Furthermore, EPO/EPO receptor (EPOR) signalling induced autophagy activation in hepatocy...
Source: Biochimica et Biophysica Acta - March 6, 2018 Category: Biochemistry Authors: Hong T, Ge Z, Meng R, Wang H, Zhang P, Tang S, Lu J, Gu T, Zhu D, Bi Y Tags: Biochim Biophys Acta Source Type: research

miR-192-5p regulates lipid synthesis in non-alcoholic fatty liver disease through SCD-1.
CONCLUSION: This study demonstrates that miR-192-5p has a negative regulatory role in lipid synthesis, which is mediated through its direct regulation of SCD-1. PMID: 29290651 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - December 14, 2017 Category: Gastroenterology Authors: Liu XL, Cao HX, Wang BC, Xin FZ, Zhang RN, Zhou D, Yang RX, Zhao ZH, Pan Q, Fan JG Tags: World J Gastroenterol Source Type: research

Omega-3 polyunsaturated fatty acids protect human hepatoma cells from developing steatosis through FFA4 (GPR120)
Publication date: Available online 7 November 2017 Source:Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids Author(s): Saeromi Kang, Jin Huang, Bo-Kyung Lee, Young-Suk Jung, Eunok Im, Jung-Min Koh, Dong-Soon Im Protective effect of omega-3 polyunsaturated fatty acids (n-3 PUFA) on non-alcoholic fatty liver disease has been demonstrated. FFA4 (also known as GPR120; a G protein-coupled receptor) has been suggested to be a target of n-3 PUFA. FFA4 expression in hepatocytes has also been reported from liver biopsies in child fatty liver patients. In order to assess the functional role of FFA4 in hepat...
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - November 8, 2017 Category: Lipidology Source Type: research

Omega-3 polyunsaturated fatty acids protect human hepatoma cells from developing steatosis through FFA4 (GPR120).
Abstract Protective effect of omega-3 polyunsaturated fatty acids (n-3 PUFA) on non-alcoholic fatty liver disease has been demonstrated. FFA4 (also known as GPR120; a G protein-coupled receptor) has been suggested to be a target of n-3 PUFA. FFA4 expression in hepatocytes has also been reported from liver biopsies in child fatty liver patients. In order to assess the functional role of FFA4 in hepatic steatosis, we used an in vitro model of liver X receptor (LXR)-mediated hepatocellular steatosis. FFA4 expression was confirmed in Hep3B and HepG2 human hepatoma cells. T0901317 (a specific LXR activator) induced lip...
Source: Biochimica et Biophysica Acta - November 7, 2017 Category: Biochemistry Authors: Kang S, Huang J, Lee BK, Jung YS, Im E, Koh JM, Im DS Tags: Biochim Biophys Acta Source Type: research

PKC δ Silencing Alleviates Saturated Fatty Acid-Induced ER Stress by Enhancing SERCA Activity.
Conclusion : To the best of our knowledge, this is the first report demonstrating that the inhibition of PKCδ alleviates ERS by enhancing SERCA activity and stabilizing calcium homeostasis. PMID: 29046367 [PubMed - as supplied by publisher]
Source: Bioscience Reports - October 18, 2017 Category: Biomedical Science Authors: Lai S, Li Y, Kuang Y, Cui H, Yang Y, Sun W, Liu K, Chen D, Yan Q, Wen L Tags: Biosci Rep Source Type: research

Apelin protects against liver X receptor-mediated steatosis through AMPK and PPAR α in human and mouse hepatocytes.
Apelin protects against liver X receptor-mediated steatosis through AMPK and PPARα in human and mouse hepatocytes. Cell Signal. 2017 Aug 15;39:84-94 Authors: Huang J, Kang S, Park SJ, Im DS Abstract Non-alcoholic fatty liver disease is the most commonly occurring chronic liver disease, and hepatic steatosis, a condition defined as extensive lipid accumulation in hepatocytes, is associated with liver dysfunction and metabolic diseases, such as, obesity and type II diabetes. Apelin is an adipokine that acts on a G protein-coupled receptor named APJ, and has been established to play pivotal roles in var...
Source: Cellular Signalling - August 15, 2017 Category: Cytology Authors: Huang J, Kang S, Park SJ, Im DS Tags: Cell Signal Source Type: research

Sirtuin 3 acts as a negative regulator of autophagy dictating hepatocyte susceptibility to lipotoxicity
Conclusion: Our data indicate that SIRT3 is a negative regulator of autophagy whose activation by SFAs contributes to lipotoxicity in hepatocytes and suggest that restraining SIRT3 overactivation can be a potential therapeutic choice for the treatment of NAFLD as well as other metabolic disorders, with lipotoxicity being the principal pathomechanism. (Hepatology 2017).
Source: Hepatology - July 20, 2017 Category: Internal Medicine Authors: Songtao Li, Xiaobing Dou, Hua Ning, Qing Song, Wei Wei, Ximei Zhang, Chen Shen, Jiaxin Li, Changhao Sun, Zhenyuan Song Tags: Steatohepatitis and Metabolic Liver Disease Source Type: research

SIRT3 Acts As a Negative Regulator of Autophagy Dictating Hepatocyte Susceptibility to Lipotoxicity
Conclusion: our data identified SIRT3 to be a novel negative regulator of autophagy, whose activation by SFAs contributes to lipotoxicity in hepatocytes and suggest that restraining SIRT3 overactivation can be a potential therapeutic choice for the treatment of NAFLD as well as other metabolic disorders, with lipotoxicity being the principal pathomechanism. This article is protected by copyright. All rights reserved.
Source: Hepatology - April 24, 2017 Category: Internal Medicine Authors: Songtao Li, Xiaobing Dou, Hua Ning, Qing Song, Wei Wei, Ximei Zhang, Chen Shen, Jiaxin Li, Changhao Sun, Zhenyuan Song Tags: Steatohepatitis and Metabolic Liver Disease Source Type: research

Mutation of miR-21 targets endogenous lipoprotein receptor-related protein 6 and nonalcoholic fatty liver disease.
Authors: Li CP, Li HJ, Nie J, Chen X, Zhou X Abstract Nonalcoholic fatty liver disease (NAFLD) is a chronic disorder characterized by hepatic fat accumulation and abnormal lipid metabolism. Although miR-21 has been implicated in nonalcoholic fatty liver disease, it is unknown whether miR-21 could function as a therapeutic target. Here, we perform transfection analysis of miR-21 mimic or control mimic to evaluate the effects of miR-21 expression levels on human HepG2 nonalcoholic fatty liver cells. We used siRNA techniques to knock down miR-21 in HepG2 and control 293T cell lines, and then monitored lipid production...
Source: American Journal of Translational Research - March 27, 2017 Category: Research Tags: Am J Transl Res Source Type: research

Nrf2 Is Crucial For The Down-Regulation Of Cyp7a1 Induced By Arachidonic Acid In Hepg2 Cells
In conclusion, Nrf2 plays a significant role in the down-regulation of CYP7A1 induced by AA in HepG2 cells.Abbreviations: AA, arachidonic acid; CYP7A1, cholesterol 7α-hydroxylase; FA, fatty acid; HFD, high-fat diet; NAFLD, non-alcoholic fatty liver disease; Nrf2, nuclear factor erythroid-derived 2-like 2; siRNA, small interfering RNA.
Source: Environmental Toxicology and Pharmacology - March 7, 2017 Category: Environmental Health Source Type: research

MiR-30c-5p ameliorates hepatic steatosis in leptin receptor-deficient (db/db) mice via down-regulating FASN.
In this study, we observed a significant reduction of miR-30c-5p in the liver of leptin receptor-deficient (db/db) mice. Remarkably, recombinant adeno-associated virus (rAAV)-mediated delivery of miR-30c-5p was sufficient to attenuate triglyceride accumulation and hepatic steatosis in db/db mice. Through computational prediction, KEGG analysis and Ago2 co-immunoprecipitation, we identified that miR-30c-5p directly targeted fatty acid synthase, a key enzyme in fatty acid biosynthesis. Moreover, down-regulation of FASN by siRNA attenuated some key features of NAFLD, including decreased triglyceride accumulate and lipid depos...
Source: Oncotarget - January 16, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

CD98 siRNA-loaded nanoparticles decrease hepatic steatosis in mice
Non-alcoholic fatty liver disease (NAFLD) is characterized by excessive lipid hepatic accumulation. Here, we investigated whether a reduction of CD98 expression mediated by CD98 siRNA-loaded nanoparticles (NPs) could attenuate liver disease markers in a mouse model of NAFLD. NPs were generated using a double emulsion/solvent evaporation technique. Mice fed a high fat diet for 8 weeks to induce fatty liver were treated with vein tail injections of CD98 siRNA-loaded NPs. In vitro, HepG2 treated with CD98 siRNA-loaded NPs showed significant downregulation of CD98 leading to a significant decrease of major pro-inflammatory cytokines and markers.
Source: Digestive and Liver Disease - November 16, 2016 Category: Gastroenterology Authors: Brandon S.B. Canup, Heliang Song, Vu Le Ngo, Xiangxiao Meng, Timothy L. Denning, Pallavi Garg, Hamed Laroui Tags: Liver, Pancreas and Biliary Tract Source Type: research

HNF-4alpha Negatively Regulates Hepcidin Expression Through BMPR1A in HepG2 Cells.
In conclusion, the present study suggests that HNF-4α has a suppressive effect on hepcidin expression by inactivating the BMP pathway, specifically via BMPR1A, in HepG2 cells. PMID: 27660075 [PubMed - as supplied by publisher]
Source: Biological Trace Element Research - September 22, 2016 Category: Biology Authors: Shi W, Wang H, Zheng X, Jiang X, Xu Z, Shen H, Li M Tags: Biol Trace Elem Res Source Type: research

Rubicon inhibits autophagy and accelerates hepatocyte apoptosis and lipid accumulation in nonalcoholic fatty liver disease
Conclusion: Rubicon is overexpressed and plays a pathogenic role in NAFLD by accelerating hepatocellular lipoapoptosis and lipid accumulation, as well as inhibiting autophagy. Rubicon may be a novel therapeutic target for regulating NAFLD development and progression. This article is protected by copyright. All rights reserved.
Source: Hepatology - September 15, 2016 Category: Internal Medicine Authors: Satoshi Tanaka, Hayato Hikita, Tomohide Tatsumi, Ryotaro Sakamori, Yasutoshi Nozaki, Sadatsugu Sakane, Yuto Shiode, Tasuku Nakabori, Yoshinobu Saito, Naoki Hiramatsu, Keisuke Tabata, Tsuyoshi Kawabata, Maho Hamasaki, Hidetoshi Eguchi, Hiroaki Nagano, Tamo Tags: Steatohepatitis and Metabolic Liver Disease Source Type: research

Inhibition of citrate cotransporter Slc13a5/mINDY by RNAi improves hepatic insulin sensitivity and prevents diet-induced non-alcoholic fatty liver disease in mice
Conclusions We show that inducible mINDY inhibition improved hepatic insulin sensitivity and prevented diet-induced non-alcoholic fatty liver disease in adult C57BL6/J mice. These effects did not depend on changes of body weight or body composition. Graphical abstract
Source: Molecular Metabolism - August 13, 2016 Category: Endocrinology Source Type: research