Filtered By:
Condition: Fatty Liver Disease (FLD)
This page shows you your search results in order of date. This is page number 12.
Order by Relevance | Date
Total 185 results found since Jan 2013.
Amelioration of nonalcoholic fatty liver disease by hepatic stimulator substance via preservation of carnitine palmitoyl transferase-1 activity
In conclusion, HSS reduces lipotoxicity to mitochondria most likely via preservation of CPT-1.
Source: AJP: Cell Physiology - August 15, 2015 Category: Cytology Authors: Xiao, W., Ren, M., Zhang, C., Li, S., An, W. Tags: ARTICLES Source Type: research
RNAi in murine hepatocytes: the agony of choice-a study of the influence of lipid-based transfection reagents on hepatocyte metabolism.
In conclusion, these findings demonstrate that the choice of non-viral siRNA delivery agent is critical in hepatocytes. This should be remembered, especially if RNA silencing is used for studying hepatic lipid homeostasis and its regulation.
PMID: 26233687 [PubMed - as supplied by publisher]
Source: Archives of Toxicology - August 2, 2015 Category: Toxicology Authors: Böttger J, Arnold K, Thiel C, Rennert C, Aleithe S, Hofmann U, Vlaic S, Sales S, Shevchenko A, Matz-Soja M Tags: Arch Toxicol Source Type: research
Glucagon‐like peptide‐1 (GLP‐1) preserves non‐alcoholic fatty liver disease (NAFLD) through inhibition of the endoplasmic reticulum (ER) stress‐associated pathway
ConclusionGLP‐1 protected against non‐alcoholic fatty liver disease by inactivating the ER stress‐associated apoptosis pathway. In addition, the effect was possibly related to the signaling pathway of ERp46. This article is protected by copyright. All rights reserved.
Source: Hepatology Research - July 4, 2015 Category: Internal Medicine Authors: Na. Ao, Jing Yang, Xiaochen Wang, Jian Du Tags: Original Article Source Type: research
Hepatic TLR4 Signaling in Obese NAFLD.
CONCLUSION: TLR4 expression is up-regulated in a large cohort of NASH patients, when compared to those with NAFL, and this occurs within the setting of increased LPS and fatty acids.
PMID: 26113297 [PubMed - as supplied by publisher]
Source: Am J Physiol Gastroi... - June 25, 2015 Category: Gastroenterology Authors: Sharifnia T, Antoun J, Verriere TG, Suarez G, Wattacheril J, Wilson KT, Peek RM, Abumrad NN, Flynn CR Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research
Amelioration of Non-alcoholic Fatty Liver Disease by Hepatic Stimulator Substance via Preservation of Carnitine Palmitoyl Transferase-1 Activity.
In conclusion, HSS reduces lipotoxicity to mitochondria most likely via preservation of CPT-1.
PMID: 26108664 [PubMed - as supplied by publisher]
Source: Am J Physiol Cell Ph... - June 24, 2015 Category: Cytology Authors: Xiao W, Ren M, Zhang C, Li S, An W Tags: Am J Physiol Cell Physiol Source Type: research
Resveratrol improves hepatic steatosis by inducing autophagy through the cAMP signaling pathway
Conclusions: RSV improved hepatic steatosis partially by inducing autophagy in vitro and in vivo, via the cAMP‐PRKA‐AMPK‐SIRT1 signaling pathway, which provides new evidence regarding RSV's effects on NAFLD treatmentThis article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - May 5, 2015 Category: Food Science Authors: Yong Zhang, Ming‐liang Chen, Yong Zhou, Long Yi, Yan‐xiang Gao, Li Ran, Shi‐hui Chen, Ting Zhang, Xi Zhou, Dan Zou, Bin Wu, Ying Wu, Hui Chang, Jun‐dong Zhu, Qian‐yong Zhang, Man‐tian Mi Tags: Research Article Source Type: research
Essential role of NRF2 in the protective effect of lipoic acid against lipoapoptosis in hepatocytes.
In conclusion, our work has revealed that in hepatocytes, Nrf2 is an essential early player in the rescue of oxidative stress by LA leading to protection against PA-mediated lipoapoptosis.
PMID: 25841776 [PubMed - as supplied by publisher]
Source: Free Radical Biology and Medicine - April 1, 2015 Category: Biology Authors: Pilar Valdecantos M, Prieto-Hontoria PL, Pardo V, Módol T, Santamaría B, Weber M, Herrero L, Serra D, Muntané J, Cuadrado A, Moreno-Aliaga MJ, Alfredo Martínez J, Valverde ÁM Tags: Free Radic Biol Med Source Type: research
Monoacylglycerol O-acyltransferase 1 is regulated by peroxisome proliferator-activated receptor γ in human hepatocytes and increases lipid accumulation.
In this study, we evaluated the differences between MGAT subtypes and their association with peroxisome proliferator-activated receptor γ (PPARγ), a regulator of mouse MGAT1 expression. In human primary hepatocytes, basal expression of MGAT1 was lower than that of MGAT2 or MGAT3, but was strongly induced by PPARγ overexpression. A luciferase assay as well as an electromobility shift assay revealed that human MGAT1 promoter activity is driven by PPARγ by direct binding to at least two regions of the promoter in 293T and HepG2 cells. Moreover, siRNA-mediated suppression of MGAT1 expression significantly attenuated lipid ...
Source: Biochemical and Biophysical Research communications - March 30, 2015 Category: Biochemistry Authors: Yu JH, Lee YJ, Kim HJ, Choi H, Choi Y, Seok JW, Kim JW Tags: Biochem Biophys Res Commun Source Type: research
ASPP2 attenuates triglycerides to protect against hepatocyte injury by reducing autophagy in a cell and mouse model of non‐alcoholic fatty liver disease
In conclusion, ASPP2 may participate in the lipid metabolism of non‐alcoholic steatohepatitis and attenuate liver failure.
Source: Journal of Cellular and Molecular Medicine - September 25, 2014 Category: Molecular Biology Authors: Fang Xie, Lin Jia, Minghua Lin, Ying Shi, Jiming Yin, Yin Liu, Dexi Chen, Qinghua Meng Tags: Original Article Source Type: research
ASPP2 attenuates triglycerides to protect against hepatocyte injury by reducing autophagy in a cell and mouse model of non-alcoholic fatty liver disease.
In conclusion, ASPP2 may participate in the lipid metabolism of non-alcoholic steatohepatitis and attenuate liver failure.
PMID: 25256142 [PubMed - as supplied by publisher]
Source: J Cell Mol Med - September 25, 2014 Category: Molecular Biology Authors: Xie F, Jia L, Lin M, Shi Y, Yin J, Liu Y, Chen D, Meng Q Tags: J Cell Mol Med Source Type: research
Metabolic profiling reveals that PNPLA3 induces widespread effects on metabolism beyond triacylglycerol remodeling in Huh-7 hepatoma cells
PNPLA3 was recently associated with the susceptibility to nonalcoholic fatty liver disease, a common cause of chronic liver disease characterized by abnormal triglyceride accumulation. Although it is established that PNPLA3 has both triacylglycerol lipase and acylglycerol O-acyltransferase activities, is still unknown whether the gene has any additional role in the modulation of the human liver metabolome. To uncover the functional role of PNPLA3 on liver metabolism, we performed high-throughput metabolic profiling of PNPLA3 siRNA-silencing and overexpression of wild-type and mutant Ile148Met variants (isoleucine/methionin...
Source: AJP: Gastrointestinal and Liver Physiology - July 1, 2014 Category: Gastroenterology Authors: Min, H.-K., Sookoian, S., Pirola, C. J., Cheng, J., Mirshahi, F., Sanyal, A. J. Tags: LIVER AND BILIARY TRACT Source Type: research
Metabolic profiling reveals that pnpla3 induces widespread effects on metabolism beyond triacylglycerol remodeling in huh-7 hepatoma cells.
METABOLIC PROFILING REVEALS THAT PNPLA3 INDUCES WIDESPREAD EFFECTS ON METABOLISM BEYOND TRIACYLGLYCEROL REMODELING IN HUH-7 HEPATOMA CELLS.
Am J Physiol Gastrointest Liver Physiol. 2014 Apr 24;
Authors: Min HK, Sookoian SC, Pirola CJ, Cheng J, Mirshahi F, Sanyal AJ
Abstract
PNPLA3 was recently associated with the susceptibility to nonalcoholic fatty liver disease, a common cause of chronic liver disease characterized by abnormal triglyceride accumulation. While it is established that PNPLA3 has both triacylglycerol lipase and acylglycerol O-acyltransferase activities, is still unknown whether the gene...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - April 24, 2014 Category: Physiology Authors: Min HK, Sookoian SC, Pirola CJ, Cheng J, Mirshahi F, Sanyal AJ Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research
Isoquercitrin activates the AMP¿activated protein kinase (AMPK) signal pathway in rat H4IIE cells
Conclusions:
Isoquercitrin appears to regulate AMPK activation, thereby enhancing AdipoR1 expression, suppressing SREBP-1 and FAS expressions, and resulting in the regulation of lipid accumulation. These results suggest that isoquercitrin is a novel dietary compound that can be potentially be used to prevent lipid metabolic disorder and nonalcoholic fatty liver disease.
Source: BMC Complementary and Alternative Medicine - February 3, 2014 Category: Complementary Medicine Authors: Jingxin ZhouHisae YoshitomiTonghua LiuBoxin ZhouWen SunLingling QinXiangyu GuoLiansha HuangLili WuMing Gao Source Type: research
Isoquercitrin activates the AMP-activated protein kinase (AMPK) signal pathway in rat H4IIE cells
Conclusions:
Isoquercitrin appears to regulate AMPK activation, thereby enhancing AdipoR1 expression, suppressing SREBP-1 and FAS expressions, and resulting in the regulation of lipid accumulation. These results suggest that isoquercitrin is a novel dietary compound that can be potentially be used to prevent lipid metabolic disorder and nonalcoholic fatty liver disease.
Source: BMC Complementary and Alternative Medicine - February 3, 2014 Category: Complementary Medicine Authors: Jingxin ZhouHisae YoshitomiTonghua LiuBoxin ZhouWen SunLingling QinXiangyu GuoLiansha HuangLili WuMing Gao Source Type: research
Ceacam1 deletion causes vascular alterations in large vessels
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) promotes hepatic insulin clearance and endothelial survival. However, its role in the morphology of macrovessels remains unknown. Mice lacking Ceacam1 (Cc1–/–) exhibit hyperinsulinemia, which causes insulin resistance and fatty liver. With increasing evidence of an association among hyperinsulinemia, fatty liver disease, and atherosclerosis, we investigated whether Cc1–/– exhibited vascular lesions in atherogenic-prone aortae. Histological analysis revealed impaired endothelial integrity with restricted fat deposition and aortic pla...
Source: AJP: Endocrinology and Metabolism - August 15, 2013 Category: Endocrinology Authors: Najjar, S. M., Ledford, K. J., Abdallah, S. L., Paus, A., Russo, L., Kaw, M. K., Ramakrishnan, S. K., Muturi, H. T., Raphael, C. K., Lester, S. G., Heinrich, G., Pierre, S. V., Benndorf, R., Kleff, V., Jaffa, A. A., Levy, E., Vazquez, G., Goldberg, I. J., Tags: Articles Source Type: research
