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Condition: Fatty Liver Disease (FLD)

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Total 185 results found since Jan 2013.

ATF4-mediated CD36 Upregulation Contributes to Palmitate-induced Lipotoxicity in Hepatocytes
In this study, our data revealed for the first time that ATF4 plays a critical role in mediating hepatic CD36 expression. Genetic inhibition of ATF4 attenuated CD36 upregulation induced by either palmitate or ER stress inducer tunicamycin in hepatocytes. In mice, tunicamycin upregulates liver CD36 expression, whereas hepatocyte-specific ATF4 knockout mice manifest lower hepatic CD36 expression when compared to control animals. Furthermore, we demonstrated that CD36 upregulation upon palmitate exposure represents a feedforward mechanism in that siRNA knockdown of CD36 in hepatocytes blunted ATF4 activation induced by both p...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - February 28, 2023 Category: Physiology Authors: Alexandra Griffiths Jun Wang Qing Song Samuel Man Lee Jose Cordoba-Chacon Zhenyuan Song Source Type: research

GSE225616 Hepatocyte mARC1 Promotes Fatty Liver Disease
Conclusions: Collectively, our findings from human genetics, and in vitro and in vivo hepatocyte-specific mARC1 knockdown support the potential efficacy of hepatocyte-specific targeting of mARC1 for treatment of NAFLD.
Source: GEO: Gene Expression Omnibus - February 20, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

Molecules, Vol. 28, Pages 1874: Berberine Ameliorates Metabolic-Associated Fatty Liver Disease Mediated Metabolism Disorder and Redox Homeostasis by Upregulating Clock Genes: Clock and Bmal1 Expressions
Shijian Quan Metabolic-associated fatty liver disease (MAFLD) is one of the most common chronic liver diseases, which in turn triggers mild inflammation, metabolic dysfunction, fibrosis, and even cancer. Accumulating evidence has suggested that Berberine (BBR) could significantly improve MAFLD progression. Clock and Bmal1 as heterodimer proteins highly participated in the development of MAFLD, but whether BBR targets Clock and Bmal1 in MAFLD remains poorly understood. The result suggested that the protein levels of Clock and Bmal1 were decreased in MAFLD mice, which was negatively correlated with elevated reactive o...
Source: Molecules - February 16, 2023 Category: Chemistry Authors: Cunsi Ye Yajing Zhang Shaomin Lin Yi Chen Zimiao Wang Haoyinghua Feng Guangqing Fang Shijian Quan Tags: Article Source Type: research

Oroxylin-A alleviates hepatic lipid accumulation and apoptosis under hyperlipidemic conditions via AMPK/FGF21 signaling
In conclusion, OA improves inflammation through the AMPK/FGF21 pathway, thereby attenuating lipid accumulation and apoptosis in hepatocytes. This study may help identify new targets for developing treatments for NAFLD.PMID:36736092 | DOI:10.1016/j.bbrc.2023.01.090
Source: Biochemical and Biophysical Research communications - February 3, 2023 Category: Biochemistry Authors: Wonjun Cho Sung Woo Choi Heeseung Oh A M Abd El-Aty Ahmet Hacimuftuoglu Ji Hoon Jeong Jin-Ho Song Yong Kyoo Shin Tae Woo Jung Source Type: research

Caveolin-1 ameliorates acetaminophen-aggravated inflammatory damage and lipid deposition in non-alcoholic fatty liver disease via the ROS/TXNIP/NLRP3 pathway
Int Immunopharmacol. 2023 Jan;114:109558. doi: 10.1016/j.intimp.2022.109558. Epub 2022 Dec 21.ABSTRACTThe overuse of acetaminophen (APAP) may cause more severe hepatotoxicity in patients with non-alcoholic fatty liver disease (NAFLD). Caveolin-1 (CAV1), is an essential regulator of metabolic function, which can alleviate liver damage by scavenging reactive oxygen species (ROS). Evidence suggests that the NOD-like receptor family pyrin domain-containing 3 (NLRP3) -mediated pyroptosis is involved in the development of NAFLD. Moreover, thioredoxin-interactive protein (TXNIP) activation is a key event linking ROS to NLRP3 infl...
Source: International Immunopharmacology - January 26, 2023 Category: Allergy & Immunology Authors: Xiangfu Jiang Yu Li Dongdong Fu Tingyu You Shuai Wu Jiao Xin Jiagen Wen Yan Huang Chengmu Hu Source Type: research

GSE222499 Liver-specific FGFR4 knockdown in mice on a HFD increases bile acid synthesis and improves hepatic steatosis II
Contributor : Softic SamirSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusNonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease with increased risk in patients with metabolic syndrome. There are no FDA approved treatments, but farnesoid X receptor (FXR) agonists have shown promising results in clinical studies for NAFLD management. In addition to FXR,  fibroblast growth factor receptor FGFR4 is a key mediator of hepatic bile acid synthesis. Using N-acetylgalactosamine-conjugated siRNA, we knocked down FGFR4 specifically in the liver of mice on chow or...
Source: GEO: Gene Expression Omnibus - January 11, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

Dnmt1/Tet2-mediated changes in Cmip methylation regulate the development of nonalcoholic fatty liver disease by controlling the Gbp2-Ppar γ-CD36 axis
Exp Mol Med. 2023 Jan 6. doi: 10.1038/s12276-022-00919-5. Online ahead of print.ABSTRACTDynamic alteration of DNA methylation leads to various human diseases, including nonalcoholic fatty liver disease (NAFLD). Although C-Maf-inducing protein (Cmip) has been reported to be associated with NAFLD, its exact underlying mechanism remains unclear. Here, we aimed to elucidate this mechanism in NAFLD in vitro and in vivo. We first identified alterations in the methylation status of the Cmip intron 1 region in mouse liver tissues with high-fat high-sucrose diet-induced NAFLD. Knockdown of DNA methyltransferase (Dnmt) 1 significant...
Source: Molecular Medicine - January 7, 2023 Category: Molecular Biology Authors: Jangho Lee Ji-Hye Song Jae-Ho Park Min-Yu Chung Seung-Hyun Lee Sae-Bom Jeon So Hee Park Jin-Taek Hwang Hyo-Kyoung Choi Source Type: research

Caveolin-1 alleviates acetaminophen-induced vascular oxidative stress and inflammation in non-alcoholic fatty liver disease
In conclusion, our findings confirmed that CAV1 exerts a protective effect against vascular injury by inhibiting oxidative stress and inflammation through the PKC/MAPK pathway. Therefore, restoration of CAV1 may have clinical benefits in reducing APAP-induced vascular damage in NAFLD patients.PMID:36596386 | DOI:10.1016/j.freeradbiomed.2022.12.095
Source: Free Radical Biology and Medicine - January 3, 2023 Category: Biology Authors: Dongdong Fu Shuai Wu Xiangfu Jiang Tingyu You Yu Li Jiao Xin Xiaowen Feng Jiagen Wen Yan Huang Chengmu Hu Source Type: research