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Condition: Fatty Liver Disease (FLD)

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Total 185 results found since Jan 2013.

Salsalate and Adiponectin Ameliorate Hepatic Steatosis by Inhibition of the Hepatokine Feutin-A.
In conclusion, salsalate and fAd improved palmitate-induced steatosis and impairment of lipid metabolism in hepatocytes via fetuin-A inhibition through the AMPK-NFκB pathway. PMID: 23948064 [PubMed - as supplied by publisher]
Source: Biochemical Pharmacology - August 12, 2013 Category: Drugs & Pharmacology Authors: Jung TW, Youn BS, Choi HY, Lee SY, Hong HC, Yang SJ, Yoo HJ, Kim BH, Baik SH, Choi KM Tags: Biochem Pharmacol Source Type: research

Ceacam1 Null Deletion Causes Vascular Alterations in Large Vessels.
Abstract Carcinoembryonic antigen-related cell adhesion molecule1 (CEACAM1) promotes hepatic insulin clearance and endothelial survival. However, its role in the morphology of macrovessels remains unknown. Mice lacking Ceacam1 (Cc1(-/-)) exhibit hyperinsulinemia, which causes insulin resistance and fatty liver. With increasing evidence of an association between hyperinsulinemia, fatty liver disease and atherosclerosis, we investigated whether Cc1(-/-) exhibit vascular lesions in atherogenic-prone aortae. Histological analysis revealed impaired endothelial integrity with restricted fat deposition and aortic plaque-...
Source: American Journal of Physiology. Endocrinology and Metabolism - June 25, 2013 Category: Physiology Authors: Najjar SM, Ledford KJ, Abdallah SL, Paus A, Russo L, Kaw MK, Ramakrishnan S, Muturi HT, Raphael CK, Lester SG, Heinrich G, Pierre SV, Benndorf R, Kleff V, Jaffa AA, Levy E, Vazquez G, Goldberg IJ, Beauchemin N, Scalia R, Ergün S Tags: Am J Physiol Endocrinol Metab Source Type: research

Quercetin and allopurinol reduce liver thioredoxin‐interacting protein to alleviate inflammation and lipid accumulation in diabetic rats
Conclusions and ImplicationsInhibition of hepatic TXNIP by quercetin and allopurinol contributes to the reduction in liver inflammation and lipid accumulation under hyperglycaemic conditions. The targeting of hepatic TXNIP by quercetin and allopurinol may have therapeutic implications for prevention of type 1 diabetes‐associated NAFLD.
Source: British Journal of Pharmacology - June 21, 2013 Category: Drugs & Pharmacology Authors: Wei Wang, Chuang Wang, Xiao‐Qin Ding, Ying Pan, Ting‐Ting Gu, Ming‐Xing Wang, Yang‐Liu Liu, Fu‐Meng Wang, Shui‐Juan Wang, Ling‐Dong Kong Tags: Research Paper Source Type: research

Quercetin and Allopurinol Reduce Liver Thioredoxin‐Interacting Protein to Improve Inflammation and Lipid Accumulation in Diabetic Rats
Conclusions and ImplicationsThese results demonstrate that hepatic TXNIP inhibition by quercetin and allopurinol contributes to the improvement of liver inflammation and lipid accumulation under hyperglycemia condition. Therefore, quercetin and allopurinol targeting hepatic TXNIP may have therapeutic application to prevent type 1 diabetes‐associated NAFLD.
Source: British Journal of Pharmacology - May 3, 2013 Category: Drugs & Pharmacology Authors: Wei Wang, Chuang Wang, Xiao‐Qin Ding, Ying Pan, Ting‐Ting Gu, Ming‐Xing Wang, Yang‐Liu Liu, Fu‐Meng Wang, Shui‐Juan Wang, Ling‐Dong Kong Tags: Research Paper Source Type: research

Nordihydroguaiaretic acid improves metabolic dysregulation and aberrant hepatic lipid metabolism in mice by both PPAR{alpha}-dependent and -independent pathways
In conclusion, the beneficial actions of NDGA on dyslipidemia and hepatic steatosis in ob/ob mice are exerted primarily through enhanced fatty acid oxidation via PPARα-dependent pathways. However, PPARα-independent pathways also contribute to NDGA's action to ameliorate hepatic steatosis.
Source: AJP: Gastrointestinal and Liver Physiology - January 1, 2013 Category: Gastroenterology Authors: Zhang, H., Shen, W.-J., Cortez, Y., Kraemer, F. B., Azhar, S. Tags: LIVER AND BILIARY TRACT Source Type: research