Ceacam1 Null Deletion Causes Vascular Alterations in Large Vessels.

Ceacam1 Null Deletion Causes Vascular Alterations in Large Vessels. Am J Physiol Endocrinol Metab. 2013 Jun 25; Authors: Najjar SM, Ledford KJ, Abdallah SL, Paus A, Russo L, Kaw MK, Ramakrishnan S, Muturi HT, Raphael CK, Lester SG, Heinrich G, Pierre SV, Benndorf R, Kleff V, Jaffa AA, Levy E, Vazquez G, Goldberg IJ, Beauchemin N, Scalia R, Ergün S Abstract Carcinoembryonic antigen-related cell adhesion molecule1 (CEACAM1) promotes hepatic insulin clearance and endothelial survival. However, its role in the morphology of macrovessels remains unknown. Mice lacking Ceacam1 (Cc1(-/-)) exhibit hyperinsulinemia, which causes insulin resistance and fatty liver. With increasing evidence of an association between hyperinsulinemia, fatty liver disease and atherosclerosis, we investigated whether Cc1(-/-) exhibit vascular lesions in atherogenic-prone aortae. Histological analysis revealed impaired endothelial integrity with restricted fat deposition and aortic plaque-like lesions in Cc1(-/-) aortae, likely owing to their limited lipidemia. Immunohistochemical analysis indicated macrophage deposition, and in vitro studies showed increased leukocytes adhesion to aortic wall, mediated in part by elevation in VCAM-1 levels. Basal aortic eNOS protein and nitric oxide (NO) content were reduced, in parallel to reduced Akt/eNOS and Akt/Foxo1 phosphorylation. Ligand-induced vasorelaxation was compromised in aortic rings. Increased NADPH oxidase activity and plas...
Source: American Journal of Physiology. Endocrinology and Metabolism - Category: Physiology Authors: Tags: Am J Physiol Endocrinol Metab Source Type: research