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Cancer: Colon Cancer

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Total 665 results found since Jan 2013.

SOX-17 is involved in invasion and apoptosis of colorectal cancer cells through regulating miR-302b-3p expression
This study was conducted to explore the regulatory effect of SOX-17 on the expression of miR-302b-3p, and the involvement of SOX-17 in the invasion and apoptosis of CRC cells. The expression of SOX-17 and miR-302a,b,c,d-3p in colorectal cancer and normal colon epithelial cell lines was measured by real-time PCR and/or Western blot. The regulatory effects of SOX-17 on miR-302b-3p gene in HT29 and LoVo cells were tested using ChiP assay. The biological activities of SOX-17 and miR-302b-3p were evaluated by invasion and apoptosis assay. Results showed that transfection of SOX-17 siRNA (siSOX-17) significantly increased, where...
Source: Cell Biology International - March 19, 2021 Category: Cytology Authors: Fan Hu Mei Li Li Mo You Xiao Xiaoyan Wang Biao Xie Source Type: research

Overexpression of Long Noncoding RNA LBX2-AS1 Promotes the Proliferation of Colorectal Cancer
CONCLUSIONS: LBX2-AS1 plays a crucial role in the tumorigenesis of CRC, providing a potential therapeutic target for CRC patients.PMID:33733923 | DOI:10.1177/1533033821997829
Source: Technology in Cancer Research and Treatment - March 18, 2021 Category: Cancer & Oncology Authors: Qing Li Hui Xie Zefu Jin Jing Huang Shuting Wang Zijian Zhang Source Type: research

Neutral endopeptidase depletion decreases colon cancer cell proliferation and TGF- β1 synthesis in indirect co-cultures with normal colon fibroblasts
ConclusionsThe results suggest that the expression of NEP by colon cancer cells is essential for their proliferation and TGF- β1 synthesis during paracrine interactions with NCFs.
Source: Clinical and Translational Oncology - February 4, 2021 Category: Cancer & Oncology Source Type: research

LINC00538 promotes the progression of colon cancer through inhibiting NKD2 expression.
CONCLUSIONS: This study demonstrated for the first time that LINC00538 was highly expressed in colon cancer and was associated with poor prognosis of patients. Knockdown of LINC00538 in colon cancer cell lines was able to inhibit the cell proliferation and cell cycle, while it promoted the apoptosis. It's mechanism of participating in the development of colon cancer may be through the down-regulation of NKD2 and the regulation of EZH2. PMID: 33455110 [PubMed - in process]
Source: Journal of B.U.ON. - January 20, 2021 Category: Cancer & Oncology Tags: J BUON Source Type: research

Long noncoding RNA DLEU2 affects the proliferative and invasive ability of colorectal cancer cells
This study sought to investigate the effects of DLEU2 on CRC pathogenesis, and the underlying mechanism involved. Using a quantitative real-time polymerase chain reaction (qRT-PCR) assay, we demonstrated that the expression levels of DLEU2 in 45 pairs of CRC tissues were higher than those in the corresponding normal colon mucosal tissues. In addition, CRC patients with high DLEU2 expression levels exhibited poor overall survival (OS) and recurrence-free survival (RFS), as determined by analyses and measurements from the GEO and GEPIA databases. When DLEU2 was silenced using short interfering RNA (siRNA) in CRC cell line, t...
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Xiaoyun He, Bingbing Yu, Gaoyan Kuang, Yongrong Wu, Meili Zhang, Pengfei Cao, Chunlin Ou Tags: Research Paper Source Type: research

CUL4A promotes proliferation and inhibits apoptosis of colon cancer cells via regulating Hippo pathway.
CONCLUSIONS: CUL4A is highly expressed in CC and promotes the proliferation and inhibits the apoptosis of CC cells by regulating the Hippo pathway. PMID: 33155207 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - November 10, 2020 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Targeting LncRNA EPIC1 to inhibit human colon cancer cell progression.
Abstract Long non-coding RNA EPIC1 (Lnc-EPIC1) binds MYC protein, which is essential for MYC function and expression of MYC target genes. The current study tested its expression and potential functions in human colon cancer cells. We show that Lnc-EPIC1 expression is elevated in human colon cancer tissues and primary human colon cancer cells. Whereas its expression is relatively low in normal colon tissues and colon epithelial cells. In the primary human colon cancer cells, Lnc-EPIC1 siRNA largely inhibited cancer cell growth, proliferation, migration and invasion. Further, Lnc-EPIC1 silencing induced significant ...
Source: Aging - November 7, 2020 Category: Biomedical Science Authors: Wu Q, Wei J, Zhao C, Xiang S, Shi M, Wang Y Tags: Aging (Albany NY) Source Type: research

Mesenchymal stroma/stem-like cells of GARP knockdown inhibits cell proliferation and invasion of mouse colon cancer cells (MC38) through exosomes.
In conclusion, MSC-derived exosomes targeting GARP are a potential strategy for cancer therapy. PMID: 33155413 [PubMed - as supplied by publisher]
Source: J Cell Mol Med - November 5, 2020 Category: Molecular Biology Authors: Xing H, Liang C, Xu X, Sun H, Ma X, Jiang Z Tags: J Cell Mol Med Source Type: research

Knockdown of Angiopoietin-like protein 4 suppresses the development of colorectal cancer.
Authors: Wen L, Zhang Y, Yang B, Han F, Ebadi AG, Toughani M Abstract Colorectal cancer, is the growth of cancer cells in the part of the colon. Angiopeptin is one of the growth factors in the human body that is particularly effective in the regulatory process. In this research, the regulatory role and its mechanism of Angiopoietin-like protein 4 (ANGPTL4) in colorectal cancer (CRC) metastasis, has been studied. Protein expression of ANGPLT4 was analyzed by immunohistochemistry in tumor samples and adjacent normal specimens of 40 patients with CRC cancer of various phases. A gene knockout test was conducted, two ef...
Source: Cellular and Molecular Biology - October 14, 2020 Category: Molecular Biology Tags: Cell Mol Biol (Noisy-le-grand) Source Type: research