LINC00538 promotes the progression of colon cancer through inhibiting NKD2 expression.

CONCLUSIONS: This study demonstrated for the first time that LINC00538 was highly expressed in colon cancer and was associated with poor prognosis of patients. Knockdown of LINC00538 in colon cancer cell lines was able to inhibit the cell proliferation and cell cycle, while it promoted the apoptosis. It's mechanism of participating in the development of colon cancer may be through the down-regulation of NKD2 and the regulation of EZH2. PMID: 33455110 [PubMed - in process]
Source: Journal of B.U.ON. - Category: Cancer & Oncology Tags: J BUON Source Type: research