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Total 665 results found since Jan 2013.
Targeting GRP78 suppresses oncogenic KRAS protein expression and reduces viability of cancer cells bearing various KRAS mutations
Neoplasia. 2022 Nov;33:100837. doi: 10.1016/j.neo.2022.100837. Epub 2022 Sep 24.ABSTRACTKRAS is the most commonly mutated oncogene in human cancers with limited therapeutic options, thus there is a critical need to identify novel targets and inhibiting agents. The 78-kDa glucose-regulated protein GRP78, which is upregulated in KRAS cancers, is an essential chaperone and the master regulator of the unfolded protein response (UPR). Following up on our recent discoveries that GRP78 haploinsufficiency suppresses both KRASG12D-driven pancreatic and lung tumorigenesis, we seek to determine the underlying mechanisms. Here, we rep...
Source: Neoplasia - September 26, 2022 Category: Cancer & Oncology Authors: Dat P Ha Bo Huang Han Wang Daisy Flores Rangel Richard Van Krieken Ze Liu Soma Samanta Nouri Neamati Amy S Lee Source Type: research
PARP14 regulates EP4 receptor expression in human colon cancer HCA-7 cells
Biochem Biophys Res Commun. 2022 Jul 19;623:133-139. doi: 10.1016/j.bbrc.2022.07.055. Online ahead of print.ABSTRACTE type prostanoid 4 (EP4) receptors and their signaling pathways have been implicated in the development and malignant transformation of colorectal cancer. We herein demonstrated that the mono(ADP-ribosyl)ation of histone deacetylase (HDAC)1 and HDAC2 by poly(ADP-ribose) polymerase 14 (PARP14) may be required to induce the expression of EP4 receptors. The suppression of PARP14 activity by siRNA and/or its inhibitors reduced the mRNA expression of EP4 receptors. Thus, the expression of their proteins to approx...
Source: Biochemical and Biophysical Research communications - August 1, 2022 Category: Biochemistry Authors: Masato Mashimo Asuka Shimizu Aimi Mori Ayaka Hamaguchi Keijo Fukushima Naofumi Seira Takeshi Fujii Hiromichi Fujino Source Type: research
GSE208785 Differentially expressed genes after siRNA transfection in human cancer cell line
Contributors : R Yasudome ; N SekiSeries Type : Expression profiling by arrayOrganism : Homo sapiensTo identify differentially expressed genes by siRNAs transfection in human colon cancer cell line, HCT116 was subjected to Agilent whole genome microarrays.
Source: GEO: Gene Expression Omnibus - July 31, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
Abstracts of Presentations at the Association of Clinical Scientists 143 < sup > rd < /sup > Meeting Louisville, KY May 11-14,2022
Conclusion: These assays are suitable for routine diagnostic. The UltraFast NextGenPCR is the fastest with average time (30mins), followed by Agilent (2 hrs) and MassArray (6hrs). Upon completion of this activity, participants should be able to examine, measure and compare results from different assays for SARS detection, evaluate and diagnose accurately, as well as being able to plan, organize and recommend a diagnostic procedure for diagnostic laboratory. Key words: SARS-CoV-2, RNA extraction, RT-PCR, limit of detection, quantification cycle, COVID-19, in vitro diagnostic tests, Agilent, Massarray, Ultrafast. [20] From t...
Source: Annals of Clinical and Laboratory Science - July 1, 2022 Category: Laboratory Medicine Source Type: research
