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Total 665 results found since Jan 2013.
Cancers, Vol. 15, Pages 4572: Tumor-Promoting Role of GNA14 in Colon Cancer Development
In this study, we examined the effect of GNA14 on CRC through genetic approaches in vitro and in vivo. We found that GNA14 knockdown by small interfering RNA (siRNA) inhibited the proliferation of CRC cells SW403 and HT29. Gna14 knockout mice developed normally without obvious abnormalities. However, the number of polyps in the small intestine was significantly reduced in Gna14 knockout mice compared to control mice after mating with ApcMin mice, a representative CRC mouse model. In particular, deletion of the Gna14 inhibited polyp growth, especially in the distal end of the small intestine. Histological examination showed...
Source: Cancers - September 15, 2023 Category: Cancer & Oncology Authors: Rahui Park Seungmin Lee Hyunjung Chin Anh Thai-Quynh Nguyen Daekee Lee Tags: Article Source Type: research
Cancers, Vol. 15, Pages 4467: Increased Response to Immune Checkpoint Inhibitors with Dietary Methionine Restriction in A Colorectal Cancer Model
In this study, we combined DMR with immune checkpoint inhibitors (ICIs) in a model of colon adenocarcinoma. In vitro, we observed that MR increased the expression of MHC-I and PD-L1 in both mouse and human colorectal cancer cells. We also saw an increase in the gene expression of STING, a known inducer of type I interferon signaling. Inhibition of the cGAS–STING pathway, pharmacologically or with siRNA, blunted the increase in MHC-I and PD-L1 surface and gene expression following MR. This indicated that the cGAS–STING pathway, and interferon in general, played a role in the immune response to MR...
Source: Cancers - September 7, 2023 Category: Cancer & Oncology Authors: Lauren C. Morehead Sarita Garg Katherine F. Wallis Camila C. Simoes Eric R. Siegel Alan J. Tackett Isabelle R. Miousse Tags: Article Source Type: research
Aberrant PI3K δ splice isoform as a potential biomarker and novel therapeutic target for endocrine cancers
ConclusionIn summary, our study has suggested a promising potential of utilizing PI3Kδ-S (an oncogenic isoform conferring drug resistance and exempt from PTEN regulation) as a prognostic biomarker and drug target in advanced endocrine cancers.
Source: Frontiers in Endocrinology - August 21, 2023 Category: Endocrinology Source Type: research
Targeting m6A reader YTHDF1 augments antitumour immunity and boosts anti-PD-1 efficacy in colorectal cancer
Conclusion
YTHDF1 impairs antitumour immunity via an m6A-p65-CXCL1/CXCR2 axis to promote CRC and serves as a therapeutic target in immune checkpoint blockade therapy.
Source: Gut - July 6, 2023 Category: Gastroenterology Authors: Bao, Y., Zhai, J., Chen, H., Wong, C. C., Liang, C., Ding, Y., Huang, D., Gou, H., Chen, D., Pan, Y., Kang, W., To, K. F., Yu, J. Tags: Open access, Gut Colon Source Type: research
The Expression and Role of NADPH Oxidase 2 in Colon Cancer
CONCLUSION: NOX2 expression level has a close association with the prognosis of colon cancer patients and physiological functions of colon cancer cells. NOX2 may be a useful prognostic biomarker for colon cancer patients.PMID:37247898 | DOI:10.21873/anticanres.16427
Source: Cell Research - May 29, 2023 Category: Cytology Authors: Koichi Takiguchi Hiroki Shimizu Katsutoshi Shoda Kensuke Shiraishi Shinji Furuya Naohiro Hosomura Hidenori Akaike Yoshihiko Kawaguchi Hidetake Amemiya Hiromichi Kawaida Kunio Mochizuki Tetsuo Kondo Daisuke Ichikawa Source Type: research
SUMO1 modification stabilizes TET3 protein and increases colorectal cancer radiotherapy sensitivity
CONCLUSIONS: we elucidated the sensitizing role of TET3 protein in the radiation of CRC cells, depending on SUMO1 modification of TET3 at the lysine sites (K479, K758, K1012, K1188, K1397, K1623), in turn stabilizing TET3 expression in the nucleus and subsequently increasing the sensitivity of colorectal cancer to radiotherapy. Together, this study highlights the potentially critical role of TET3 SUMOylation in radiation regulation, which may contribute to an enhanced understanding of the relationship between DNA demethylation and radiotherapy.PMID:37244630 | DOI:10.1016/j.ijrobp.2023.05.037
Source: Cancer Control - May 27, 2023 Category: Cancer & Oncology Authors: Fengting Liu Ya Ma Hao Sun Hui Cai Xin Liang Chang Xu Liqing Du Yan Wang Qiang Liu Source Type: research
Inhibition of ubiquitin specific peptidase 8 is effective against 5-fluorouracil resistance in colon cancer via suppressing EGFR and EGFR-mediated signaling pathways
CONCLUSIONS: Our work is the first to reveal the essential role of USP8 in colon cancer via EGFR oncogenic signalling pathways. Our findings provide a proof-of-concept that USP8 inhibitors are promising candidates to overcome 5-FU resistance in colon cancer.PMID:37222451 | DOI:10.14670/HH-18-629
Source: Histology and Histopathology - May 24, 2023 Category: Cytology Authors: Changlei Xi Zhilin Gong Hui Ye Longlei Cao Jie Yu Source Type: research
NKD1 promotes glucose uptake in colon cancer cells by activating YWHAE transcription
CONCLUSION: NKD1 protein activates the transcriptional activity of YWHAE gene to promote glucose uptake in colon cancer cells.PMID:37202194 | PMC:PMC10202780 | DOI:10.12122/j.issn.1673-4254.2023.04.11
Source: Journal of Southern Medical University - May 18, 2023 Category: Universities & Medical Training Authors: Q Liu Y Dai H Yu Y Shen J Deng W Lu J Jin Source Type: research
