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Cancer: Colon Cancer
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Total 665 results found since Jan 2013.
NEAT1 siRNA Packed with Chitosan Nanoparticles Regulates the Development of Colon Cancer Cells via lncRNA NEAT1/miR-377-3p Axis
This study was for verifying that transfecting colon cancer cells (CCCs) with lncRNA NEAT1 packed with siRNA chitosan nanoparticles (CNPs) can suppress lncRNA NEAT1 and biological behaviors of the cells. siRNA targeting lncRNA NEAT1 expression vector was constructed and then transfected into CCCs after being packed with CNPs. Subsequently, the impact of the transfection on biological behaviors of the cells was evaluated. As a result, with high expression in CCCs, NEAT1 was negatively bound up with miR-377-3p in cases with colon cancer (CC), and dual luciferase reporter assay confirmed the potential binding region. Addition...
Source: Biomed Res - May 31, 2021 Category: Research Authors: Tianyu Li Nenghui Deng Ruimei Xu Zhihao Fan Junli He Zirun Zheng Hailian Deng Riyu Liao Xinqi Lv Cailian Pang Source Type: research
Responses of porcupine and Wntless proteins to oxidative, hypoxic and endoplasmic reticulum stresses
Cell Signal. 2021 May 17:110047. doi: 10.1016/j.cellsig.2021.110047. Online ahead of print.ABSTRACTThe WNT (Wingless and Int-1) proteins play a role in stem cell development and cell differentiation. Mutations in the WNT proteins lead to the development of various tumours, including gastric tumours. Porcupine (PORCN) is a palmitoyltransferase and Wntless (WLS) is a chaperone protein that modify and fold the WNT proteins respectively and are involved in their proper secretion and binding to the frizzled (FZD) receptor and the lipoprotein receptor-related protein 5 or 6 (LRP5/6). We investigated how modifications of PORCN an...
Source: Cellular Signalling - May 20, 2021 Category: Cytology Authors: Rowida Mohamed Catherine Kennedy William G Willmore Source Type: research
Worenine reverses the Warburg effect and inhibits colon cancer cell growth by negatively regulating HIF-1 α
CONCLUSION: It is suggested that worenine targets HIF-1α to inhibit colorectal cancer cell growth, proliferation, cell cycle progression and the Warburg effect.PMID:34006215 | PMC:PMC8130299 | DOI:10.1186/s11658-021-00263-y
Source: Cellular and Molecular Biology Letters - May 19, 2021 Category: Biochemistry Authors: Lijiang Ji Weixing Shen Feng Zhang Jie Qian Jie Jiang Liping Weng Jiani Tan Liu Li Yugen Chen Haibo Cheng Dongdong Sun Source Type: research
Worenine reverses the Warburg effect and inhibits colon cancer cell growth by negatively regulating HIF-1alpha
CONCLUSION: It is suggested that worenine targets HIF-1α to inhibit colorectal cancer cell growth, proliferation, cell cycle progression and the Warburg effect.PMID:34006215 | DOI:10.1186/s11658-021-00263-y
Source: Mol Biol Cell - May 19, 2021 Category: Molecular Biology Authors: Lijiang Ji Weixing Shen Feng Zhang Jie Qian Jie Jiang Liping Weng Jiani Tan Liu Li Yugen Chen Haibo Cheng Dongdong Sun Source Type: research
Worenine reverses the Warburg effect and inhibits colon cancer cell growth by negatively regulating HIF-1 α
CONCLUSION: It is suggested that worenine targets HIF-1α to inhibit colorectal cancer cell growth, proliferation, cell cycle progression and the Warburg effect.PMID:34006215 | DOI:10.1186/s11658-021-00263-y
Source: Cellular and Molecular Biology Letters - May 19, 2021 Category: Biochemistry Authors: Lijiang Ji Weixing Shen Feng Zhang Jie Qian Jie Jiang Liping Weng Jiani Tan Liu Li Yugen Chen Haibo Cheng Dongdong Sun Source Type: research
GSE155231 RNA-seq data of prefoldin subunits PFDN2 and PFDN5 knockdowns in HCT116 human colon carcinoma cells
We report gene expression data from total RNA-seq of HCT116 human colon carcinoma cells treated with siRNA against PFDN2 and PFDN5 (both part of a complex known as prefoldin). Cells were independently treated with one of the previously mentioned siRNAs or with an exogenous control siRNA (luciferase GL2). All cells were treated with the different siRNAs for 24 hours, then serum-starved them for 48 hours, and finally stimulated by adding serum for 90 minutes. Samples were taken before and after serum stimulation. Prefoldin depletion provoked transcriptional alterations across the genome of human cells. Severe pre-mRNA splici...
Source: GEO: Gene Expression Omnibus - May 4, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Cancers, Vol. 13, Pages 1759: Zona Pellucida Protein 2 (ZP2) Is Expressed in Colon Cancer and Promotes Cell Proliferation
Conclusion: ZP2 shows an enhanced expression level in colon cancer tissue and, thus, can be used as a diagnostic tool, albeit in combination with other biomarkers. Its character as a membrane protein makes ZP2 even a potential target molecule for tumor therapy, especially as it positively affects colon cancer cell proliferation.
Source: Cancers - April 7, 2021 Category: Cancer & Oncology Authors: Dominik Kraus Alexander Glassmann Carsten Golletz Glen Kristiansen Jochen Winter Rainer Probstmeier Tags: Article Source Type: research
