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Cancer: Prostate Cancer

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Total 879 results found since Jan 2013.

Pim-2 Cooperates with Downstream Factor XIAP to Inhibit Apoptosis and Intensify Malignant Grade in Prostate Cancer.
Abstract To find the exact downstream effector of Pim-2 pathway in prostate cancer cells, and to determine the means by which it affects prostate cancer. XIAP, Pim-2 and p-eIF4B expressions were detected in PCA and BPH tissues. Then the Pim-2 and XIAP expressions were manipulated using transfection or RNAi in prostatic cells. Finally, Pim-2/eIF4B/XIAP levels were examined in PCA tissues with different clinicopathologic features. XIAP was significantly higher in PCA than in BPH tissues. When Pim-2 was transfected into noncancerous prostate epithelial cells RWPE-1, Pim-2, p-eIF4B and XIAP were all significantly incr...
Source: Pathology Oncology Research - November 9, 2017 Category: Pathology Authors: Ren K, Gou X, Xiao M, He W, Kang J Tags: Pathol Oncol Res Source Type: research

GSE107438 25D3 and 1,25D3 target gene profiles in LNCaP
In this study, we investigated whole genome target gene profiles and intracellular behaviors of VDR after administration of 25D3 or 1,25D3 in prostate cancer LNCaP cells to elucidate the hormonal activity of 25D3. First, we confirmed that LNCaP cells possessed functional 25D3-VDR as well as 1,25D3-VDR signaling systems by qRT-PCR. By immunofluorescent examination of nuclear translocation, western blotting and most importantly, knockdown o f CYP27B1 and/or VDR after the introduction of the respective siRNA into these cells, we found that, just like 1,25D3, 10-7 M of 25D3, which is within its uppermost physiological concentr...
Source: GEO: Gene Expression Omnibus - December 1, 2017 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

Induction of apoptosis in prostate cancer by ginsenoside Rh2.
In conclusion, our findings have demonstrated that ginsenoside Rh2 induces prostate cancer DU145 cells apoptosis through up-regulation of PPAR-delta expression which is associated with p-STAT3 up-regulation and ROS/superoxide induction. Rh2 may be potentially useful in the treatment of prostate cancer. PMID: 29541400 [PubMed]
Source: Oncotarget - March 16, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Androgen receptor induces EPHA3 expression by interacting with transcription factor SP1.
This study is aimed to investigate the association between EPHA3 expression and androgen receptor (AR) signaling and the potential mechanism. We determined mRNA and protein levels of EPHA3 and AR signaling‑related genes in the PCa cell line 22Rv1 by reverse transcription‑polymerase chain reaction (RT‑PCR) and western blotting, respectively. The EPHA3 mRNA and protein levels were both found to be elevated by dihydrotestosterone (DHT) hormone in a dose‑ and time‑dependent manner, as AR and prostate‑specific antigen (PSA) expression were increased. Similarly, EPHA3 protein levels were also increased in the PCa cel...
Source: Oncology Reports - June 22, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Overexpressed LRIG3 gene ameliorates prostate cancer through suppression of cell invasion and migration.
In conclusion, these data of the current study indicated that overexpressed LRIG3 gene expression might inhibit the viability, adhesion, invasion and migration and promote the apoptosis of PC cells. rAd-mediated LRIG3 may facilitate a novel aspect of the treatment of patients suffering from with PC. PMID: 30412760 [PubMed - as supplied by publisher]
Source: International Journal of Biological Macromolecules - November 6, 2018 Category: Biochemistry Authors: Chen Y, Wang Q, Wang M, Li M Tags: Int J Biol Macromol Source Type: research

The Utility of 18 FDASA-23 for Molecular Imaging of Prostate Cancer with Positron Emission Tomography
ConclusionHerein, we evaluated a F-18-labeled PKM2-specific radiotracer, [18F]DASA-23, for the molecular imaging of prostate cancer with PET. [18F]DASA-23 revealed rapid and extensive uptake levels in cellular uptake studies of prostate cancer cells; however, there was only modest tumor uptake when evaluated in mouse subcutaneous tumor models.
Source: Molecular Imaging and Biology - November 13, 2018 Category: Molecular Biology Source Type: research

Honokiol induces endoplasmic reticulum stress-mediated apoptosis in human lung cancer cells
Publication date: Available online 29 January 2019Source: Life SciencesAuthor(s): Jianfei Zhu, Shuonan Xu, Wenli Gao, Jianyu Feng, Guolong ZhaoAbstractAimsHonokiol is a hydroxylated biphenyl natural product and displays potent antitumor activity against several cancers including prostate cancer, melanoma, leukemia, and colorectal cancer. The present study was to investigate the in vitro activity of honokiol against A549 and 95-D human lung cancer cells.Main methodsA549 and 95-D cells were used with honokiol treatment. Cell viability was determined by CCK-8 assay. The cell migration and apoptosis were evaluated by wound hea...
Source: Life Sciences - January 29, 2019 Category: Biology Source Type: research

MTBP regulates migration and invasion of prostate cancer cells in vitro.
CONCLUSIONS: MTBP overexpression promotes the migration and invasion of human prostate cancer cells possibly relation to the induction of EMT. PMID: 30692060 [PubMed - in process]
Source: Journal of Southern Medical University - January 30, 2019 Category: Universities & Medical Training Authors: Xiao Z, Chen M, Yang J, Yang C, Lü X, Tian H, Liu C Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research

Hsp-27 and NF- κB pathway is associated with AR/AR-V7 expression in prostate cancer cells.
In conclusion, inhibition of NF-κB and Hsp-27 is also important, along with therapies for androgen receptor variant-7 inhibition. PMID: 30807779 [PubMed - as supplied by publisher]
Source: Gene - February 23, 2019 Category: Genetics & Stem Cells Authors: Kiliccioglu I, Konac E, Dikmen AU, Sozen S, Bilen CY Tags: Gene Source Type: research

Effect of PTEN loss on metabolic reprogramming in prostate cancer cells.
Authors: Zhou X, Yang X, Sun X, Xu X, Li X, Guo Y, Wang J, Li X, Yao L, Wang H, Shen L Abstract The tumor suppressor gene PTEN is one of the most often deleted genes in human prostate cancer. Loss of PTEN is an important event in prostate carcinogenesis. Metabolic reprogramming induced by PTEN loss fuels malignant growth and proliferation of prostate cancer cells. Targeted metabolomics analysis was used to investigate the effects of PTEN loss on intracellular metabolic pathways in prostate cancer cells. DU-145 cells were transfected with PTEN siRNAs (siRNA-1 and siRNA-2) for 48 h, and endogenous PTEN expression was...
Source: Oncology Letters - March 13, 2019 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Prolyl isomerase Pin1 binds to and stabilizes acetyl CoA carboxylase 1 protein, thereby supporting cancer cell proliferation.
Authors: Ueda K, Nakatsu Y, Yamamotoya T, Ono H, Inoue Y, Inoue MK, Mizuno Y, Matsunaga Y, Kushiyama A, Sakoda H, Fujishiro M, Takahashi SI, Matsubara A, Asano T Abstract The prolyl isomerase Pin1 expression level is reportedly increased in most malignant tissues and correlates with poor outcomes. On the other hand, acetyl CoA carboxylase 1 (ACC1), the rate limiting enzyme of lipogenesis is also abundantly expressed in cancer cells, to satisfy the demand for the fatty acids (FAs) needed for rapid cell proliferation. We found Pin1 expression levels to correlate positively with ACC1 levels in human prostate cancers, ...
Source: Oncotarget - March 23, 2019 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

High Expression of DEPDC1 Promotes Malignant Phenotypes of Breast Cancer Cells and Predicts Poor Prognosis in Patients With Breast Cancer
In this study, the immunohistochemistry results demonstrated that DEPDC1 was high-expressed in breast cancer tissues compared with the paired adjacent normal breast tissues, and its tendency at protein level was consistent with mRNA level from TCGA data. Moreover, DEPDC1 mRNA level revealed the strongest association with poor prognosis and development in breast cancer. In vitro assays showed that DEPDC1 overexpression resulted in significant promotion of proliferation by regulating cell cycle in MCF-7 cells, whilst an opposite effect was found in the MDA-MB-231 cells with DEPDC1 deletion. Notably, further investigation ind...
Source: Frontiers in Oncology - April 11, 2019 Category: Cancer & Oncology Source Type: research

Downregulated LINC00460 inhibits cell proliferation and promotes cell apoptosis in prostate cancer.
CONCLUSIONS: LINC00460 could regulate cell proliferation and cell apoptosis, which might be a novel marker in prostate cancer. PMID: 31364108 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - August 2, 2019 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Protein kinase CK2 is involved in zinc homeostasis in breast and prostate cancer cells.
This study employs two breast and two prostate cancer cell lines to investigate the role of protein kinase CK2 in regulating zinc homeostasis. CK2 was targeted by its specific inhibitors 4,5,6,7-tetrabromobenzotriazole (TBB) and CX-4945, and by the specific siRNA against each of the three CK2 genes. The effect of zinc exposure after the above CK2 manipulation was observed by MTT [3-(4,5-dimethyliazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide] cell viability assay and confocal microscopy for intracellular zinc level. The results demonstrate that CK2 is involved in regulating zinc homeostasis in breast and prostate cancer ce...
Source: Biometals - October 2, 2019 Category: Biochemistry Authors: Zaman MS, Johnson AJ, Petersingham G, Muench GW, Dong Q, Wu MJ Tags: Biometals Source Type: research

GSE125826 Regulation of the Integrated Stress Response through ATF4 and FAM129A in Prostate Cancer
Contributors : Nora P ällmann ; Marte Livgårda ; Martina Tesikova ; Hatice Z Nenseth ; Yixin Jin ; Dogukan Koc ; Nermin Kahraman ; Hamada M Mokhlis ; Bulent Ozpolat ; Ladan Fazli ; Paul S Rennie ; Yang Jin ; Fahri SaatciogluSeries Type : Expression profiling by arrayOrganism : Homo sapiensCancer cells exploit many of the cellular adaptive responses to support their survival needs. One such critical pathway in eukaryotic cells is the integrated stress response (ISR) that is important in normal physiology as well as disease states, including cancer. Since ISR can serve as a lever between survival and death, regulated contr...
Source: GEO: Gene Expression Omnibus - November 1, 2019 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research