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Cancer: Prostate Cancer

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Total 879 results found since Jan 2013.

A cell-based high-throughput screening assay for radiation susceptibility using automated cell counting
Conclusions: We developed a simple assay for radiation susceptibility that can be used for high-throughput screening. This will aid the identification of molecular targets for radiosensitization, thereby contributing to improving the efficacy of radiotherapy.
Source: Radiation Oncology - February 27, 2015 Category: Cancer & Oncology Authors: Jasmina HodzicIlse DingjanMariëlle MaasIda van der Meulen-MuilemanRenee de MenezesStan HeukelomMarcel VerheijWinald GerritsenAlbert GeldofBaukelien van TriestVictor van Beusechem Source Type: research

DDR2 inhibition reduces migration and invasion of murine metastatic melanoma cells by suppressing MMP2/9 expression through ERK/NF-κB pathway.
Abstract Metastatic melanoma is one of the most deadly and evasive cancers. Collagen I in the extracellular matrix promotes the migration and invasion of tumor cells through the production of matrix metalloproteinase (MMP) 2 and 9. Discoidin domain receptor (DDR) 2 is a collagen receptor that is implicated in several cancer types including breast and prostate cancers. However, the role of DDR2 in the migration and invasion of murine melanoma cells is less studied. In the present study, we investigated the effects and underlying mechanisms of DDR2 in migration and invasion of B16BL6 melanoma cells in response to co...
Source: Acta Biochimica et Biophysica Sinica - March 1, 2015 Category: Biochemistry Authors: Poudel B, Lee YM, Kim DK Tags: Acta Biochim Biophys Sin (Shanghai) Source Type: research

Abstract 4106: Lyn kinase promotes metastasis through EMT in cancers
Conclusion: Expression of Lyn kinase can be correlated to low prognosis and aggressive/metastatic phenotype. We show that targeting Lyn activity initiates a switch to a more epithelial phenotype reducing cell migration and invasion.Impact: The data suggests that Lyn tyrosine kinase plays a role in Epithelial Mesenchymal Transition and could be considered as a target for metastatic disease; especially in the more aggressive forms of cancer like Triple Negative Breast Cancer or Castration Resistant Prostate Cancer. This could be a realistic therapeutic option, as the Lyn small molecule inhibitor Bafetinib, is currently in cl...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Thaper, D., Vahid, S., Nip, K. M., Ketola, K., Bishop, J., Zoubeidi, A. Tags: Tumor Biology Source Type: research

Abstract 4956: Hsp27 negatively affects Hippo tumor suppressor pathway to regulate cell survival in cancer
Conclusion: Hsp27 overexpression contributes to inactivation of Hippo pathway. Targeting Hsp27 leads to inactivation of YAP and TAZ onco-proteins affecting cancer cell survival.Impact: Our data further supports the significance of targeting Hsp27 as a treatment option in cancers, especially metastatic malignancies like CRPC.Citation Format: Sepideh Vahid, Daksh Thaper, Amina Zoubeidi. Hsp27 negatively affects Hippo tumor suppressor pathway to regulate cell survival in cancer. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelph...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Vahid, S., Thaper, D., Zoubeidi, A. Tags: Molecular and Cellular Biology Source Type: research

Multiple Sites of Type II Site Ligand (Luteolin and BMHPC) Regulation of Gene Expression in PC-3 Cells.
Authors: Markaverich BM, Vijjeswarapu M Abstract Type II [(3)H]estradiol binding site ligands including luteolin (a naturally occurring bioflavonoid) and synthetic compounds such as 2,6-bis((3-methoxy-4-hydroxyphenyl)methylene)cyclohexanone (BMHPC) inhibit normal and malignant prostate cell (PC-3, LNCaP, DU-145) proliferation in vitro and in vivo. Type II sites represent a binding domain on histone H4 possibly involved in an epigenetic mechanism for controlling gene transcription. Treatment of PC-3 human prostate cancer cells with luteolin or BMHPC modulated the expression of a number of genes in the epidermal grow...
Source: International Journal of Biomedical Science - December 12, 2015 Category: Biomedical Science Tags: Int J Biomed Sci Source Type: research

Increase of human prostate cancer cell (DU145) apoptosis by telmisartan through PPAR-delta pathway.
In conclusion, telmisartan induces prostate cancer DU145 cells apoptosis through the up-regulation of PPAR-delta protein expression. Pharmacological inhibition or genetic silencing of PPAR-delta activity can both reverse the telmisartan-induced apoptotic effect. Thus the PPAR-delta pathway might be a potential target for the treatment of prostate cancer. PMID: 26852954 [PubMed - as supplied by publisher]
Source: European Journal of Pharmacology - February 4, 2016 Category: Drugs & Pharmacology Authors: Wu TT, Niu HS, Chen LJ, Cheng JT, Tong YC Tags: Eur J Pharmacol Source Type: research

Inhibiting malignant phenotypes of the bladder cancer cells by silencing long noncoding RNA SChLAP1
Conclusions Our data suggest that SChLAP1 plays oncogenic roles and can be used as a therapeutic target for treating human bladder cancer.
Source: International Urology and Nephrology - February 9, 2016 Category: Urology & Nephrology Source Type: research

Fluciclovine (18F) is a marker for high-affinity glutamine transporter ASCT2-mediated amino acid transport in breast cancer
Conclusion: Unlike prostate cancer, fluciclovine appears to be predominantly transported by the high-affinity glutamine transporter ASCT2 in breast cancer. This raises the potential for future clinical use in imaging response to inhibitors of glutamine metabolism, ASCT2 and pathways which regulate ASCT2. Research support: CRUK/EPSRC Cancer Imaging Centre in Oxford, Blue Earth Diagnostics Ltd
Source: Journal of Nuclear Medicine - May 24, 2017 Category: Nuclear Medicine Authors: Teoh, E., Morotti, M., Bridges, E., Jones, D., Miar, A., Wigfield, S., Zois, C., Gleeson, F., Harris, A. Tags: Oncology: Basic, Translational & amp; Therapy (Basic Science) Posters Source Type: research

ZEB1 promotes prostate cancer proliferation and invasion through ERK1/2 signaling pathway.
CONCLUSIONS: Inhibition of ZEB1 promoted prostate cancer apoptosis, restrained proliferation, and suppressed invasion through down-regulating ERK1/2 signaling pathway. PMID: 29028100 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - October 17, 2017 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Inhibition of prostate cancer DU145 cell growth with small interfering RNA targeting the SATB1 gene.
Authors: Wang Q, Yang CS, Ma ZX, Chen JC, Zheng JN, Sun XQ, Wang JQ Abstract Prostate cancer is a common visceral cancer of men worldwide. It is important to develop a more effective treatment for prostate cancer to overcome the treatment resistance that occurs with recurrence. RNA interference has been demonstrated to be a powerful tool for gene knockdown and has potential as a cancer treatment. It has been previously demonstrated that staining of special AT-rich sequence-binding protein 1 (SATB1) was stronger in prostatic carcinoma with metastasis compared with prostatic carcinoma without metastasis. In the prese...
Source: Experimental and Therapeutic Medicine - March 31, 2018 Category: General Medicine Tags: Exp Ther Med Source Type: research

YAP1 Is Involved in Tumorigenic Properties of Prostate Cancer Cells.
In this study, YAP1 expression was upregulated in the whole cell lysates and cytoplasmic/nuclear extracts of AR negative (PC3) compared to AR positive (LNCaP) prostate cancer cell lines and primary prostate epithelial cells (PrePEC). pYAP1 expression elevated in LNCaP compared to PC3 and PrePEC in whole cell lysates and cytoplasmic extracts. The treatment of LNCaP and PC3 with YAP1-targeting siRNA oligonucleotides (YAP1 siRNA) significantly reduced their proliferation in vitro. Furthermore, treatment with YAP1 siRNA diminished the clonogenicity, anchorage-independent growth on soft agar, migration and invasion of PC3 cells...
Source: Pathology Oncology Research - March 10, 2019 Category: Pathology Authors: Collak FK, Demir U, Sagir F Tags: Pathol Oncol Res Source Type: research

Combination simvastatin and metformin synergistically inhibits endometrial cancer cell growth.
CONCLUSIONS: MET+SIM treatment synergistically inhibits endometrial cancer cell viability. This may be mediated by apoptosis and mTOR pathway inhibition. Our results provide preclinical evidence that the combination of these well-tolerated drugs may warrant further clinical investigation for endometrial cancer treatment. PMID: 31178149 [PubMed - as supplied by publisher]
Source: Gynecologic Oncology - June 5, 2019 Category: Cancer & Oncology Authors: Kim JS, Turbov J, Rosales R, Thaete LG, Rodriguez GC Tags: Gynecol Oncol Source Type: research

WD repeat domain 5 promotes chemoresistance and Programmed Death-Ligand 1 expression in prostate cancer
Conclusions: These data revealed that targeting WDR5 suppressed proliferation, enhanced apoptosis, chemosensitivity to cisplatin and immunotherapy in PCa. Therefore, our findings provide insight into OICR-9429 is a multi-potency and promising therapy drug, which improves the antitumor effect of cisplatin or immunotherapy in PCa.
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Qianghua Zhou, Xu Chen, Haixia He, Shengmeng Peng, Yangjie Zhang, Jingtong Zhang, Liang Cheng, Sen Liu, Ming Huang, Ruihui Xie, Tianxin Lin, Jian Huang Tags: Research Paper Source Type: research

Molecular interaction of HIC, an agonist of P2Y1 receptor, and its role in prostate cancer apoptosis
Int J Biol Macromol. 2021 Aug 20:S0141-8130(21)01762-1. doi: 10.1016/j.ijbiomac.2021.08.103. Online ahead of print.ABSTRACTProstate cancer is a heterogeneous, slow growing asymptomatic cancer that predominantly affects man. A purinergic G-protein coupled receptor, P2Y1R, is targeted for its therapeutic value since it plays a crucial role in many key molecular events of cancer progression and invasion. Our previous study demonstrated that indoline derivative, 1 ((1-(2-Hydroxy-5-nitrophenyl) (4-hydroxyphenyl) methyl)indoline-4‑carbonitrile; HIC), stimulates prostate cancer cell (PCa) growth inhibition via P2Y1R. However, t...
Source: International Journal of Biological Macromolecules - August 23, 2021 Category: Biochemistry Authors: Hien Thi Thu Le Akshaya Murugesan Thiyagarajan Ramesh Olli Yli-Harja Konda Mani Saravanan Meenakshisundaram Kandhavelu Source Type: research