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Cancer: Prostate Cancer

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Total 879 results found since Jan 2013.

Bone-targeted nanoplatform enables efficient modulation of bone tumor microenvironment for prostate cancer bone metastasis treatment
Drug Deliv. 2022 Dec;29(1):889-905. doi: 10.1080/10717544.2022.2050845.ABSTRACTAs there is currently no effective therapy for patients with prostate cancer (PCa) bone metastasis, it was stringent to explore the relevant treatment strategies. Actually, the interaction between cancer cells and bone microenvironment plays important role in prostate cancer bone metastasis, especially the Sonic hedgehog protein (SHH) signaling in the bone microenvironment. The SHH promotes osteoblast maturation and osteoblast then secretes RANKL to induce osteoclastogenesis. Herein, this study develops bone-targeting calcium phosphate lipid hyb...
Source: Drug Delivery - March 14, 2022 Category: Drugs & Pharmacology Authors: Xiangyu Zhang Qingbin Liu Tingting Zhang Pei Gao Hui Wang Lu Yao Jingwen Huang Shulong Jiang Source Type: research

Aberrant PI3K δ splice isoform as a potential biomarker and novel therapeutic target for endocrine cancers
ConclusionIn summary, our study has suggested a promising potential of utilizing PI3Kδ-S (an oncogenic isoform conferring drug resistance and exempt from PTEN regulation) as a prognostic biomarker and drug target in advanced endocrine cancers.
Source: Frontiers in Endocrinology - August 21, 2023 Category: Endocrinology Source Type: research

RNF126 Promotes Cancer Cell Proliferation
To identify novel oncogenic E3 ubiquitin ligases as anticancer targets, we screened an E3 ubiquitin ligase siRNA library containing siRNA pools against 555 individual E3s using the sulphorhodamine B assay in the MDA-MB-231 breast cancer cell line and the PC3 prostate cancer cell line. RNF126 was identified and validated as a candidate from this screening. Knockdown of RNF126 dramatically decreased cell viability in these cancer cell lines. Consistently, RNF126 knockdown delayed cell-cycle G1–S progression and decreased cell proliferation. Using protein array analysis we found that RNF126 silencing increased cell-cycle de...
Source: Cancer Research - January 2, 2013 Category: Cancer & Oncology Authors: Zhi, X., Zhao, D., Wang, Z., Zhou, Z., Wang, C., Chen, W., Liu, R., Chen, C. Tags: Tumor and Stem Cell Biology Source Type: research

TWIST1, A novel androgen-regulated gene, is a target for NKX3-1 in prostate cancer cells
Conclusion: Our finding that NKX3-1 represses TWIST1 expression emphasizes the functional importance of NKX3-1 in regulating TWIST1 expression during prostate cancer progression to metastatic disease.
Source: Cancer Cell International - January 31, 2013 Category: Cancer & Oncology Authors: Turid EideHåkon RambergCarlotta GlackinDonald TindallKristin Taskén Source Type: research

CK2 Inhibitor Enhances Vitamin D-Mediated Antitumor Effects
Vitamin D has broad range of physiological functions and antitumor effects. 24-Hydroxylase, encoded by the CYP24A1 gene, is the key enzyme for degrading many forms of vitamin D including the most active form, 1,25D3. Inhibition of CYP24A1 enhances 1,25D3 antitumor activity. To isolate regulators of CYP24A1 expression in prostate cancer cells, we established a stable prostate cancer cell line PC3 with CYP24A1 promoter driving luciferase expression to screen a small molecular library for compounds that inhibit CYP24A1 promoter activity. From this screening, we identified, 4,5,6,7-tetrabromobenzimidazole (TBBz), a protein kin...
Source: Cancer Research - April 2, 2013 Category: Cancer & Oncology Authors: Luo, W., Yu, W.-D., Ma, Y., Chernov, M., Trump, D. L., Johnson, C. S. Tags: Therapeutics, Targets, and Chemical Biology Source Type: research

A novel hydroxysuberamide derivative potentiates MG132‐mediated anticancer activity against human hormone refractory prostate cancers—the role of histone deacetylase and endoplasmic reticulum stress
CONCLUSIONSThe data suggest that WJ25591 inhibited HDAC activity, leading to cell‐cycle arrest and inhibition of DNA repair. Caspase cascades are subsequently triggered to execute cell apoptosis. MG‐132 dramatically sensitizes WJ25591‐mediated apoptosis, at least partly, through ER stress response. The data also reveal that combination of HDAC inhibitors and proteasome inhibitors may be a potential strategy against hormone‐refractory prostate cancers. Prostate © 2013 Wiley Periodicals, Inc.
Source: The Prostate - June 28, 2013 Category: Urology & Nephrology Authors: Yi‐Cheng Chen, Wei‐Jan Huang, Jui‐Ling Hsu, Chia‐Chun Yu, Wei‐Ting Wang, Jih‐Hwa Guh Tags: Original Article Source Type: research

Lysophosphatidic acid induces reactive oxygen species generation by activating protein kinase C in PC-3 human prostate cancer cells.
Abstract Prostate cancer is one of the most frequently diagnosed cancers in males, and PC-3 is a cell model popularly used for investigating the behavior of late stage prostate cancer. Lysophosphatidic acid (LPA) is a lysophospholipid that mediates multiple behaviors in cancer cells, such as proliferation, migration and adhesion. We have previously demonstrated that LPA enhances vascular endothelial growth factor (VEGF)-C expression in PC-3 cells by activating the generation of reactive oxygen species (ROS), which is known to be an important mediator in cancer progression. Using flow cytometry, we showed that LPA ...
Source: Biochemical and Biophysical Research communications - October 7, 2013 Category: Biochemistry Authors: Lin CC, Lin CE, Lin YC, Ju TK, Huang YL, Lee MS, Chen JH, Lee H Tags: Biochem Biophys Res Commun Source Type: research

Zinc Finger X-Chromosomal Protein (ZFX) Promotes Solid Agar Colony Growth of Osteosarcoma Cells.
Abstract Zinc finger X-chromosomal protein (ZFX) is a member of the zinc finger family of proteins. The importance of ZFX in several cancer types, including prostate cancer, laryngeal squamous cell carcinoma, and glioma, has been addressed. However, the role of ZFX in human osteosarcoma remains unknown. Here we investigated the phenotype of ZFX knockdown on cell proliferation and in vitro tumorigenesis using lentivirus-mediated loss-of-function strategy. The results demonstrated that the proliferation and colony formation ability of human osteosarcoma Saos-2 and MG63 cells was impaired by ZFX small interfering RNA...
Source: Oncology Research - October 23, 2013 Category: Cancer & Oncology Authors: Jiang R, Wang JC, Sun M, Zhang XY, Wu H Tags: Oncol Res Source Type: research

Tristetraprolin regulates prostate cancer cell growth through suppression of E2F1.
Abstract The transcription factor E2F1 is active during the G1 to S transition and is involved in cell cycle and progression. A recent study reported that increased E2F1 is associated with DNA damage and tumour development in several tissues using transgenic models. Here, we show that E2F1 expression is regulated by tristetraprolin (TTP) in prostate cancer. Overexpression of TTP decreased the stability of E2F1 mRNA and the expression level of E2F1. In contrast, inhibition of TTP using siRNA increased the E2F1 expression. E2F1 mRNA contains three AREs within the 3'UTR and TTP destabilized a luciferase mRNA that con...
Source: Journal of Microbiology and Biotechnology - October 22, 2013 Category: Biotechnology Authors: Lee HH, Lee SR, Leem SH Tags: J Microbiol Biotechnol Source Type: research

The Role of Hypoxia-Inducible Factor-1α and -2α in Androgen Insensitive Prostate Cancer Cells
Conclusions: Our results demonstrate that HIF-1α and -2α are important for cell proliferation and invasion ability in prostate cancer. Together, our results indicate that combinations of target agents with HIF knockdown may represent a promising strategy for the treatment of prostate cancer.
Source: Urologic Oncology: Seminars and Original Investigations - April 27, 2012 Category: Urology & Nephrology Authors: Chang Wook Jeong, Cheol Yong Yoon, Seong Jin Jeong, Sung Kyu Hong, Seok-Soo Byun, Cheol Kwak, Sang Eun Lee Tags: Clinical - Prostate Source Type: research

Myc Silencing in Prostate Cancer Stem Cells
In this study, we investigated the effects of silencing Myc transcription on prostate CSC in cell culture and xenograft models of human prostate cancer. Treatment with an effective promoter-targeting siRNA reduced the fraction of CSCs, leading to reduced self-renewal, tumor-initiating, and metastatic capability. Combined analysis of stem-like cells and senescence markers indicated that Myc silencing triggered a phenotypic shift and senescence in the CSC subpopulation. Notably, systemic delivery of the promoter-targeting siRNA in the xenograft model produced a striking suppression in the development of prostate tumors. Our ...
Source: Cancer Research - November 14, 2013 Category: Cancer & Oncology Authors: Civenni, G., Malek, A., Albino, D., Garcia-Escudero, R., Napoli, S., Di Marco, S., Pinton, S., Sarti, M., Carbone, G. M., Catapano, C. V. Tags: Tumor and Stem Cell Biology Source Type: research

Bradykinin promotes vascular endothelial growth factor expression and increases angiogenesis in human prostate cancer cells.
Abstract Prostate cancer is the most commonly diagnosed malignancy in men and shows a tendency for metastasis to distant organs. Angiogenesis is required for metastasis. Bradykinin (BK) is an inflammatory mediator involved in tumor growth and metastasis, but its role in vascular endothelial growth factor (VEGF) expression and angiogenesis in human prostate cancer remains unknown. The aim of this study was to examine whether BK promotes prostate cancer angiogenesis via VEGF expression. We found that exogenous BK increased VEGF expression in prostate cancer cells and further promoted tube formation in endothelial pr...
Source: Biochemical Pharmacology - November 10, 2013 Category: Drugs & Pharmacology Authors: Yu HS, Wang SW, Chang AC, Tai HC, Yeh HI, Lin YM, Tang CH Tags: Biochem Pharmacol Source Type: research