Fluciclovine (18F) is a marker for high-affinity glutamine transporter ASCT2-mediated amino acid transport in breast cancer

Conclusion: Unlike prostate cancer, fluciclovine appears to be predominantly transported by the high-affinity glutamine transporter ASCT2 in breast cancer. This raises the potential for future clinical use in imaging response to inhibitors of glutamine metabolism, ASCT2 and pathways which regulate ASCT2. Research support: CRUK/EPSRC Cancer Imaging Centre in Oxford, Blue Earth Diagnostics Ltd

Source: Journal of Nuclear Medicine - May 24, 2017 Category: Nuclear Medicine Authors: Teoh, E., Morotti, M., Bridges, E., Jones, D., Miar, A., Wigfield, S., Zois, C., Gleeson, F., Harris, A. Tags: Oncology: Basic, Translational & amp; Therapy (Basic Science) Posters Source Type: research