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Cancer: Melanoma
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Total 1255 results found since Jan 2013.
A novel molecular mechanism of vascular fibrosis in Takayasu arteritis: macrophage-derived GPNMB promoting adventitial fibroblast extracellular matrix production in the aorta
This study provides evidence that targeting GPNMB is a potential therapeutic strategy for treating vascular fibrosis in TAK.PMID:36566014 | DOI:10.1016/j.trsl.2022.12.004
Source: Translational Research : the journal of laboratory and clinical medicine - December 24, 2022 Category: Laboratory Medicine Authors: Xiaojuan Dai Ying Sun Lingying Ma Jun Hou Li Wang Yu Gong Xiaoning Sun Sifan Wu Jinghua Wang Zongfei Ji Huiyong Chen Lili Ma Lindi Jiang Xiufang Kong Source Type: research
Gallic Acid has an inhibitory effect on skin squamous cell carcinoma and acts on the heat shock protein HSP90AB1
Gene. 2022 Nov 11:147041. doi: 10.1016/j.gene.2022.147041. Online ahead of print.ABSTRACTDifferences in the features of aggressiveness of non-melanoma skin cancer (NMSC) subtypes, between basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are relevant characteristics. Comparing the characteristics between NMSC subtypes might help identify molecules associated with cancer metastasis and invasion. Considering these facts, the current study aimed to identify a molecular target for inhibiting skin cancer metastasis and invasion. Proteomic analysis suggested that heat shock protein 90 kDa, alpha, class B member 1 (HSP...
Source: Gene - November 14, 2022 Category: Genetics & Stem Cells Authors: Sabrina Ferreira de Jesus Marcela Gon çalves de Souza Lorena Dos Reis Pereira Queiroz Daniela Paola Santos de Paula Angeliny Tamiarana Lima Tabosa Wislene Sarajane Moreira Alves Luiz Henrique da Silveira Andr é Teixeira da Silva Ferreira Ozires Jos é D Source Type: research
Silencing of SiX-4 enhances the chemosensitivity of melanoma cells to Cisplatin
In this study, we investigated whether silencing of SIX4 in a melanoma cell line (A375 cells) in combination with Cisplatin can affect the apoptosis and suppression of cell cycle progression, migration of the melanoma cells. MTT test and colony formation assay was applied to determine the IC50 of Cisplatin and the combined effect of SIX4 siRNA and Cisplatin on the viability and clonogenesis of the A-375 cells. qRT-PCR was performed to determine the c-myc, BCL-2, BAX, MMP-9, CXCR4, and Rock genes expression. Furthermore, flow cytometry was applied to evaluate apoptosis, autophagy, and the cell cycle status in different grou...
Source: Cell Research - November 12, 2022 Category: Cytology Authors: Aysan Fallah Vazirabad Saeed Noorolyai Elham Baghbani Soltanali Mahboob Felor Zargari Shima Rahmani Amin Sorkhabi Nooshin Montazami Pouriya Sameti Behzad Baradaran Source Type: research
Cancers, Vol. 14, Pages 4776: Role of the Hedgehog Pathway and CAXII in Controlling Melanoma Cell Migration and Invasion in Hypoxia
Conclusion: Our results suggest that CAXII and the Hh pathway are relevant in melanoma invasion and may be novel and promising therapeutical targets for melanoma clinical management.
Source: Cancers - September 29, 2022 Category: Cancer & Oncology Authors: Gaia Giuntini Federica Coppola Alessandro Falsini Irene Filippi Sara Monaci Antonella Naldini Fabio Carraro Tags: Article Source Type: research
WZB117 enhanced the anti-tumor effect of apatinib against melanoma via blocking STAT3/PKM2 axis
Conclusion: WZB117 enhanced the anti-tumor effect of apatinib against melanoma via modulating glycolysis by blocking the STAT3/PKM2 axis, which suggested the combination of apatinib with WZB117 could be a potential therapeutic candidate for melanoma.
Source: Frontiers in Pharmacology - September 16, 2022 Category: Drugs & Pharmacology Source Type: research
Synthesis and anti-melanoma effect of 3-O-prenyl glycyrrhetinic acid against B16F10 cells via induction of endoplasmic reticulum stress-mediated autophagy through ERK/AKT signaling pathway
In this study, 4-phenylbutyric acid (4PBA, a chemical chaperone) and small interference RNA (siRNA) knockdown of C/EBP Homologous Protein (CHOP)/growth arrest- and DNA damage-inducible gene 153(GAD153) blocked NPC-402-mediated autophagy induction, thus confirming the role of ER stress and autophagy in melanoma cell death. NPC-402 induced oxidative stress and apoptosis in melanoma cells, which were effectively mitigated by treatment with N-acetylcysteine (NAC). In vivo studies showed that intraperitoneal (i.p.) injection of NPC-402 at 10 mg/kg (5 days in 1 week) significantly retarded angiogenesis in the Matrigel plug assay...
Source: Frontiers in Oncology - August 2, 2022 Category: Cancer & Oncology Source Type: research
652 EPAC-mTORC1 signaling regulates proliferation of primary melanoma cells and loss of dependence on EPAC signaling correlates with melanoma progression
In this study, we show that pharmacological inhibition or siRNA-mediated knockdown of EPAC selectively inhibits the growth and survival of primary melanoma cells by downregulation of cell cycle proteins and inhibiting the cell cycle progression independent of ERK1/2 phosphorylation.
Source: Journal of Investigative Dermatology - July 20, 2022 Category: Dermatology Authors: M.K. Singh, A. Krishnan, A.I. Bhasker, C.I. Rodriguez, E. Castro-Perez, M. Ndiaye, N. Ahmad, H. Khan, S.M. Schieke, V. Setaluri Source Type: research
EPAC Regulates Melanoma Growth by Stimulating mTORC1 Signaling and Loss of EPAC Signaling Dependence Correlates with Melanoma Progression
This study establishes loss of dependency on EPAC-mTORC1 signaling as hallmark of primary melanoma evolution and targeting this escape mechanism is a promising strategy for metastatic melanoma.PMID:35834616 | DOI:10.1158/1541-7786.MCR-22-0026
Source: Cell Research - July 14, 2022 Category: Cytology Authors: Aishwarya Krishnan Aishwarya I Bhasker Mithalesh K Singh Carlos I Rodriguez Edgardo Castro-Perez Sarah Altameemi Marcos Lares Hamidullah Khan Mary Ndiaye Nihal Ahmad Stefan M Schieke Vijayasaradhi Setaluri Source Type: research
Abstracts of Presentations at the Association of Clinical Scientists 143 < sup > rd < /sup > Meeting Louisville, KY May 11-14,2022
Conclusion: These assays are suitable for routine diagnostic. The UltraFast NextGenPCR is the fastest with average time (30mins), followed by Agilent (2 hrs) and MassArray (6hrs). Upon completion of this activity, participants should be able to examine, measure and compare results from different assays for SARS detection, evaluate and diagnose accurately, as well as being able to plan, organize and recommend a diagnostic procedure for diagnostic laboratory. Key words: SARS-CoV-2, RNA extraction, RT-PCR, limit of detection, quantification cycle, COVID-19, in vitro diagnostic tests, Agilent, Massarray, Ultrafast. [20] From t...
Source: Annals of Clinical and Laboratory Science - July 1, 2022 Category: Laboratory Medicine Source Type: research
