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Cancer: Melanoma
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Total 1255 results found since Jan 2013.
Knockdown of neurotrophin receptor-interacting melanoma-associated antigen homolog inhibits acute myeloid leukemia cell growth via the ERK pathway
In this study, NRAGE was identified as a tumor promoter in AML, which had an effect on cell proliferation, cell survival, and cell cycle through the ERK signaling pathway in AML cells.PMID:37635487 | DOI:10.4103/cjop.CJOP-D-22-00162
Source: The Chinese Journal of Physiology - August 28, 2023 Category: Physiology Authors: Hongxia Zhang Guangsheng Wu Beili Chen Source Type: research
3-deazaneplanocin A, a histone methyltransferase inhibitor, improved the chemoresistance induced under hypoxia in melanoma cells
In conclusion, a histone methyltransferase EZH2 inhibitor, DZNep was capable of tackling acquired chemoresistance via the suppression of histone methylation induced under hypoxic tumor microenvironment.PMID:37542772 | DOI:10.1016/j.bbrc.2023.08.003
Source: Biochemical and Biophysical Research communications - August 5, 2023 Category: Biochemistry Authors: Mika Hosokawa Sekai Tetsumoto Mirano Yasui Yusuke Kono Ken-Ichi Ogawara Source Type: research
Glycolysis regulator PFKP induces human melanoma cell proliferation and tumor growth
ConclusionCollectively, these results indicate that PFKP expression in melanoma cells increases proliferation and glycolytic activity in vitro and promotes tumorigenesis in vivo, suggesting that suppression of PKFP and inhibition of glycolysis may potently suppress melanoma progression.
Source: Clinical and Translational Oncology - June 25, 2023 Category: Cancer & Oncology Source Type: research
Inflammasomes during SARS-CoV-2 infection and development of their corresponding inhibitors
Corona Virus Disease 2019 (COVID-19) continues to be a burden for human health since its outbreak in Wuhan, China in December 2019. Recently, the emergence of new variants of concerns (VOCs) is challenging for vaccines and drugs efficiency. In severe cases, SARS-CoV-2 provokes inappropriate hyperinflammatory immune responses leading to acute respiratory distress syndrome (ARDS) and even death. This process is regulated by inflammasomes which are activated after binding of the viral spike (S) protein to cellular angiotensin-converting enzyme 2 (ACE2) receptor and triggers innate immune responses. Therefore, the formation of...
Source: Frontiers in cellular and infection microbiology - June 9, 2023 Category: Microbiology Source Type: research
Advances in chitosan-based drug delivery systems in melanoma: A narrative review
Curr Med Chem. 2023 May 18. doi: 10.2174/0929867330666230518143654. Online ahead of print.ABSTRACTMelanoma accounts for the minority of skin cancer cases. However, it has the highest mortality rate among the subtypes of skin cancer. At the early stages of the disease, patients show a good prognosis after the surgery, but developing metastases leads to a remarkable drop in patients' 5-year survival rate. Despite the advances made in the therapeutic approaches to this disease, melanoma treatment is still facing several obstacles. Systemic toxicity, water insolubility, instability, lack of proper biodistribution, inadequate c...
Source: Current Medicinal Chemistry - May 19, 2023 Category: Chemistry Authors: Parisa Maleki Dana Jamal Hallajzadeh Zatollah Asemi Mohammad Ali Mansournia Bahman Yousefi Source Type: research
Nanocarriers for Sirna Delivery Aimed at the Treatment of Melanoma: Systematic Review
CONCLUSION: Such being the case, the development of these systems becomes a non-invasive and promising option for the treatment of melanoma.PMID:37170995 | DOI:10.2174/1567201820666230425234700
Source: Current Drug Delivery - May 12, 2023 Category: Drugs & Pharmacology Authors: Brenda Regina de Araujo Tatielle do Nascimento Ana Paula Dos Santos Matos Vanessa Brand ão de Souza Belmiro Mariana Sato de Souza de Bustamante Monteiro Ralph Santos-Oliveira Eduardo Ricci-Junior Source Type: research
