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Cancer: Melanoma

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Total 1255 results found since Jan 2013.

Autophagy inhibition mediated by MCOLN1/TRPML1 suppresses cancer metastasis via regulating a ROS-driven TP53/p53 pathway
This study demonstrates that autophagy inhibition induced by MCOLN1/TRPML1 suppresses cancer metastasis by evoking the ROS-mediated TP53/p53 pathway. First, we found that MCOLN1-mediated autophagy inhibition not only profoundly inhibits both migration and invasion in malignant melanoma and glioma cell lines in vitro, but also suppresses melanoma metastasis in vivo. Second, our study reveals that autophagy inhibition induced by MCOLN1 leads to damaged mitochondria accumulation followed by large quantities of ROS release. Third, we demonstrate that the elevated ROS resulting from autophagy inhibition subsequently triggers TP...
Source: Autophagy - December 8, 2021 Category: Cytology Authors: Yanhong Xing Xiangqing Wei Yucheng Liu Meng-Meng Wang Zhongheng Sui Xinyan Wang Wucheng Zhu Mengmei Wu Chen Lu Yuan-Hui Fei Yi Jiang Yang Zhang Yuqing Wang Feng Guo Jun-Li Cao Jiansong Qi Wuyang Wang Source Type: research

Cancers, Vol. 13, Pages 5863: IGF1R/IR Mediates Resistance to BRAF and MEK Inhibitors in BRAF-Mutant Melanoma
T. Garrett The use of BRAF and MEK inhibitors for patients with BRAF-mutant melanoma is limited as patients relapse on treatment as quickly as 6 months due to acquired resistance. We generated trametinib and dabrafenib resistant melanoma (TDR) cell lines to the MEK and BRAF inhibitors, respectively. TDR cells exhibited increased viability and maintenance of downstream p-ERK and p-Akt as compared to parental cells. Receptor tyrosine kinase arrays revealed an increase in p-IGF1R and p-IR in the drug resistant cells versus drug sensitive cells. RNA-sequencing analysis identified IGF1R and INSR upregulated in resistant ce...
Source: Cancers - November 22, 2021 Category: Cancer & Oncology Authors: Hima Patel Rosalin Mishra Nour Yacoub Samar Alanazi Mary Kate Kilroy Joan T. Garrett Tags: Article Source Type: research

Contribution of endoplasmic reticulum stress, MAPK and PI3K/Akt pathways to the apoptotic death induced by a penicillin derivative in melanoma cells
AbstractWe have previously examined the in vitro and in vivo antitumor action of TAP7f, a synthetic triazolylpeptidyl penicillin, on murine melanoma cells. In this work, we explored the signal transduction pathways modulated by TAP7f in murine B16-F0 and human A375 melanoma cells, and the contribution of some intracellular signals to the apoptotic cell death. TAP7f decreased ERK1/2 phosphorylation and increased phospho-p38, phospho-JNK and phospho-Akt levels. ERK1/2 blockage suppressed cell growth, while inhibition of p38, JNK and PI3K-I pathways reduced the antitumor effect of TAP7f. Pharmacological inhibition of p38 and ...
Source: Apoptosis - November 12, 2021 Category: Molecular Biology Source Type: research

GSE131048 PERK signaling through C/EBP δ contributes to ER stress-induced expression of immunomodulatory and tumor promoting chemokines by cancer cells.
Contributors : Namratha Sheshadri ; Esta SterneckSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensExpression of the transcription factor CEBPD is induced at early stages of the endoplasmic reticulum (ER) stress response. In order to identify the genes modulated by CEBPD during the ER stress response, we transiently silenced CEBPD expression in MDA-MB-435 melanoma cells and isolated mRNA at 6 h of treatment with Thapsigargin or DMSO control. As control, cells were transfected with two different control siRNA oligonucleotides. Results provide insights into which genes are modulated by CE...
Source: GEO: Gene Expression Omnibus - November 1, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

& lt;i & lt;FOXC1-Mediated Effects of miR-204-5p on Melanoma Cell Proliferation
Mol Biol (Mosk). 2021 Jul-Aug;55(4):667-675. doi: 10.31857/S0026898421030058.ABSTRACTMicroRNAs epigenetically regulate physiological and pathological processes. Previously, we found that miR-204-5p is expressed at low levels in melanoma cells, and an increase in its level leads to a change in proliferation, migration, and invasion of these cancer cells. Now, using bioinformatics analysis, it has been shown that the target of miR-204-5p is FOXC1 transcription factor, which is implicated in carcinogenesis. Using the luciferase reporter assay, it was found that miR-204-5p suppresses expression of the FOXC1 gene by binding to ...
Source: Mol Biol Cell - August 25, 2021 Category: Molecular Biology Authors: I Yu Dubovtseva M B Aksenenko E D Nikolaeva A S Averchuk A V Moshev A A Savchenko S V Markova T G Ruksha Source Type: research