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Cancer: Melanoma
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Abstracts of Presentations at the Association of Clinical Scientists 143 < sup > rd < /sup > Meeting Louisville, KY May 11-14,2022
Conclusion: These assays are suitable for routine diagnostic. The UltraFast NextGenPCR is the fastest with average time (30mins), followed by Agilent (2 hrs) and MassArray (6hrs). Upon completion of this activity, participants should be able to examine, measure and compare results from different assays for SARS detection, evaluate and diagnose accurately, as well as being able to plan, organize and recommend a diagnostic procedure for diagnostic laboratory. Key words: SARS-CoV-2, RNA extraction, RT-PCR, limit of detection, quantification cycle, COVID-19, in vitro diagnostic tests, Agilent, Massarray, Ultrafast. [20] From t...
Source: Annals of Clinical and Laboratory Science - July 1, 2022 Category: Laboratory Medicine Source Type: research
Cancers, Vol. 14, Pages 3122: Cordycepin (3 & prime;-Deoxyadenosine) Suppresses Heat Shock Protein 90 Function and Targets Tumor Growth in an Adenosine Deaminase-Dependent Manner
Cancers, Vol. 14, Pages 3122: Cordycepin (3′-Deoxyadenosine) Suppresses Heat Shock Protein 90 Function and Targets Tumor Growth in an Adenosine Deaminase-Dependent Manner
Cancers doi: 10.3390/cancers14133122
Authors:
Su-Chan Lee
Lujain Alaali
HyukJean Kwon
Mohammed Rigi
Charles G. Eberhart
Alterations in metabolism and energy production are increasingly being recognized as important drivers of neoplasia, raising the possibility that metabolic analogs could disrupt oncogenic pathways. 3&prime;-deoxyadenosine, also known as cordycepin, is an adenosine analog that inhibits the growth of sever...
Source: Cancers - June 25, 2022 Category: Cancer & Oncology Authors: Su-Chan Lee Lujain Alaali HyukJean Kwon Mohammed Rigi Charles G. Eberhart Tags: Article Source Type: research
Inhibition of CD146 lessens uveal melanoma progression through reducing angiogenesis and vasculogenic mimicry
ConclusionsCD146 is a novel mediator of both angiogenesis and vasculogenic mimicry in uveal melanoma. Its antibody AA98 has the potency to be developed as a new antibody drug for treating uveal melanoma. Our results warrant further assessment of CD146 as a potential target to improve therapeutic management of uveal melanoma in a clinical setting.
Source: Cellular Oncology - June 18, 2022 Category: Cancer & Oncology Source Type: research
Sclerostin Suppression Facilitates Uveal Melanoma Progression Through Activating Wnt/ β-Catenin Signaling Via Binding to Membrane Receptors LRP5/LRP6
ConclusionSOST silencing may facilitate the malignant progression of UM cells through activating Wnt/β-catenin signaling. Mechanistically, SOST may exert this function by interacting with LRP5/LRP6 membrane receptors.
Source: Frontiers in Oncology - June 17, 2022 Category: Cancer & Oncology Source Type: research
UVB-Induced Secretion of IL-1 < em > β < /em > Promotes Melanogenesis by Upregulating TYR/TRP-1 Expression In Vitro
CONCLUSIONS: UVB-induced melanogenesis is mediated in part by IL-1β, leading to upregulation of the TYR/TRP1 expression in melanoma B16 cells. IL-1β can also stimulate the expression of COX-2 and SCF in HaCaT cells, which in turn increase melanin synthesis in melanocytes. These results suggest that anti-inflammatory approaches could possibly mitigate UVB-induced hyperpigmentation.PMID:35572734 | PMC:PMC9106468 | DOI:10.1155/2022/8230646
Source: Biomed Res - May 16, 2022 Category: Research Authors: Chun-Yan Yang Yanni Guo Wen-Juan Wu Mao-Qiang Man Ying Tu Li He Source Type: research
Cancers, Vol. 14, Pages 2151: Role of Amino Acid Transporter SNAT1/SLC38A1 in Human Melanoma
In this study, we revealed a significant upregulation of SNAT1 expression in human melanoma tissue in comparison to healthy epidermis and an increased SNAT1 expression level in human melanoma cell lines when compared to normal human melanocytes (NHEMs). We demonstrated that functional inhibition of SNAT1 with &alpha;-(methylamino) isobutyric acid (MeAIB), as well as siRNA-mediated downregulation reduces cancer cell growth, cellular migration, invasion, and leads to induction of senescence in melanoma cells. Consequently, these results demonstrate that the amino acid transporter SNAT1 is essential for cancer growth,...
Source: Cancers - April 26, 2022 Category: Cancer & Oncology Authors: Ines B öhme-Schäfer Sandra L örentz Anja Katrin Bosserhoff Tags: Article Source Type: research
Low doses of niclosamide and quinacrine combination yields synergistic effect in melanoma via activating autophagy-mediated p53-dependent apoptosis
In this study, we developed a novel anti-melanoma strategy by using anti-tapeworm drug niclosamide and anti-malarial drug quinacrine, and investigated the molecular mechanism by in vitro and in vivo assays. Meanwhile, other types of tumor cells, immortalized epithelial cells and bone marrow mesenchymal stem cells were used to evaluate the universal role of anti-cancer and safety of the strategy. The results showed, briefly, an exposure to niclosamide and quinacrine led to an increased apoptosis-related protein p53, cleaved caspase-3 and cleaved PARP and autophagy-related protein LC3B expression, and a decreased expression ...
Source: Translational Oncology - April 23, 2022 Category: Cancer & Oncology Authors: Xuan Zheng Jianyun Zhang Shuangting Li Xiaolei Gao Yixin Zhang Meng Wang Liying Dong Liangjie Sun Na Zhao Zeyun Ma Chong Ding Yixiang Wang Source Type: research
