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Total 1255 results found since Jan 2013.

Use of Iontophoresis Technology for Transdermal Delivery of a Minimal mRNA Vaccine as a Potential Melanoma Therapeutic
Biol Pharm Bull. 2023;46(2):301-308. doi: 10.1248/bpb.b22-00746.ABSTRACTmRNA vaccines have attracted considerable attention as a result of the 2019 coronavirus pandemic; however, challenges remain regarding use of mRNA vaccines, including insufficient delivery owing to the high molecular weights and high negative charges associated with mRNA. These characteristics of mRNA vaccines impair intracellular uptake and subsequent protein translation. In the current study, we prepared a minimal mRNA vaccine encoding a tumor associated antigen human gp10025-33 peptide (KVPRNQDWL), as a potential treatment for melanoma. Minimal mRNA...
Source: Biological and Pharmaceutical Bulletin - February 1, 2023 Category: Drugs & Pharmacology Authors: Rabab A Husseini Naoko Abe Tomoaki Hara Hiroshi Abe Kentaro Kogure Source Type: research

Anti-LGI4 Antibody Is a Novel Juxtaparanodal Autoantibody for Chronic Inflammatory Demyelinating Polyneuropathy
The objective of this study was to discover novel nodal autoantibodies in chronic inflammatory demyelinating polyneuropathy (CIDP). Methods We screened for autoantibodies that bind to mouse sciatic nerves and dorsal root ganglia (DRG) using indirect immunofluorescence (IFA) assays with sera from 113 patients with CIDP seronegative for anti-neurofascin 155 and anticontactin-1 antibodies and 127 controls. Western blotting, IFA assays using HEK293T cells transfected with relevant antigen expression plasmids, and cell-based RNA interference assays were used to identify target antigens. Krox20 and Periaxin expression, both of ...
Source: Neurology Neuroimmunology and Neuroinflammation - January 11, 2023 Category: Neurology Authors: Zhang, X., Kira, J.-I., Ogata, H., Imamura, T., Mitsuishi, M., Fujii, T., Kobayashi, M., Kitagawa, K., Namihira, Y., Ohya, Y., Maimaitijiang, G., Yamasaki, R., Fukata, Y., Fukata, M., Isobe, N., Nakamura, Y. Tags: Research Article Source Type: research

Oncogenic < em > BRAF < /em > < sup > V600E < /sup > induces microglial proliferation through extracellular signal-regulated kinase and neuronal death through c-Jun N-terminal kinase
Neural Regen Res. 2023 Jul;18(7):1613-1622. doi: 10.4103/1673-5374.361516.ABSTRACTActivating V600E in v-Raf murine sarcoma viral oncogene homolog B (BRAF) is a common driver mutation in cancers of multiple tissue origins, including melanoma and glioma. BRAFV600E has also been implicated in neurodegeneration. The present study aims to characterize BRAFV600E during cell death and proliferation of three major cell types of the central nervous system: neurons, astrocytes, and microglia. Multiple primary cultures (primary cortical mixed culture) and cell lines of glial cells (BV2) and neurons (SH-SY5Y) were employed. BRAFV600E ...
Source: Cell Research - December 26, 2022 Category: Cytology Authors: Qing Ye Pranay Srivastava Nasser Al-Kuwari Xiqun Chen Source Type: research

A novel molecular mechanism of vascular fibrosis in Takayasu arteritis: macrophage-derived GPNMB promoting adventitial fibroblast extracellular matrix production in the aorta
This study provides evidence that targeting GPNMB is a potential therapeutic strategy for treating vascular fibrosis in TAK.PMID:36566014 | DOI:10.1016/j.trsl.2022.12.004
Source: Cell Research - December 24, 2022 Category: Cytology Authors: Xiaojuan Dai Ying Sun Lingying Ma Jun Hou Li Wang Yu Gong Xiaoning Sun Sifan Wu Jinghua Wang Zongfei Ji Huiyong Chen Lili Ma Lindi Jiang Xiufang Kong Source Type: research