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Cancer: Melanoma
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Total 1255 results found since Jan 2013.
Ferumoxytol- β-glucan Inhibits Melanoma Growth via Interacting with Dectin-1 to Polarize Macrophages into M1 Phenotype
Conclusion: The nanocomposite FMT-β-glucan suppressed melanoma growth by inducing the M1 macrophage-activated tumor microenvironment.PMID:34400883 | PMC:PMC8364471 | DOI:10.7150/ijms.61525
Source: International Journal of Medical Sciences - August 17, 2021 Category: Biomedical Science Authors: Xinghan Liu Yujun Xu Yi Li Yuchen Pan Shuli Zhao Yayi Hou Source Type: research
ASAP Treatment of Melanoma by Nano-conjugate-Delivered Wee1 siRNA
Molecular PharmaceuticsDOI: 10.1021/acs.molpharmaceut.1c00316
Source: Molecular Pharmaceutics - August 10, 2021 Category: Drugs & Pharmacology Authors: Xueyan Zhang, Anqi Cai, Yan Gao, Yuanfa Zhang, Xingmei Duan, and Ke Men Source Type: research
Survey of cancer cell anatomy in non-adhesive confinement reveals a role for filamin-A and fascin-1 in leader bleb-based migration
Mol Biol Cell. 2021 Jul 14:mbcE21040174. doi: 10.1091/mbc.E21-04-0174. Online ahead of print.ABSTRACTCancer cells migrating in confined microenvironments exhibit plasticity of migration modes. Confinement of contractile cells in a non-adhesive environment drives 'leader bleb-based migration' (LBBM), morphologically characterized by a long bleb that points in the direction of movement separated from a cell body by a contractile neck. Although cells undergoing LBBM have been visualized within tumors, the organization of organelles and actin regulatory proteins mediating LBBM is unknown. We analyzed the localization of fluore...
Source: Mol Biol Cell - July 14, 2021 Category: Molecular Biology Authors: Gregory Adams Magdalena Preciado L ópez Alexander X Cartagena-Rivera Clare M Waterman Source Type: research
GSE115791 Transcriptome of primary and metastatic human melanoma with silenced STAT3
Contributors : Bozena Kaminska ; Dorota W Kulesza ; Kavita Ramji ; Jakub MieczkowskiSeries Type : Expression profiling by arrayOrganism : Homo sapiensPrimary and metastatic human melanoma cells were transfected with control siRNA or siSTAT3 to silence its expression. The global gene expression was evaluated after 48 h and related to gene levels in cells transfected with siRNA control.
Source: GEO: Gene Expression Omnibus - June 14, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
Up-regulation of KISS1 as a novel target of Let-7i in melanoma serves as a potential suppressor of migration and proliferation in vitro
This study was aimed to determine the role of Let-7i and KISS1 in melanoma cell migration and proliferation. At first, the expression of Let-7i and KISS1 was determined in patients with melanoma. In the in vitro part of the study, Let-7i mimics were transfected and the impact of its restoration on target gene expression, proliferation, migration and apoptosis of SK-MEL-3 melanoma cell line was assessed by real-time PCR and Western blotting, MTT assay, wound-healing assay and flow cytometry, respectively. Besides, KISS1 inhibitor siRNA alone and along with Let-7i was transfected to determine their probable correlation. The ...
Source: Molecular Medicine - June 7, 2021 Category: Molecular Biology Authors: Haider A Alkafaji Ahmed Raji Heshu S Rahman Angelina O Zekiy Ali Adili Mohammadmahdi Jalili Tahereh Hojjatipour Angel Cid-Arregui Navid Shomali Saeed Tarzi Rozita Tamjidifar Ramin Heshmati Faroogh Marofi Morteza Akbari Ali Hasanzadeh Mina Deljavanghodrati Source Type: research
