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Cancer: Melanoma
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Total 1255 results found since Jan 2013.
Lysosome activable polymeric vorinostat encapsulating PD-L1KD for a combination of HDACi and immunotherapy
In this study, we develop PDDS{polyethylene glycol-b-asparaginate(diethylenetriamine-vorinostat), (PEG-b-P[Asp(DET-SAHA)n] PPDS)}encapsulating siRNA-PD-L1to provide micelles siRNA-PD-L1-loaded micelles (siRNA@PPDS). Transmission electron microscope (TEM) images demonstrate that siRNA@PPDS micelles presented spherical morphology with a size of about 120 nm; hydrodynamic data analysis indicates pH sensitivity of siRNA@PPDS micelles. The experiments reveal that siRNA@PPDS micelles could be well uptaken by the tumor cells to silence the expression of PD-L1 protein in a dose-dependent manner; compared with the free SAHA, the SA...
Source: Drug Delivery - May 26, 2021 Category: Drugs & Pharmacology Authors: Fengkun Lu Lei Hou Sizhen Wang Yingjie Yu Yunchang Zhang Linhong Sun Chen Wang Zhiqiang Ma Feng Yang Source Type: research
Silencing of Mcl-1 overcomes resistance of melanoma cells against TRAIL-armed oncolytic adenovirus by enhancement of apoptosis
J Mol Med (Berl). 2021 May 24. doi: 10.1007/s00109-021-02081-3. Online ahead of print.ABSTRACTArming of oncolytic viruses with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been shown as a viable approach to increase the antitumor efficacy in melanoma. However, melanoma cells may be partially or completely resistant to TRAIL or develop TRAIL resistance, thus counteracting the antitumor efficiency of TRAIL-armed oncolytic viruses. Recently, we found that TRAIL resistance in melanoma cells can be overcome by inhibition of antiapoptotic Bcl-2 protein myeloid cell leukemia 1 (Mcl-1). Here, we investigated...
Source: Molecular Medicine - May 24, 2021 Category: Molecular Biology Authors: Beatrice Tolksdorf Sina Zarif J ürgen Eberle Ahmet Hazini Babette Dieringer Franziska J önsson Florian Kreppel Jens Kurreck Henry Fechner Source Type: research
Cancers, Vol. 13, Pages 1871: Inhibiting FAK –Paxillin Interaction Reduces Migration and Invadopodia-Mediated Matrix Degradation in Metastatic Melanoma Cells
In conclusion, our data show that targeting FAK–paxillin interactions could be a potential therapeutic strategy to prevent metastasis formation, and molecules targeting this interface could be alternative to inhibitors of FAK kinase activity which display unexpected effects.
Source: Cancers - April 14, 2021 Category: Cancer & Oncology Authors: Antoine Mousson Marl ène Legrand Tania Steffan Romain Vauchelles Philippe Carl Jean-Pierre Gies Maxime Lehmann Guy Zuber Jan De Mey Denis Dujardin Emilie Sick Philippe Rond é Tags: Article Source Type: research
Keratin 1 plays significant roles in maintaining the survival and oxidative stress state of B16-F10 melanoma cell lines
Int J Physiol Pathophysiol Pharmacol. 2021 Feb 15;13(1):12-16. eCollection 2021.ABSTRACTKeratins play multiple significant biological roles in epithelium. Keratin 1 (K1)/keratin 10 (K10) heterodimer is a hallmark for keratinocyte differentiation. While keratins are absent in normal melanocyte, keratins have been found in both melanoma cell lines and human melanoma. The biological significance of the keratins in melanoma cells has remained unclear. In our current study we applied K1 siRNA to investigate the biological significance of K1 in B16-F10 melanoma cells. We found that as low as a 16% decrease in the K1 level led to...
Source: International Journal of Physiology, Pathophysiology and Pharmacology - April 5, 2021 Category: Physiology Authors: Yujia Li Mingchao Zhang Weihai Ying Source Type: research
Increased Melanoma-Associated Antigen C2 Expression Affords Resistance to Apoptotic Deathin Suspension-Cultured Tumor Cells
CONCLUSIONS: High MAGEC2 expression may play an important role in the survival of ASCs by maintaining the expression of activated STAT3 to prevent apoptotic cell death.PMID:33818016 | DOI:10.4048/jbc.2021.24.e6
Source: Journal of Breast Cancer - April 5, 2021 Category: Cancer & Oncology Authors: Doyeon Park Sora Han Hyunjeong Joo Hye In Ka Sujung Soh Jiyoung Park Young Yang Source Type: research
Keratin 1 plays significant roles in maintaining the survival and oxidative stress state of B16-F10 melanoma cell lines
Int J Physiol Pathophysiol Pharmacol. 2021 Feb 15;13(1):12-16. eCollection 2021.ABSTRACTKeratins play multiple significant biological roles in epithelium. Keratin 1 (K1)/keratin 10 (K10) heterodimer is a hallmark for keratinocyte differentiation. While keratins are absent in normal melanocyte, keratins have been found in both melanoma cell lines and human melanoma. The biological significance of the keratins in melanoma cells has remained unclear. In our current study we applied K1 siRNA to investigate the biological significance of K1 in B16-F10 melanoma cells. We found that as low as a 16% decrease in the K1 level led to...
Source: International Journal of Physiology, Pathophysiology and Pharmacology - April 5, 2021 Category: Physiology Authors: Yujia Li Mingchao Zhang Weihai Ying Source Type: research
Increased Melanoma-Associated Antigen C2 Expression Affords Resistance to Apoptotic Deathin Suspension-Cultured Tumor Cells
CONCLUSIONS: High MAGEC2 expression may play an important role in the survival of ASCs by maintaining the expression of activated STAT3 to prevent apoptotic cell death.PMID:33818016 | DOI:10.4048/jbc.2021.24.e6
Source: Journal of Breast Cancer - April 5, 2021 Category: Cancer & Oncology Authors: Doyeon Park Sora Han Hyunjeong Joo Hye In Ka Sujung Soh Jiyoung Park Young Yang Source Type: research
Keratin 1 plays significant roles in maintaining the survival and oxidative stress state of B16-F10 melanoma cell lines
Int J Physiol Pathophysiol Pharmacol. 2021 Feb 15;13(1):12-16. eCollection 2021.ABSTRACTKeratins play multiple significant biological roles in epithelium. Keratin 1 (K1)/keratin 10 (K10) heterodimer is a hallmark for keratinocyte differentiation. While keratins are absent in normal melanocyte, keratins have been found in both melanoma cell lines and human melanoma. The biological significance of the keratins in melanoma cells has remained unclear. In our current study we applied K1 siRNA to investigate the biological significance of K1 in B16-F10 melanoma cells. We found that as low as a 16% decrease in the K1 level led to...
Source: International Journal of Physiology, Pathophysiology and Pharmacology - April 5, 2021 Category: Physiology Authors: Yujia Li Mingchao Zhang Weihai Ying Source Type: research
