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Cancer: Melanoma
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Total 1255 results found since Jan 2013.
The Role of Melanotransferrin (CD228) in the regulation of the differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells (hBM-MSC)
We examined a possible role for CD228 in the regulation of osteogenesis and adipogenesis of hBM-MSC. Surprisingly, siRNA-mediated CD228 knockdown increased the expression of the transcription factor DLX5 and enhanced osteogenesis of hBM-MSC evidenced by an increased expression of the runt-related transcription factor 2 (RUNX2), osterix (Osx), and osteocalcin (OC), as well as higher alkaline phosphatase (ALP) activity and extracellular calcium deposition. Interestingly, hBM-MSC transfected with CD228 siRNA also showed an increase in intracellular lipid level during adipogenesis, indicated by oil red O staining of differenti...
Source: International Journal of Medical Sciences - March 22, 2021 Category: Biomedical Science Authors: Maria Dubon Sooho Lee Ji-Hong Park Jae-Yong Lee Dongchul Kang Source Type: research
Neem leaf glycoprotein salvages T cell functions from Myeloid-derived suppressor cells-suppression by altering IL-10/STAT3 axis in melanoma tumor microenvironment
Myeloid-derived suppressor cells (MDSCs) suppress antitumor immune functions. We have observed that an immunomodulator, neem leaf glycoprotein (NLGP), inhibits tumor-resident MDSCs and enhances antitumor CD8+ T cell immunity. NLGP inhibits the number as well as functions of tumor-resident MDSCs (Gr1±CD11b±) and enhances antitumor CD8± T cell immunity by downregulating arginase 1 and inducible nitric oxide synthase production in MDSCs. Accordingly, decreased T cell anergy and helper to regulatory T cell conversion have been observed in the presence of NLGP, which ultimately augments T cell functions. Mechanistically, NLG...
Source: Melanoma Research - March 11, 2021 Category: Cancer & Oncology Tags: Original Articles: Basic Science Source Type: research
GSE167945 IRF4 genome wide binding and transciptomic profile in 501Mel melanoma cell line
Contributors : Ramile Dilshat ; Berglind O Einarsd óttirSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensTo map genome wide binding sites of IRF4, we performed ChIP-seq against eGFP tagged IRF4 in human melanoma cells. To assess whether IRF4 binding influences its target gene expression, RNA-seq was performed after siRNA mediated depletion of IRF4 in 501Mel cells. Subsequently, target genes of IRF4 obtained from ChIP-seq and RNA-seq studies were used to interrogate melanocyte meQTL and identified 131 candidate downstre...
Source: GEO: Gene Expression Omnibus - March 2, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research
Correction to: Thick melanoma in Tuscany
G Ital Dermatol Venereol. 2020 Dec;155(6):807. doi: 10.23736/S0392-0488.21.06995-9.ABSTRACTThis corrects the article DOI: 10.23736/S0392-0488.17.05584-5.PMID:33645939 | DOI:10.23736/S0392-0488.21.06995-9
Source: Giornale Italiano di Dermatologia e Venereologia - March 1, 2021 Category: Dermatology Authors: Alessandra Chiarugi Paolo Nardini Lorenzo Borgognoni Paola Brandani Gianni Gerlini Pietro Rubegni Arianna Lamberti Camilla Salvini Giovanni Lo Scocco Roberto Cecchi Riccardo Sirna Stefano Lorenzi Riccardo Gattai Silvio Battistini Emanuele Crocetti Source Type: research
