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Cancer: Melanoma
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& lt;i & lt;FOXC1-Mediated Effects of miR-204-5p on Melanoma Cell Proliferation
Mol Biol (Mosk). 2021 Jul-Aug;55(4):667-675. doi: 10.31857/S0026898421030058.ABSTRACTMicroRNAs epigenetically regulate physiological and pathological processes. Previously, we found that miR-204-5p is expressed at low levels in melanoma cells, and an increase in its level leads to a change in proliferation, migration, and invasion of these cancer cells. Now, using bioinformatics analysis, it has been shown that the target of miR-204-5p is FOXC1 transcription factor, which is implicated in carcinogenesis. Using the luciferase reporter assay, it was found that miR-204-5p suppresses expression of the FOXC1 gene by binding to ...
Source: Molekuliarnaia Biologiia - August 25, 2021 Category: Molecular Biology Authors: I Yu Dubovtseva M B Aksenenko E D Nikolaeva A S Averchuk A V Moshev A A Savchenko S V Markova T G Ruksha Source Type: research
Ferumoxytol- β-glucan Inhibits Melanoma Growth via Interacting with Dectin-1 to Polarize Macrophages into M1 Phenotype
Conclusion: The nanocomposite FMT-β-glucan suppressed melanoma growth by inducing the M1 macrophage-activated tumor microenvironment.PMID:34400883 | PMC:PMC8364471 | DOI:10.7150/ijms.61525
Source: International Journal of Medical Sciences - August 17, 2021 Category: Biomedical Science Authors: Xinghan Liu Yujun Xu Yi Li Yuchen Pan Shuli Zhao Yayi Hou Source Type: research
