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Cancer: Melanoma
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Total 1255 results found since Jan 2013.
Low doses of niclosamide and quinacrine combination yields synergistic effect in melanoma via activating autophagy-mediated p53-dependent apoptosis
In this study, we developed a novel anti-melanoma strategy by using anti-tapeworm drug niclosamide and anti-malarial drug quinacrine, and investigated the molecular mechanism by in vitro and in vivo assays. Meanwhile, other types of tumor cells, immortalized epithelial cells and bone marrow mesenchymal stem cells were used to evaluate the universal role of anti-cancer and safety of the strategy. The results showed, briefly, an exposure to niclosamide and quinacrine led to an increased apoptosis-related protein p53, cleaved caspase-3 and cleaved PARP and autophagy-related protein LC3B expression, and a decreased expression ...
Source: Translational Oncology - April 23, 2022 Category: Cancer & Oncology Authors: Xuan Zheng Jianyun Zhang Shuangting Li Xiaolei Gao Yixin Zhang Meng Wang Liying Dong Liangjie Sun Na Zhao Zeyun Ma Chong Ding Yixiang Wang Source Type: research
Corrigendum Linc00961 inhibits the proliferation and invasion of skin melanoma by targeting the miR ‑367/PTEN axis
Int J Oncol. 2022 Jun;60(6):62. doi: 10.3892/ijo.2022.5352. Epub 2022 Apr 13.ABSTRACTFollowing the publication of the above article, the authors have informed us that they found errors in two of the published figures that occurred whilst compiling them. In Fig. 8, the representative images selected for the migratory and invasive A375 cells in the Lv‑control + miR‑367 NC group experiments were found to be overlapping. After having consulted their original data, the authors noted that the error arose during the data acquisition process, and an area of the image captured for the migratory A375 cells was inadvertently reâ€...
Source: International Journal of Oncology - April 13, 2022 Category: Cancer & Oncology Authors: Xin Mu Kuan-Hou Mou Rui Ge Dan Han Yan Zhou Li-Juan Wang Source Type: research
Genetic Engineering of Dendritic Cells Using Partially Zwitterionic Dendrimer-Entrapped Gold Nanoparticles Boosts Efficient Tumor Immunotherapy
Biomacromolecules. 2022 Mar 2. doi: 10.1021/acs.biomac.1c01571. Online ahead of print.ABSTRACTEffective processing and cross-priming of tumor neoantigen by dendritic cells (DCs) to T cells for spontaneous immune response generation to effectively kill cancer cells remain challenging in cancer immunotherapy. Here, we report a general approach to genetically engineer DCs through silencing their YTHDF1 protein (an important reader protein responsible for RNA m6A methylation) expression via a dendrimeric non-viral vector to boost effective tumor immunotherapy. Poly(amidoamine) dendrimers of generation 5 were partially decorate...
Source: Biomacromolecules - March 2, 2022 Category: Biochemistry Authors: Zhijun Ouyang Yue Gao Rui Yang Mingwu Shen Xiangyang Shi Source Type: research
Cancers, Vol. 14, Pages 1071: ADCK2 Knockdown Affects the Migration of Melanoma Cells via MYL6
Conclusion: ADCK2 affects melanoma cell motility, most probably via MYL6. Our results allow the conclusion that ADCK2 could act as a tumor suppressor in melanoma.
Source: Cancers - February 20, 2022 Category: Cancer & Oncology Authors: Marlene Vierthaler Qian Sun Yiman Wang Tamara Steinfass Juliane Poelchen Thomas Hielscher Daniel Novak Viktor Umansky Jochen Utikal Tags: Article Source Type: research
High expression of CD28 enhanced the anti-cancer effect of siRNA-PD-1 through prompting the immune response of melanoma-bearing mice
Int Immunopharmacol. 2022 Jan 27;105:108572. doi: 10.1016/j.intimp.2022.108572. Online ahead of print.ABSTRACTImmune checkpoint blockade is considered to be an effective method of tumor immunotherapy. As one of the main immune checkpoints, blocking PD-1/PD-L1 pathway has been proved to be effective in the treatment of many cancers via activating T cells; however, many patients still do not respond to the blocking PD-1/PD-L1 treatment with satisfying results. Related research demonstrated that the activation of T cells required a co-stimulatory signal generated by the interaction between CD28 and CD80/CD86, whereas in many ...
Source: International Immunopharmacology - January 30, 2022 Category: Allergy & Immunology Authors: Huijie Jia Jing Guo Zhiang Liu Pengfei Chen Yang Li Ruipeng Li Yunfan Yang Xinyi Li Pengkun Wei Jiateng Zhong Feng Ren Mingyong Wang Jianzhuang Ren Zhiwei Feng Tiesuo Zhao Source Type: research
Mahogunin Ring Finger 1 regulates pigmentation by controlling the pH of melanosomes in melanocytes and melanoma cells
Cell Mol Life Sci. 2021 Dec 18. doi: 10.1007/s00018-021-04053-9. Online ahead of print.ABSTRACTMahogunin Ring Finger 1 (MGRN1) is an E3-ubiquitin ligase absent in dark-furred mahoganoid mice. We investigated the mechanisms of hyperpigmentation in Mgrn1-null melan-md1 melanocytes, Mgrn1-KO cells obtained by CRISPR-Cas9-mediated knockdown of Mgrn1 in melan-a6 melanocytes, and melan-a6 cells depleted of MGRN1 by siRNA treatment. Mgrn1-deficient melanocytes showed higher melanin content associated with increased melanosome abundance and higher fraction of melanosomes in highly melanized maturation stages III-IV. Expression, po...
Source: Cellular and Molecular Life Sciences : CMLS - December 18, 2021 Category: Cytology Authors: Julia Sir és-Campos Ana Lambertos C édric Delevoye Gra ça Raposo Dorothy C Bennett Elena Sviderskaya Celia Jim énez-Cervantes Conchi Olivares Jos é Carlos GarcÃa-Borrón Source Type: research
Autophagy inhibition mediated by MCOLN1/TRPML1 suppresses cancer metastasis via regulating a ROS-driven TP53/p53 pathway
This study demonstrates that autophagy inhibition induced by MCOLN1/TRPML1 suppresses cancer metastasis by evoking the ROS-mediated TP53/p53 pathway. First, we found that MCOLN1-mediated autophagy inhibition not only profoundly inhibits both migration and invasion in malignant melanoma and glioma cell lines in vitro, but also suppresses melanoma metastasis in vivo. Second, our study reveals that autophagy inhibition induced by MCOLN1 leads to damaged mitochondria accumulation followed by large quantities of ROS release. Third, we demonstrate that the elevated ROS resulting from autophagy inhibition subsequently triggers TP...
Source: Autophagy - December 8, 2021 Category: Cytology Authors: Yanhong Xing Xiangqing Wei Yucheng Liu Meng-Meng Wang Zhongheng Sui Xinyan Wang Wucheng Zhu Mengmei Wu Chen Lu Yuan-Hui Fei Yi Jiang Yang Zhang Yuqing Wang Feng Guo Jun-Li Cao Jiansong Qi Wuyang Wang Source Type: research
