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Cancer: Liver Cancer

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Total 1432 results found since Jan 2013.

SOS1 regulates HCC cell epithelial-mesenchymal transition via the PI3K/AKT/mTOR pathway
Biochem Biophys Res Commun. 2022 Nov 12;637:161-169. doi: 10.1016/j.bbrc.2022.11.015. Online ahead of print.ABSTRACTThe influence of son of sevenless homolog 1 (SOS1) on invasion and metastasis of hepatocellular carcinoma (HCC) cells was investigated. HCC cells were transfected with siRNA and lentivirus to achieve SOS1 knock down/overexpression and changes in RNA and protein levels analyzed by q-PCR and Western blotting (WB). Transwell assay was utilized to assess variations in cell invasion and migration in vitro and by a lung metastasis model of liver cancer in vivo. High expression of SOS1 was observed in most human liv...
Source: Biochemical and Biophysical Research communications - November 20, 2022 Category: Biochemistry Authors: Yonghe Li Yaolin Yin Yi He Kun He Jingdong Li Source Type: research

LCMT1 indicates poor prognosis and is essential for cell proliferation in hepatocellular carcinoma
CONCLUSIONS: Our data revealed a novel role of LCMT1 in the proliferation of HCC cells. In addition, we provided novel insights into the effects of glycolysis-related pathways on the LCMT1regulated progression of HCC, suggesting LCMT1 as a novel therapeutic target for HCC therapy.PMID:36401967 | DOI:10.1016/j.tranon.2022.101572
Source: Translational Oncology - November 19, 2022 Category: Cancer & Oncology Authors: Ning Zhang Cailing Lu Jiao Mo Xinhang Wang Simi Liao Ningjing Liang Mei Feng Tingting Tang Yijie Wu Yunqing Li Chunhua Lan Chengying Chen Qianqian Shi Lancheng Wei Zhijian Zheng Yu Lei Zhiming Zhang Shen Tang Xiyi Li Source Type: research

Metformin Suppresses Hepatocellular Carcinoma through Regulating Alternative Splicing of LGR4
CONCLUSIONS: LGR4 could promote the ability of cell proliferation, migration, and invasion in HCC, which could be reduced by metformin through alternative splicing.PMID:36385965 | PMC:PMC9652085 | DOI:10.1155/2022/1774095
Source: Journal of Oncology - November 17, 2022 Category: Cancer & Oncology Authors: Han Zhuo Shuying Miao Zhenquan Jin Deming Zhu Zhenggang Xu Dongwei Sun Jie Ji Zhongming Tan Source Type: research

NAP1L5 targeting combined with MYH9 Inhibit HCC progression through PI3K/AKT/mTOR signaling pathway
In this study, low expression of NAP1L5 was found in hepatocellular carcinoma, and the downregulation of NAP1L5 was related to shorter survival and disease-free survival. In addition, its expression is also related to the tumor size and recurrence of hepatocellular carcinoma. The overexpression and knockdown of NAP1L5 by plasmid and siRNA showed that NAP1L5 inhibited the proliferation, migration and invasion and induced apoptosis of hepatoma cells. In vivo experiments confirmed that NAP1L5 can inhibit the growth and metastasis of hepatocellular carcinoma cells. In the mechanistic study, we found that NAP1L5 affects the occ...
Source: Aging - November 14, 2022 Category: Biomedical Science Authors: Rui Zhao Yuzhen Ge Yongjun Gong Bo Li Benli Xiao Shi Zuo Source Type: research

Anticancer Effect of Polyphyllin I in Suppressing Stem Cell-Like Properties of Hepatocellular Carcinoma via the AKT/GSK-3 < em > β < /em > / < em > β < /em > -Catenin Signaling Pathway
Oxid Med Cell Longev. 2022 Oct 22;2022:4031008. doi: 10.1155/2022/4031008. eCollection 2022.ABSTRACTPolyphyllin I (PPI), also called Chong Lou saponin I, is a steroidal saponin isolated from the rhizome of Paris polyphylla. PPI has been demonstrated to have strong anticancer activity. However, its effect on the stemness of liver cancer stem cells (LCSCs) is not completely understood. Herein, we aimed to investigate the effect of PPI on the stem cell-like features of LCSCs and hepatocellular carcinoma (HCC). LCSCs were enriched in a serum-free medium and treated with PPI, sorafenib (Sora), or PPI and Sora. Several endpoints...
Source: Molecular Medicine - November 1, 2022 Category: Molecular Biology Authors: Mianmian Liao Haiyan Du Bing Wang Jinzhen Huang Danping Huang Guangdong Tong Source Type: research

Adiponectin Stimulates Apolipoprotein A-1 Gene Expression in HepG2 Cells via AMPK, PPAR α, and LXRs Signaling Mechanisms
AbstractAdiponectin is an adipose tissue hormone, participating in energy metabolism and involved in atherogenesis. Previously, it was found that adiponectin increases expression of theAPOA1 (apolipoprotein A-1) gene in hepatocytes, but the mechanisms of this effect remained unexplored. Our aim was to investigate the role of adiponectin receptors AdipoR1/R2, AMP-activated protein kinase (AMPK), nuclear peroxisome proliferator-activated receptor alpha (PPAR α) and liver X receptors (LXRs) in mediating the action of adiponectin on hepaticAPOA1 expression in human hepatoma HepG2 cells. The level ofAPOA1 expression was determ...
Source: Biochemistry (Moscow) - November 1, 2022 Category: Biochemistry Source Type: research

Cyclin ‐dependent kinase subunit2 (CKS2) promotes malignant phenotypes and epithelial‐mesenchymal transition‐like process in glioma by activating TGFβ/SMAD signaling
ConclusionsWe identified CKS2 as a critical contributor to the gliomagenesis, which might provide a novel therapeutic target for inhibiting the spread and infiltration of glioma.
Source: Cancer Medicine - October 26, 2022 Category: Cancer & Oncology Authors: Fan Feng, Zongqing Zhao, Xuechang Cai, Xueyuan Heng, Ximeng Ma Tags: RESEARCH ARTICLE Source Type: research

Increased Expression of NXPH4 Correlates with Immune Cell Infiltration and Unfavorable Prognosis in Hepatocellular Carcinoma
This study suggested that the upregulation of NXPH4 is associated with adverse prognosis and immune cell infiltration in HCC. NXPH4 could be a novel biomarker of unfavorable prognosis and an underlying target for immunotherapy in HCC.PMID:36245978 | PMC:PMC9560829 | DOI:10.1155/2022/5005747
Source: Journal of Oncology - October 17, 2022 Category: Cancer & Oncology Authors: Qin Tang Yue-Ming Chen Mei-Mei Shen Wen Dai Hang Liang Jun-Nan Liu Jian Gao Source Type: research

circRERE regulates the expression of GBX2 through miR-1299 and ZC3H13/N < sup > 6 < /sup > -methyladenosine (m < sup > 6 < /sup > A) to promote growth and invasion of hepatocellular carcinoma cells
J Biosci. 2022;47:52.ABSTRACTHepatocellular carcinoma (HCC) is one of the most common malignant tumours in the world. Current studies have shown that circular RNAs (circRNAs) and N6-methyladenosine (m6A) methylation play important roles in the progression of HCC, but further studies are needed to confirm the underlying mechanisms. The expression of circRERE was significantly upregulated in HCC cells, and its downregulation reduced HCC cell viability and invasion while increasing apoptosis. Further study showed that circRERE bound directly to miR- 1299. After downregulating the expression of circRERE, miR-1299 expression wa...
Source: Journal of Biosciences - October 12, 2022 Category: Biomedical Science Authors: Yong-Hua Lin Bao-Yan Zhang Zhi-Chao Singh Chen Source Type: research

Blockade of growth hormone receptor signaling by using pegvisomant: A functional therapeutic strategy in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is an aggressive neoplasm with poor clinical outcome because most patients present at an advanced stage, at which point curative surgical options, such as tumor excision or liver transplantation, are not feasible. Therefore, the majority of HCC patients require systemic therapy. Nonetheless, the currently approved systemic therapies have limited effects, particularly in patients with advanced and resistant disease. Hence, there is a critical need to identify new molecular targets and effective systemic therapies to improve HCC outcome. The liver is a major target of the growth hormone recepto...
Source: Frontiers in Oncology - October 6, 2022 Category: Cancer & Oncology Source Type: research

RAB6B is a potential prognostic marker and correlated with the remolding of tumor immune microenvironment in hepatocellular carcinoma
Conclusion: Our study revealed that RAB6B is a potential biomarker for poor prognosis in HCC patients and correlates with the formation of the immunosuppressive microenvironment in HCC.PMID:36120364 | PMC:PMC9478551 | DOI:10.3389/fphar.2022.989655
Source: Cancer Control - September 19, 2022 Category: Cancer & Oncology Authors: Hao Peng Erwei Zhu Jitao Wang Xuanlong Du Chonggao Wang Meng Yang Yewei Zhang Source Type: research