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Cancers, Vol. 14, Pages 4060: Defective DNAM-1 Dependent Cytotoxicity in Hepatocellular Carcinoma-Infiltrating NK Cells
Conclusions: We provide evidence of alterations in the DNAM-1/CD155 axis in HCC, suggesting a possible mechanism of tumor resistance to innate immune surveillance.
Source: Cancers - August 22, 2022 Category: Cancer & Oncology Authors: Stefania Mantovani Stefania Varchetta Dalila Mele Roberta Maiello Matteo Donadon Cristiana Soldani Barbara Franceschini Guido Torzilli Giuseppe Tartaglia Marcello Maestri Gaetano Piccolo Matteo Barabino Enrico Opocher Stefano Bernuzzi Mario U. Mondelli Ba Tags: Article Source Type: research
Alpha7 nicotinic acetylcholine receptor expression in Sorafenib-resistant Hepatocellular carcinoma cells
AbstractHepatocellular carcinoma (HCC), the most prevalent kind of liver cancer, remains one of the world ’s main causes of death. The alpha7 nicotinic acetylcholine receptor (α7nAchR) has been recognized to be overexpressed in malignancies and chemoresistance. Since little is known about the role of α7nAchR expression in drug-resistant cells, this study was designed to investigate the effect of α7 nAchR suppression in combination with Sorafenib (SOR) on SOR-resistant HCC cells. First, SOR-resistant HCC cells were generated. To suppress the expression of α7nAchR, cells were treated with SOR following siRNA transfecti...
Source: Medical Oncology - August 16, 2022 Category: Cancer & Oncology Source Type: research
siRNA targeting PD-L1 delivered with attenuated Salmonella enhanced the anti-tumor effect of lenvatinib on mice bearing Hepatocellular carcinoma
Int Immunopharmacol. 2022 Aug 11;111:109127. doi: 10.1016/j.intimp.2022.109127. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC) is a primary liver cancer representing serious harm to human health. The effective treatment of HCC is challenging. Lenvatinib is an inhibitor of polytyrosine kinase that exerts an effect against HCC by blocking the VEGF signaling pathway. However, its efficacy in most patients remains unsatisfactory. The factors influencing tumorigenesis are diverse; thus, combined treatment is an important strategy against tumors. Programmed death ligand-1 (PD-L1), which binds to programmed death-1 ...
Source: International Immunopharmacology - August 14, 2022 Category: Allergy & Immunology Authors: Pengfei Chen Yingjing Li Pengkun Wei Lirui Liang Baozhu Li Yuhao Cao Xinwei Han Yanling Wang Xuhua Duan Huijie Jia Tieuso Zhao Jianzhuang Ren Source Type: research
GOLM1 depletion modifies cellular sphingolipid metabolism and adversely affects cell growth
In conclusion, we demonstrate that GOLM1 depletion affects sphingolipid metabolism, mitochondrial function, Golgi structure, and proliferation of HCC cells.PMID:35948172 | DOI:10.1016/j.jlr.2022.100259
Source: Cell Research - August 10, 2022 Category: Cytology Authors: Meghana Nagaraj Marcus H öring Maria A Ahonen Van Dien Nguyen You Zhou Helena Vihinen Eija Jokitalo Gerhard Liebisch P A Nidhina Haridas Vesa M Olkkonen Source Type: research
Overexpression of Protein Phosphatase 2 Regulatory Subunit B"Alpha Promotes Glycolysis by Regulating Hexokinase 1 in Hepatocellular Carcinoma
CONCLUSION: Our findings showed the correlation of PPP2R3A and HK1 in the glycolysis of HCC, which reveals a new mechanism for the oncogenic roles of PPP2R3A in cancer.PMID:35945177 | DOI:10.3967/bes2022.082
Source: Biomedical and Environmental Sciences : BES - August 9, 2022 Category: Biomedical Science Authors: Ning Jiao Wan Sheng Ji Biao Zhang Yu Kui Shang Yu Chen Zhang Wei Qun Yu Hai Long Jin Chao Li Cheng Ying Zhang Cheng Yan Wen Yue Qing Zhang Source Type: research
