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Total 1432 results found since Jan 2013.
Remodeling Serine Synthesis and Metabolism via Nanoparticles (NPs)-Mediated CFL1 Silencing to Enhance the Sensitivity of Hepatocellular Carcinoma to Sorafenib
Adv Sci (Weinh). 2023 May 18:e2207118. doi: 10.1002/advs.202207118. Online ahead of print.ABSTRACTTyrosine kinase inhibitors represented by sorafenib are the first-line treatment for hepatocellular carcinoma (HCC), but the low response rate of HCC patient has become a clinical pain-point. Emerging evidences have revealed that metabolic reprogramming plays an important role in regulating the sensitivity of tumor cells to various chemotherapeutics including sorafenib. However, the underlying mechanisms are very complex and are not fully elucidated. By comparing the transcriptome sequencing data of sorafenib-sensitive and -in...
Source: Adv Data - May 19, 2023 Category: Epidemiology Authors: Senlin Li Lei Xu Guo Wu Ziqi Huang Linzhuo Huang Fengqian Zhang Chunfang Wei Qian Shen Rong Li Lei Zhang Xiaoding Xu Source Type: research
MiR-767-3p promotes the progression of hepatocellular carcinoma via targeting CASP-3/-9
CONCLUSION: MiR-767-3p promoted proliferation and prevented apoptosis in human hepatocellular carcinoma (HCC) through inhibiting the caspase-3/caspase-9 pathway.PMID:37193190 | PMC:PMC10182511
Source: American Journal of Translational Research - May 16, 2023 Category: Research Authors: Maolin Wu Jing Deng Dejiao Yao Shijie Li Source Type: research
