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Transcriptomics integrated with metabolomics reveals perfluorobutane sulfonate (PFBS) exposure effect during pregnancy and lactation on lipid metabolism in rat offspring
Chemosphere. 2023 Sep 9:140120. doi: 10.1016/j.chemosphere.2023.140120. Online ahead of print.ABSTRACTEmerging epidemiological evidence indicates potential associations between gestational perfluorobutane sulfonate (PFBS) exposure and adverse metabolic outcomes in offspring. However, the underlying mechanisms remain unclear. Our study aimed to investigate PFBS exposure effects during pregnancy and lactation on rat offspring lipid profiles and the possible underlying mechanisms. Although the biochemical index difference including total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL), low-density lipoprot...
Source: Chemosphere - September 11, 2023 Category: Chemistry Authors: Xi Meng Guoqi Yu Tingyu Luo Ruiyuan Zhang Jun Zhang Yongjie Liu Source Type: research
Travel Medicine
Ann Intern Med. 2023 Sep 12. doi: 10.7326/AITC202309190. Online ahead of print.ABSTRACTInternational travel can cause new illness or exacerbate existing conditions. Because primary care providers are frequent sources of health advice to travelers, they should be familiar with destination-specific disease risks, be knowledgeable about travel and routine vaccines, be prepared to prescribe chemoprophylaxis and self-treatment regimens, and be aware of travel medicine resources. Primary care providers should recognize travelers who would benefit from referral to a specialized travel clinic for evaluation. Those requiring yellow...
Source: Annals of Internal Medicine - September 11, 2023 Category: Internal Medicine Authors: Robert J Rolfe Edward T Ryan Regina C LaRocque Source Type: research
Money, chores and emotional support: Kenyan and Zambian fathers' perceptions of male partner involvement in maternal and infant health within the context of HIV
Cult Health Sex. 2023 Sep 11:1-16. doi: 10.1080/13691058.2023.2249078. Online ahead of print.ABSTRACTIn sub-Saharan Africa, involving male partners in the prevention of mother-to-child transmission of HIV improves maternal and infant outcomes. Male involvement is typically conceptualised as male partners attending antenatal care, which is difficult for many men. Little is known about how men view their involvement in family health within the context of HIV, particularly outside of clinic attendance. Through interviews with 35 male partners of pregnant or postpartum women living with HIV in Kenya and Zambia, this study elic...
Source: Culture, Health and Sexuality - September 11, 2023 Category: International Medicine & Public Health Authors: Karen Hampanda Jean Scandlyn Marcella Fasano Tulani Francis L Matenga Maricianah Onono Tobias O Odwar Wilbroad Mutale Perfect Shankalala Benjamin H Chi Janet M Turan Lisa L Abuogi Source Type: research
Adverse birth outcomes related to concentrations of per- and polyfluoroalkyl substances (PFAS) in maternal blood collected from pregnant women in 1960-1966
CONCLUSIONS: Using data from this US-based cohort study, we found that 1) maternal PFAS levels from the 1960s exceeded values in contemporaneous populations and 2) that gestational concentrations of certain PFAS were associated with lower birth weight and infant ponderal index. Additional studies with larger sample size are needed to further examine the associations of gestational exposure to individual PFAS and their mixtures with adverse birth outcomes.PMID:37696323 | DOI:10.1016/j.envres.2023.117010
Source: Environmental Research - September 11, 2023 Category: Environmental Health Authors: T Zheng K Kelsey C Zhu K D Pennell Q Yao K E Manz Y F Zheng J M Braun Y Liu G Papandonatos Q Liu K Shi S Brochman S L Buka Source Type: research
Ambient temperature and preeclampsia: A historical cohort study
Environ Res. 2023 Sep 9:117107. doi: 10.1016/j.envres.2023.117107. Online ahead of print.ABSTRACTPrevious studies found inconsistent associations between ambient temperature during pregnancy and the risk of preeclampsia. If such associations are causal, they may impact the future burden of preeclampsia in the context of climate change. We used a historical cohort of 129,009 pregnancies (5074 preeclampsia cases) from southern Israel that was merged with temperature assessments from a hybrid satellite-based exposure model. Distributed-lag and cause-specific hazard models were employed to study time to all preeclampsia cases,...
Source: Environmental Research - September 11, 2023 Category: Environmental Health Authors: Iaroslav Youssim Offer Erez Lena Novack Daniel Nevo Itai Kloog Raanan Raz Source Type: research
Preliminary evidence of psychological improvements and increased maternal-fetal attachment associated with a mindfulness sleep programme: secondary analysis of uncontrolled data in 11 pregnant women with insomnia disorder
J Sleep Res. 2023 Sep 10:e14040. doi: 10.1111/jsr.14040. Online ahead of print.ABSTRACTTreating insomnia during pregnancy improves sleep and depressed mood. However, given well-established links between poor sleep and a broad spectrum of adverse maternal outcomes, the benefits of insomnia care may reach beyond sleep and depression. The present study evaluated the preliminary efficacy of 'Perinatal Understanding of Mindful Awareness for Sleep' (PUMAS)-a mindfulness sleep programme tailored to pregnancy that combines behavioural sleep strategies and meditation-for enhancing everyday mindfulness and maternal-fetal attachment,...
Source: Journal of Sleep Research - September 11, 2023 Category: Sleep Medicine Authors: David A Kalmbach Anthony N Reffi Jason C Ong Philip Cheng Olivia Walch D'Angela S Pitts Grace M Seymour Mika Hirata Andrea Roth Thomas Roth Christopher L Drake Source Type: research
Long exposure to a mixture of endocrine disruptors prediposes the ventral prostate of rats to preneoplastic lesions
Environ Sci Pollut Res Int. 2023 Sep 11. doi: 10.1007/s11356-023-29768-z. Online ahead of print.ABSTRACTEndocrine disruptors (ED) are compounds dispersed in the environment that modify hormone biosynthesis, affecting hormone-dependent organs such as the prostate. Studies have only focused on evaluating the effects of ED alone or in small groups and short intervals and have not adequately portrayed human exposure. Therefore, we characterized the prostate histoarchitecture of rats exposed to an ED mixture (ED Mix) mimicking human exposure. Pregnant females of the Sprague-Dawley strain were randomly distributed into two exper...
Source: Cancer Control - September 11, 2023 Category: Cancer & Oncology Authors: Thaina Cavalleri Sousa Let ícia Pereira de Souza Maria Luiza Silva Ricardo Andreia Yuri Yoshigae Karianne Delalibera Hinokuma Ana Beatriz Ratto Gorzoni Ariana Musa de Aquino Wellerson Rodrigo Scarano Anthony C ésar de Sousa Castillho Maria Eduarda Almei Source Type: research
Pharmacological and electronic cigarette interventions for smoking cessation in adults: component network meta-analyses
CONCLUSIONS: The most effective interventions were nicotine e-cigarettes, varenicline and cytisine (all high certainty), as well as combination NRT (additive effect, certainty not rated). There was also high-certainty evidence for the effectiveness of nicotine patch, fast-acting NRT and bupropion. Less certain evidence of benefit was present for nortriptyline (moderate certainty), non-nicotine e-cigarettes and tapering of nicotine dose (both low certainty). There was moderate-certainty evidence that bupropion may slightly increase the frequency of SAEs, although there was also the possibility of no increased risk. There wa...
Source: Cochrane Database of Systematic Reviews - September 11, 2023 Category: General Medicine Authors: Nicola Lindson Annika Theodoulou Jos é M Ordóñez-Mena Thomas R Fanshawe Alex J Sutton Jonathan Livingstone-Banks Anisa Hajizadeh Sufen Zhu Paul Aveyard Suzanne C Freeman Sanjay Agrawal Jamie Hartmann-Boyce Source Type: research
Transcriptomics integrated with metabolomics reveals perfluorobutane sulfonate (PFBS) exposure effect during pregnancy and lactation on lipid metabolism in rat offspring
Chemosphere. 2023 Sep 9:140120. doi: 10.1016/j.chemosphere.2023.140120. Online ahead of print.ABSTRACTEmerging epidemiological evidence indicates potential associations between gestational perfluorobutane sulfonate (PFBS) exposure and adverse metabolic outcomes in offspring. However, the underlying mechanisms remain unclear. Our study aimed to investigate PFBS exposure effects during pregnancy and lactation on rat offspring lipid profiles and the possible underlying mechanisms. Although the biochemical index difference including total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL), low-density lipoprot...
Source: Chemosphere - September 11, 2023 Category: Chemistry Authors: Xi Meng Guoqi Yu Tingyu Luo Ruiyuan Zhang Jun Zhang Yongjie Liu Source Type: research
Genome-wide identification of transcriptional enhancers During human placental development and association with function, differentiation, and disease
Biol Reprod. 2023 Sep 11:ioad119. doi: 10.1093/biolre/ioad119. Online ahead of print.ABSTRACTThe placenta is a dynamic organ which must perform a remarkable variety of functions during its relatively short existence in order to support a developing fetus. These functions include nutrient delivery, gas exchange, waste removal, hormone production, and immune barrier functions. Proper placenta development and function is critical for healthy pregnancy outcomes, but the underlying genomic regulatory events that control this process remain largely unknown. We hypothesized that mapping sites of transcriptional enhancer activity ...
Source: Biology of Reproduction - September 11, 2023 Category: Reproduction Medicine Authors: David M Owen Minjung Kwon Xuan Huang Anusha Nagari Tulip Nandu W Lee Kraus Source Type: research
Role of the placenta in developmental programming: Observations from models using large animals
Anim Reprod Sci. 2023 Aug 30;257:107322. doi: 10.1016/j.anireprosci.2023.107322. Online ahead of print.ABSTRACTDevelopmental programming, which proposes that "insults" or "stressors" during intrauterine or postnatal development can have not only immediate but also long-term consequences for healthy and productivity, has emerged as a major biological principle, and based on studies in many animal species also seems to be a universal phenomenon. In eutherians, the placenta appears to be programmed during its development, which has consequences for fetal growth and development throughout pregnancy, and likewise has long-term ...
Source: Animal Reproduction Science - September 11, 2023 Category: Zoology Authors: L P Reynolds C R Dahlen A K Ward M S Crouse P P Borowicz B J Davila-Ruiz C Kanjanaruch K A Bochantin K J McLean K L McCarthy A C B Menezes W J S Diniz R A Cushman J S Caton Source Type: research
A wearable system to track vital signs communicated from the mother to the fetus
CONCLUSION: The study highlights the potential benefits of mobile systems in distributing processing for health systems, particularly in addressing cardiovascular problems during pregnancy. The creation of a mobile system for displaying cardiovascular data could significantly improve monitoring and early detection.PMID:37694324 | DOI:10.3233/THC-230587
Source: Technology and Health Care - September 11, 2023 Category: Medical Devices Authors: Sarah M Allabun Source Type: research
Characteristics of Premature Myocardial Infarction Among Women With Prior Adverse Pregnancy Outcomes
CONCLUSIONS: Among women with premature MIs, 39% had a history of an APO. Women with APO history presented sooner after pregnancy but had similar MI characteristics vs those without APOs. Pregnancy history may identify women who warrant early, aggressive cardiovascular disease prevention.PMID:37694271 | PMC:PMC10487279 | DOI:10.1016/j.jacadv.2023.100411
Source: Adv Data - September 11, 2023 Category: Epidemiology Authors: Malamo E Countouris Agnes Koczo Harmony R Reynolds Anais Hausvater Harnoor Mann Yisi Wang Danielle Sharbaugh Floyd W Thoma Suresh R Mulukutla Janet M Catov Source Type: research
Effects of exposure to PM < sub > 2.5 < /sub > during pregnancy on the multigenerational reproductive outcomes of male mouse offspring and the role of Sertoli cells
This study explored the effects of PM2.5 exposure during pregnancy on the spermatogenesis of three consecutive generations of male mouse offspring. We randomized pregnant C57BL/6 mice into the control group, the Quartz Fiber Membrane control group, and two experimental groups exposed to different concentrations of PM2.5 (4.8 and 43.2 mg/kg B.Wt.). Pregnant mice from experimental groups received intratracheal instillation of PM2.5 of different doses on a three-day basis until birth. F1 mature male offspring from PM2.5-exposed pregnant mice were mated with normal female C57BL/6 mice. Likewise, their F2 mature male followed t...
Source: Cell Research - September 11, 2023 Category: Cytology Authors: Jing Huang Hong Lu Jiwei Du Lianshuang Zhang Jialiu Wei Qifang Huang Shaowei Wu Xianqing Zhou Lihua Ren Source Type: research
Timing of umbilical cord occlusion, delayed vs early, in preterm babies: A randomized controlled trial (CODE-P Trial)
CONCLUSION: The primary and secondary outcomes of our study were not achieved. Therefore, more meta-analysis and trials are needed to evaluate the appropriate timing of cord clamping in preterm birth.PMID:37696147 | DOI:10.1016/j.ejogrb.2023.08.376
Source: Reproductive Biology - September 11, 2023 Category: Reproduction Medicine Authors: A Gregoraci M Carbonell A Linde M Goya N Maiz P Gabriel Y Villena S B érgamo D Beneitez I Montserrat M C C éspedes M Vargas F Castillo E Carreras Source Type: research
