Role of the placenta in developmental programming: Observations from models using large animals

Anim Reprod Sci. 2023 Aug 30;257:107322. doi: 10.1016/j.anireprosci.2023.107322. Online ahead of print.ABSTRACTDevelopmental programming, which proposes that "insults" or "stressors" during intrauterine or postnatal development can have not only immediate but also long-term consequences for healthy and productivity, has emerged as a major biological principle, and based on studies in many animal species also seems to be a universal phenomenon. In eutherians, the placenta appears to be programmed during its development, which has consequences for fetal growth and development throughout pregnancy, and likewise has long-term consequences for postnatal development, leading to programming of organ function of the offspring even into adulthood. This review summarizes our current understanding of the placenta's role in developmental programming, the mechanisms involved, and the challenges remaining.PMID:37696224 | DOI:10.1016/j.anireprosci.2023.107322

Source: Animal Reproduction Science - September 11, 2023 Category: Zoology Authors: L P Reynolds C R Dahlen A K Ward M S Crouse P P Borowicz B J Davila-Ruiz C Kanjanaruch K A Bochantin K J McLean K L McCarthy A C B Menezes W J S Diniz R A Cushman J S Caton Source Type: research