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Condition: Pregnancy
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Total 69693 results found since Jan 2013.
Beyond TORCH: A Narrative Review of the Impact of Antenatal and Perinatal Infections on the Risk of Disability
Neurosci Biobehav Rev. 2023 Sep 12:105390. doi: 10.1016/j.neubiorev.2023.105390. Online ahead of print.ABSTRACTInfections and inflammation during pregnancy or early life can alter child neurodevelopment and increase the risk for structural brain abnormalities and mental health disorders. There is strong evidence that TORCH infections (i.e., Treponema pallidum, Toxoplasma gondii, rubella virus, cytomegalovirus, herpes virus) alter fetal neurodevelopment across multiple developmental domains and contribute to motor and cognitive disabilities. However, the impact of a broader range of viral and bacterial infections on fetal d...
Source: Herpes - September 14, 2023 Category: Infectious Diseases Authors: Monica Devaraju Amanda Li Sandy Ha Miranda Li Megana Shivakumar Hanning Li Erika Phelps Nishiguchi Patrick G érardin Kristina Adams Waldorf Benjamin J S Al-Haddad Source Type: research
What Do We Know About Why Women Bleed and What Do We Not Know?
J Thromb Haemost. 2023 Sep 12:S1538-7836(23)00671-2. doi: 10.1016/j.jtha.2023.08.034. Online ahead of print.ABSTRACTWomen, or people with a uterus, are vulnerable to both normal and abnormal bleeding. During the reproductive years, the uterus is prepared physiologically to accept an embryo and support its growth and development during pregnancy, or in the absence of implantation of an embryo, recycle through the process of menstruation and accept an embryo a month or so later. If fertilization takes place and an embryo or embryos implant in the uterus, the fetal trophoblast, or outer cell layer of the embryo, invades and d...
Source: Thrombosis and Haemostasis - September 14, 2023 Category: Hematology Authors: Andra H James Paula D James Source Type: research
Care and Monitoring of Pregnant Patients With Left Ventricular Assist Devices
Obstet Gynecol. 2023 Sep 14. doi: 10.1097/AOG.0000000000005351. Online ahead of print.ABSTRACTCardiovascular disease is one of the leading causes of maternal mortality in the United States. Although still rare, pregnancy in patients with left ventricular assist devices (LVADs) is becoming more common. Typical indications for the use of LVADs in reproductive-aged females include ischemic cardiomyopathy, nonischemic (familial) dilated cardiomyopathy, peripartum cardiomyopathy, and some forms of myocarditis. An LVAD drains blood through a cannula placed into the apex of the left ventricle and then returns it to the proximal a...
Source: Obstetrics and Gynecology - September 14, 2023 Category: OBGYN Authors: Luis D Pacheco Antonio F Saad Scott D Lick Jose C Iturrizaga George R Saade Source Type: research
Utility of Weekly Laboratory Monitoring in the Expectant Management of Hypertensive Disorders of Pregnancy
Obstet Gynecol. 2023 Sep 14. doi: 10.1097/AOG.0000000000005372. Online ahead of print.ABSTRACTOur retrospective cohort study evaluates the diagnostic yield of weekly laboratory surveillance in outpatient management of hypertensive disorders of pregnancy (HDP) based on patient clinical status at the time of laboratory testing. The study included 459 patients and 1,082 laboratory episodes: 356 (32.9%) episodes were performed in the setting of concerning clinical findings and 726 (67.1%) when the patient was asymptomatic. Overall, the diagnostic yield for abnormal laboratory values (n=11) was 1.0% (95% CI 0.4-1.6%) of all ass...
Source: Obstetrics and Gynecology - September 14, 2023 Category: OBGYN Authors: John A Morgan Joseph R Biggio Jane K Martin Naiha Mussarat Shannon McCloskey Frank B Williams Source Type: research
Letrozole During Frozen Embryo Transfer in Women With Polycystic Ovarian Syndrome: A Randomized Controlled Trial
CONCLUSION: There was no difference in pregnancy outcomes between letrozole application compared with artificial cycle for endometrial preparation in women with PCOS who underwent FET. The risk of GDM was higher in the letrozole application group, and the singleton birth weight was lower in the artificial cycle group.CLINICAL TRIAL REGISTRATION: Chinese Clinical Trial Registry, ChiCTR1800014746.PMID:37708500 | DOI:10.1097/AOG.0000000000005367
Source: Obstetrics and Gynecology - September 14, 2023 Category: OBGYN Authors: Yuan Yuan Qiyuan Chang Yangxing Wen Jun Gao Sunxing Huang Yanwen Xu Canquan Zhou Qingyun Mai Source Type: research
Experiences and Communication Preferences in Pregnancy Care Among Patients With a Spanish Language Preference: A Qualitative Study
CONCLUSION: Our findings highlight the importance of relationship to overcome language discordance among patients with limited English proficiency during pregnancy care. These findings inform potential structural change and patient-clinician dyad interventions to better meet the communication needs of patients with limited English proficiency.PMID:37708499 | DOI:10.1097/AOG.0000000000005369
Source: Obstetrics and Gynecology - September 14, 2023 Category: OBGYN Authors: Kevin E Salinas Maria Bazan Luis Rivera Haylie Butler Elysia Larson Jeanne-Marie Guise Michele R Hacker Anjali J Kaimal Rose L Molina Source Type: research
Rosuvastatin effects on the HDL proteome in hyperlipidemic patients
Acta Pharm. 2023 Sep 14;73(3):363-384. doi: 10.2478/acph-2023-0034. Print 2023 Sep 1.ABSTRACTThe advancements in proteomics have provided a better understanding of the functionality of apolipoproteins and lipoprotein-associated proteins, with the HDL lipoprotein fraction being the most studied. The focus of this study was to evaluate the HDL proteome in dyslipidemic subjects without an established cardiovascular disease, as well as to test whether rosuvastatin treatment alters the HDL proteome. Patients with primary hypercholesterolemia or mixed dyslipidemia were assigned to 20 mg/day rosuvastatin and blood samples were dr...
Source: Acta Pharmaceutica - September 14, 2023 Category: Drugs & Pharmacology Authors: Ana Vavlukis Kristina Mladenovska Katarina Davalieva Marija Vavlukis Aleksandar Dimovski Source Type: research
Temporal trends and predictors of gestational exposure to organophosphate ester flame retardants and plasticizers
We examined biomarker concentrations, their variability during pregnancy, and temporal trends over the study period. In addition, we identified sociodemographic and pregnancy characteristics associated with biomarker concentrations. Analyses were conducted using both the within-subject pregnancy geometric means and biomarker concentrations measured at individual study visits.RESULTS: Five OPE biomarkers were detected in at least 60% of the study participants. Biomarkers were not strongly correlated with one another and intraclass correlation coefficients, measuring within-subject variability during pregnancy, ranged from 0...
Source: Environment International - September 14, 2023 Category: Environmental Health Authors: P A Bommarito A Friedman B M Welch D E Cantonwine M Ospina A M Calafat J D Meeker T F McElrath K K Ferguson Source Type: research
The role of a multidisciplinary team in managing variants of uncertain clinical significance in prenatal genetic diagnosis
CONCLUSION: In this study three out of nine VUS could be re-classified as likely pathogenic after clinical follow-up. In order to protect pregnant couples from the burden of uncertain results, the genetic professionals have to take the responsibility to limit the reporting of VUS. This can be done not only by automated filtering of data, by following professional guidelines and by building standardized decision flows, but also by discussing individual cases considering personal situations and the involved disease and by sharing professional experience and responsibility in a multidisciplinary prenatal team setting.PMID:377...
Source: European Journal of Medical Genetics - September 14, 2023 Category: Genetics & Stem Cells Authors: Karin E M Diderich Jasmijn E Klapwijk Vyne van der Schoot Myrthe van den Born Martina Wilke Marieke Joosten Kyra E Stuurman Lies H Hoefsloot Diane Van Opstal Hennie T Br üggenwirth Malgorzata I Srebniak Source Type: research
Timed intercourse for couples trying to conceive
CONCLUSIONS: The new evidence presented in this review update shows that timed intercourse using urine ovulation tests probably improves live birth and pregnancy rates (clinical or positive urine pregnancy tests but not yet confirmed by ultrasound) in women under 40, trying to conceive for less than 12 months, compared to intercourse without ovulation prediction. However, there are insufficient data to determine the effects of urine ovulation tests on adverse events, clinical pregnancy, time to pregnancy, and quality of life. Similarly, due to limited data, we are uncertain of the effect of FABM on pregnancy outcomes, adve...
Source: Cochrane Database of Systematic Reviews - September 14, 2023 Category: General Medicine Authors: Tatjana Gibbons Jane Reavey Ektoras X Georgiou Christian M Becker Source Type: research
Comparative effectiveness of therapeutic interventions in pregnancy and lactation-associated osteoporosis: a systematic review and meta-analysis
CONCLUSIONS: Due to high heterogeneity and lack of robust comparative data, no safe conclusions can be made regarding the optimal therapeutic intervention in women with PLO.PMID:37708365 | DOI:10.1210/clinem/dgad548
Source: The Journal of Clinical Endocrinology and Metabolism - September 14, 2023 Category: Endocrinology Authors: Panagiotis Anagnostis Kalliopi Lampropoulou-Adamidou Julia K Bosdou Georgios Trovas Petros Galanis Efstathios Chronopoulos Dimitrios G Goulis Symeon Tournis Source Type: research
Increased Circulating IL-32 is Associated with Placenta Macrophage-derived IL-32 and Gestational Diabetes Mellitus
CONCLUSIONS: Increased circulating IL-32 throughout pregnancy was closely associated with placenta macrophage-derived IL-32 expression and GDM. First trimester IL-32 level in peripheral blood may serve to predict the development of GDM.PMID:37708356 | DOI:10.1210/clinem/dgad531
Source: The Journal of Clinical Endocrinology and Metabolism - September 14, 2023 Category: Endocrinology Authors: Xinmei Huang Yue Li Xiaoxu Tong Yueyue Wu Rui Zhang Li Sheng Jiong Xu Zhiyan Yu Zaoping Chen Tiange Sun Fang Wang Qian Yang Zhangyan Li Cuijun Gao Ling Ma Heyuan Ding Shufei Zang Ni Yang Tie-Ning Zhang Jun Liu Source Type: research
Prevalence, risk factors, clinical and biochemical characteristics of Alemtuzumab-induced Graves' disease
CONCLUSION: GD is a very common complication of alemtuzumab treatment and is characterized by alternating hyper- and hypothyroidism. Both remission rates and the prevalence of TED were lower than those reported for conventional GD. Pregnancies were uncomplicated and GD was associated with a lower risk of subsequent MS activity.PMID:37708353 | DOI:10.1210/clinem/dgad540
Source: The Journal of Clinical Endocrinology and Metabolism - September 14, 2023 Category: Endocrinology Authors: Grethe Åstrøm Ueland Hans Olav Ueland Ann-Elin Meling Stokland Alok Bhan Anne Sch ønberg Stina T Sollid Dina Edvarda Morgas Trygve Holm øy Kari Lima Paal Methlie Kristian L øvås Øivind Torkildsen Eystein S Husebye Source Type: research
A 10-Year Observational Study on Twin Pregnancy: Role of Fetal Sex Pairing on Obstetric Outcome
Twin Res Hum Genet. 2023 Sep 14:1-7. doi: 10.1017/thg.2023.38. Online ahead of print.ABSTRACTFetal sex contributes to the determination of obstetric outcome, as pregnancies carrying male babies seem to have an increased risk of maternal-fetal complications. Most studies have been conducted on singleton pregnancies, whereas less evidence is available for twins. A 10-year retrospective observational study was conducted on a cohort of 1180 women with twin pregnancy delivered at a single tertiary hospital. Clinical data on maternal characteristics, and obstetric and neonatal outcomes were collected, and the analysis was perfor...
Source: Twin Research and Human Genetics - September 14, 2023 Category: Genetics & Stem Cells Authors: Silvia Vannuccini Sara Bolzonella Chiara Colucci Costanza Nicchi Noemi Strambi Mariarosaria Di Tommaso Source Type: research
Xenobiotic metabolites modify immune responses of the cervicovaginal epithelium: potential mechanisms underlying barrier disruption
CONCLUSIONS: Xenobiotic metabolites present in the cervicovaginal space during pregnancy modify immune responses, unveiling potential pathways through which environmental exposures may contribute to the pathogenesis of cervical remodelling preceding preterm birth. Future work identifying xenobiotic sources and routes of exposure offers the potential to modify environmental risks to improve pregnancy outcomes.PMID:37705143 | DOI:10.1111/1471-0528.17654
Source: BJOG : An International Journal of Obstetrics and Gynaecology - September 14, 2023 Category: OBGYN Authors: Kristin D Gerson Aaron Loder Zachary Landau Lauren Anton Source Type: research
