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Condition: Pregnancy
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Total 69693 results found since Jan 2013.
Abstract P310: Atuplex Formulated With Small Interfering RNA For Soluble Fms-like Tyrosine Kinase-1 (sFLT1) Selectively Silences Maternal And Placental sFLT1 In A Preeclamptic Rat Model Session Title: Pregnancy and Preeclampsia and Developmental Programming of Cardiovascular Disease
Preeclampsia is a pregnancy-related disorder characterized by hypertension and proteinuria, affecting about 5-8% of pregnancies. It is a major cause of fetal and maternal morbidity/mortality. The disease is most probably multifactorial and caused by several placental dysfunctions. As an important mediator, sFLT1 is induced in the placenta and in the serum of preeclamptic women, acting as a decoy receptor for placenta like growth factors (PLGF) and inducing an antiangiogenic balance. RNAi mediated gene specific silencing could represent a new therapeutic option in preeclampsia management. We tested sFLT1-specific small inte...
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Nadine Haase, Kristin Kraker, Ute Schaeper, Jens Endruschat, Dominik N Muller, Ralf Dechend Tags: Poster Abstract Presentations Source Type: research
Generation of transgenic pigs carrying siRNA vector directed against human tissue factor expression
ConclusionsThe AVR is currently the bottleneck in porcine‐to‐primate organ xenotransplantation. Controlling TF‐induced coagulation might provide protective effects for porcine xenografts. Thus, TF knockdown pigs could be critical in producing the ultimate multi‐transgenic pig as organ donor for human patients.
References[1] Toomey J, Kratzer K, Lasky N, Stanton J, Broze GJ. Targeted disruption of the murine tissue factor gene results in embryonic lethality. Blood. 1996; 88(5): 1583–1587.
Source: Xenotransplantation - April 19, 2014 Category: Transplant Surgery Authors: Hellen Ahrens, Björn Petersen, Doris Herrmann, Andrea Lucas‐Hahn, Petra Hassel, Maren Ziegler, Wilfried Kues, Heiner Niemann Tags: Program and Abstracts Source Type: research
Efficient siRNA transfer to knockdown a placenta specific lncRNA using RGD-modified nano-liposome: A new preeclampsia-like mouse model
Publication date: 30 July 2018 Source:International Journal of Pharmaceutics, Volume 546, Issues 1–2 Author(s): Qianwen Yu, Yue Qiu, Xuhui Wang, Jiajing Tang, Yayuan Liu, Ling Mei, Man Li, Ming Yang, Li Tang, Huile Gao, Zhirong Zhang, Wenming Xu, Qin He Preeclampsia is one of the most serious pregnancy complications. Many animal models have already been developed by researchers to study the pathogenesis and treatment of preeclampsia. However, most of these animal models were established by systemic administration or by surgery in the uterine cavity, which could lead to unwanted systemic toxicity or operative wounds and ...
Source: International Journal of Pharmaceutics - May 17, 2018 Category: Drugs & Pharmacology Source Type: research
MiR-133b regulates oxidative stress injury of trophoblasts in preeclampsia by mediating the JAK2/STAT3 signaling pathway
AbstractPreeclampsia (PE) is a pregnancy-related syndrome. Aberrant placental microRNAs (miRNAs) expression might associate with PE, including miR-133b. However, its role in the pathogenesis of preeclampsia remains elusive. Therefore, this study explored the role of miR-133b in oxidative stress injury of trophoblasts in preeclampsia (PE) by mediating the JAK2/STAT3 signaling pathway. Placental tissues were collected from PE patients to detect the expression of miR-133b and JAK2/STAT3. Then, in vitro experiments were performed on human extravillous trophoblast-derived HTR-8/SVneo cells, which were divided into Normal, hypox...
Source: Journal of Molecular Histology - October 8, 2021 Category: Laboratory Medicine Source Type: research
Interventions for Prevention of Intimate Partner Violence Against Women in Humanitarian Settings: A Protocol for a Systematic Review
The objective of the systematic review is to identify existing IPV prevention interventions, strategies and programs among refugee, internally displaced, or conflict-affected female in humanitarian settings; and to assess their effects. It will seek to answer the following questions:
What are the existing types of intervention for primary or secondary prevention of IPV against women in humanitarian settings?
What is the effect of various types of interventions on prevention or reduction of physical, sexual or emotional IPV in humanitarian settings?
How do various types of intervention related to IPV affect he...
Source: PLOS Currents Disasters - July 12, 2017 Category: International Medicine & Public Health Authors: Marjan Delkhosh Source Type: research
Application of Behavioral Theories to Disaster and Emergency Health Preparedness: A Systematic Review
CONCLUSIONS
Based on the articles archived and selected, behavioral theories and models are applied to disasters and emergencies preparedness more commonly in developed countries (USA and Europe). In Asia, where the annual number of disasters events and victims exceed those in other continents, only 3 studies applying behavioral theories and models to disasters and emergencies were identifies. This identified a need for additional research to target the use of behavioral change theories in the Asian countries that bear the brunt of disasters and their consequences. This does not, however, mean that these theories have not ...
Source: PLOS Currents Disasters - July 1, 2015 Category: Global & Universal Authors: Luche Tadesse Ejeta Source Type: research
Epidermal Growth Factor: Porcine Uterine Luminal Epithelial Cell Migratory Signal during the Peri-implantation Period of Pregnancy
Publication date: Available online 24 November 2015 Source:Molecular and Cellular Endocrinology Author(s): Wooyoung Jeong, Seoungo Jung, Fuller W. Bazer, Gwonhwa Song, Jinyoung Kim The majority of early conceptus mortality in pregnancy occurs during the peri-implantation period, suggesting that this period is important for conceptus viability and the establishment of pregnancy. Successful establishment of pregnancy in all mammalian species depends on the orchestrated molecular events that transpire at the conceptus-uterine interface during the peri-implantation period of pregnancy. This maternal-conceptus interactio...
Source: Molecular and Cellular Endocrinology - November 24, 2015 Category: Endocrinology Source Type: research
Mass Casualty Decontamination Guidance and Psychosocial Aspects of CBRN Incident Management: A Review and Synthesis
Introduction
The likelihood of incidents involving chemical, biological, radiological, and nuclear agents has increased in recent years, due to advances in technology, and the increased willingness of terrorists to use unconventional weapons (1,2,3). While such incidents are still relatively low probability, evidence suggests that if an incident of this type were to occur, it would have a high impact on society. CBRN agents are invisible, consequences of exposure are often unknown, and there is the potential for delayed effects from contamination (4,5,6); they therefore score highly in terms of so-called dread risk (define...
Source: PLOS Currents Disasters - August 27, 2016 Category: Global & Universal Authors: hollycarter Source Type: research
Developing Topic-specific Search Filters for PubMed with Click-through Data.
Conclusion: Based on PubMed click-through data, we successfully developed a high-performance method for generating topic-specific search filters that is significantly more efficient than existing manual methods. All data sets (topic-relevant and irrelevant document sets) used in this study and a demonstration system are publicly available at http://www.ncbi.nlm.nih.gov/CBBresearch/Lu/downloads/CQ_filter/
PMID: 23666447 [PubMed - as supplied by publisher]
Source: Methods of Information in Medicine - May 13, 2013 Category: Information Technology Authors: Li J, Lu Z Tags: Methods Inf Med Source Type: research
A Simple Question That Will Change Your Search for Love
Most dating advice focuses on the skills of seeking, not the skills of loving. Apps, events and websites offer endless opportunities for meeting, but as I describe in Deeper Dating: How to Drop The Games of Seduction and Discover the Power of Intimacy, until we learn how to choose healthy intimacy and nurture its tender new shoots, it's unlikely we'll find the love we seek. When we approach our search for love as an intimacy journey, not as a race against time or a search for a needle in a haystack, everything changes.
In my decades of seeking a relationship, I spent incalculable hours looking for love in places that lack...
Source: Healthy Living - The Huffington Post - December 5, 2014 Category: Consumer Health News Source Type: news
Mobile phone-based interventions for improving contraception use
CONCLUSIONS: This review demonstrates there is evidence to support the use of mobile phone-based interventions in improving the use of contraception, with moderate-certainty evidence. Interactive mobile phone interventions appear more effective than unidirectional methods. The cost-effectiveness, cost benefits, safety and long-term effects of these interventions remain unknown, as does the evidence of this approach to support contraception use among specific populations. Future research should investigate the effectiveness and safety of mobile phone-based interventions with better quality trials to help establish the effec...
Source: Cochrane Database of Systematic Reviews - July 17, 2023 Category: General Medicine Authors: Tanaraj Perinpanathan Shilpa Maiya Michelle Helena Hmmt van Velthoven Amy T Nguyen Caroline Free Chris Smith Source Type: research
In vivo oxygen, temperature and pH dynamics in the female reproductive tract and their importance in human conception: a systematic review
AbstractBACKGROUNDDespite advances in ART, implantation and pregnancy rates per embryo transfer still remain low. IVF laboratories strive to ensure that the process of handling gametesin vitro closely mimics thein vivo environment. However, there remains a lack of knowledge regarding thein vivo regulation and dynamic variation in biophysical parameters such as oxygen concentration, pH and temperature within the reproductive tract.OBJECTIVE AND RATIONALETo undertake a systematic review of the current understanding of the physico-chemical parameters of oxygen tension (pO2), pH and temperature within the female reproductive t...
Source: Human Reproduction Update - October 25, 2017 Category: OBGYN Source Type: research
Understanding Mental Health in the Context of Adolescent Pregnancy and HIV in Sub-Saharan Africa: A Systematic Review Identifying a Critical Evidence Gap
This study reported on depressive symptomology amongst 14 pregnant adolescents living with HIV in Kenya, identifying a prevalence of 92.9%. This included study did not meet the high methodological quality of this review. No studies were identified reporting on risk and protective factors for common mental disorder, and no studies were found identifying any specific interventions for common mental disorder for this group, either for prevention or for treatment. The limited data identified within this review provides no good quality evidence relating to the prevalence of common mental disorder among adolescents living with H...
Source: AIDS and Behavior - January 15, 2021 Category: Infectious Diseases Source Type: research
Natural cycle in vitro fertilisation (IVF) for subfertile couples.
CONCLUSIONS: Further evidence from well conducted large trials is awaited on natural cycle IVF treatment. Future trials should compare natural cycle IVF with standard IVF. Outcomes should include cumulative live birth and pregnancy rates, the number of treatment cycles necessary to reach live birth, treatment costs and adverse effects.
PMID: 23990351 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - August 30, 2013 Category: Journals (General) Authors: Allersma T, Farquhar C, Cantineau AE Tags: Cochrane Database Syst Rev Source Type: research
