Selenosis in a Woman With Systemic Lupus Erythematosus
This case report describes hypointensity in the cerebellum and midbrain in a 56-year-old woman with double vision and weakness and ptosis of eyelids. (Source: JAMA Neurology)
Source: JAMA Neurology - April 29, 2024 Category: Neurology Source Type: research
Modelling the Impact of NETosis During the Initial Stage of Systemic Lupus Erythematosus
Bull Math Biol. 2024 Apr 28;86(6):66. doi: 10.1007/s11538-024-01291-3.ABSTRACTThe development of autoimmune diseases often takes years before clinical symptoms become detectable. We propose a mathematical model for the immune response during the initial stage of Systemic Lupus Erythematosus which models the process of aberrant apoptosis and activation of macrophages and neutrophils. NETosis is a type of cell death characterised by the release of neutrophil extracellular traps, or NETs, containing material from the neutrophil's nucleus, in response to a pathogenic stimulus. This process is hypothesised to contribute to the ...
Source: Bulletin of Mathematical Biology - April 28, 2024 Category: Bioinformatics Authors: Vladimira Suvandjieva Ivanka Tsacheva Marlene Santos Georgios Kararigas Peter Rashkov Source Type: research
A novel dosing approach for rituximab in glomerular diseases based on a population pharmacokinetic analysis
CONCLUSION: In order to ensure reliable and comparable exposure of rituximab with respect to the full range of glomerular diseases, the dosing schedule should be adjusted for membranous nephropathy, focal-segmental glomerulosclerosis and lupus nephritis. This is largely, but not solely, due to the enhanced level of unselective proteinuria in these diseases.PMID:38678967 | DOI:10.1016/j.biopha.2024.116655 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 28, 2024 Category: Drugs & Pharmacology Authors: Jan Miroslav Hartinger Martin Šíma Zdenka Hru šková Alena Pilkov á Vojt ěch Krátký Romana Ry šavá Eva Jan čová Daniel Bobek Ji ří Douša Ivana Francov á Vladim ír Tesař Ond řej Slanař Source Type: research
Modelling the Impact of NETosis During the Initial Stage of Systemic Lupus Erythematosus
Bull Math Biol. 2024 Apr 28;86(6):66. doi: 10.1007/s11538-024-01291-3.ABSTRACTThe development of autoimmune diseases often takes years before clinical symptoms become detectable. We propose a mathematical model for the immune response during the initial stage of Systemic Lupus Erythematosus which models the process of aberrant apoptosis and activation of macrophages and neutrophils. NETosis is a type of cell death characterised by the release of neutrophil extracellular traps, or NETs, containing material from the neutrophil's nucleus, in response to a pathogenic stimulus. This process is hypothesised to contribute to the ...
Source: Bulletin of Mathematical Biology - April 28, 2024 Category: Bioinformatics Authors: Vladimira Suvandjieva Ivanka Tsacheva Marlene Santos Georgios Kararigas Peter Rashkov Source Type: research
A novel dosing approach for rituximab in glomerular diseases based on a population pharmacokinetic analysis
CONCLUSION: In order to ensure reliable and comparable exposure of rituximab with respect to the full range of glomerular diseases, the dosing schedule should be adjusted for membranous nephropathy, focal-segmental glomerulosclerosis and lupus nephritis. This is largely, but not solely, due to the enhanced level of unselective proteinuria in these diseases.PMID:38678967 | DOI:10.1016/j.biopha.2024.116655 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 28, 2024 Category: Drugs & Pharmacology Authors: Jan Miroslav Hartinger Martin Šíma Zdenka Hru šková Alena Pilkov á Vojt ěch Krátký Romana Ry šavá Eva Jan čová Daniel Bobek Ji ří Douša Ivana Francov á Vladim ír Tesař Ond řej Slanař Source Type: research
Modelling the Impact of NETosis During the Initial Stage of Systemic Lupus Erythematosus
Bull Math Biol. 2024 Apr 28;86(6):66. doi: 10.1007/s11538-024-01291-3.ABSTRACTThe development of autoimmune diseases often takes years before clinical symptoms become detectable. We propose a mathematical model for the immune response during the initial stage of Systemic Lupus Erythematosus which models the process of aberrant apoptosis and activation of macrophages and neutrophils. NETosis is a type of cell death characterised by the release of neutrophil extracellular traps, or NETs, containing material from the neutrophil's nucleus, in response to a pathogenic stimulus. This process is hypothesised to contribute to the ...
Source: Bulletin of Mathematical Biology - April 28, 2024 Category: Bioinformatics Authors: Vladimira Suvandjieva Ivanka Tsacheva Marlene Santos Georgios Kararigas Peter Rashkov Source Type: research
Modelling the Impact of NETosis During the Initial Stage of Systemic Lupus Erythematosus
Bull Math Biol. 2024 Apr 28;86(6):66. doi: 10.1007/s11538-024-01291-3.ABSTRACTThe development of autoimmune diseases often takes years before clinical symptoms become detectable. We propose a mathematical model for the immune response during the initial stage of Systemic Lupus Erythematosus which models the process of aberrant apoptosis and activation of macrophages and neutrophils. NETosis is a type of cell death characterised by the release of neutrophil extracellular traps, or NETs, containing material from the neutrophil's nucleus, in response to a pathogenic stimulus. This process is hypothesised to contribute to the ...
Source: Bulletin of Mathematical Biology - April 28, 2024 Category: Bioinformatics Authors: Vladimira Suvandjieva Ivanka Tsacheva Marlene Santos Georgios Kararigas Peter Rashkov Source Type: research
Modelling the Impact of NETosis During the Initial Stage of Systemic Lupus Erythematosus
Bull Math Biol. 2024 Apr 28;86(6):66. doi: 10.1007/s11538-024-01291-3.ABSTRACTThe development of autoimmune diseases often takes years before clinical symptoms become detectable. We propose a mathematical model for the immune response during the initial stage of Systemic Lupus Erythematosus which models the process of aberrant apoptosis and activation of macrophages and neutrophils. NETosis is a type of cell death characterised by the release of neutrophil extracellular traps, or NETs, containing material from the neutrophil's nucleus, in response to a pathogenic stimulus. This process is hypothesised to contribute to the ...
Source: Bulletin of Mathematical Biology - April 28, 2024 Category: Bioinformatics Authors: Vladimira Suvandjieva Ivanka Tsacheva Marlene Santos Georgios Kararigas Peter Rashkov Source Type: research
Effects of Cannabidiol, ∆9-Tetrahydrocannabinol, and WIN 55-212-22 on the Viability of Canine and Human Non-Hodgkin Lymphoma Cell Lines
Biomolecules. 2024 Apr 19;14(4):495. doi: 10.3390/biom14040495.ABSTRACTIn our previous study, we demonstrated the impact of overexpression of CB1 and CB2 cannabinoid receptors and the inhibitory effect of endocannabinoids (2-arachidonoylglycerol (2-AG) and Anandamide (AEA)) on canine (Canis lupus familiaris) and human (Homo sapiens) non-Hodgkin lymphoma (NHL) cell lines' viability compared to cells treated with a vehicle. The purpose of this study was to demonstrate the anti-cancer effects of the phytocannabinoids, cannabidiol (CBD) and ∆9-tetrahydrocannabinol (THC), and the synthetic cannabinoid WIN 55-212-22 (WIN) in c...
Source: Cancer Control - April 27, 2024 Category: Cancer & Oncology Authors: Saba Omer Suhrud Pathak Mahmoud Mansour Rishi Nadar Dylan Bowen Muralikrishnan Dhanasekaran Satyanarayana R Pondugula Dawn Boothe Source Type: research
B- and T-Lymphocyte Attenuator in Systemic Lupus Erythematosus Disease Pathogenesis
In this study, we evaluated the role of BTLA and HVEM expression in the pathogenesis of systemic lupus erythematosus (SLE), a multisystem autoimmune disease. Peripheral blood mononuclear cells from healthy volunteers (N = 7) were evaluated by mass cytometry by time-of-flight to establish baseline expression of BTLA and HVEM on human lymphocytes compared with patients with SLE during a self-reported flare (N = 5). High levels of BTLA protein were observed on B cells, CD4+, and CD8+ T cells, and plasmacytoid dendritic cells in healthy participants. HVEM protein levels were lower in patients with SLE compared with healthy par...
Source: Clinical Pharmacology and Therapeutics - April 27, 2024 Category: Drugs & Pharmacology Authors: Andrew C Vendel Lukasz Jaroszewski Matthew D Linnik Adam Godzik Source Type: research
B- and T-Lymphocyte Attenuator in Systemic Lupus Erythematosus Disease Pathogenesis
In this study, we evaluated the role of BTLA and HVEM expression in the pathogenesis of systemic lupus erythematosus (SLE), a multisystem autoimmune disease. Peripheral blood mononuclear cells from healthy volunteers (N = 7) were evaluated by mass cytometry by time-of-flight to establish baseline expression of BTLA and HVEM on human lymphocytes compared with patients with SLE during a self-reported flare (N = 5). High levels of BTLA protein were observed on B cells, CD4+, and CD8+ T cells, and plasmacytoid dendritic cells in healthy participants. HVEM protein levels were lower in patients with SLE compared with healthy par...
Source: Herpes - April 27, 2024 Category: Infectious Diseases Authors: Andrew C Vendel Lukasz Jaroszewski Matthew D Linnik Adam Godzik Source Type: research
B- and T-Lymphocyte Attenuator in Systemic Lupus Erythematosus Disease Pathogenesis
In this study, we evaluated the role of BTLA and HVEM expression in the pathogenesis of systemic lupus erythematosus (SLE), a multisystem autoimmune disease. Peripheral blood mononuclear cells from healthy volunteers (N = 7) were evaluated by mass cytometry by time-of-flight to establish baseline expression of BTLA and HVEM on human lymphocytes compared with patients with SLE during a self-reported flare (N = 5). High levels of BTLA protein were observed on B cells, CD4+, and CD8+ T cells, and plasmacytoid dendritic cells in healthy participants. HVEM protein levels were lower in patients with SLE compared with healthy par...
Source: Clinical Pharmacology and Therapeutics - April 27, 2024 Category: Drugs & Pharmacology Authors: Andrew C Vendel Lukasz Jaroszewski Matthew D Linnik Adam Godzik Source Type: research
B- and T-Lymphocyte Attenuator in Systemic Lupus Erythematosus Disease Pathogenesis
In this study, we evaluated the role of BTLA and HVEM expression in the pathogenesis of systemic lupus erythematosus (SLE), a multisystem autoimmune disease. Peripheral blood mononuclear cells from healthy volunteers (N = 7) were evaluated by mass cytometry by time-of-flight to establish baseline expression of BTLA and HVEM on human lymphocytes compared with patients with SLE during a self-reported flare (N = 5). High levels of BTLA protein were observed on B cells, CD4+, and CD8+ T cells, and plasmacytoid dendritic cells in healthy participants. HVEM protein levels were lower in patients with SLE compared with healthy par...
Source: Herpes - April 27, 2024 Category: Infectious Diseases Authors: Andrew C Vendel Lukasz Jaroszewski Matthew D Linnik Adam Godzik Source Type: research
PCR-positive meningococcal CSF infection without pleocytosis but high IL-6 and IL-8
ConclusionsWe present a rare case of meningococcal infection of the CSF in a SLE patient without further CSF abnormalities. We discuss the involvement of early antibiotic treatment and the role of the patient ’s immune status in the normal CSF findings of this case. Moreover, this case demonstrates the importance of early antibiotic therapy in bacterial meningitis for the clinical outcome. (Source: Infection)
Source: Infection - April 27, 2024 Category: Infectious Diseases Source Type: research
