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Cathepsin K deficiency prevented stress-related thrombosis in a mouse FeCl < sub > 3 < /sub > model
CONCLUSIONS: CTSK appeared to contribute to stress-related thrombosis in mice subjected to FeCl3 stress, possibly via the modulation of vascular inflammation, oxidative production and apoptosis, suggesting that CTSK could be an effective therapeutic target for CPS-related thrombotic events in patients with CCVDs.PMID:38703204 | DOI:10.1007/s00018-024-05240-0 (Source: Cellular and Molecular Life Sciences : CMLS)
Source: Cellular and Molecular Life Sciences : CMLS - May 4, 2024 Category: Cytology Authors: Xueying Jin Xueling Yue Zhe Huang Xiangkun Meng Shengnan Xu Yuna Wu Ying Wan Aiko Inoue Megumi Narisawa Lina Hu Guo-Ping Shi Hiroyuki Umegaki Toyoaki Murohara Yanna Lei Masafumi Kuzuya Xian Wu Cheng Source Type: research

SIRT1 maintains bone homeostasis by regulating osteoblast glycolysis through GOT1
In conclusion, our study suggested that Sirt1 played a crucial role in regulating osteoblast metabolism to maintain bone homeostasis through its deacetylase activity on GOT1. These findings provided a novel insight into the potential targeting of osteoblast metabolism for the treatment of bone-related diseases.PMID:38700532 | DOI:10.1007/s00018-023-05043-9 (Source: Cellular and Molecular Life Sciences : CMLS)
Source: Cellular and Molecular Life Sciences : CMLS - May 3, 2024 Category: Cytology Authors: Xinxin Jin Xulei Sun Xiao Ma Zixuan Qin Xin Gao Xiaomin Kang Huixia Li Hongzhi Sun Source Type: research

Rv2231c, a unique histidinol phosphate aminotransferase from Mycobacterium tuberculosis, supports virulence by inhibiting host-directed defense
Cell Mol Life Sci. 2024 May 2;81(1):203. doi: 10.1007/s00018-024-05200-8.ABSTRACTNitrogen metabolism of M. tuberculosis is critical for its survival in infected host cells. M. tuberculosis has evolved sophisticated strategies to switch between de novo synthesis and uptake of various amino acids from host cells for metabolic demands. Pyridoxal phosphate-dependent histidinol phosphate aminotransferase-HspAT enzyme is critically required for histidine biosynthesis. HspAT is involved in metabolic synthesis of histidine, phenylalanine, tyrosine, tryptophan, and novobiocin. We showed that M. tuberculosis Rv2231c is a conserved e...
Source: Cellular and Molecular Life Sciences : CMLS - May 2, 2024 Category: Cytology Authors: Sheeba Zarin Mohd Shariq Nilisha Rastogi Yashika Ahuja P Manjunath Anwar Alam Seyed Ehtesham Hasnain Nasreen Zafar Ehtesham Source Type: research

Update in genetic and epigenetic causes of hypertension
Cell Mol Life Sci. 2024 Apr 30;81(1):201. doi: 10.1007/s00018-024-05220-4.ABSTRACTHypertension is a heritable disease that affects one-fourth of the population and accounts for about 50% of cardiovascular deaths. The genetic basis of hypertension is multifaceted, involving both monogenic and most commonly complex polygenic forms. With the advent of the human genome project, genome-wide association studies (GWAS) have identified a plethora of loci linked to hypertension by examining common genetic variations. It's notable, however, that the majority of these genetic variants do not affect the protein-coding sequences, posin...
Source: Cellular and Molecular Life Sciences : CMLS - May 1, 2024 Category: Cytology Authors: Arya Mani Source Type: research

Functional implications of NHR-210 enrichment in C. elegans cephalic sheath glia: insights into metabolic and mitochondrial disruptions in Parkinson's disease models
In conclusion, the deficiency of the nuclear hormone receptor nhr-210 in alpha-synuclein expressing strain of C. elegans, results in altered mitochondrial function, coupled with alterations in vital metabolite levels. These findings underline the functional and physiological importance of nhr-210 enrichment in CEPsh glia.PMID:38691171 | DOI:10.1007/s00018-024-05179-2 (Source: Cellular and Molecular Life Sciences : CMLS)
Source: Cellular and Molecular Life Sciences : CMLS - May 1, 2024 Category: Cytology Authors: Rohil Hameed Anam Naseer Ankit Saxena Mahmood Akbar Pranoy Toppo Arunabh Sarkar Sanjeev K Shukla Aamir Nazir Source Type: research

Tyrosine kinase 2 modulates splenic B cells through type I IFN and TLR7 signaling
In conclusion, there is a crosstalk between TYK2 and TLR7 mediated by an IFN-I feedback loop, which contributes to the establishment of MZ B cells and to B cell proliferation and differentiation.PMID:38683377 | PMC:PMC11058799 | DOI:10.1007/s00018-024-05234-y (Source: Cellular and Molecular Life Sciences : CMLS)
Source: Cellular and Molecular Life Sciences : CMLS - April 29, 2024 Category: Cytology Authors: Irene Bodega-Mayor Pablo Delgado-Wicke Alejandro Arrabal Est íbaliz Alegría-Carrasco Ana Nicolao-G ómez Marta Ja én-Castaño Cristina Espadas Ana Dopazo Enrique Mart ín-Gayo Mar ía Luisa Gaspar Bel én de Andrés Elena Fern ández-Ruiz Source Type: research

Delineating the heterogeneity of senescence-induced-functional alterations in hepatocytes
CONCLUSION: In our study, we demonstrated that each senescence inducer activates a unique combination of senescence markers in PMH. Doxorubicin demonstrated the highest efficacy in inducing senescence, followed by cisplatin and H2O2, with no impact on apoptosis. Each inducer prompted DNA damage response and mitochondrial dysfunction, independent of MAPK/AKT.PMID:38684535 | PMC:PMC11058795 | DOI:10.1007/s00018-024-05230-2 (Source: Cellular and Molecular Life Sciences : CMLS)
Source: Cellular and Molecular Life Sciences : CMLS - April 29, 2024 Category: Cytology Authors: Pavitra Kumar Mohsin Hassan Frank Tacke Cornelius Engelmann Source Type: research

Tyrosine kinase 2 modulates splenic B cells through type I IFN and TLR7 signaling
In conclusion, there is a crosstalk between TYK2 and TLR7 mediated by an IFN-I feedback loop, which contributes to the establishment of MZ B cells and to B cell proliferation and differentiation.PMID:38683377 | DOI:10.1007/s00018-024-05234-y (Source: Cellular and Molecular Life Sciences : CMLS)
Source: Cellular and Molecular Life Sciences : CMLS - April 29, 2024 Category: Cytology Authors: Irene Bodega-Mayor Pablo Delgado-Wicke Alejandro Arrabal Est íbaliz Alegría-Carrasco Ana Nicolao-G ómez Marta Ja én-Castaño Cristina Espadas Ana Dopazo Enrique Mart ín-Gayo Mar ía Luisa Gaspar Bel én de Andrés Elena Fern ández-Ruiz Source Type: research

Delineating the heterogeneity of senescence-induced-functional alterations in hepatocytes
CONCLUSION: In our study, we demonstrated that each senescence inducer activates a unique combination of senescence markers in PMH. Doxorubicin demonstrated the highest efficacy in inducing senescence, followed by cisplatin and H2O2, with no impact on apoptosis. Each inducer prompted DNA damage response and mitochondrial dysfunction, independent of MAPK/AKT.PMID:38684535 | DOI:10.1007/s00018-024-05230-2 (Source: Cellular and Molecular Life Sciences : CMLS)
Source: Cellular and Molecular Life Sciences : CMLS - April 29, 2024 Category: Cytology Authors: Pavitra Kumar Mohsin Hassan Frank Tacke Cornelius Engelmann Source Type: research

Molecular mechanisms and therapeutic strategies for neuromuscular diseases
Cell Mol Life Sci. 2024 Apr 28;81(1):198. doi: 10.1007/s00018-024-05229-9.ABSTRACTNeuromuscular diseases encompass a heterogeneous array of disorders characterized by varying onset ages, clinical presentations, severity, and progression. While these conditions can stem from acquired or inherited causes, this review specifically focuses on disorders arising from genetic abnormalities, excluding metabolic conditions. The pathogenic defect may primarily affect the anterior horn cells, the axonal or myelin component of peripheral nerves, the neuromuscular junction, or skeletal and/or cardiac muscles. While inherited neuromuscu...
Source: Cellular and Molecular Life Sciences : CMLS - April 28, 2024 Category: Cytology Authors: Zambon Alberto Andrea Falzone Yuri Matteo Bolino Alessandra Previtali Stefano Carlo Source Type: research