Cellular and Molecular Life Sciences : CMLS This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Mitochondrial impairment, decreased sirtuin activity and protein acetylation in dorsal root ganglia in Friedreich Ataxia models
Cell Mol Life Sci. 2023 Dec 21;81(1):12. doi: 10.1007/s00018-023-05064-4.ABSTRACTFriedreich ataxia (FA) is a rare, recessive neuro-cardiodegenerative disease caused by deficiency of the mitochondrial protein frataxin. Mitochondrial dysfunction, a reduction in the activity of iron-sulfur enzymes, iron accumulation, and increased oxidative stress have been described. Dorsal root ganglion (DRG) sensory neurons are among the cellular types most affected in the early stages of this disease. However, its effect on mitochondrial function remains to be elucidated. In the present study, we found that in primary cultures of DRG neur...
Source: Cellular and Molecular Life Sciences : CMLS - December 21, 2023 Category: Cytology Authors: Arabela Sanz-Alc ázar Elena Britti Fabien Delaspre Marta Medina-Carbonero Maria Pazos-Gil Jordi Tamarit Joaquim Ros Elisa Cabiscol Source Type: research

Metabolic bone disorders and the promise of marine osteoactive compounds
Cell Mol Life Sci. 2023 Dec 20;81(1):11. doi: 10.1007/s00018-023-05033-x.ABSTRACTMetabolic bone disorders and associated fragility fractures are major causes of disability and mortality worldwide and place an important financial burden on the global health systems. These disorders result from an unbalance between bone anabolic and resorptive processes and are characterized by different pathophysiological mechanisms. Drugs are available to treat bone metabolic pathologies, but they are either poorly effective or associated with undesired side effects that limit their use. The molecular mechanism underlying the most common m...
Source: Cellular and Molecular Life Sciences : CMLS - December 20, 2023 Category: Cytology Authors: Alessio Carletti Paulo Jorge Gavaia Maria Leonor Cancela Vincent Laiz é Source Type: research

miR-181a plays the tumor-suppressor role in chronic myeloid leukemia CD34 < sup > + < /sup > cells partially via SERPINE1
Cell Mol Life Sci. 2023 Dec 16;81(1):10. doi: 10.1007/s00018-023-05036-8.ABSTRACTThe formation of the BCR-ABL fusion gene drives human chronic myeloid leukemia (CML). The last 2 decades have witnessed that specific tyrosine kinase inhibitors (TKIs, e.g., imatinib mesylate, IM) against ABL1 improve disease treatment, although some patients still suffer from relapse and TKI resistance. Therefore, a better understanding of the molecular pathology of CML is still urgently needed. miR-181a-5p (miR-181a) acts as a tumor suppressor in CML; however, the molecular mechanism of miR-181a in CML stem/progenitor cells remains elusive. ...
Source: Cellular and Molecular Life Sciences : CMLS - December 16, 2023 Category: Cytology Authors: Xiuyan Zhang Wenjuan Ma Wen Xue Yu Wang Pan Chen Quanxue Li Yuan-Yuan Li Xiaohui Hu Yun Zhao Haixia Zhou Source Type: research

Biophysical control of plasticity and patterning in regeneration and cancer
Cell Mol Life Sci. 2023 Dec 15;81(1):9. doi: 10.1007/s00018-023-05054-6.ABSTRACTCells and tissues display a remarkable range of plasticity and tissue-patterning activities that are emergent of complex signaling dynamics within their microenvironments. These properties, which when operating normally guide embryogenesis and regeneration, become highly disordered in diseases such as cancer. While morphogens and other molecular factors help determine the shapes of tissues and their patterned cellular organization, the parallel contributions of biophysical control mechanisms must be considered to accurately predict and model im...
Source: Cellular and Molecular Life Sciences : CMLS - December 15, 2023 Category: Cytology Authors: Nirosha J Murugan Solsa Cariba Sawith Abeygunawardena Nicolas Rouleau Samantha L Payne Source Type: research

Inhibition of the membrane repair protein annexin-A2 prevents tumor invasion and metastasis
Cell Mol Life Sci. 2023 Dec 13;81(1):7. doi: 10.1007/s00018-023-05049-3.ABSTRACTCancer cells are exposed to major compressive and shearing forces during invasion and metastasis, leading to extensive plasma membrane damage. To survive this mechanical stress, they need to repair membrane injury efficiently. Targeting the membrane repair machinery is thus potentially a new way to prevent invasion and metastasis. We show here that annexin-A2 (ANXA2) is required for membrane repair in invasive breast and pancreatic cancer cells. Mechanistically, we show by fluorescence and electron microscopy that cells fail to reseal shear-str...
Source: Cellular and Molecular Life Sciences : CMLS - December 13, 2023 Category: Cytology Authors: C Gounou L Rouyer G Siegfried E Hart é F Bouvet L d'Agata E Darbo M Lefeuvre M A Derieppe L Bouton M M élane D Chapeau J Martineau V Prouzet-Mauleon S Tan W Souleyreau F Saltel F Argoul A M Khatib A R Brisson R Iggo A Bouter Source Type: research

Different glycosylation profiles of cystatin F alter the cytotoxic potential of natural killer cells
Cell Mol Life Sci. 2023 Dec 13;81(1):8. doi: 10.1007/s00018-023-05041-x.ABSTRACTCystatin F, a cysteine peptidase inhibitor, is a potent modulator of NK cytotoxicity. By inhibiting granule-mediated cytotoxicity pathway, cystatin F induces formation of non-functional NK cell stage, called split-anergy. We show that N-glycosylation determines the localization and cellular function of cystatin F. Cystatin F mostly exhibited high-mannose glycosylation in U-937 cells, both high-mannose and complex glycosylation in NK-92 and primary NKs, and predominantly complex glycosylation in super-charged NKs. Manipulating N-glycosylation wi...
Source: Cellular and Molecular Life Sciences : CMLS - December 13, 2023 Category: Cytology Authors: Emanuela Senjor Martina Pirro Urban Švajger Mateja Prunk Jerica Saboti č Anahid Jewett Paul J Hensbergen Milica Peri šić Nanut Janko Kos Source Type: research

SHP2 clinical phenotype, cancer, or RASopathies, can be predicted by mutant conformational propensities
Cell Mol Life Sci. 2023 Dec 12;81(1):5. doi: 10.1007/s00018-023-05052-8.ABSTRACTSHP2 phosphatase promotes full activation of the RTK-dependent Ras/MAPK pathway. Its mutations can drive cancer and RASopathies, a group of neurodevelopmental disorders (NDDs). Here we ask how same residue mutations in SHP2 can lead to both cancer and NDD phenotypes, and whether we can predict what the outcome will be. We collected and analyzed mutation data from the literature and cancer databases and performed molecular dynamics simulations of SHP2 mutants. We show that both cancer and Noonan syndrome (NS, a RASopathy) mutations favor catalys...
Source: Cellular and Molecular Life Sciences : CMLS - December 12, 2023 Category: Cytology Authors: Yonglan Liu Wengang Zhang Hyunbum Jang Ruth Nussinov Source Type: research