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The antiviral response triggered by the cGAS/STING pathway is subverted by the foot-and-mouth disease virus proteases
Cell Mol Life Sci. 2024 Mar 20;81(1):148. doi: 10.1007/s00018-024-05190-7.ABSTRACTPropagation of viruses requires interaction with host factors in infected cells and repression of innate immune responses triggered by the host viral sensors. Cytosolic DNA sensing pathway of cyclic GMP-AMP synthase (cGAS) and stimulator of interferon genes (STING) is a major component of the antiviral response to DNA viruses, also known to play a relevant role in response to infection by RNA viruses, including foot-and-mouth disease virus (FMDV). Here, we provide supporting evidence of cGAS degradation in swine cells during FMDV infection an...
Source: Cellular and Molecular Life Sciences : CMLS - March 21, 2024 Category: Cytology Authors: Miguel Ángel Sanz Miryam Polo Miguel Rodr íguez-Pulido Ranjitha Huildore Bommanna Margarita S áiz Source Type: research

The exon junction complex is required for DMD gene splicing fidelity and myogenic differentiation
Cell Mol Life Sci. 2024 Mar 21;81(1):150. doi: 10.1007/s00018-024-05188-1.ABSTRACTDeposition of the exon junction complex (EJC) upstream of exon-exon junctions helps maintain transcriptome integrity by preventing spurious re-splicing events in already spliced mRNAs. Here we investigate the importance of EJC for the correct splicing of the 2.2-megabase-long human DMD pre-mRNA, which encodes dystrophin, an essential protein involved in cytoskeletal organization and cell signaling. Using targeted RNA-seq, we show that knock-down of the eIF4A3 and Y14 core components of EJC in a human muscle cell line causes an accumulation of...
Source: Cellular and Molecular Life Sciences : CMLS - March 21, 2024 Category: Cytology Authors: Dylan Da Cunha Julie Miro Charles Van Goethem C écile Notarnicola G érald Hugon Gilles Carnac Mireille Coss ée Michel Koenig Sylvie Tuffery-Giraud Source Type: research

cGAS-STING pathway mediates activation of dendritic cell sensing of immunogenic tumors
Cell Mol Life Sci. 2024 Mar 21;81(1):149. doi: 10.1007/s00018-024-05191-6.ABSTRACTType I interferons (IFN-I) play pivotal roles in tumor therapy for three decades, underscoring the critical importance of maintaining the integrity of the IFN-1 signaling pathway in radiotherapy, chemotherapy, targeted therapy, and immunotherapy. However, the specific mechanism by which IFN-I contributes to these therapies, particularly in terms of activating dendritic cells (DCs), remains unclear. Based on recent studies, aberrant DNA in the cytoplasm activates the cyclic GMP-AMP synthase (cGAS)- stimulator of interferon genes (STING) signal...
Source: Cellular and Molecular Life Sciences : CMLS - March 21, 2024 Category: Cytology Authors: Guohao Li Xiangqian Zhao Zuda Zheng Hucheng Zhang Yundi Wu Yangkun Shen Qi Chen Source Type: research

Neonatal GABAergic transmission primes vestibular gating of output for adult spatial navigation
Cell Mol Life Sci. 2024 Mar 19;81(1):147. doi: 10.1007/s00018-024-05170-x.ABSTRACTGABAergic interneurons are poised with the capacity to shape circuit output via inhibitory gating. How early in the development of medial vestibular nucleus (MVN) are GABAergic neurons recruited for feedforward shaping of outputs to higher centers for spatial navigation? The role of early GABAergic transmission in assembling vestibular circuits for spatial navigation was explored by neonatal perturbation. Immunohistochemistry and confocal imaging were utilized to reveal the expression of parvalbumin (PV)-expressing MVN neurons and their perin...
Source: Cellular and Molecular Life Sciences : CMLS - March 19, 2024 Category: Cytology Authors: Qiufen Jiang Kenneth Lap-Kei Wu Xiao-Qian Hu Man-Him Cheung Wenqiang Chen Chun-Wai Ma Daisy Kwok-Yan Shum Ying-Shing Chan Source Type: research

Single-cell analysis of age-related changes in leukocytes of diabetic mouse hindpaws
Cell Mol Life Sci. 2024 Mar 19;81(1):146. doi: 10.1007/s00018-024-05128-z.ABSTRACTComplications associated with Type 1 and Type 2 diabetes, such as diabetic peripheral neuropathy and diabetic foot ulcers, are a growing health-care concern. In addition, this concern increases as diabetic patients age due to their increased susceptibility to complications. To address this growing problem, it is important to understand fluctuations in physiology which lead to pathological changes associated with the metabolic disturbances of diabetes. Our study explores dysregulation of immune cell populations in the hindpaws of healthy and d...
Source: Cellular and Molecular Life Sciences : CMLS - March 19, 2024 Category: Cytology Authors: James M Nichols Hoang Vu Pham Eric F Lee Rajasekaran Mahalingam Andrew J Shepherd Source Type: research

Molecular engineering of a spheroid-penetrating phage nanovector for photodynamic treatment of colon cancer cells
Cell Mol Life Sci. 2024 Mar 17;81(1):144. doi: 10.1007/s00018-024-05174-7.ABSTRACTPhotodynamic therapy (PDT) represents an emerging strategy to treat various malignancies, including colorectal cancer (CC), the third most common cancer type. This work presents an engineered M13 phage retargeted towards CC cells through pentavalent display of a disulfide-constrained peptide nonamer. The M13CC nanovector was conjugated with the photosensitizer Rose Bengal (RB), and the photodynamic anticancer effects of the resulting M13CC-RB bioconjugate were investigated on CC cells. We show that upon irradiation M13CC-RB is able to impair ...
Source: Cellular and Molecular Life Sciences : CMLS - March 18, 2024 Category: Cytology Authors: Eleonora Turrini Luca Ulfo Paolo Emidio Costantini Roberto Saporetti Matteo Di Giosia Michela Nigro Annapaola Petrosino Lucia Pappagallo Alena Kaltenbrunner Andrea Cantelli Valentina Pellicioni Elena Catanzaro Carmela Fimognari Matteo Calvaresi Alberto Da Source Type: research

USP28 promotes tumorigenesis and cisplatin resistance by deubiquitinating MAST1 protein in cancer cells
Cell Mol Life Sci. 2024 Mar 18;81(1):145. doi: 10.1007/s00018-024-05187-2.ABSTRACTCisplatin is a chemotherapy drug that causes a plethora of DNA lesions and inhibits DNA transcription and replication, resulting in the induction of apoptosis in cancer cells. However, over time, patients develop resistance to cisplatin due to repeated treatment and thus the treatment efficacy is limited. Therefore, identifying an alternative therapeutic strategy combining cisplatin treatment along with targeting factors that drive cisplatin resistance is needed. CRISPR/Cas9 system-based genome-wide screening for the deubiquitinating enzyme (...
Source: Cellular and Molecular Life Sciences : CMLS - March 18, 2024 Category: Cytology Authors: Janardhan Keshav Karapurkar Jencia Carminha Colaco Bharathi Suresh Apoorvi Tyagi Sang Hyeon Woo Won-Jun Jo Nare Ko Vijai Singh Seok-Ho Hong Seung Jun Oh Kye-Seong Kim Suresh Ramakrishna Source Type: research

YAP1-CPNE3 positive feedback pathway promotes gastric cancer cell progression
This study elucidated the pivotal involvement of an aberrantly activated CPNE3/YAP1 positive feedback loop in the malignant progression of GC, thereby uncovering novel prognostic factors and therapeutic targets in GC.PMID:38493426 | DOI:10.1007/s00018-024-05178-3 (Source: Cellular and Molecular Life Sciences : CMLS)
Source: Cellular and Molecular Life Sciences : CMLS - March 17, 2024 Category: Cytology Authors: Xuan Li Hongguang Zhong Qianqian Shi Ruiwen Ruan Chunye Huang Qin Wen Shaocheng Zeng Yang Xia Qinru Zeng Jianping Xiong Shanshan Wang Jun Chen Wan Lei Jun Deng Source Type: research

Lamin B1 curtails early human papillomavirus infection by safeguarding nuclear compartmentalization and autophagic capacity
Cell Mol Life Sci. 2024 Mar 14;81(1):141. doi: 10.1007/s00018-024-05194-3.ABSTRACTHuman papillomavirus (HPV) infection is a primary cause of cervical and head-and-neck cancers. The HPV genome enters the nucleus during mitosis when the nuclear envelope disassembles. Given that lamins maintain nuclear integrity during interphase, we asked to what extent their loss would affect early HPV infection. To address this question, we infected human cervical cancer cells and keratinocytes lacking the major lamins with a HPV16 pseudovirus (HP-PsV) encoding an EGFP reporter. We found that a sustained reduction or complete loss of lamin...
Source: Cellular and Molecular Life Sciences : CMLS - March 15, 2024 Category: Cytology Authors: Freya Molenberghs Marlies Verschuuren Lauran Vandeweyer Sarah Peeters Johannes J Bogers Claudina Perez Novo Wim Vanden Berghe Hans De Reu Nathalie Cools Mario Schelhaas Winnok H De Vos Source Type: research