Cellular and Molecular Life Sciences : CMLS This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

De novo GRIN variants in M3 helix associated with neurological disorders control channel gating of NMDA receptor
In this study, we report the functional consequences of 48 de novo missense variants in GRIN1, GRIN2A, and GRIN2B that alter residues in the M3 transmembrane helix. These de novo variants were identified in children with neurological and neuropsychiatric disorders including epilepsy, developmental delay, intellectual disability, hypotonia and attention deficit hyperactivity disorder. All 48 variants in M3 for which comprehensive testing was completed produce a gain-of-function (28/48) compared to loss-of-function (9/48); 11 variants had an indeterminant phenotype. This supports the idea that a key structural feature of the...
Source: Cellular and Molecular Life Sciences : CMLS - March 28, 2024 Category: Cytology Authors: Yuchen Xu Rui Song Riley E Perszyk Wenjuan Chen Sukhan Kim Kristen L Park James P Allen Kelsey A Nocilla Jing Zhang Wenshu XiangWei Anel Tankovic Ellington D McDaniels Rehan Sheikh Ruth K Mizu Manish M Karamchandani Chun Hu Hirofumi Kusumoto Joseph Pecha Source Type: research

Aberrant activated Notch1 promotes prostate enlargement driven by androgen signaling via disrupting mitochondrial function in mouse
In conclusion, our study revealed that over-activated Notch1 signaling induces prostatic enlargement by increasing androgen receptor sensitivity, disrupting cellular mitochondrial metabolism, increasing ROS, and a higher number of progenitor cells, all of which can be effectively rescued by NAC treatment.PMID:38538986 | DOI:10.1007/s00018-024-05143-0 (Source: Cellular and Molecular Life Sciences : CMLS)
Source: Cellular and Molecular Life Sciences : CMLS - March 28, 2024 Category: Cytology Authors: Jin-Wen Kang Jia-Peng He Ying-Nan Liu Yu Zhang Shan-Shan Song Qi-Xin Xu Shu-Wen Wei Lei Lu Xiang-Qi Meng Lin Xu Bin Guo Ren-Wei Su Source Type: research

Discovery and verification of mmu_Circ_26986/hsa_Circ_0072463 as a potential biomarker and intervention target for sepsis-associated acute kidney injury
Cell Mol Life Sci. 2024 Mar 28;81(1):154. doi: 10.1007/s00018-023-05079-x.ABSTRACTApproximately 60% of septic patients developed acute kidney injury (AKI). The mortality rate of septic AKI (SA-AKI) is two to three times higher than that of septic without AKI (SA-non-AKI). The actual functions and mechanisms of CircRNAs in the pathophysiology of SA-AKI remain incompletely understood. Herein, we observed that the mmu_Circ_26986 could be induced by lipopolysaccharide (LPS) and cecum ligation and puncture (CLP) in BUMPT cell line and C57BL/6 mouse kidney, respectively. Functionally, mmu_Circ_26986 suppressed BUMPT cell apoptos...
Source: Cellular and Molecular Life Sciences : CMLS - March 28, 2024 Category: Cytology Authors: Xujun Peng Huiling Li Wenbo Zhang Dongshan Zhang Source Type: research

Macrophage re-programming by JAK inhibitors relies on MAFB
Cell Mol Life Sci. 2024 Mar 25;81(1):152. doi: 10.1007/s00018-024-05196-1.ABSTRACTMonocyte-derived macrophages play a key pathogenic role in inflammatory diseases. In the case of rheumatoid arthritis (RA), the presence of specific synovial tissue-infiltrating macrophage subsets is associated with either active disease or inflammation resolution. JAK inhibitors (JAKi) are the first targeted synthetic disease-modifying antirheumatic drugs (tsDMARD) approved for treatment of RA with comparable efficacy to biologics. However, the effects of JAKi on macrophage specification and differentiation are currently unknown. We have ana...
Source: Cellular and Molecular Life Sciences : CMLS - March 26, 2024 Category: Cytology Authors: Baltasar L ópez-Navarro Miriam Sim ón-Fuentes Israel R íos Mar ía Teresa Schiaffino Alicia Sanchez M ónica Torres-Torresano Alicia Nieto-Valle Isabel Castrej ón Amaya Puig-Kr öger Source Type: research

Obesogenic diet in pregnancy disrupts placental iron handling and ferroptosis and stress signalling in association with fetal growth alterations
Cell Mol Life Sci. 2024 Mar 25;81(1):151. doi: 10.1007/s00018-024-05192-5.ABSTRACTObesity and gestational diabetes (GDM) impact fetal growth during pregnancy. Iron is an essential micronutrient needed for energy-intense feto-placental development, but if mis-handled can lead to oxidative stress and ferroptosis (iron-dependent cell death). In a mouse model showing maternal obesity and glucose intolerance, we investigated the association of materno-fetal iron handling and placental ferroptosis, oxidative damage and stress signalling activation with fetal growth. Female mice were fed a standard chow or high fat, high sugar (H...
Source: Cellular and Molecular Life Sciences : CMLS - March 25, 2024 Category: Cytology Authors: Jonas Zaugg Jorge Lopez-Tello Barbara Musial Owen R Vaughan Abigail L Fowden Christiane Albrecht Amanda N Sferruzzi-Perri Source Type: research

The antiviral response triggered by the cGAS/STING pathway is subverted by the foot-and-mouth disease virus proteases
Cell Mol Life Sci. 2024 Mar 20;81(1):148. doi: 10.1007/s00018-024-05190-7.ABSTRACTPropagation of viruses requires interaction with host factors in infected cells and repression of innate immune responses triggered by the host viral sensors. Cytosolic DNA sensing pathway of cyclic GMP-AMP synthase (cGAS) and stimulator of interferon genes (STING) is a major component of the antiviral response to DNA viruses, also known to play a relevant role in response to infection by RNA viruses, including foot-and-mouth disease virus (FMDV). Here, we provide supporting evidence of cGAS degradation in swine cells during FMDV infection an...
Source: Cellular and Molecular Life Sciences : CMLS - March 21, 2024 Category: Cytology Authors: Miguel Ángel Sanz Miryam Polo Miguel Rodr íguez-Pulido Ranjitha Huildore Bommanna Margarita S áiz Source Type: research

The exon junction complex is required for DMD gene splicing fidelity and myogenic differentiation
Cell Mol Life Sci. 2024 Mar 21;81(1):150. doi: 10.1007/s00018-024-05188-1.ABSTRACTDeposition of the exon junction complex (EJC) upstream of exon-exon junctions helps maintain transcriptome integrity by preventing spurious re-splicing events in already spliced mRNAs. Here we investigate the importance of EJC for the correct splicing of the 2.2-megabase-long human DMD pre-mRNA, which encodes dystrophin, an essential protein involved in cytoskeletal organization and cell signaling. Using targeted RNA-seq, we show that knock-down of the eIF4A3 and Y14 core components of EJC in a human muscle cell line causes an accumulation of...
Source: Cellular and Molecular Life Sciences : CMLS - March 21, 2024 Category: Cytology Authors: Dylan Da Cunha Julie Miro Charles Van Goethem C écile Notarnicola G érald Hugon Gilles Carnac Mireille Coss ée Michel Koenig Sylvie Tuffery-Giraud Source Type: research

cGAS-STING pathway mediates activation of dendritic cell sensing of immunogenic tumors
Cell Mol Life Sci. 2024 Mar 21;81(1):149. doi: 10.1007/s00018-024-05191-6.ABSTRACTType I interferons (IFN-I) play pivotal roles in tumor therapy for three decades, underscoring the critical importance of maintaining the integrity of the IFN-1 signaling pathway in radiotherapy, chemotherapy, targeted therapy, and immunotherapy. However, the specific mechanism by which IFN-I contributes to these therapies, particularly in terms of activating dendritic cells (DCs), remains unclear. Based on recent studies, aberrant DNA in the cytoplasm activates the cyclic GMP-AMP synthase (cGAS)- stimulator of interferon genes (STING) signal...
Source: Cellular and Molecular Life Sciences : CMLS - March 21, 2024 Category: Cytology Authors: Guohao Li Xiangqian Zhao Zuda Zheng Hucheng Zhang Yundi Wu Yangkun Shen Qi Chen Source Type: research