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Neutrophil extracellular traps mediate cardiomyocyte ferroptosis via the Hippo-Yap pathway to exacerbate doxorubicin-induced cardiotoxicity
This study confirmed the presence of NETs in DIC in vivo. Furthermore, we demonstrated that depleting neutrophils effectively reduced the occurrence of doxorubicin-induced ferroptosis and myocardial injury in DIC. Additionally, our findings showed the pivotal role of high mobility group box 1 (HMGB1) as a critical molecule implicated in DIC and emphasized its involvement in the modulation of ferroptosis subsequent to NETs inhibition. Mechanistically, we obtained preliminary evidence suggesting that doxorubicin-induced NETs could modulate yes-associated protein (YAP) activity by releasing HMGB1, which subsequently bound to ...
Source: Cellular and Molecular Life Sciences : CMLS - March 8, 2024 Category: Cytology Authors: Peng Zhao You Li Xiangli Xu Haobo Yang Xintong Li Shuai Fu Zihong Guo Jianing Zhang Hairu Li Jiawei Tian Source Type: research

LncRNA LUESCC promotes esophageal squamous cell carcinoma by targeting the miR-6785-5p/NRSN2 axis
Cell Mol Life Sci. 2024 Mar 8;81(1):121. doi: 10.1007/s00018-024-05172-9.ABSTRACTEsophageal squamous cell carcinoma (ESCC) is one of the most prevalent gastrointestinal malignancies with high mortality worldwide. Emerging evidence indicates that long noncoding RNAs (lncRNAs) are involved in human cancers, including ESCC. However, the detailed mechanisms of lncRNAs in the regulation of ESCC progression remain incompletely understood. LUESCC was upregulated in ESCC tissues compared with adjacent normal tissues, which was associated with gender, deep invasion, lymph node metastasis, and poor prognosis of ESCC patients. LUESCC...
Source: Cellular and Molecular Life Sciences : CMLS - March 8, 2024 Category: Cytology Authors: Song-Tao Xue Shi-Qiang Cao Jian-Cheng Ding Wen-Juan Li Guo-Sheng Hu Jian-Cong Zheng Xiao Lin Chun Chen Wen Liu Bin Zheng Source Type: research

PRMT5-mediated homologous recombination repair is essential to maintain genomic integrity of neural progenitor cells
Cell Mol Life Sci. 2024 Mar 8;81(1):123. doi: 10.1007/s00018-024-05154-x.ABSTRACTMaintaining genomic stability is a prerequisite for proliferating NPCs to ensure genetic fidelity. Though histone arginine methylation has been shown to play important roles in safeguarding genomic stability, the underlying mechanism during brain development is not fully understood. Protein arginine N-methyltransferase 5 (PRMT5) is a type II protein arginine methyltransferase that plays a role in transcriptional regulation. Here, we identify PRMT5 as a key regulator of DNA repair in response to double-strand breaks (DSBs) during NPC proliferat...
Source: Cellular and Molecular Life Sciences : CMLS - March 8, 2024 Category: Cytology Authors: Ya-Jun Wang Jian-Bo Cao Jing Yang Tong Liu Hua-Li Yu Zi-Xuan He Shi-Lai Bao Xiao-Xiao He Xiao-Juan Zhu Source Type: research

The role of fatty acid metabolism in acute lung injury: a special focus on immunometabolism
Cell Mol Life Sci. 2024 Mar 8;81(1):120. doi: 10.1007/s00018-024-05131-4.ABSTRACTReputable evidence from multiple studies suggests that excessive and uncontrolled inflammation plays an indispensable role in mediating, amplifying, and protracting acute lung injury (ALI). Traditionally, immunity and energy metabolism are regarded as separate functions regulated by distinct mechanisms, but recently, more and more evidence show that immunity and energy metabolism exhibit a strong interaction which has given rise to an emerging field of immunometabolism. Mammalian lungs are organs with active fatty acid metabolism, however, dur...
Source: Cellular and Molecular Life Sciences : CMLS - March 8, 2024 Category: Cytology Authors: Xiao Lu Guorui Li Yi Liu Guoqing Luo Song Ding Tianyu Zhang Ning Li Qing Geng Source Type: research

Disrupting PIAS3-mediated SUMOylation of MLK3 ameliorates poststroke neuronal damage and deficits in cognitive and sensorimotor behaviors
Cell Mol Life Sci. 2024 Mar 8;81(1):119. doi: 10.1007/s00018-024-05166-7.ABSTRACTActivated small ubiquitin-like modifiers (SUMOs) have been implicated in neuropathological processes following ischemic stroke. However, the target proteins of SUMOylation and their contribution to neuronal injury remain to be elucidated. MLK3 (mixed-lineage kinase 3), a member of the mitogen-activated protein kinase kinase kinase (MAPKKK) family, is a critical regulator of neuronal lesions following cerebral ischemia. Here, we found that SUMOylation of MLK3 increases in both global and focal ischemic rodent models and primary neuronal models ...
Source: Cellular and Molecular Life Sciences : CMLS - March 8, 2024 Category: Cytology Authors: Yu Jiang Lulu Hu Baixue Wang Bingge Zhang Mengwen Shao Li Meng Yan Xu Rourou Chen Meng Li Caiping Du Source Type: research

Tektin bundle interacting protein, TEKTIP1, functions to stabilize the tektin bundle and axoneme in mouse sperm flagella
In this study, we generated Tektip1-knockout (Tektip1-/-) mice and showed that they were male subfertile primarily due to reduced sperm motility. A high percentage of sperm from Tektip1-/- mice showed moderately disorganized axoneme structures and abnormal flagellar waveforms. TEKTIP1 predominately interacted with TEKT3 among tektins. Loss of TEKTIP1 partially disturbed the organization of tektin bundle by mainly affecting the native status of TEKT3 and its interaction with other tektins. Collectively, our study reveals the physiological role and potential molecular mechanism of TEKTIP1 in axonemal structure and sperm moti...
Source: Cellular and Molecular Life Sciences : CMLS - March 6, 2024 Category: Cytology Authors: Xin-Yan Geng Hui-Juan Jin Lan Xia Bin-Bin Wang Su-Ren Chen Source Type: research

The genome of Haberlea rhodopensis provides insights into the mechanisms for tolerance to multiple extreme environments
Cell Mol Life Sci. 2024 Mar 5;81(1):117. doi: 10.1007/s00018-024-05140-3.ABSTRACTHaberlea rhodopensis, a resurrection species, is the only plant known to be able to survive multiple extreme environments, including desiccation, freezing temperatures, and long-term darkness. However, the molecular mechanisms underlying tolerance to these stresses are poorly studied. Here, we present a high-quality genome of Haberlea and found that ~ 23.55% of the 44,306 genes are orphan. Comparative genomics analysis identified 89 significantly expanded gene families, of which 25 were specific to Haberlea. Moreover, we demonstrated that Habe...
Source: Cellular and Molecular Life Sciences : CMLS - March 5, 2024 Category: Cytology Authors: Saurabh Gupta Veselin Petrov Vanika Garg Bernd Mueller-Roeber Alisdair R Fernie Zoran Nikoloski Tsanko Gechev Source Type: research