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MDSC-derived S100A8/9 contributes to lupus pathogenesis by promoting TLR7-mediated activation of macrophages and dendritic cells
Cell Mol Life Sci. 2024 Mar 1;81(1):110. doi: 10.1007/s00018-024-05155-w.ABSTRACTToll-like receptors (TLRs), especially TLR7, play an important role in systemic lupus erythematosus (SLE) pathogenesis. However, the regulatory mechanism underlying the abnormal activation of TLR pathways in patients with SLE has not been elucidated. Notably, accumulating evidence indicates that myeloid-derived suppressor cells (MDSCs) are important regulators of inflammation and autoimmune diseases. Compared with healthy control subjects, patients with SLE have a greater proportion of MDSCs among peripheral blood mononuclear cells (PBMCs); ho...
Source: Cellular and Molecular Life Sciences : CMLS - March 1, 2024 Category: Cytology Authors: Yonghong Yang Xin Zhang Lina Jing Yucai Xiao Yangzhe Gao Yuxin Hu Shujiao Jia Guangxi Zhou Huabao Xiong Guanjun Dong Source Type: research

FAM76B regulates PI3K/Akt/NF- κB-mediated M1 macrophage polarization by influencing the stability of PIK3CD mRNA
Cell Mol Life Sci. 2024 Feb 29;81(1):107. doi: 10.1007/s00018-024-05133-2.ABSTRACTMacrophage polarization is closely related to inflammation development, yet how macrophages are polarized remains unclear. In our study, the number of M1 macrophages was markedly increased in Fam76b knockout U937 cells vs. wild-type U937 cells, and FAM76B expression was decreased in M1 macrophages induced from different sources of macrophages. Moreover, Fam76b knockout enhanced the mRNA and protein levels of M1 macrophage-associated marker genes. These results suggest that FAM76B inhibits M1 macrophage polarization. We then further explored t...
Source: Cellular and Molecular Life Sciences : CMLS - February 29, 2024 Category: Cytology Authors: Juan Wang Xinyue Zhao Qizhi Wang Xiaojing Zheng Dilihumaer Simayi Junli Zhao Peiyan Yang Qinwen Mao Haibin Xia Source Type: research

Spem2, a novel testis-enriched gene, is required for spermiogenesis and fertilization in mice
Cell Mol Life Sci. 2024 Feb 29;81(1):108. doi: 10.1007/s00018-024-05147-w.ABSTRACTSpermiogenesis is considered to be crucial for the production of haploid spermatozoa with normal morphology, structure and function, but the mechanisms underlying this process remain largely unclear. Here, we demonstrate that SPEM family member 2 (Spem2), as a novel testis-enriched gene, is essential for spermiogenesis and male fertility. Spem2 is predominantly expressed in the haploid male germ cells and is highly conserved across mammals. Mice deficient for Spem2 develop male infertility associated with spermiogenesis impairment. Specifical...
Source: Cellular and Molecular Life Sciences : CMLS - February 29, 2024 Category: Cytology Authors: Chaojie Li Chunling Shen Wenfeng Xiong Haoyang Ge Yan Shen Jun Chi Hongxin Zhang Lingyun Tang Shunyuan Lu Jinjin Wang Jian Fei Zhugang Wang Source Type: research

Targeting the NF- κB pathway as a potential regulator of immune checkpoints in cancer immunotherapy
Cell Mol Life Sci. 2024 Feb 29;81(1):106. doi: 10.1007/s00018-023-05098-8.ABSTRACTAdvances in cancer immunotherapy over the last decade have led to the development of several agents that affect immune checkpoints. Inhibitory receptors expressed on T cells that negatively regulate the immune response include cytotoxic T‑lymphocyte antigen 4 (CTLA4) and programmed cell death protein 1 (PD1), which have been studied more than similar receptors. Inhibition of these proteins and other immune checkpoints can stimulate the immune system to attack cancer cells, and prevent the tumor from escaping the immune response. However, th...
Source: Cellular and Molecular Life Sciences : CMLS - February 28, 2024 Category: Cytology Authors: Nasim Ebrahimi Al-Hasnawi Rasool Riyadh Abdulwahid Atena Mansouri Nasrin Karimi Rashid Jafardoust Bostani Sheida Beiranvand Samaneh Adelian Roya Khorram Reza Vafadar Michael R Hamblin Amir Reza Aref Source Type: research

BOP1 contributes to the activation of autophagy in polycystic ovary syndrome via nucleolar stress response
In this study, we aimed to investigate whether Block of Proliferation 1 (BOP1) is involved in the onset of autophagy activation of granulosa cells in PCOS. Firstly, we found that BOP1 expression was significantly down-regulated in the ovaries of PCOS mice, which was associated with the development of PCOS. Next, local injection of lentiviral vectors in the ovary for the overexpression of BOP1 significantly alleviated the phenotypes of elevated androgens, disturbed estrous cycle, and abnormal follicular development in PCOS mice. Subsequently, we found that knockdown of BOP1 activated autophagy of granulosa cells in the in v...
Source: Cellular and Molecular Life Sciences : CMLS - February 27, 2024 Category: Cytology Authors: Rui Ji Zhimo Zhang Zhe Yang Xin Chen Tailang Yin Jing Yang Source Type: research

The impact of VPS35 D620N mutation on alternative autophagy and its reversal by estrogen in Parkinson's disease
In conclusion, alternative autophagy might be important for maintaining neuronal homeostasis and may be associated with the neuroprotective effect of estrogen in PD with VPS35 D620N.PMID:38409392 | PMC:PMC10896810 | DOI:10.1007/s00018-024-05123-4 (Source: Cellular and Molecular Life Sciences : CMLS)
Source: Cellular and Molecular Life Sciences : CMLS - February 27, 2024 Category: Cytology Authors: Tomotaka Shiraishi Keiko Bono Hiromi Hiraki Yoko Manome Hisayoshi Oka Yasuyuki Iguchi Hirotaka James Okano Source Type: research

Pathological mutations reveal the key role of the cytosolic iRhom2 N-terminus for phosphorylation-independent 14-3-3 interaction and ADAM17 binding, stability, and activity
Cell Mol Life Sci. 2024 Feb 27;81(1):102. doi: 10.1007/s00018-024-05132-3.ABSTRACTThe protease ADAM17 plays an important role in inflammation and cancer and is regulated by iRhom2. Mutations in the cytosolic N-terminus of human iRhom2 cause tylosis with oesophageal cancer (TOC). In mice, partial deletion of the N-terminus results in a curly hair phenotype (cub). These pathological consequences are consistent with our findings that iRhom2 is highly expressed in keratinocytes and in oesophageal cancer. Cub and TOC are associated with hyperactivation of ADAM17-dependent EGFR signalling. However, the underlying molecular mecha...
Source: Cellular and Molecular Life Sciences : CMLS - February 27, 2024 Category: Cytology Authors: Katharina Bl äsius Lena Ludwig Sarah Knapp Charlotte Fla ßhove Friederike Sonnabend Diandra Keller Nikola Tacken Xintong Gao Selcan Kahveci-T ürköz Caroline Grannemann Aaron Babendreyer Colin Adrain Sebastian Huth Jens Malte Baron Andreas Ludwig Stefa Source Type: research

MicroRNA-9 promotes axon regeneration of mauthner-cell in zebrafish via her6/ calcium activity pathway
Cell Mol Life Sci. 2024 Feb 27;81(1):104. doi: 10.1007/s00018-024-05117-2.ABSTRACTMicroRNA (miRNA), functioning as a post-transcriptional regulatory element, plays a significant role in numerous regulatory mechanisms and serves as a crucial intrinsic factor influencing axon regeneration. Prior investigations have elucidated the involvement of miRNA-9 in various processes, however, its specific contribution to axon regeneration in the central nervous system (CNS) remains uncertain. Hence, the zebrafish Mauthner axon regeneration model was employed to manipulate the expression of miRNA-9 in single cells, revealing that upreg...
Source: Cellular and Molecular Life Sciences : CMLS - February 27, 2024 Category: Cytology Authors: Yueru Shen Xinghan Chen Zheng Song Huaitong Yao Along Han Yawen Zhang Yuan Cai Bing Hu Source Type: research

Ketamine's rapid and sustained antidepressant effects are driven by distinct mechanisms
Cell Mol Life Sci. 2024 Feb 27;81(1):105. doi: 10.1007/s00018-024-05121-6.ABSTRACTAdministration of multiple subanesthetic doses of ketamine increases the duration of antidepressant effects relative to a single ketamine dose, but the mechanisms mediating this sustained effect are unclear. Here, we demonstrate that ketamine's rapid and sustained effects on affective behavior are mediated by separate and temporally distinct mechanisms. The rapid effects of a single dose of ketamine result from increased activity of immature neurons in the hippocampal dentate gyrus without an increase in neurogenesis. Treatment with six doses...
Source: Cellular and Molecular Life Sciences : CMLS - February 27, 2024 Category: Cytology Authors: Radhika Rawat Elif Tunc-Ozcan Sara Dunlop Yung-Hsu Tsai Fangze Li Ryan Bertossi Chian-Yu Peng John A Kessler Source Type: research

The impact of VPS35 D620N mutation on alternative autophagy and its reversal by estrogen in Parkinson's disease
In conclusion, alternative autophagy might be important for maintaining neuronal homeostasis and may be associated with the neuroprotective effect of estrogen in PD with VPS35 D620N.PMID:38409392 | DOI:10.1007/s00018-024-05123-4 (Source: Cellular and Molecular Life Sciences : CMLS)
Source: Cellular and Molecular Life Sciences : CMLS - February 27, 2024 Category: Cytology Authors: Tomotaka Shiraishi Keiko Bono Hiromi Hiraki Yoko Manome Hisayoshi Oka Yasuyuki Iguchi Hirotaka James Okano Source Type: research