Cellular and Molecular Life Sciences : CMLS This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

JOSD2 mediates isoprenaline-induced heart failure by deubiquitinating CaMKII δ in cardiomyocytes
In conclusion, our study highlights the role of JOSD2 in mediating ISO-induced cardiac remodeling through the regulation of CaMKIIδ ubiquitination, and suggests its potential as a therapeutic target for combating the disease. Please check and confirm that the authors and their respective affiliations have been correctly identified and amend if necessary. All have been checked.PMID:38195959 | DOI:10.1007/s00018-023-05037-7 (Source: Cellular and Molecular Life Sciences : CMLS)
Source: Cellular and Molecular Life Sciences : CMLS - January 10, 2024 Category: Cytology Authors: Jiachen Xu Shiqi Liang Qinyan Wang Qingsong Zheng Mengyang Wang Jinfu Qian Tianxiang Yu Shuaijie Lou Wu Luo Hao Zhou Guang Liang Source Type: research

Calcium-sensing receptor and NF- κB pathways in TN breast cancer contribute to cancer-induced cardiomyocyte damage via activating neutrophil extracellular traps formation
Cell Mol Life Sci. 2024 Jan 10;81(1):19. doi: 10.1007/s00018-023-05051-9.ABSTRACTCardiovascular disorders are commonly prevalent in cancer patients, yet the mechanistic link between them remains poorly understood. Because neutrophil extracellular traps (NETs) have implications not just in cardiovascular diseases (CVD), but also in breast cancer (BC), it was hypothesized to contribute to CVD in the context of oncogenesis. We established a mouse model using nude mice to simulate liver metastasis of triple-negative BC (TNBC) through the injection of MDA-MB-231 cells. Multiple imaging and analysis techniques were employed to a...
Source: Cellular and Molecular Life Sciences : CMLS - January 10, 2024 Category: Cytology Authors: Jingya Zeng Yangyang Cheng Wanlin Xie Xin Lin Chenglong Ding Huimin Xu Baohong Cui Yixin Chen Song Gao Siwen Zhang Kaiyue Liu Yue Lu Jialing Zhou Zhongxiang Shi Yihua Sun Source Type: research

Delineating the mechanism of fragility at BCL6 breakpoint region associated with translocations in diffuse large B cell lymphoma
Cell Mol Life Sci. 2024 Jan 10;81(1):21. doi: 10.1007/s00018-023-05042-w.ABSTRACTBCL6 translocation is one of the most common chromosomal translocations in cancer and results in its enhanced expression in germinal center B cells. It involves the fusion of BCL6 with any of its twenty-six Ig and non-Ig translocation partners associated with diffuse large B cell lymphoma (DLBCL). Despite being discovered long back, the mechanism of BCL6 fragility is largely unknown. Analysis of the translocation breakpoints in 5' UTR of BCL6 reveals the clustering of most of the breakpoints around a region termed Cluster II. In silico analysi...
Source: Cellular and Molecular Life Sciences : CMLS - January 10, 2024 Category: Cytology Authors: Vidya Gopalakrishnan Urbi Roy Shikha Srivastava Khyati M Kariya Shivangi Sharma Saniya M Javedakar Bibha Choudhary Sathees C Raghavan Source Type: research

IGF2BP3-mediated enhanced stability of MYLK represses MSC adipogenesis and alleviates obesity and insulin resistance in HFD mice
In this study, we investigated the impact of IGF2BP3, a prominent m6A reader, on MSC adipogenesis. Our findings revealed a decrease in IGF2BP3 expression during the natural adipogenic differentiation of MSCs. Furthermore, IGF2BP3 was found to repress MSC adipogenesis by augmenting the levels of MYLK, a calcium/calmodulin-dependent kinase. Mechanistically, IGF2BP3 interacted with MYLK mRNA in an m6A-dependent manner, extending its half-life and subsequently inhibiting the phosphorylation of the ERK1/2 pathway, thereby impeding the adipogenic differentiation of MSCs. Additionally, we successfully achieved the overexpression ...
Source: Cellular and Molecular Life Sciences : CMLS - January 10, 2024 Category: Cytology Authors: Xiuji Huang Wuhui He Shuai Fan Hui Li Guiwen Ye Source Type: research

Loss of TDP-43 mediates severe neurotoxicity by suppressing PJA1 gene transcription in the monkey brain
In this study, we report that TDP-43 knockdown at the similar effectiveness, induces more damage to neuronal cells in the monkey brain than rodent mouse. Importantly, the loss of TDP-43 suppresses the E3 ubiquitin ligase PJA1 expression in the monkey brain at transcriptional level, but yields an opposite upregulation of PJA1 in the mouse brain. This distinct effect is due to the species-dependent binding of nuclear TDP-43 to the unique promoter sequences of the PJA1 genes. Further analyses reveal that the reduction of PJA1 accelerates neurotoxicity, whereas overexpressing PJA1 diminishes neuronal cell death by the TDP-43 k...
Source: Cellular and Molecular Life Sciences : CMLS - January 9, 2024 Category: Cytology Authors: Longhong Zhu Fuyu Deng Dazhang Bai Junqi Hou Qingqing Jia Chen Zhang Kaili Ou Shihua Li Xiao-Jiang Li Peng Yin Source Type: research

Versatile and automated workflow for the analysis of oligodendroglial calcium signals
We describe a new analytical pipeline containing two free, open source and cross-platform software programs, Occam and post-prOccam, that enable the fully automated analysis of one- and two-photon Ca2+ imaging datasets from oligodendroglia obtained by either ex vivo or in vivo Ca2+ imaging techniques. Easily configurable, our software solution is optimized to obtain unbiased results from large datasets acquired with different imaging techniques. Compared to other recent software, our solution proved to be fast, low memory demanding and faithful in the analysis of oligodendroglial Ca2+ signals in all tested imaging conditio...
Source: Cellular and Molecular Life Sciences : CMLS - January 9, 2024 Category: Cytology Authors: Dorien A Maas Blandine Manot-Saillet Philippe Bun Chlo é Habermacher Corinne Poilbout Filippo Rusconi Maria Cecilia Angulo Source Type: research

GR/Ahi1 regulates WDR68-DYRK1A binding and mediates cognitive impairment in prenatally stressed offspring
Cell Mol Life Sci. 2024 Jan 10;81(1):20. doi: 10.1007/s00018-023-05075-1.ABSTRACTAccumulating research shows that prenatal exposure to maternal stress increases the risk of behavioral and mental health problems for offspring later in life. However, how prenatal stress affects offspring behavior remains unknown. Here, we found that prenatal stress (PNS) leads to reduced Ahi1, decreased synaptic plasticity and cognitive impairment in offspring. Mechanistically, Ahi1 and GR stabilize each other, inhibit GR nuclear translocation, promote Ahi1 and WDR68 binding, and inhibit DYRK1A and WDR68 binding. When Ahi1 deletion or prenat...
Source: Cellular and Molecular Life Sciences : CMLS - January 9, 2024 Category: Cytology Authors: Bin Wei Haixia Shi Xi Yu Yajun Shi Hongtao Zeng Yan Zhao Zejun Zhao Yueyang Song Miao Sun Bin Wang Source Type: research

Benzomorphan and non-benzomorphan agonists differentially alter sigma-1 receptor quaternary structure, as does types of cellular stress
In this study we utilize cellular and an in-vivo model to study changes in quaternary structure of S1R upon activation. We incubated cells with cellular stressors (H2O2 and thapsigargin) or exogenous ligands, then quantified monomeric and oligomeric forms. We observed that benzomorphan-based S1R agonists induce monomerization of S1R and decrease oligomerization, which was confirmed in the liver tissue of mice injected with (+)-Pentazocine. Antagonists block this effect but do not induce any changes when used alone. Oxidative stress (H2O2) increases the monomeric/oligomeric S1R ratio whereas ER calcium depletion (thapsigarg...
Source: Cellular and Molecular Life Sciences : CMLS - January 8, 2024 Category: Cytology Authors: Simon Couly Yuko Yasui Semnyonga Foncham Ioannis Grammatikakis Ashish Lal Lei Shi Tsung-Ping Su Source Type: research

TRIOBP modulates β-catenin signaling by regulation of miR-29b in idiopathic pulmonary fibrosis
Cell Mol Life Sci. 2023 Dec 29;81(1):13. doi: 10.1007/s00018-023-05080-4.ABSTRACTIdiopathic pulmonary fibrosis (IPF) is a fatal and devastating lung disease of unknown etiology, described as the result of multiple cycles of epithelial cell injury and fibroblast activation. Despite this impressive increase in understanding, a therapy that reverses this form of fibrosis remains elusive. In our previous study, we found that miR-29b has a therapeutic effect on pulmonary fibrosis. However, its anti-fibrotic mechanism is not yet clear. Recently, our study identified that F-Actin Binding Protein (TRIOBP) is one of the target gene...
Source: Cellular and Molecular Life Sciences : CMLS - December 29, 2023 Category: Cytology Authors: Lan Wang Wenyu Zhao Cong Xia Shuaichen Ma Zhongzheng Li Ningdan Wang Linke Ding Yaxuan Wang Lianhui Cheng Huibing Liu Juntang Yang Yajun Li Ivan Rosas Guoying Yu Source Type: research

Mitochondrial impairment, decreased sirtuin activity and protein acetylation in dorsal root ganglia in Friedreich Ataxia models
Cell Mol Life Sci. 2023 Dec 21;81(1):12. doi: 10.1007/s00018-023-05064-4.ABSTRACTFriedreich ataxia (FA) is a rare, recessive neuro-cardiodegenerative disease caused by deficiency of the mitochondrial protein frataxin. Mitochondrial dysfunction, a reduction in the activity of iron-sulfur enzymes, iron accumulation, and increased oxidative stress have been described. Dorsal root ganglion (DRG) sensory neurons are among the cellular types most affected in the early stages of this disease. However, its effect on mitochondrial function remains to be elucidated. In the present study, we found that in primary cultures of DRG neur...
Source: Cellular and Molecular Life Sciences : CMLS - December 21, 2023 Category: Cytology Authors: Arabela Sanz-Alc ázar Elena Britti Fabien Delaspre Marta Medina-Carbonero Maria Pazos-Gil Jordi Tamarit Joaquim Ros Elisa Cabiscol Source Type: research