Cellular and Molecular Life Sciences : CMLS This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

METTL16 inhibits papillary thyroid cancer tumorigenicity through m < sup > 6 < /sup > A/YTHDC2/SCD1-regulated lipid metabolism
In this study, it was demonstrated that the downregulation of METTL16 enhanced lipid metabolism and promoted the malignant progression of PTC. METTL16 was expressed at lower levels in PTC tissues because of DNMT1-mediated hypermethylation of its promoter. Loss- and gain-of-function studies clarified the effects of METTL16 on PTC progression. METTL16 overexpression increased the abundance of m6A in SCD1 cells, increasing RNA decay via the m6A reader YTHDC2. The SCD1 inhibitor A939572 inhibited growth and slowed down lipid metabolism in PTC cells. These results confirm the crucial role of METTL16 in restraining PTC progressi...
Source: Cellular and Molecular Life Sciences : CMLS - February 9, 2024 Category: Cytology Authors: Qiang Li Yaju Wang Xiangshu Meng Wenjing Wang Feifan Duan Shuya Chen Yukun Zhang Zhiyong Sheng Yu Gao Lei Zhou Source Type: research

Exploring the nexus of nuclear receptors in hematological malignancies
Cell Mol Life Sci. 2024 Feb 9;81(1):78. doi: 10.1007/s00018-023-05085-z.ABSTRACTHematological malignancies (HM) represent a subset of neoplasms affecting the blood, bone marrow, and lymphatic systems, categorized primarily into leukemia, lymphoma, and multiple myeloma. Their prognosis varies considerably, with a frequent risk of relapse despite ongoing treatments. While contemporary therapeutic strategies have extended overall patient survival, they do not offer cures for advanced stages and often lead to challenges such as acquisition of drug resistance, recurrence, and severe side effects. The need for innovative therape...
Source: Cellular and Molecular Life Sciences : CMLS - February 9, 2024 Category: Cytology Authors: Mukesh Kumar Manickasamy Anjana Sajeev Bandari BharathwajChetty Mohammed S Alqahtani Mohamed Abbas Mangala Hegde Babu Santha Aswani Mehdi Shakibaei Gautam Sethi Ajaikumar B Kunnumakkara Source Type: research

Wnt/ β-catenin-driven EMT regulation in human cancers
Cell Mol Life Sci. 2024 Feb 9;81(1):79. doi: 10.1007/s00018-023-05099-7.ABSTRACTMetastasis accounts for 90% of cancer-related deaths among the patients. The transformation of epithelial cells into mesenchymal cells with molecular alterations can occur during epithelial-mesenchymal transition (EMT). The EMT mechanism accelerates the cancer metastasis and drug resistance ability in human cancers. Among the different regulators of EMT, Wnt/β-catenin axis has been emerged as a versatile modulator. Wnt is in active form in physiological condition due to the function of GSK-3β that destructs β-catenin, while ligand-receptor i...
Source: Cellular and Molecular Life Sciences : CMLS - February 9, 2024 Category: Cytology Authors: Wenhua Xue Lin Yang Chengxin Chen Milad Ashrafizadeh Yu Tian Ranran Sun Source Type: research

A glimpse into novel acylations and their emerging role in regulating cancer metastasis
Cell Mol Life Sci. 2024 Feb 5;81(1):76. doi: 10.1007/s00018-023-05104-z.ABSTRACTMetastatic cancer is a major cause of cancer-related mortality; however, the complex regulation process remains to be further elucidated. A large amount of preliminary investigations focus on the role of epigenetic mechanisms in cancer metastasis. Notably, the posttranslational modifications were found to be critically involved in malignancy, thus attracting considerable attention. Beyond acetylation, novel forms of acylation have been recently identified following advances in mass spectrometry, proteomics technologies, and bioinformatics, such...
Source: Cellular and Molecular Life Sciences : CMLS - February 5, 2024 Category: Cytology Authors: Huifang Shi Weigang Cui Yan Qin Lei Chen Tao Yu Jie Lv Source Type: research

Decreased expression of the NLRP6 inflammasome is associated with increased intestinal permeability and inflammation in obesity with type 2 diabetes
CONCLUSIONS: The increased levels of intestinal damage markers together with the downregulation of NLRP6 and IL18 in the jejunum in obesity-associated T2D suggest a defective inflammasome sensing, driving to an impaired epithelial intestinal barrier that may regulate the progression of multiple obesity-associated comorbidities.PMID:38315242 | PMC:PMC10844155 | DOI:10.1007/s00018-024-05124-3 (Source: Cellular and Molecular Life Sciences : CMLS)
Source: Cellular and Molecular Life Sciences : CMLS - February 5, 2024 Category: Cytology Authors: Gema Fr ühbeck Javier G ómez-Ambrosi Beatriz Ram írez Sara Becerril Amaia Rodr íguez Amaia Mentxaka V íctor Valentí Rafael Moncada Gabriel Reina Jorge Baixauli Marcos Casado Camilo Silva Javier Escalada Victoria Catal án Source Type: research

LRP10 and α-synuclein transmission in Lewy body diseases
Cell Mol Life Sci. 2024 Feb 5;81(1):75. doi: 10.1007/s00018-024-05135-0.ABSTRACTAutosomal dominant variants in LRP10 have been identified in patients with Lewy body diseases (LBDs), including Parkinson's disease (PD), Parkinson's disease-dementia (PDD), and dementia with Lewy bodies (DLB). Nevertheless, there is little mechanistic insight into the role of LRP10 in disease pathogenesis. In the brains of control individuals, LRP10 is typically expressed in non-neuronal cells like astrocytes and neurovasculature, but in idiopathic and genetic cases of PD, PDD, and DLB, it is also present in α-synuclein-positive neuronal Lewy...
Source: Cellular and Molecular Life Sciences : CMLS - February 5, 2024 Category: Cytology Authors: Ana Carreras Mascaro Martyna M Grochowska Valerie Boumeester Natasja F J Dits Ece Naz Bilgi ҫ Guido J Breedveld Leonie Vergouw Frank Jan de Jong Martin E van Royen Vincenzo Bonifati Wim Mandemakers Source Type: research

Intervertebral disc-intrinsic Hedgehog signaling maintains disc cell phenotypes and prevents disc degeneration through both cell autonomous and non-autonomous mechanisms
Cell Mol Life Sci. 2024 Feb 3;81(1):74. doi: 10.1007/s00018-023-05106-x.ABSTRACTIntervertebral disc degeneration is closely related to abnormal phenotypic changes in disc cells. However, the mechanism by which disc cell phenotypes are maintained remains poorly understood. Here, Hedgehog-responsive cells were found to be specifically localized in the inner annulus fibrosus and cartilaginous endplate of postnatal discs, likely activated by Indian Hedgehog. Global inhibition of Hedgehog signaling using a pharmacological inhibitor or Agc1-CreERT2-mediated deletion of Smo in disc cells of juvenile mice led to spontaneous degene...
Source: Cellular and Molecular Life Sciences : CMLS - February 3, 2024 Category: Cytology Authors: Lei Zhang Siyuan Hu Chunmei Xiu Meng Li Yixin Zheng Rui Zhang Bin Li Jianquan Chen Source Type: research

N4-acetylcytidine modifies primary microRNAs for processing in cancer cells
In this study, we identified that NAT10/THUMPD1 acetylates primary microRNAs (pri-miRNAs) with ac4C modification. Knockdown of NAT10 suppresses and augments the expression levels of mature miRNAs and pri-miRNAs, respectively. Molecular mechanism studies found that pri-miRNA ac4C promotes the processing of pri-miRNA into precursor miRNA (pre-miRNA) by enhancing the interaction of pri-miRNA and DGCR8, thereby increasing the biogenesis of mature miRNA. Knockdown of NAT10 attenuates the oncogenic characters of lung cancer cells by regulating miRNA production in cancers. Moreover, NAT10 is highly expressed in various clinical c...
Source: Cellular and Molecular Life Sciences : CMLS - February 3, 2024 Category: Cytology Authors: Hailong Zhang Runhui Lu Jiayi Huang Lian Li Yingting Cao Caihu Huang Ran Chen Yanli Wang Jian Huang Xian Zhao Jianxiu Yu Source Type: research

Glucosylceramide in bunyavirus particles is essential for virus binding to host cells
This study also highlights the importance of glycolipids on virions in facilitating interactions with host cell receptors and infectious entry of enveloped viruses.PMID:38300320 | PMC:PMC10834583 | DOI:10.1007/s00018-023-05103-0 (Source: Cellular and Molecular Life Sciences : CMLS)
Source: Cellular and Molecular Life Sciences : CMLS - February 1, 2024 Category: Cytology Authors: Zina M Uckeley Ma ëva Duboeuf Yu Gu Alexandra Erny Magalie Mazelier Christian L üchtenborg Sophie L Winter Paulina Schad Cyrille Mathieu Jana Koch Steeve Boulant Petr Chlanda Carine Maisse Britta Br ügger Pierre-Yves Lozach Source Type: research

Combinatorial regulation by ERK1/2 and CK1 δ protein kinases leads to HIF-1α association with microtubules and facilitates its symmetrical distribution during mitosis
Cell Mol Life Sci. 2024 Feb 1;81(1):72. doi: 10.1007/s00018-024-05120-7.ABSTRACTHypoxia-inducible factor-1 (HIF-1) is the key transcriptional mediator of the cellular response to hypoxia and is also involved in cancer progression. Regulation of its oxygen-sensitive HIF-1α subunit involves post-translational modifications that control its stability, subcellular localization, and activity. We have previously reported that phosphorylation of the HIF-1α C-terminal domain by ERK1/2 promotes HIF-1α nuclear accumulation and stimulates HIF-1 activity while lack of this modification triggers HIF-1α nuclear export and its associ...
Source: Cellular and Molecular Life Sciences : CMLS - February 1, 2024 Category: Cytology Authors: Christina Arseni Martina Samiotaki George Panayotou George Simos Ilias Mylonis Source Type: research

Mirk/Dyrk1B controls ventral spinal cord development via Shh pathway
Cell Mol Life Sci. 2024 Jan 31;81(1):70. doi: 10.1007/s00018-023-05097-9.ABSTRACTCross-talk between Mirk/Dyrk1B kinase and Sonic hedgehog (Shh)/Gli pathway affects physiology and pathology. Here, we reveal a novel role for Dyrk1B in regulating ventral progenitor and neuron subtypes in the embryonic chick spinal cord (SC) via the Shh pathway. Using in ovo gain-and-loss-of-function approaches at E2, we report that Dyrk1B affects the proliferation and differentiation of neuronal progenitors at E4 and impacts on apoptosis specifically in the motor neuron (MN) domain. Especially, Dyrk1B overexpression decreases the numbers of v...
Source: Cellular and Molecular Life Sciences : CMLS - January 31, 2024 Category: Cytology Authors: N Kokkorakis K Douka A Nalmpanti P K Politis L Zagoraiou R Matsas M Gaitanou Source Type: research

SIRT3/6: an amazing challenge and opportunity in the fight against fibrosis and aging
Cell Mol Life Sci. 2024 Jan 31;81(1):69. doi: 10.1007/s00018-023-05093-z.ABSTRACTFibrosis is a typical aging-related pathological process involving almost all organs, including the heart, kidney, liver, lung, and skin. Fibrogenesis is a highly orchestrated process defined by sequences of cellular response and molecular signals mechanisms underlying the disease. In pathophysiologic conditions associated with organ fibrosis, a variety of injurious stimuli such as metabolic disorders, epigenetic changes, and aging may induce the progression of fibrosis. Sirtuins protein is a kind of deacetylase which can regulate cell metabol...
Source: Cellular and Molecular Life Sciences : CMLS - January 31, 2024 Category: Cytology Authors: Wenxin Wei Tian Li Jinlong Chen Zhen Fan Feng Gao Zhibiao Yu Yihao Jiang Source Type: research

MuSCs and IPCs: roles in skeletal muscle homeostasis, aging and injury
Cell Mol Life Sci. 2024 Jan 30;81(1):67. doi: 10.1007/s00018-023-05096-w.ABSTRACTSkeletal muscle is a highly specialized tissue composed of myofibres that performs crucial functions in movement and metabolism. In response to external stimuli and injuries, a range of stem/progenitor cells, with muscle stem cells or satellite cells (MuSCs) being the predominant cell type, are rapidly activated to repair and regenerate skeletal muscle within weeks. Under normal conditions, MuSCs remain in a quiescent state, but become proliferative and differentiate into new myofibres in response to injury. In addition to MuSCs, some intersti...
Source: Cellular and Molecular Life Sciences : CMLS - January 30, 2024 Category: Cytology Authors: Haiyan Jiang Boya Liu Junfei Lin Tong Xue Yimin Han Chunfeng Lu Songlin Zhou Yun Gu Feng Xu Yuntian Shen Lingchi Xu Hualin Sun Source Type: research

A novel aminopeptidase N/CD13 inhibitor selectively targets an endothelial form of CD13 after coupling to proteins
In conclusion, ECs express a catalytically inactive form of CD13 characterized by an accessible conformation that can be selectively targeted by G4-protein conjugates. This form of CD13 may represent a specific target receptor for ligand-directed targeted delivery of therapeutics to tumors.PMID:38289472 | PMC:PMC10827914 | DOI:10.1007/s00018-023-05102-1 (Source: Cellular and Molecular Life Sciences : CMLS)
Source: Cellular and Molecular Life Sciences : CMLS - January 30, 2024 Category: Cytology Authors: Giulia Anderluzzi Michela Ghitti Anna Maria Gasparri Giulia Tai è Angelina Sacchi Alessandro Gori Annapaola Andolfo Federica Pozzi Giovanna Musco Flavio Curnis Angelo Corti Source Type: research

Correction: Molecular tracking of interactions between progenitor and endothelial cells via Raman and FTIR spectroscopy imaging: a proof of concept of a new analytical strategy for in vitro research
Cell Mol Life Sci. 2024 Jan 28;81(1):66. doi: 10.1007/s00018-023-05038-6.NO ABSTRACTPMID:38281201 | PMC:PMC10822786 | DOI:10.1007/s00018-023-05038-6 (Source: Cellular and Molecular Life Sciences : CMLS)
Source: Cellular and Molecular Life Sciences : CMLS - January 28, 2024 Category: Cytology Authors: Karolina Augustyniak Aleksandra Pragnaca Monika Lesniak Marta Halasa Agata Borkowska Ewa Pieta Wojciech M Kwiatek Claudine Kieda Robert Zdanowski Kamilla Malek Source Type: research